PL374666A1 - Pyrrolidine derivatives as oxytocin antagonists - Google Patents

Pyrrolidine derivatives as oxytocin antagonists

Info

Publication number
PL374666A1
PL374666A1 PL03374666A PL37466603A PL374666A1 PL 374666 A1 PL374666 A1 PL 374666A1 PL 03374666 A PL03374666 A PL 03374666A PL 37466603 A PL37466603 A PL 37466603A PL 374666 A1 PL374666 A1 PL 374666A1
Authority
PL
Poland
Prior art keywords
sub
pyrrolidine derivatives
oxytocin antagonists
sup
forms
Prior art date
Application number
PL03374666A
Other languages
Polish (pl)
Inventor
Catherine Jorand-Lebrun
Jerome Dorbais
Anna Quattropani
Matthias Schwarz
Delphine Valognes
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of PL374666A1 publication Critical patent/PL374666A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The present invention relates to novel pyrrolidine derivative of formula (I), its geometrical isomers, its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate forms, as well as salts thereof, wherein R<SUP>1 </SUP>is selected from the group comprising or consisting of H and C<SUB>1</SUB>-C<SUB>6</SUB>-alkyl, for the prevention and/or treatment of preterm labor, premature birth or dysmenorrhea.
PL03374666A 2002-07-05 2003-07-04 Pyrrolidine derivatives as oxytocin antagonists PL374666A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02100784 2002-07-05

Publications (1)

Publication Number Publication Date
PL374666A1 true PL374666A1 (en) 2005-10-31

Family

ID=30011225

Family Applications (1)

Application Number Title Priority Date Filing Date
PL03374666A PL374666A1 (en) 2002-07-05 2003-07-04 Pyrrolidine derivatives as oxytocin antagonists

Country Status (20)

Country Link
US (1) US7115754B2 (en)
EP (1) EP1532109B1 (en)
JP (1) JP4851085B2 (en)
CN (1) CN1330633C (en)
AT (1) ATE442354T1 (en)
BR (1) BR0312586A (en)
CA (1) CA2487532C (en)
DE (1) DE60329189D1 (en)
EA (1) EA008479B1 (en)
ES (1) ES2330841T3 (en)
HK (1) HK1076107A1 (en)
HR (1) HRP20041208A2 (en)
IL (1) IL166103A0 (en)
MX (1) MXPA05000326A (en)
NO (1) NO20050612L (en)
PL (1) PL374666A1 (en)
RS (1) RS115804A (en)
UA (1) UA78058C2 (en)
WO (1) WO2004005249A1 (en)
ZA (1) ZA200409820B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE200400022A (en) * 2001-06-18 2004-04-15 Applied Research Systems Ars Holding N.V. Pyrrolidine oxadiazole and thiadiazole derivatives, process for their preparation and pharmaceutical compositions containing them
US10722645B2 (en) 2011-12-21 2020-07-28 Deka Products Limited Partnership Syringe pump, and related method and system
EP2845850A1 (en) 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
EP2886107A1 (en) * 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
CN114105850A (en) * 2014-07-02 2022-03-01 奥布赛瓦股份公司 Crystals useful in methods of treating disorders associated with OT-R activity
EP3501533A1 (en) * 2014-12-22 2019-06-26 Ferring B.V. Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies
ES2915948T3 (en) 2016-01-04 2022-06-27 ObsEva SA Co-administration of alpha-amino ester of hydroxypropylthiazolidine-carboxamide derivative and a tocolytic agent
UA127283C2 (en) 2016-07-21 2023-07-12 Обсева С.А. Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
US20220323410A1 (en) 2019-09-03 2022-10-13 ObsEva S.A. Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
CA3167121A1 (en) 2020-02-10 2021-08-19 ObsEva S.A. Biomarkers for oxytocin receptor antagonist therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329418B1 (en) * 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
EE200200555A (en) * 2000-03-27 2004-06-15 Applied Research Systems Ars Holding N.V. Pharmaceutically active pyrrolidine derivatives

Also Published As

Publication number Publication date
IL166103A0 (en) 2006-01-15
WO2004005249A1 (en) 2004-01-15
ES2330841T3 (en) 2009-12-16
EA200500133A1 (en) 2005-08-25
DE60329189D1 (en) 2009-10-22
JP2005533828A (en) 2005-11-10
RS115804A (en) 2007-02-05
HK1076107A1 (en) 2006-01-06
ATE442354T1 (en) 2009-09-15
JP4851085B2 (en) 2012-01-11
US20060004020A1 (en) 2006-01-05
US7115754B2 (en) 2006-10-03
BR0312586A (en) 2005-04-12
CN1678576A (en) 2005-10-05
HRP20041208A2 (en) 2005-06-30
CA2487532A1 (en) 2004-01-15
EA008479B1 (en) 2007-06-29
CN1330633C (en) 2007-08-08
UA78058C2 (en) 2007-02-15
AU2003254498A1 (en) 2004-01-23
EP1532109A1 (en) 2005-05-25
EP1532109B1 (en) 2009-09-09
NO20050612L (en) 2005-02-03
CA2487532C (en) 2011-03-08
MXPA05000326A (en) 2005-03-31
ZA200409820B (en) 2006-07-26

Similar Documents

Publication Publication Date Title
HK1076107A1 (en) Pyrrolidine derivatives as oxytocin antagonists
NO20050134L (en) Diphenyllazidide ions substituted with acid groups, process for their preparation, drugs containing these compounds and their use
BR0314688A (en) New piperidine derivatives for use in the treatment of chemokine mediated disease states
EA200301216A1 (en) MULTICYCLIC HETEROARYLS SUBSTITUTED WITH QUINUCLIDINES FOR THE DISEASE TREATMENT
AP1822A (en) Substituted pyridinones as modulators of P38 MAP kinase.
CO5611065A2 (en) DIFLUOROMETILTIAZOLILCARBOXANILIDAS
EA200301306A1 (en) DERIVATIVES 1-PHENYLSULFONIL-1,3-DIHYDRO-2H-INDOL-2-SHE, THEIR PRODUCTION AND THEIR THERAPEUTIC APPLICATION
DE60315674D1 (en) NEW IMIDAZOPYRIDINE AND ITS USE
MXPA03011638A (en) 4-piperazinylindole derivatives with 5-ht6 receptor affinity.
ATE357434T1 (en) DISUBSTITUTED THIAZOLYLCARBOXANILIDES AND THEIR USE AS MICROBICIDES
AR041298A1 (en) PIRROLIDONE DERIVATIVES AS MAOB INHIBITORS
HK1155146A1 (en) Indene derivatives as pharmaceutical agents
TR200000670T2 (en) Aromatic C16-C20-substituted tetrahydro prostaglandins useful as FP agonists.
EA200601194A1 (en) NEW DERIVATIVES OF BENZOFURANE USED FOR THE PREVENTION OR TREATMENT OF DISTURBANCES ASSOCIATED WITH 5-HT-RECEPTOR
NO20060718L (en) Substituted thiophones and their use
SE0200919D0 (en) Chemical compounds
EA200301203A1 (en) NEW COMPOUNDS AND COMPOSITIONS AS KATEPSIN INHIBITORS
ES2202156T3 (en) NEW ANALOGS OF 2-DESCARBOXI-2-PHOSPHINIC PROSTAGLANDINA F.
NO20054418L (en) Substituted benzoylureidopyridylpiperidine and pyrrolidinecarboxylic acid derivatives, their preparation and use
DE50304891D1 (en) N-ARYL-4,5-DIAMINOPYRACOLE AND STAINERS CONTAINING THESE COMPOUNDS
WO2001070693A3 (en) Difluorobutyric acid derivatives and their use as metalloprotease inhibitors
WO2002046152A3 (en) Coniosetin and derivatives thereof, method for producing the same and use thereof
IL153784A0 (en) Novel n-(2-phenyl-3-aminopropyl) naphthamides
NO20052413L (en) Substituted aralkyl derivatives
SG146685A1 (en) Dihydroporphine derivatives, processes for their preparation, and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)