BR0312586A - Derivados de pirolidina como antagonistas e oxitocina - Google Patents

Derivados de pirolidina como antagonistas e oxitocina

Info

Publication number
BR0312586A
BR0312586A BR0312586-6A BR0312586A BR0312586A BR 0312586 A BR0312586 A BR 0312586A BR 0312586 A BR0312586 A BR 0312586A BR 0312586 A BR0312586 A BR 0312586A
Authority
BR
Brazil
Prior art keywords
sub
oxytocin
antagonists
sup
pyrolidine
Prior art date
Application number
BR0312586-6A
Other languages
English (en)
Inventor
Catherine Jorand-Lebrun
Jerome Dorbais
Anna Quattropani
Matthias Schwarz
Delphine Valognes
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of BR0312586A publication Critical patent/BR0312586A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADOS DE PIROLIDINA COMO ANTAGONISTAS DE OXITOCINA". A presente invenção diz respeito a um novo derivado de pirolidina da fórmula (I), seus isómeros geométricos, suas formas oticamente ativas como enantiomeros, diastereomeros, misturas destes e suas formas "racemates", assim como sais, onde R^ 1^ é selecionado do grupo incluindo ou que consiste em H e C~ 1~-C~ 4~-alquil, para a prevenção e/ou tratamento de trabalho de parto antecipado, nascimento prematuro ou dismenorréia.
BR0312586-6A 2002-07-05 2003-07-04 Derivados de pirolidina como antagonistas e oxitocina BR0312586A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02100784 2002-07-05
PCT/EP2003/050286 WO2004005249A1 (en) 2002-07-05 2003-07-04 Pyrrolidine derivatives as oxytocin antagonists

Publications (1)

Publication Number Publication Date
BR0312586A true BR0312586A (pt) 2005-04-12

Family

ID=30011225

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312586-6A BR0312586A (pt) 2002-07-05 2003-07-04 Derivados de pirolidina como antagonistas e oxitocina

Country Status (20)

Country Link
US (1) US7115754B2 (pt)
EP (1) EP1532109B1 (pt)
JP (1) JP4851085B2 (pt)
CN (1) CN1330633C (pt)
AT (1) ATE442354T1 (pt)
BR (1) BR0312586A (pt)
CA (1) CA2487532C (pt)
DE (1) DE60329189D1 (pt)
EA (1) EA008479B1 (pt)
ES (1) ES2330841T3 (pt)
HK (1) HK1076107A1 (pt)
HR (1) HRP20041208A2 (pt)
IL (1) IL166103A0 (pt)
MX (1) MXPA05000326A (pt)
NO (1) NO20050612L (pt)
PL (1) PL374666A1 (pt)
RS (1) RS115804A (pt)
UA (1) UA78058C2 (pt)
WO (1) WO2004005249A1 (pt)
ZA (1) ZA200409820B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20033475A3 (en) * 2001-06-18 2004-05-12 Appliedáresearchásystemsáarsáholdingán@V Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists.
US10722645B2 (en) 2011-12-21 2020-07-28 Deka Products Limited Partnership Syringe pump, and related method and system
EP2845850A1 (en) * 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
EP2886107A1 (en) * 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
CN106795110A (zh) * 2014-07-02 2017-05-31 奥布赛瓦股份公司 治疗ot‑r活性相关的病症的方法中可用的晶体(3z，5s)‑5‑(羟甲基)‑1‑[(2’‑甲基‑1，1’‑联苯‑4‑基)羰基]吡咯烷‑3‑酮o‑甲基肟
EP3037101B1 (en) 2014-12-22 2019-03-06 Ferring B.V. Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies
IL284912B (en) 2016-01-04 2022-07-01 Merck Serono Sa L-Valinate derivative of hydroxypropylthiazolidine carboxamide and salt form, crystalline polymorph thereof
CA3031252A1 (en) 2016-07-21 2018-01-25 ObsEva S.A. Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
CN114667141A (zh) 2019-09-03 2022-06-24 奥布赛瓦股份公司 用于促进胚胎移植和预防流产的催产素拮抗剂给药方案
US20230102503A1 (en) 2020-02-10 2023-03-30 ObsEva S.A. Biomarkers for oxytocin receptor antagonist therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
ES2261404T3 (es) * 2000-03-27 2006-11-16 Applied Research Systems Ars Holding N.V. Derivados de pirrolidina utiles como inhibidores de bax.

Also Published As

Publication number Publication date
CA2487532A1 (en) 2004-01-15
CN1330633C (zh) 2007-08-08
EP1532109B1 (en) 2009-09-09
UA78058C2 (en) 2007-02-15
CN1678576A (zh) 2005-10-05
US20060004020A1 (en) 2006-01-05
CA2487532C (en) 2011-03-08
DE60329189D1 (de) 2009-10-22
AU2003254498A1 (en) 2004-01-23
IL166103A0 (en) 2006-01-15
US7115754B2 (en) 2006-10-03
ATE442354T1 (de) 2009-09-15
RS115804A (en) 2007-02-05
NO20050612L (no) 2005-02-03
EA008479B1 (ru) 2007-06-29
PL374666A1 (en) 2005-10-31
ES2330841T3 (es) 2009-12-16
HK1076107A1 (en) 2006-01-06
EA200500133A1 (ru) 2005-08-25
WO2004005249A1 (en) 2004-01-15
HRP20041208A2 (en) 2005-06-30
JP2005533828A (ja) 2005-11-10
ZA200409820B (en) 2006-07-26
MXPA05000326A (es) 2005-03-31
JP4851085B2 (ja) 2012-01-11
EP1532109A1 (en) 2005-05-25

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A. E 7A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2064 DE 27/07/2010.