BR0110255A - Cromenilmetil pirimidinadiaminas como agentes antibacterianos - Google Patents

Cromenilmetil pirimidinadiaminas como agentes antibacterianos

Info

Publication number
BR0110255A
BR0110255A BR0110255-9A BR0110255A BR0110255A BR 0110255 A BR0110255 A BR 0110255A BR 0110255 A BR0110255 A BR 0110255A BR 0110255 A BR0110255 A BR 0110255A
Authority
BR
Brazil
Prior art keywords
pyrimidinadiamines
chromylmethyl
medicaments
substances
antibacterial agents
Prior art date
Application number
BR0110255-9A
Other languages
English (en)
Inventor
Peter Mohr
Philippe Pflieger
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of BR0110255A publication Critical patent/BR0110255A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"CROMENILMETIL PIRIMIDINADIAMINAS COMO AGENTES ANTIBACTERIANOS". A presente invenção refere-se a derivados de cromeno substituídos de fórmula geral: em que R^ 1^ representa alquila ou cicloalquilalquila; R^ 2^ e R^ 3^ cada qual independentemente representam alquila ou cicloalquila ou tomados juntos com o átomo de carbono adjacente representam um anel carbocíclico ou heterocíclico saturado de 3 a 6 membros, o grupo alquila, cicloalquila do anel carbocíclico ou heterocíclico sendo não-substituído ou sendo substituído; e R^ 4^ representa hidrogênio, halogênio, ciano, alquila, alquiltio, alquenila, alquinila, hidroxialquila, hidroxialquinila, alcoxialquila, alcoxialquinila, trialquilsilila, arila ou heteroarila; e sais de adição ácidos farmaceuticamente aceitáveis desses compostos, seu uso como substâncias terapeuticamente ativas; medicamentos baseados nessas substâncias, opcionalmente em combinação com sulfonamidas e sua produção; uso dessas substâncias como medicamentos para produção de medicamentos antibióticos ativos; assim como a fabricação dos compostos de fórmula (I) e seus sais de adição ácidos farmaceuticamente aceitáveis e intermediários para sua fabricação.
BR0110255-9A 2000-04-27 2001-04-20 Cromenilmetil pirimidinadiaminas como agentes antibacterianos BR0110255A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00108945 2000-04-27
PCT/EP2001/004541 WO2001083476A1 (en) 2000-04-27 2001-04-20 Chromenylmethyl pyrimidinediamines as antibacterial agents

Publications (1)

Publication Number Publication Date
BR0110255A true BR0110255A (pt) 2003-01-07

Family

ID=8168565

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0110255-9A BR0110255A (pt) 2000-04-27 2001-04-20 Cromenilmetil pirimidinadiaminas como agentes antibacterianos

Country Status (14)

Country Link
US (1) US6818649B2 (pt)
EP (1) EP1278742B1 (pt)
JP (1) JP4033676B2 (pt)
KR (1) KR20020093966A (pt)
CN (1) CN1249057C (pt)
AT (1) ATE284882T1 (pt)
AU (1) AU2001252269A1 (pt)
BR (1) BR0110255A (pt)
CA (1) CA2405614A1 (pt)
DE (1) DE60107832T2 (pt)
ES (1) ES2232614T3 (pt)
MX (1) MXPA02010518A (pt)
WO (1) WO2001083476A1 (pt)
ZA (1) ZA200208271B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243173B (en) 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
NZ546834A (en) 2003-10-01 2010-03-26 Adolor Corp Spirocyclic heterocyclic derivatives and methods of their use
EP2161275A1 (en) * 2005-01-19 2010-03-10 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP1770089A1 (en) * 2005-10-03 2007-04-04 Institut Pasteur Pyranodibenzofuran derivatives with antifungal and antibacterial activity
US7855194B2 (en) 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
CN109134493A (zh) * 2018-09-19 2019-01-04 浙江师范大学 一种具有抗菌活性的2-氧代色烯并噻吩衍生物及其合成方法和应用
CN109988156B (zh) * 2019-03-12 2021-12-28 广东中科药物研究有限公司 一种氨基嘧啶化合物
CN112824412B (zh) * 2019-11-21 2022-09-16 中国科学院大连化学物理研究所 手性1′H-螺[吲哚啉-3,4′-吡喃并[2,3-c]吡唑]-2-酮类化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE212629T1 (de) 1995-12-04 2002-02-15 Arpida Ag Diaminopyrimidine, diese enthaltende pharmazeutische zusammensetzungen und ihre verwendung als antibakterielle mittel

Also Published As

Publication number Publication date
EP1278742A1 (en) 2003-01-29
JP4033676B2 (ja) 2008-01-16
CN1507445A (zh) 2004-06-23
AU2001252269A1 (en) 2001-11-12
US20030144246A1 (en) 2003-07-31
DE60107832T2 (de) 2005-06-16
KR20020093966A (ko) 2002-12-16
JP2004509839A (ja) 2004-04-02
US6818649B2 (en) 2004-11-16
ZA200208271B (en) 2004-01-26
WO2001083476A1 (en) 2001-11-08
ES2232614T3 (es) 2005-06-01
CN1249057C (zh) 2006-04-05
CA2405614A1 (en) 2001-11-08
DE60107832D1 (en) 2005-01-20
MXPA02010518A (es) 2003-03-10
EP1278742B1 (en) 2004-12-15
ATE284882T1 (de) 2005-01-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1963 DE 19.08.2008.