RS115804A - Pyrrolidine derivatives as oxytocin antagonists - Google Patents

Pyrrolidine derivatives as oxytocin antagonists

Info

Publication number
RS115804A
RS115804A YUP-1158/04A YUP115804A RS115804A RS 115804 A RS115804 A RS 115804A YU P115804 A YUP115804 A YU P115804A RS 115804 A RS115804 A RS 115804A
Authority
RS
Serbia
Prior art keywords
pyrrolidine derivatives
oxytocin antagonists
forms
dysmenorrhea
diastereomers
Prior art date
Application number
YUP-1158/04A
Other languages
English (en)
Inventor
Catherine Jorand Le Brun
Jerome Dorbais
Anna Quattropani
Matthias Schwarz
Delphine Valognes
Original Assignee
Applied Research Systems Ars Holding N.V.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V., filed Critical Applied Research Systems Ars Holding N.V.,
Publication of RS115804A publication Critical patent/RS115804A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Ovaj pronalazak se odnosi na novi derivat pirolidina Formule I, njegove geometrijske izomere, njegove optički aktivne oblike u vidu enanciomera, dijastereomera i njihove mešavine kao i na njegove racemske oblike i njihove soli, što je naznačeno time da je R1 odabrano iz grupe koja obuhvata ili se sastoji od H i C1-C6-alkila.
YUP-1158/04A 2002-07-05 2003-07-04 Pyrrolidine derivatives as oxytocin antagonists RS115804A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02100784 2002-07-05
PCT/EP2003/050286 WO2004005249A1 (en) 2002-07-05 2003-07-04 Pyrrolidine derivatives as oxytocin antagonists

Publications (1)

Publication Number Publication Date
RS115804A true RS115804A (en) 2007-02-05

Family

ID=30011225

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-1158/04A RS115804A (en) 2002-07-05 2003-07-04 Pyrrolidine derivatives as oxytocin antagonists

Country Status (20)

Country Link
US (1) US7115754B2 (sr)
EP (1) EP1532109B1 (sr)
JP (1) JP4851085B2 (sr)
CN (1) CN1330633C (sr)
AT (1) ATE442354T1 (sr)
BR (1) BR0312586A (sr)
CA (1) CA2487532C (sr)
DE (1) DE60329189D1 (sr)
EA (1) EA008479B1 (sr)
ES (1) ES2330841T3 (sr)
HK (1) HK1076107A1 (sr)
HR (1) HRP20041208A2 (sr)
IL (1) IL166103A0 (sr)
MX (1) MXPA05000326A (sr)
NO (1) NO20050612L (sr)
PL (1) PL374666A1 (sr)
RS (1) RS115804A (sr)
UA (1) UA78058C2 (sr)
WO (1) WO2004005249A1 (sr)
ZA (1) ZA200409820B (sr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0211030A (pt) * 2001-06-18 2004-06-22 Applied Research Systems Derivado de pirrolidina oxadiazole, uso de um derivado de pirrolidina oxadiazole, composição farmacêutica contendo pelo menos um derivado de pirrolidina oxadiazole, método para preparação de um composto de pirrolidina oxadiazole
US10722645B2 (en) 2011-12-21 2020-07-28 Deka Products Limited Partnership Syringe pump, and related method and system
EP2845850A1 (en) * 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
EP3753921A1 (en) * 2014-07-02 2020-12-23 ObsEva S.A. Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime useful in methods of treating conditions related to the ot-r activity
PL3037101T3 (pl) 2014-12-22 2019-06-28 Ferring B.V. Terapia antagonistą receptora oksytocyny w fazie lutealnej w celu implantacji i uzyskania ciąży u kobiet poddawanych technikom wspomaganego rozrodu
LT3397622T (lt) 2016-01-04 2022-06-27 ObsEva S.A. Hidroksipropiltiazolidino karboksamido darinio alfa-amino esterio ir tokolitinio agento įvedimas kartu
WO2018015497A2 (en) 2016-07-21 2018-01-25 ObsEva S.A. Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
CN114667141A (zh) 2019-09-03 2022-06-24 奥布赛瓦股份公司 用于促进胚胎移植和预防流产的催产素拮抗剂给药方案
US20230102503A1 (en) 2020-02-10 2023-03-30 ObsEva S.A. Biomarkers for oxytocin receptor antagonist therapy
WO2024165071A1 (zh) * 2023-02-09 2024-08-15 上海葆正医药科技有限公司 亚胺化合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329418B1 (en) * 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
MXPA02009382A (es) * 2000-03-27 2003-01-28 Applied Research Systems Derivados de pirrolidina farmaceuticamente activos.

Also Published As

Publication number Publication date
CA2487532C (en) 2011-03-08
HK1076107A1 (en) 2006-01-06
EA200500133A1 (ru) 2005-08-25
EP1532109B1 (en) 2009-09-09
UA78058C2 (en) 2007-02-15
DE60329189D1 (de) 2009-10-22
JP2005533828A (ja) 2005-11-10
JP4851085B2 (ja) 2012-01-11
CN1330633C (zh) 2007-08-08
PL374666A1 (en) 2005-10-31
CN1678576A (zh) 2005-10-05
MXPA05000326A (es) 2005-03-31
NO20050612L (no) 2005-02-03
ATE442354T1 (de) 2009-09-15
US7115754B2 (en) 2006-10-03
ZA200409820B (en) 2006-07-26
US20060004020A1 (en) 2006-01-05
EP1532109A1 (en) 2005-05-25
BR0312586A (pt) 2005-04-12
IL166103A0 (en) 2006-01-15
WO2004005249A1 (en) 2004-01-15
ES2330841T3 (es) 2009-12-16
AU2003254498A1 (en) 2004-01-23
EA008479B1 (ru) 2007-06-29
CA2487532A1 (en) 2004-01-15
HRP20041208A2 (en) 2005-06-30

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