DE60329189D1 - Pyrrolidinderivate als oxytocin antagonisten - Google Patents
Pyrrolidinderivate als oxytocin antagonistenInfo
- Publication number
- DE60329189D1 DE60329189D1 DE60329189T DE60329189T DE60329189D1 DE 60329189 D1 DE60329189 D1 DE 60329189D1 DE 60329189 T DE60329189 T DE 60329189T DE 60329189 T DE60329189 T DE 60329189T DE 60329189 D1 DE60329189 D1 DE 60329189D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- pyrrolidine derivatives
- oxytocin antagonists
- sup
- forms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02100784 | 2002-07-05 | ||
| PCT/EP2003/050286 WO2004005249A1 (en) | 2002-07-05 | 2003-07-04 | Pyrrolidine derivatives as oxytocin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60329189D1 true DE60329189D1 (de) | 2009-10-22 |
Family
ID=30011225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60329189T Expired - Lifetime DE60329189D1 (de) | 2002-07-05 | 2003-07-04 | Pyrrolidinderivate als oxytocin antagonisten |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7115754B2 (de) |
| EP (1) | EP1532109B1 (de) |
| JP (1) | JP4851085B2 (de) |
| CN (1) | CN1330633C (de) |
| AT (1) | ATE442354T1 (de) |
| BR (1) | BR0312586A (de) |
| CA (1) | CA2487532C (de) |
| DE (1) | DE60329189D1 (de) |
| EA (1) | EA008479B1 (de) |
| ES (1) | ES2330841T3 (de) |
| HK (1) | HK1076107A1 (de) |
| HR (1) | HRP20041208A2 (de) |
| IL (1) | IL166103A0 (de) |
| MX (1) | MXPA05000326A (de) |
| NO (1) | NO20050612L (de) |
| PL (1) | PL374666A1 (de) |
| RS (1) | RS115804A (de) |
| UA (1) | UA78058C2 (de) |
| WO (1) | WO2004005249A1 (de) |
| ZA (1) | ZA200409820B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100564378C (zh) * | 2001-06-18 | 2009-12-02 | 雪兰诺实验室有限公司 | 吡咯烷噁二唑及噻二唑衍生物 |
| US10722645B2 (en) | 2011-12-21 | 2020-07-28 | Deka Products Limited Partnership | Syringe pump, and related method and system |
| EP2845850A1 (de) | 2013-09-10 | 2015-03-11 | ObsEva S.A. | Pyrrolidinderivate als Oxytocin/Vasopressin-V1a-Rezeptorantagonisten |
| EP2886107A1 (de) * | 2013-12-17 | 2015-06-24 | ObsEva S.A. | Orale Formulierungen von Pyrrolydinderivaten |
| AU2015283133B2 (en) * | 2014-07-02 | 2019-05-16 | ObsEva SA | Crystalline (3Z,5S)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one O-methyloxime useful in methods of treating conditions related to the OT-R activity |
| EP3037101B1 (de) * | 2014-12-22 | 2019-03-06 | Ferring B.V. | Oxytocinrezeptorantagonistentherapie in der Lutealphase für Implantation und Schwangerschaft bei mit Technologien zur unterstützten Fortpflanzung behandelten Frauen |
| PL3400217T3 (pl) | 2016-01-04 | 2022-07-04 | Merck Serono S.A. | L-walinian pochodnej hydroksypropylotiazolidynokarboksyamidu, jego sól i postać krystaliczna |
| KR20230165386A (ko) | 2016-07-21 | 2023-12-05 | 옵스에파 에스에이 | 배아 착상을 촉진하고 유산을 예방하기 위한 옥시토신 길항제 투약 레지멘 |
| CA3149898A1 (en) | 2019-09-03 | 2021-03-11 | Ernest Loumaye | Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage |
| CA3167121A1 (en) | 2020-02-10 | 2021-08-19 | ObsEva S.A. | Biomarkers for oxytocin receptor antagonist therapy |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329418B1 (en) | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
| MXPA02009382A (es) * | 2000-03-27 | 2003-01-28 | Applied Research Systems | Derivados de pirrolidina farmaceuticamente activos. |
-
2003
- 2003-04-07 UA UA20041210895A patent/UA78058C2/uk unknown
- 2003-07-04 CA CA2487532A patent/CA2487532C/en not_active Expired - Fee Related
- 2003-07-04 AT AT03762692T patent/ATE442354T1/de not_active IP Right Cessation
- 2003-07-04 MX MXPA05000326A patent/MXPA05000326A/es active IP Right Grant
- 2003-07-04 EP EP03762692A patent/EP1532109B1/de not_active Expired - Lifetime
- 2003-07-04 DE DE60329189T patent/DE60329189D1/de not_active Expired - Lifetime
- 2003-07-04 EA EA200500133A patent/EA008479B1/ru not_active IP Right Cessation
- 2003-07-04 RS YUP-1158/04A patent/RS115804A/sr unknown
- 2003-07-04 US US10/518,543 patent/US7115754B2/en not_active Expired - Lifetime
- 2003-07-04 PL PL03374666A patent/PL374666A1/xx not_active Application Discontinuation
- 2003-07-04 CN CNB038204010A patent/CN1330633C/zh not_active Expired - Fee Related
- 2003-07-04 WO PCT/EP2003/050286 patent/WO2004005249A1/en active Application Filing
- 2003-07-04 JP JP2004518783A patent/JP4851085B2/ja not_active Expired - Fee Related
- 2003-07-04 ES ES03762692T patent/ES2330841T3/es not_active Expired - Lifetime
- 2003-07-04 BR BR0312586-6A patent/BR0312586A/pt not_active IP Right Cessation
-
2004
- 2004-12-03 ZA ZA200409820A patent/ZA200409820B/en unknown
- 2004-12-23 HR HR20041208A patent/HRP20041208A2/xx not_active Application Discontinuation
-
2005
- 2005-01-03 IL IL16610305A patent/IL166103A0/xx unknown
- 2005-02-03 NO NO20050612A patent/NO20050612L/no not_active Application Discontinuation
- 2005-11-17 HK HK05110274A patent/HK1076107A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EA200500133A1 (ru) | 2005-08-25 |
| EA008479B1 (ru) | 2007-06-29 |
| ZA200409820B (en) | 2006-07-26 |
| NO20050612L (no) | 2005-02-03 |
| ATE442354T1 (de) | 2009-09-15 |
| US7115754B2 (en) | 2006-10-03 |
| CN1330633C (zh) | 2007-08-08 |
| EP1532109B1 (de) | 2009-09-09 |
| CA2487532A1 (en) | 2004-01-15 |
| HK1076107A1 (en) | 2006-01-06 |
| MXPA05000326A (es) | 2005-03-31 |
| ES2330841T3 (es) | 2009-12-16 |
| CN1678576A (zh) | 2005-10-05 |
| US20060004020A1 (en) | 2006-01-05 |
| BR0312586A (pt) | 2005-04-12 |
| AU2003254498A1 (en) | 2004-01-23 |
| EP1532109A1 (de) | 2005-05-25 |
| JP2005533828A (ja) | 2005-11-10 |
| PL374666A1 (en) | 2005-10-31 |
| UA78058C2 (en) | 2007-02-15 |
| WO2004005249A1 (en) | 2004-01-15 |
| RS115804A (en) | 2007-02-05 |
| CA2487532C (en) | 2011-03-08 |
| HRP20041208A2 (en) | 2005-06-30 |
| JP4851085B2 (ja) | 2012-01-11 |
| IL166103A0 (en) | 2006-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |