BRPI0414972A - derivados de imidazopiridinas como inibidores de no-sintase induzìvel - Google Patents
derivados de imidazopiridinas como inibidores de no-sintase induzìvelInfo
- Publication number
- BRPI0414972A BRPI0414972A BRPI0414972-6A BRPI0414972A BRPI0414972A BR PI0414972 A BRPI0414972 A BR PI0414972A BR PI0414972 A BRPI0414972 A BR PI0414972A BR PI0414972 A BRPI0414972 A BR PI0414972A
- Authority
- BR
- Brazil
- Prior art keywords
- inducibly
- synthase inhibitors
- imidazopyridine derivatives
- inducible
- inducible synthase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
"DERIVADOS DE IMIDAZOPIRIDINAS COMO INIBIDORES DE NO-SINTASE INDUZìVEL". A presente invenção refere-se a compostos da fórmula (I) nos quais R1, R2, R3, R4, R5 e A têm os significados fornecidos no relatório descritivo, que são inibidores eficazes inusitados de iNOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03022053 | 2003-10-01 | ||
PCT/EP2004/052378 WO2005030771A1 (en) | 2003-10-01 | 2004-09-30 | Imidazopyridine-derivatives as inductible no-synthase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0414972A true BRPI0414972A (pt) | 2006-11-07 |
Family
ID=34384571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0414972-6A BRPI0414972A (pt) | 2003-10-01 | 2004-09-30 | derivados de imidazopiridinas como inibidores de no-sintase induzìvel |
Country Status (20)
Country | Link |
---|---|
US (2) | US7468377B2 (pt) |
EP (1) | EP1675854B1 (pt) |
JP (1) | JP2007507467A (pt) |
KR (1) | KR20060092220A (pt) |
CN (1) | CN100415745C (pt) |
AT (1) | ATE399169T1 (pt) |
AU (1) | AU2004276015A1 (pt) |
BR (1) | BRPI0414972A (pt) |
CA (1) | CA2540083A1 (pt) |
DE (1) | DE602004014630D1 (pt) |
EA (1) | EA010261B1 (pt) |
ES (1) | ES2309567T3 (pt) |
HK (1) | HK1096548A1 (pt) |
IL (1) | IL173895A0 (pt) |
MX (1) | MXPA06003349A (pt) |
NO (1) | NO20061344L (pt) |
NZ (1) | NZ546437A (pt) |
RS (1) | RS20060196A (pt) |
WO (1) | WO2005030771A1 (pt) |
ZA (1) | ZA200601642B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA200600607A1 (ru) | 2003-10-01 | 2006-10-27 | Алтана Фарма Аг | Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы |
MXPA06003345A (es) | 2003-10-01 | 2006-06-08 | Altana Pharma Ag | Derivados de aminopiridina como inhibidores de la no-sintasa inducible. |
JP2007507463A (ja) | 2003-10-01 | 2007-03-29 | アルタナ ファルマ アクチエンゲゼルシャフト | 誘導性NOシンターゼ阻害剤としてのイミダゾ[4,5−b]ピリジン誘導体 |
ES2309567T3 (es) * | 2003-10-01 | 2008-12-16 | Nycomed Gmbh | Derivados de imidazopiridinas como inhibidores de no-sintasa inducible. |
AR057525A1 (es) * | 2005-10-03 | 2007-12-05 | Astrazeneca Ab | Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion |
UY29825A1 (es) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones |
US9133186B2 (en) * | 2010-09-10 | 2015-09-15 | Shionogi & Co., Ltd. | Hetero ring-fused imidazole derivative having AMPK activating effect |
GB201512635D0 (en) | 2015-07-17 | 2015-08-26 | Ucl Business Plc | Uses of therapeutic compounds |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4045564A (en) * | 1974-02-18 | 1977-08-30 | Ab Hassle | Benzimidazole derivatives useful as gastric acid secretion inhibitors |
SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
SE512835C2 (sv) | 1996-01-08 | 2000-05-22 | Astrazeneca Ab | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
AUPP873799A0 (en) * | 1999-02-17 | 1999-03-11 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine compounds |
ATE384722T1 (de) * | 2002-03-27 | 2008-02-15 | Nycomed Gmbh | Alkoxypyridinderivate |
WO2004039806A1 (ja) * | 2002-10-30 | 2004-05-13 | Ajinomoto Co., Inc. | 複素環化合物 |
EA200600607A1 (ru) * | 2003-10-01 | 2006-10-27 | Алтана Фарма Аг | Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы |
RS20060195A (en) | 2003-10-01 | 2008-08-07 | Altana Pharma Ag., | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
MXPA06003345A (es) | 2003-10-01 | 2006-06-08 | Altana Pharma Ag | Derivados de aminopiridina como inhibidores de la no-sintasa inducible. |
JP2007507463A (ja) | 2003-10-01 | 2007-03-29 | アルタナ ファルマ アクチエンゲゼルシャフト | 誘導性NOシンターゼ阻害剤としてのイミダゾ[4,5−b]ピリジン誘導体 |
ES2309567T3 (es) * | 2003-10-01 | 2008-12-16 | Nycomed Gmbh | Derivados de imidazopiridinas como inhibidores de no-sintasa inducible. |
-
2004
- 2004-09-30 ES ES04787263T patent/ES2309567T3/es active Active
- 2004-09-30 WO PCT/EP2004/052378 patent/WO2005030771A1/en active IP Right Grant
- 2004-09-30 DE DE602004014630T patent/DE602004014630D1/de active Active
- 2004-09-30 RS YUP-2006/0196A patent/RS20060196A/sr unknown
- 2004-09-30 US US10/573,484 patent/US7468377B2/en not_active Expired - Fee Related
- 2004-09-30 AT AT04787263T patent/ATE399169T1/de not_active IP Right Cessation
- 2004-09-30 CA CA002540083A patent/CA2540083A1/en not_active Abandoned
- 2004-09-30 EA EA200600608A patent/EA010261B1/ru not_active IP Right Cessation
- 2004-09-30 CN CNB2004800275920A patent/CN100415745C/zh not_active Expired - Fee Related
- 2004-09-30 NZ NZ546437A patent/NZ546437A/en unknown
- 2004-09-30 BR BRPI0414972-6A patent/BRPI0414972A/pt not_active IP Right Cessation
- 2004-09-30 KR KR1020067005873A patent/KR20060092220A/ko not_active Application Discontinuation
- 2004-09-30 JP JP2006530264A patent/JP2007507467A/ja not_active Withdrawn
- 2004-09-30 EP EP04787263A patent/EP1675854B1/en active Active
- 2004-09-30 MX MXPA06003349A patent/MXPA06003349A/es not_active Application Discontinuation
- 2004-09-30 AU AU2004276015A patent/AU2004276015A1/en not_active Abandoned
-
2006
- 2006-02-23 IL IL173895A patent/IL173895A0/en unknown
- 2006-02-24 ZA ZA200601642A patent/ZA200601642B/en unknown
- 2006-03-24 NO NO20061344A patent/NO20061344L/no not_active Application Discontinuation
-
2007
- 2007-04-11 HK HK07103760.5A patent/HK1096548A1/xx unknown
-
2008
- 2008-09-26 US US12/232,973 patent/US20090036482A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1675854B1 (en) | 2008-06-25 |
US20090036482A1 (en) | 2009-02-05 |
EP1675854A1 (en) | 2006-07-05 |
NZ546437A (en) | 2009-09-25 |
AU2004276015A1 (en) | 2005-04-07 |
NO20061344L (no) | 2006-03-24 |
CA2540083A1 (en) | 2005-04-07 |
US20070043073A1 (en) | 2007-02-22 |
ES2309567T3 (es) | 2008-12-16 |
ATE399169T1 (de) | 2008-07-15 |
IL173895A0 (en) | 2006-07-05 |
RS20060196A (en) | 2008-08-07 |
KR20060092220A (ko) | 2006-08-22 |
CN100415745C (zh) | 2008-09-03 |
JP2007507467A (ja) | 2007-03-29 |
MXPA06003349A (es) | 2006-06-08 |
CN1856491A (zh) | 2006-11-01 |
DE602004014630D1 (de) | 2008-08-07 |
EA200600608A1 (ru) | 2006-10-27 |
EA010261B1 (ru) | 2008-06-30 |
WO2005030771A1 (en) | 2005-04-07 |
ZA200601642B (en) | 2007-05-30 |
HK1096548A1 (en) | 2007-06-01 |
US7468377B2 (en) | 2008-12-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20061317L (no) | Imidazopyridinderivater som induserbare NO-syntaseinhibatorer | |
BRPI0608886B8 (pt) | derivados de n-sulfonilpirróis e seus usos | |
EA200501928A1 (ru) | Пирролодигидроизохинолины как ингибиторы pde10 | |
BR0313330A (pt) | Piperidina-ftalazonas substituìdas com pirrolidinadiona como inibidores de pde4 | |
GEP20094785B (en) | Pyrrolopyrazoles, potent kinase inhibitors | |
EA201270630A1 (ru) | Гетероциклические сетр ингибиторы | |
EA201200891A1 (ru) | Производные 3,4,4a,10d-тетрагидро-1h-тиопирано[4,3-c]изохинолина | |
NO20061344L (no) | Imidazopyridinderivater som induserbare NO-syntaseoinhibitorer | |
EA200801366A1 (ru) | Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина | |
NO20061316L (no) | Imidazopyndinderivater som induserbare NO-syntaseinhibitorer | |
NO20082185L (no) | Heterocykliske CETP-inhibitorer | |
NO20061343L (no) | Imidazo[4,5-b]pyridinderivater som induserbare NO-syntaseinhibitorer | |
EA200600601A1 (ru) | Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы | |
ATE419242T1 (de) | Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren | |
ATE433975T1 (de) | Als inos-inhibitoren geeignete imidazopyridinderivate | |
NO20054289D0 (no) | Imiciazo[4,5-b]kinolinderivater og dem anvendelse som NO-syntaseinhibitorer | |
BR0317126A (pt) | Derivados de indol e o uso dos mesmos como ligantes de 5-ht | |
EA200700254A1 (ru) | Димерные производные пипередина | |
ATE417040T1 (de) | Nitratester von phenylaminothiophen- essigsäurederivaten |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |