DE60129728D1 - Verfahren zur herstellung von nateglinidin-kristallen - Google Patents

Verfahren zur herstellung von nateglinidin-kristallen

Info

Publication number
DE60129728D1
DE60129728D1 DE60129728T DE60129728T DE60129728D1 DE 60129728 D1 DE60129728 D1 DE 60129728D1 DE 60129728 T DE60129728 T DE 60129728T DE 60129728 T DE60129728 T DE 60129728T DE 60129728 D1 DE60129728 D1 DE 60129728D1
Authority
DE
Germany
Prior art keywords
nateglinide
crystals
nateglinidine
production
reaction mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60129728T
Other languages
English (en)
Other versions
DE60129728T2 (de
Inventor
Daisuke Takahashi
Seiichi Nishi
Satoji Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of DE60129728D1 publication Critical patent/DE60129728D1/de
Application granted granted Critical
Publication of DE60129728T2 publication Critical patent/DE60129728T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60129728T 2000-10-18 2001-10-16 Verfahren zur herstellung von nateglinid-kristallen Expired - Lifetime DE60129728T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000317604 2000-10-18
JP2000317604 2000-10-18
PCT/JP2001/009069 WO2002032854A1 (fr) 2000-10-18 2001-10-16 Procede de production de cristaux de nateglinide

Publications (2)

Publication Number Publication Date
DE60129728D1 true DE60129728D1 (de) 2007-09-13
DE60129728T2 DE60129728T2 (de) 2008-04-24

Family

ID=18796362

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60129728T Expired - Lifetime DE60129728T2 (de) 2000-10-18 2001-10-16 Verfahren zur herstellung von nateglinid-kristallen

Country Status (18)

Country Link
US (3) US7208622B2 (de)
EP (1) EP1334963B1 (de)
JP (1) JP4114200B2 (de)
KR (1) KR100819358B1 (de)
CN (2) CN1232502C (de)
AT (1) ATE368641T1 (de)
AU (1) AU2001294265A1 (de)
BR (1) BR0114729A (de)
CA (1) CA2425538C (de)
CY (1) CY1106837T1 (de)
DE (1) DE60129728T2 (de)
DK (1) DK1334963T3 (de)
ES (1) ES2291356T3 (de)
MX (1) MXPA03003484A (de)
PT (1) PT1334963E (de)
RU (2) RU2318801C2 (de)
TW (1) TWI251588B (de)
WO (1) WO2002032854A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ521366A (en) * 2000-03-17 2005-07-29 Ajinomoto Kk Drugs for complications of diabetes and neuropathy, and utilisation thereof
JP4114200B2 (ja) 2000-10-18 2008-07-09 味の素株式会社 ナテグリニド結晶の製造方法
BR0114728B1 (pt) * 2000-10-18 2014-01-14 Método para produzir uma acilfenilalanina
WO2002040010A1 (fr) * 2000-10-24 2002-05-23 Ajinomoto Co.,Inc. Preparations de medicament contenant du nateglinide
EP1334964B1 (de) * 2000-10-24 2007-08-15 Ajinomoto Co., Inc. Verfahren zur herstellung der b-form von nateglinid-kristallen
ES2307653T3 (es) * 2000-10-24 2008-12-01 Ajinomoto Co., Inc. Preparaciones que contienen nateglinida.
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
AU2003236243A1 (en) * 2002-04-15 2003-10-27 Ajinomoto Co., Inc. Novel nateglinide crystal
CN100384813C (zh) * 2002-07-03 2008-04-30 特瓦制药工业有限公司 制备那格列奈及其中间体的方法
US6861553B2 (en) 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
US7358390B2 (en) 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7420084B2 (en) 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7148376B2 (en) 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
IL166308A0 (en) * 2002-07-18 2006-01-15 Polymorphic forms of nateglinide
US7534913B2 (en) * 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
CN1318392C (zh) * 2003-01-17 2007-05-30 中国人民解放军军事医学科学院毒物药物研究所 那格列奈改进的制备方法
EP1616886A4 (de) * 2003-02-18 2006-06-14 Konishi Co Ltd Kuratives harz, herstellungsverfahren und kurative harzzusammensetzung
HU227073B1 (hu) * 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
DE60310734T2 (de) * 2003-11-26 2007-10-11 A.M.S.A. Anonima Matèrie Sintètiche e Affini S.p.A. Verfahren zur Herstellung von Nateglinid in der B-Form
MXPA06012793A (es) * 2004-05-07 2007-07-18 Teva Pharma Formas polimorficas de nateglinida.
GB0413084D0 (en) 2004-06-11 2004-07-14 Cipla Ltd Process
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
JP4974057B2 (ja) * 2005-01-31 2012-07-11 味の素株式会社 血糖降下剤を含有する、耐糖能異常、境界型糖尿病、インスリン抵抗性及び高インスリン血症の改善ないし治療用医薬組成物
JP5152699B2 (ja) * 2006-03-31 2013-02-27 味の素株式会社 カルボン酸クロリド化合物の製造方法
WO2007113650A2 (en) * 2006-04-05 2007-10-11 Cadila Pharmaceuticals Limited A novel and improved process fro the preparation of nateglinide and its polymorph form-h
KR100837843B1 (ko) * 2006-12-26 2008-06-13 씨제이제일제당 (주) 나테글리나이드 결정형, 그 제조방법, 및 그를 포함하는약제학적 조성물
KR101226024B1 (ko) * 2010-06-08 2013-01-24 삼성중공업 주식회사 선박
AU2011266820A1 (en) 2010-06-14 2013-01-24 Cipla Limited A process for the preparation of nateglinide
KR20150146007A (ko) 2014-06-20 2015-12-31 주식회사 씨트리 나테글리니드의 신규한 제조방법

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354321A (ja) 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤
US5041232A (en) * 1990-03-16 1991-08-20 Lever Brothers Company, Division Of Conopco, Inc. Sulfonimines as bleach catalysts
JPH0415221A (ja) 1990-05-08 1992-01-20 Daicel Chem Ind Ltd ポリカーボネートの製造法
US5463116A (en) 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
DE69217762T2 (de) * 1991-07-30 1997-10-09 Ajinomoto Kk Kristalle von N-(Trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung
JPH0717899A (ja) * 1993-07-01 1995-01-20 Ajinomoto Co Inc カルボン酸クロリドの製造法
TW492878B (en) 1996-11-15 2002-07-01 Ajinomoto Kk Tablet composition
DE60024320T2 (de) 1999-12-28 2006-08-10 Ajinomoto Co., Inc. Orale zusammensetzungen für diabetes
NZ521366A (en) 2000-03-17 2005-07-29 Ajinomoto Kk Drugs for complications of diabetes and neuropathy, and utilisation thereof
BR0114728B1 (pt) 2000-10-18 2014-01-14 Método para produzir uma acilfenilalanina
JP4114200B2 (ja) 2000-10-18 2008-07-09 味の素株式会社 ナテグリニド結晶の製造方法
EP1334964B1 (de) 2000-10-24 2007-08-15 Ajinomoto Co., Inc. Verfahren zur herstellung der b-form von nateglinid-kristallen
ES2307653T3 (es) 2000-10-24 2008-12-01 Ajinomoto Co., Inc. Preparaciones que contienen nateglinida.
US6842673B2 (en) 2002-06-05 2005-01-11 Visteon Global Technologies, Inc. Engine engagement control for a hybrid electric vehicle

Also Published As

Publication number Publication date
RU2273629C2 (ru) 2006-04-10
US7459582B2 (en) 2008-12-02
CY1106837T1 (el) 2012-05-23
PT1334963E (pt) 2007-09-20
JP4114200B2 (ja) 2008-07-09
EP1334963A1 (de) 2003-08-13
JPWO2002032854A1 (ja) 2004-02-26
US20090076301A1 (en) 2009-03-19
US20070167523A1 (en) 2007-07-19
US20040030182A1 (en) 2004-02-12
EP1334963A4 (de) 2005-08-17
KR20030059203A (ko) 2003-07-07
AU2001294265A1 (en) 2002-04-29
DE60129728T2 (de) 2008-04-24
WO2002032854A1 (fr) 2002-04-25
CN1769263A (zh) 2006-05-10
BR0114729A (pt) 2003-10-14
TWI251588B (en) 2006-03-21
CN1232502C (zh) 2005-12-21
ATE368641T1 (de) 2007-08-15
CA2425538C (en) 2010-10-12
RU2005137243A (ru) 2007-06-10
US7208622B2 (en) 2007-04-24
EP1334963B1 (de) 2007-08-01
CA2425538A1 (en) 2003-04-10
CN100384814C (zh) 2008-04-30
RU2318801C2 (ru) 2008-03-10
DK1334963T3 (da) 2007-09-24
CN1481356A (zh) 2004-03-10
KR100819358B1 (ko) 2008-04-04
MXPA03003484A (es) 2003-07-14
ES2291356T3 (es) 2008-03-01

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