AU2001294265A1 - Process for producing nateglinide crystal - Google Patents
Process for producing nateglinide crystalInfo
- Publication number
- AU2001294265A1 AU2001294265A1 AU2001294265A AU9426501A AU2001294265A1 AU 2001294265 A1 AU2001294265 A1 AU 2001294265A1 AU 2001294265 A AU2001294265 A AU 2001294265A AU 9426501 A AU9426501 A AU 9426501A AU 2001294265 A1 AU2001294265 A1 AU 2001294265A1
- Authority
- AU
- Australia
- Prior art keywords
- nateglinide
- producing
- reaction mixture
- ketone solvent
- crystals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalanine in a mixed solvent of ketone solvent and water in the presence of an alkali; and then adjusting the temperature of the mixture to 58 DEG C to 72 DEG C and the concentration of ketone solvent to more than 8wt% and less than 22wt% to conduct precipitation of nateglinide crystals. This producing method is the industrially beneficial methods for crystallization of nateglinide.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000317604 | 2000-10-18 | ||
JP2000-317604 | 2000-10-18 | ||
PCT/JP2001/009069 WO2002032854A1 (en) | 2000-10-18 | 2001-10-16 | Process for producing nateglinide crystal |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001294265A1 true AU2001294265A1 (en) | 2002-04-29 |
Family
ID=18796362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001294265A Abandoned AU2001294265A1 (en) | 2000-10-18 | 2001-10-16 | Process for producing nateglinide crystal |
Country Status (18)
Country | Link |
---|---|
US (3) | US7208622B2 (en) |
EP (1) | EP1334963B1 (en) |
JP (1) | JP4114200B2 (en) |
KR (1) | KR100819358B1 (en) |
CN (2) | CN1232502C (en) |
AT (1) | ATE368641T1 (en) |
AU (1) | AU2001294265A1 (en) |
BR (1) | BR0114729A (en) |
CA (1) | CA2425538C (en) |
CY (1) | CY1106837T1 (en) |
DE (1) | DE60129728T2 (en) |
DK (1) | DK1334963T3 (en) |
ES (1) | ES2291356T3 (en) |
MX (1) | MXPA03003484A (en) |
PT (1) | PT1334963E (en) |
RU (2) | RU2318801C2 (en) |
TW (1) | TWI251588B (en) |
WO (1) | WO2002032854A1 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001068136A1 (en) * | 2000-03-17 | 2001-09-20 | Ajinomoto Co., Inc. | Drugs for complications of diabetes and neuropathy and utilization thereof |
PT1334963E (en) * | 2000-10-18 | 2007-09-20 | Ajinomoto Kk | Process for producing nateglinide crystal |
DK1334962T3 (en) * | 2000-10-18 | 2007-12-10 | Ajinomoto Kk | Methods for preparing acylphenylalanine |
CA2426764C (en) * | 2000-10-24 | 2010-04-20 | Ajinomoto Co., Inc. | Nateglinide-containing hydrophilic pharmaceutical preparation |
ES2288997T3 (en) * | 2000-10-24 | 2008-02-01 | Ajinomoto Co., Inc. | PROCEDURE FOR PRODUCING CRYSTALS OF NATEGLINIDA TYPE B. |
CA2426263C (en) * | 2000-10-24 | 2010-05-25 | Ajinomoto Co., Inc. | Nateglinide-containing preparation |
EP1496048A4 (en) * | 2002-04-15 | 2006-08-02 | Ajinomoto Kk | Novel nateglinide crystal |
US7411089B2 (en) | 2002-04-15 | 2008-08-12 | Ajinomoto Co., Inc. | Nateglinide crystals |
CN100384813C (en) * | 2002-07-03 | 2008-04-30 | 特瓦制药工业有限公司 | Process for preparing nateglinide and intermediates thereof |
US6861553B2 (en) | 2002-07-03 | 2005-03-01 | Teva Pharmaceuticals Industries Ltd. | Process for preparing nateglinide and intermediates thereof |
US7420084B2 (en) | 2002-07-18 | 2008-09-02 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
US7534913B2 (en) | 2002-07-18 | 2009-05-19 | Teva Pharmaceutica Industries Ltd. | Crystalline form of nateglinide |
US7148376B2 (en) | 2002-07-18 | 2006-12-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
JP2006511614A (en) * | 2002-07-18 | 2006-04-06 | テバ ファーマシューティカル インダストリーズ リミティド | Polymorphic shape of nateglinide |
US7358390B2 (en) | 2002-07-18 | 2008-04-15 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
CN1318392C (en) * | 2003-01-17 | 2007-05-30 | 中国人民解放军军事医学科学院毒物药物研究所 | Improved preparation method of Nagelinei |
EP1616886A4 (en) * | 2003-02-18 | 2006-06-14 | Konishi Co Ltd | Curing resin, method for producing same and curing resin composition |
HU227073B1 (en) * | 2003-07-10 | 2010-06-28 | Richter Gedeon Nyrt | Process for the preparation of chirally pure n-(trans-4-isopropyl-cyclohexylcarbonyl)-d-phenyl-alanine (nateglinide) and it's crystalline forms and the cristalline form g |
EP1535900B1 (en) * | 2003-11-26 | 2006-12-27 | A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A. | Process for the preparation of nateglinide, preferably in b-form |
EP1656339A1 (en) * | 2004-05-07 | 2006-05-17 | Teva Pharmaceutical Industries Ltd | Polymorphic forms of nateglinide |
GB0413084D0 (en) * | 2004-06-11 | 2004-07-14 | Cipla Ltd | Process |
US7425648B2 (en) | 2005-01-03 | 2008-09-16 | A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. | Process for the preparation of nateglinide, preferably in B-form |
KR20070102694A (en) * | 2005-01-31 | 2007-10-19 | 아지노모토 가부시키가이샤 | Medicinal composition for ameliorating or treating glucose intolerance, borderline diabetes, insulin resistance and hyperinsulinemia containing hypoglycemic agent |
CN101415668B (en) * | 2006-03-31 | 2013-06-19 | 味之素株式会社 | Methods for producing carboxylic acid chloride compounds |
WO2007113650A2 (en) * | 2006-04-05 | 2007-10-11 | Cadila Pharmaceuticals Limited | A novel and improved process fro the preparation of nateglinide and its polymorph form-h |
KR100837843B1 (en) * | 2006-12-26 | 2008-06-13 | 씨제이제일제당 (주) | Crystalline form of nateglinide, process for the preparation thereof, and pharmaceutical composition comprising the same |
KR101226024B1 (en) * | 2010-06-08 | 2013-01-24 | 삼성중공업 주식회사 | A vessel |
KR20130087485A (en) | 2010-06-14 | 2013-08-06 | 씨아이피엘에이 엘티디. | A process for the preparation of nateglinide |
KR20150146007A (en) | 2014-06-20 | 2015-12-31 | 주식회사 씨트리 | A new method for producing nateglinide |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6354321A (en) * | 1985-03-27 | 1988-03-08 | Ajinomoto Co Inc | Blood sugar lowering agent |
US5041232A (en) * | 1990-03-16 | 1991-08-20 | Lever Brothers Company, Division Of Conopco, Inc. | Sulfonimines as bleach catalysts |
JPH0415221A (en) | 1990-05-08 | 1992-01-20 | Daicel Chem Ind Ltd | Preparation of polycarbonate |
ES2100291T3 (en) * | 1991-07-30 | 1997-06-16 | Ajinomoto Kk | CRYSTALS OF N- (TRANS-4-ISOPROPILCICLOHEXILCARBONIL) -D-PHENYLALANINE AND METHODS TO PREPARE THEM. |
US5463116A (en) * | 1991-07-30 | 1995-10-31 | Ajinomoto Co., Inc. | Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them |
JPH0717899A (en) * | 1993-07-01 | 1995-01-20 | Ajinomoto Co Inc | Production of carboxylic acid chloride |
WO1998022105A1 (en) * | 1996-11-15 | 1998-05-28 | Ajinomoto Co., Inc. | Tabletted preparation |
PL356300A1 (en) * | 1999-12-28 | 2004-06-28 | Ajinomoto Co, Inc. | Oral preparations for diabetes |
WO2001068136A1 (en) * | 2000-03-17 | 2001-09-20 | Ajinomoto Co., Inc. | Drugs for complications of diabetes and neuropathy and utilization thereof |
PT1334963E (en) * | 2000-10-18 | 2007-09-20 | Ajinomoto Kk | Process for producing nateglinide crystal |
DK1334962T3 (en) * | 2000-10-18 | 2007-12-10 | Ajinomoto Kk | Methods for preparing acylphenylalanine |
ES2288997T3 (en) * | 2000-10-24 | 2008-02-01 | Ajinomoto Co., Inc. | PROCEDURE FOR PRODUCING CRYSTALS OF NATEGLINIDA TYPE B. |
CA2426263C (en) * | 2000-10-24 | 2010-05-25 | Ajinomoto Co., Inc. | Nateglinide-containing preparation |
US6842673B2 (en) | 2002-06-05 | 2005-01-11 | Visteon Global Technologies, Inc. | Engine engagement control for a hybrid electric vehicle |
-
2001
- 2001-10-16 PT PT01974875T patent/PT1334963E/en unknown
- 2001-10-16 CN CNB018206581A patent/CN1232502C/en not_active Expired - Fee Related
- 2001-10-16 DE DE60129728T patent/DE60129728T2/en not_active Expired - Lifetime
- 2001-10-16 BR BR0114729-3A patent/BR0114729A/en not_active IP Right Cessation
- 2001-10-16 CN CNB2005101188521A patent/CN100384814C/en not_active Expired - Fee Related
- 2001-10-16 JP JP2002536038A patent/JP4114200B2/en not_active Expired - Lifetime
- 2001-10-16 RU RU2005137243/04A patent/RU2318801C2/en not_active IP Right Cessation
- 2001-10-16 RU RU2003111021/04A patent/RU2273629C2/en not_active IP Right Cessation
- 2001-10-16 EP EP01974875A patent/EP1334963B1/en not_active Expired - Lifetime
- 2001-10-16 ES ES01974875T patent/ES2291356T3/en not_active Expired - Lifetime
- 2001-10-16 KR KR1020037005388A patent/KR100819358B1/en not_active IP Right Cessation
- 2001-10-16 AU AU2001294265A patent/AU2001294265A1/en not_active Abandoned
- 2001-10-16 MX MXPA03003484A patent/MXPA03003484A/en active IP Right Grant
- 2001-10-16 DK DK01974875T patent/DK1334963T3/en active
- 2001-10-16 CA CA2425538A patent/CA2425538C/en not_active Expired - Fee Related
- 2001-10-16 AT AT01974875T patent/ATE368641T1/en active
- 2001-10-16 WO PCT/JP2001/009069 patent/WO2002032854A1/en active IP Right Grant
- 2001-10-17 TW TW090125697A patent/TWI251588B/en not_active IP Right Cessation
-
2003
- 2003-04-18 US US10/418,105 patent/US7208622B2/en not_active Expired - Fee Related
-
2007
- 2007-03-14 US US11/686,073 patent/US7459582B2/en not_active Expired - Fee Related
- 2007-08-28 CY CY20071101133T patent/CY1106837T1/en unknown
-
2008
- 2008-10-31 US US12/262,634 patent/US20090076301A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2002032854A1 (en) | 2002-04-25 |
EP1334963A1 (en) | 2003-08-13 |
JPWO2002032854A1 (en) | 2004-02-26 |
RU2318801C2 (en) | 2008-03-10 |
US20090076301A1 (en) | 2009-03-19 |
RU2273629C2 (en) | 2006-04-10 |
CA2425538A1 (en) | 2003-04-10 |
JP4114200B2 (en) | 2008-07-09 |
CN1481356A (en) | 2004-03-10 |
US7208622B2 (en) | 2007-04-24 |
EP1334963B1 (en) | 2007-08-01 |
DK1334963T3 (en) | 2007-09-24 |
BR0114729A (en) | 2003-10-14 |
TWI251588B (en) | 2006-03-21 |
KR20030059203A (en) | 2003-07-07 |
DE60129728T2 (en) | 2008-04-24 |
KR100819358B1 (en) | 2008-04-04 |
US7459582B2 (en) | 2008-12-02 |
PT1334963E (en) | 2007-09-20 |
DE60129728D1 (en) | 2007-09-13 |
CN100384814C (en) | 2008-04-30 |
US20040030182A1 (en) | 2004-02-12 |
CN1232502C (en) | 2005-12-21 |
EP1334963A4 (en) | 2005-08-17 |
US20070167523A1 (en) | 2007-07-19 |
CN1769263A (en) | 2006-05-10 |
RU2005137243A (en) | 2007-06-10 |
ATE368641T1 (en) | 2007-08-15 |
MXPA03003484A (en) | 2003-07-14 |
CA2425538C (en) | 2010-10-12 |
CY1106837T1 (en) | 2012-05-23 |
ES2291356T3 (en) | 2008-03-01 |
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