CY1106837T1 - Μεθοδος παραγωγης κρυσταλλων νατεγλινιδιου - Google Patents

Μεθοδος παραγωγης κρυσταλλων νατεγλινιδιου

Info

Publication number
CY1106837T1
CY1106837T1 CY20071101133T CY071101133T CY1106837T1 CY 1106837 T1 CY1106837 T1 CY 1106837T1 CY 20071101133 T CY20071101133 T CY 20071101133T CY 071101133 T CY071101133 T CY 071101133T CY 1106837 T1 CY1106837 T1 CY 1106837T1
Authority
CY
Cyprus
Prior art keywords
nateglinide
crystals
production
reaction mixture
nateglinide crystals
Prior art date
Application number
CY20071101133T
Other languages
English (en)
Inventor
Daisuke Takahashi
Seiichi Nishi
Satoji Takahashi
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Publication of CY1106837T1 publication Critical patent/CY1106837T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Παρέχεται μέθοδος παραγωγής κρυστάλλων νατεγλινιδίου, περιλαμβάνουσα τα εξής στάδια: προσθήκη οξέος (ων) σε μείγμα αντιδράσεως περιέχον νατεγλινίδιο για να γίνει αυτό όξινο, και όπου το μείγμα της αντιδράσεως λαμβάνεται δι'αντιδράσεως trans-4-ισοπροπυλοκυκλο-εξυλο-καρβονυλοχλωριδίου με D-φαινυλαλανίνη εντός μεικτού διαλύτη από διαλύτη κετόνη και νερό, παρουσία αλκάλεος · και στην συνέχεια ρύθμιση της θερμοκρασίας του μείγματος στους 58-72°C και της συγκέντρωσης του διαλύτη κετόνη σε ποσοστό μεγαλύτερο του 8% κ.β. και μικρότερο του 22% κ.β., για να καθιζήσουν κρύσταλλοι νατεγλινιδίου. Αυτή η μέθοδος παραγωγής είναι η βιομηχανικός επωφελής μέθοδος κρυστάλλωσης του νατεγλινιδίου.
CY20071101133T 2000-10-18 2007-08-28 Μεθοδος παραγωγης κρυσταλλων νατεγλινιδιου CY1106837T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000317604 2000-10-18
PCT/JP2001/009069 WO2002032854A1 (fr) 2000-10-18 2001-10-16 Procede de production de cristaux de nateglinide

Publications (1)

Publication Number Publication Date
CY1106837T1 true CY1106837T1 (el) 2012-05-23

Family

ID=18796362

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101133T CY1106837T1 (el) 2000-10-18 2007-08-28 Μεθοδος παραγωγης κρυσταλλων νατεγλινιδιου

Country Status (18)

Country Link
US (3) US7208622B2 (el)
EP (1) EP1334963B1 (el)
JP (1) JP4114200B2 (el)
KR (1) KR100819358B1 (el)
CN (2) CN1232502C (el)
AT (1) ATE368641T1 (el)
AU (1) AU2001294265A1 (el)
BR (1) BR0114729A (el)
CA (1) CA2425538C (el)
CY (1) CY1106837T1 (el)
DE (1) DE60129728T2 (el)
DK (1) DK1334963T3 (el)
ES (1) ES2291356T3 (el)
MX (1) MXPA03003484A (el)
PT (1) PT1334963E (el)
RU (2) RU2318801C2 (el)
TW (1) TWI251588B (el)
WO (1) WO2002032854A1 (el)

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RU2281764C2 (ru) * 2000-03-17 2006-08-20 Адзиномото Ко., Инк. Лекарственные средства для лечения осложнений, связанных с диабетом, и невропатии и их применения
AU2001294265A1 (en) 2000-10-18 2002-04-29 Ajinomoto Co., Inc. Process for producing nateglinide crystal
WO2002032853A1 (fr) * 2000-10-18 2002-04-25 Ajinomoto Co.,Inc. Procede de preparation d'acylphenylalanines
ES2288997T3 (es) * 2000-10-24 2008-02-01 Ajinomoto Co., Inc. Procedimiento para producir cristales de nateglinida de tipo b.
AU2001295999A1 (en) * 2000-10-24 2002-05-06 Ajinomoto Co., Inc. Nateglinide-containing preparations
ATE429217T1 (de) * 2000-10-24 2009-05-15 Ajinomoto Kk Nateglinid enthaltende hydrophile arzneimittelpräparate
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
EP1496048A4 (en) * 2002-04-15 2006-08-02 Ajinomoto Kk NEW NATEGLINID CRYSTAL
CN100384813C (zh) * 2002-07-03 2008-04-30 特瓦制药工业有限公司 制备那格列奈及其中间体的方法
US6861553B2 (en) 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
JP2006511614A (ja) * 2002-07-18 2006-04-06 テバ ファーマシューティカル インダストリーズ リミティド ナテグリニドの多形性形状
US7420084B2 (en) 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7534913B2 (en) * 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
US7148376B2 (en) 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7358390B2 (en) 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
CN1318392C (zh) * 2003-01-17 2007-05-30 中国人民解放军军事医学科学院毒物药物研究所 那格列奈改进的制备方法
JPWO2004074330A1 (ja) * 2003-02-18 2006-06-01 コニシ株式会社 硬化性樹脂、その製造方法及び硬化性樹脂組成物
HU227073B1 (hu) * 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
ES2279921T3 (es) * 2003-11-26 2007-09-01 A.M.S.A. Anonima Materie Sintetiche E Affini S.P.A. Procedimiento para la preparacion de nateglinida preferentemente en forma b.
CA2563793A1 (en) * 2004-05-07 2005-11-24 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
GB0413084D0 (en) 2004-06-11 2004-07-14 Cipla Ltd Process
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
KR20070102694A (ko) * 2005-01-31 2007-10-19 아지노모토 가부시키가이샤 혈당 강하제를 함유하는, 내당능 이상, 경계형 당뇨병,인슐린 저항성 및 고인슐린혈증 개선 또는 치료용 의약조성물
KR101399916B1 (ko) * 2006-03-31 2014-05-28 아지노모토 가부시키가이샤 카복실산 클로라이드 화합물의 제조방법
WO2007113650A2 (en) * 2006-04-05 2007-10-11 Cadila Pharmaceuticals Limited A novel and improved process fro the preparation of nateglinide and its polymorph form-h
KR100837843B1 (ko) * 2006-12-26 2008-06-13 씨제이제일제당 (주) 나테글리나이드 결정형, 그 제조방법, 및 그를 포함하는약제학적 조성물
KR101226024B1 (ko) * 2010-06-08 2013-01-24 삼성중공업 주식회사 선박
CA2802455A1 (en) 2010-06-14 2011-12-22 Cipla Limited A process for the preparation of nateglinide
KR20150146007A (ko) 2014-06-20 2015-12-31 주식회사 씨트리 나테글리니드의 신규한 제조방법

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354321A (ja) * 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤
US5041232A (en) * 1990-03-16 1991-08-20 Lever Brothers Company, Division Of Conopco, Inc. Sulfonimines as bleach catalysts
JPH0415221A (ja) 1990-05-08 1992-01-20 Daicel Chem Ind Ltd ポリカーボネートの製造法
EP0526171B1 (en) * 1991-07-30 1997-03-05 Ajinomoto Co., Inc. Crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing them
US5463116A (en) * 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
JPH0717899A (ja) * 1993-07-01 1995-01-20 Ajinomoto Co Inc カルボン酸クロリドの製造法
CN1245158C (zh) * 1996-11-15 2006-03-15 味之素株式会社 片剂组合物
ATE399000T1 (de) * 1999-12-28 2008-07-15 Ajinomoto Kk Antidiabetes-zubereitung zur oralen verabreichung
RU2281764C2 (ru) * 2000-03-17 2006-08-20 Адзиномото Ко., Инк. Лекарственные средства для лечения осложнений, связанных с диабетом, и невропатии и их применения
WO2002032853A1 (fr) * 2000-10-18 2002-04-25 Ajinomoto Co.,Inc. Procede de preparation d'acylphenylalanines
AU2001294265A1 (en) 2000-10-18 2002-04-29 Ajinomoto Co., Inc. Process for producing nateglinide crystal
AU2001295999A1 (en) * 2000-10-24 2002-05-06 Ajinomoto Co., Inc. Nateglinide-containing preparations
ES2288997T3 (es) * 2000-10-24 2008-02-01 Ajinomoto Co., Inc. Procedimiento para producir cristales de nateglinida de tipo b.
US6842673B2 (en) 2002-06-05 2005-01-11 Visteon Global Technologies, Inc. Engine engagement control for a hybrid electric vehicle

Also Published As

Publication number Publication date
TWI251588B (en) 2006-03-21
US7459582B2 (en) 2008-12-02
MXPA03003484A (es) 2003-07-14
RU2005137243A (ru) 2007-06-10
US20090076301A1 (en) 2009-03-19
RU2273629C2 (ru) 2006-04-10
ATE368641T1 (de) 2007-08-15
US20070167523A1 (en) 2007-07-19
US20040030182A1 (en) 2004-02-12
DE60129728D1 (de) 2007-09-13
PT1334963E (pt) 2007-09-20
ES2291356T3 (es) 2008-03-01
EP1334963A1 (en) 2003-08-13
EP1334963B1 (en) 2007-08-01
JPWO2002032854A1 (ja) 2004-02-26
RU2318801C2 (ru) 2008-03-10
DK1334963T3 (da) 2007-09-24
JP4114200B2 (ja) 2008-07-09
CN1232502C (zh) 2005-12-21
CN1769263A (zh) 2006-05-10
CA2425538C (en) 2010-10-12
KR100819358B1 (ko) 2008-04-04
DE60129728T2 (de) 2008-04-24
KR20030059203A (ko) 2003-07-07
CN100384814C (zh) 2008-04-30
CA2425538A1 (en) 2003-04-10
EP1334963A4 (en) 2005-08-17
US7208622B2 (en) 2007-04-24
WO2002032854A1 (fr) 2002-04-25
AU2001294265A1 (en) 2002-04-29
BR0114729A (pt) 2003-10-14
CN1481356A (zh) 2004-03-10

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