CY1106837T1 - Μεθοδος παραγωγης κρυσταλλων νατεγλινιδιου - Google Patents

Μεθοδος παραγωγης κρυσταλλων νατεγλινιδιου

Info

Publication number
CY1106837T1
CY1106837T1 CY20071101133T CY071101133T CY1106837T1 CY 1106837 T1 CY1106837 T1 CY 1106837T1 CY 20071101133 T CY20071101133 T CY 20071101133T CY 071101133 T CY071101133 T CY 071101133T CY 1106837 T1 CY1106837 T1 CY 1106837T1
Authority
CY
Cyprus
Prior art keywords
nateglinide
crystals
production
reaction mixture
nateglinide crystals
Prior art date
Application number
CY20071101133T
Other languages
English (en)
Inventor
Daisuke Takahashi
Seiichi Nishi
Satoji Takahashi
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Publication of CY1106837T1 publication Critical patent/CY1106837T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Παρέχεται μέθοδος παραγωγής κρυστάλλων νατεγλινιδίου, περιλαμβάνουσα τα εξής στάδια: προσθήκη οξέος (ων) σε μείγμα αντιδράσεως περιέχον νατεγλινίδιο για να γίνει αυτό όξινο, και όπου το μείγμα της αντιδράσεως λαμβάνεται δι'αντιδράσεως trans-4-ισοπροπυλοκυκλο-εξυλο-καρβονυλοχλωριδίου με D-φαινυλαλανίνη εντός μεικτού διαλύτη από διαλύτη κετόνη και νερό, παρουσία αλκάλεος · και στην συνέχεια ρύθμιση της θερμοκρασίας του μείγματος στους 58-72°C και της συγκέντρωσης του διαλύτη κετόνη σε ποσοστό μεγαλύτερο του 8% κ.β. και μικρότερο του 22% κ.β., για να καθιζήσουν κρύσταλλοι νατεγλινιδίου. Αυτή η μέθοδος παραγωγής είναι η βιομηχανικός επωφελής μέθοδος κρυστάλλωσης του νατεγλινιδίου.
CY20071101133T 2000-10-18 2007-08-28 Μεθοδος παραγωγης κρυσταλλων νατεγλινιδιου CY1106837T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000317604 2000-10-18
PCT/JP2001/009069 WO2002032854A1 (fr) 2000-10-18 2001-10-16 Procede de production de cristaux de nateglinide

Publications (1)

Publication Number Publication Date
CY1106837T1 true CY1106837T1 (el) 2012-05-23

Family

ID=18796362

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101133T CY1106837T1 (el) 2000-10-18 2007-08-28 Μεθοδος παραγωγης κρυσταλλων νατεγλινιδιου

Country Status (18)

Country Link
US (3) US7208622B2 (el)
EP (1) EP1334963B1 (el)
JP (1) JP4114200B2 (el)
KR (1) KR100819358B1 (el)
CN (2) CN100384814C (el)
AT (1) ATE368641T1 (el)
AU (1) AU2001294265A1 (el)
BR (1) BR0114729A (el)
CA (1) CA2425538C (el)
CY (1) CY1106837T1 (el)
DE (1) DE60129728T2 (el)
DK (1) DK1334963T3 (el)
ES (1) ES2291356T3 (el)
MX (1) MXPA03003484A (el)
PT (1) PT1334963E (el)
RU (2) RU2318801C2 (el)
TW (1) TWI251588B (el)
WO (1) WO2002032854A1 (el)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0109336A (pt) * 2000-03-17 2003-06-24 Ajinomoto C0 Inc Medicamento para a prevenção, melhora e/ou tratamento de uma complicação diabética, droga medicinal adequada ou utilizável como o mesmo, método para prevenir, melhorar e/ou tratar a complicação diabética, e a neuropatia, e, usos de um agente redutor do açúcar no sangue pós-prandial e pelo menos um agente selecionado de um agente anti-hipertensivo, um agente vasodilatador e um agente anti-hiperlipidêmico
DE60130575T2 (de) * 2000-10-18 2008-04-30 Ajinomoto Co., Inc. Verfahren zur herstellung von acylphenylalaninen
ES2291356T3 (es) * 2000-10-18 2008-03-01 Ajinomoto Co., Inc. Procedimiento para producir cristales de nateglinida.
MXPA03003575A (es) * 2000-10-24 2003-07-14 Ajinomoto Kk Procedimiento para elaborar la forma b del cristal de nateglinida.
MXPA03003686A (es) * 2000-10-24 2004-01-26 Ajinomoto Kk Preparaciones hidrofilas de farmaco que contienen nateglinida.
ATE406885T1 (de) * 2000-10-24 2008-09-15 Ajinomoto Kk Nateglinid enthaltende präparate
EP2261202A1 (en) * 2002-04-15 2010-12-15 Ajinomoto Co., Inc. New nateglinide crystals
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
US6861553B2 (en) 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
AU2003256454A1 (en) * 2002-07-03 2004-01-23 Teva Pharmaceutical Industries Ltd. Process for preparing nateglinide and intermediates thereof
US7358390B2 (en) 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7534913B2 (en) * 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
US7148376B2 (en) 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7420084B2 (en) 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
AU2003253971A1 (en) * 2002-07-18 2004-02-09 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
CN1318392C (zh) * 2003-01-17 2007-05-30 中国人民解放军军事医学科学院毒物药物研究所 那格列奈改进的制备方法
EP1616886A4 (en) * 2003-02-18 2006-06-14 Konishi Co Ltd CURABLE RESIN, PROCESS FOR PRODUCING THE SAME, AND CURABLE RESIN COMPOSITION
HU227073B1 (hu) * 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
ATE349418T1 (de) * 2003-11-26 2007-01-15 A M S A Anonima Materie Sint E Verfahren zur herstellung von nateglinidin der b- form
KR20070009726A (ko) * 2004-05-07 2007-01-18 테바 파마슈티컬 인더스트리즈 리미티드 나테글리나이드의 다형태
GB0413084D0 (en) * 2004-06-11 2004-07-14 Cipla Ltd Process
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
EP1891971A4 (en) * 2005-01-31 2010-02-03 Ajinomoto Kk MEDICAL COMPOSITION USING HYPERGLY CRAB MEDICAMENT TO TREAT OR TREAT GLUCOSE-INTOLERANCE, BORDERLINE DIABETES, INSULIN RESISTANCE AND HYPERINSULINEMIA
WO2007119580A1 (ja) * 2006-03-31 2007-10-25 Ajinomoto Co., Inc. カルボン酸クロリド化合物の製造方法
WO2007113650A2 (en) * 2006-04-05 2007-10-11 Cadila Pharmaceuticals Limited A novel and improved process fro the preparation of nateglinide and its polymorph form-h
KR100837843B1 (ko) * 2006-12-26 2008-06-13 씨제이제일제당 (주) 나테글리나이드 결정형, 그 제조방법, 및 그를 포함하는약제학적 조성물
KR101226024B1 (ko) * 2010-06-08 2013-01-24 삼성중공업 주식회사 선박
KR20130087485A (ko) 2010-06-14 2013-08-06 씨아이피엘에이 엘티디. 나테글리니드의 제조 방법
KR20150146007A (ko) 2014-06-20 2015-12-31 주식회사 씨트리 나테글리니드의 신규한 제조방법

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354321A (ja) * 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤
US5041232A (en) * 1990-03-16 1991-08-20 Lever Brothers Company, Division Of Conopco, Inc. Sulfonimines as bleach catalysts
JPH0415221A (ja) 1990-05-08 1992-01-20 Daicel Chem Ind Ltd ポリカーボネートの製造法
US5463116A (en) 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
EP0526171B1 (en) * 1991-07-30 1997-03-05 Ajinomoto Co., Inc. Crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing them
JPH0717899A (ja) * 1993-07-01 1995-01-20 Ajinomoto Co Inc カルボン酸クロリドの製造法
DE69740161D1 (de) 1996-11-15 2011-05-12 Ajinomoto Kk Nateglinide-Tablettenzubereitungen
WO2001047557A1 (fr) 1999-12-28 2001-07-05 Ajinomoto Co., Inc. Preparations orales pour diabetes
BR0109336A (pt) 2000-03-17 2003-06-24 Ajinomoto C0 Inc Medicamento para a prevenção, melhora e/ou tratamento de uma complicação diabética, droga medicinal adequada ou utilizável como o mesmo, método para prevenir, melhorar e/ou tratar a complicação diabética, e a neuropatia, e, usos de um agente redutor do açúcar no sangue pós-prandial e pelo menos um agente selecionado de um agente anti-hipertensivo, um agente vasodilatador e um agente anti-hiperlipidêmico
ES2291356T3 (es) 2000-10-18 2008-03-01 Ajinomoto Co., Inc. Procedimiento para producir cristales de nateglinida.
DE60130575T2 (de) 2000-10-18 2008-04-30 Ajinomoto Co., Inc. Verfahren zur herstellung von acylphenylalaninen
MXPA03003575A (es) 2000-10-24 2003-07-14 Ajinomoto Kk Procedimiento para elaborar la forma b del cristal de nateglinida.
ATE406885T1 (de) 2000-10-24 2008-09-15 Ajinomoto Kk Nateglinid enthaltende präparate
US6842673B2 (en) 2002-06-05 2005-01-11 Visteon Global Technologies, Inc. Engine engagement control for a hybrid electric vehicle

Also Published As

Publication number Publication date
ATE368641T1 (de) 2007-08-15
DE60129728T2 (de) 2008-04-24
CA2425538A1 (en) 2003-04-10
CN1481356A (zh) 2004-03-10
CN1232502C (zh) 2005-12-21
ES2291356T3 (es) 2008-03-01
BR0114729A (pt) 2003-10-14
US7459582B2 (en) 2008-12-02
RU2273629C2 (ru) 2006-04-10
JP4114200B2 (ja) 2008-07-09
EP1334963A1 (en) 2003-08-13
RU2318801C2 (ru) 2008-03-10
RU2005137243A (ru) 2007-06-10
US20090076301A1 (en) 2009-03-19
JPWO2002032854A1 (ja) 2004-02-26
CN1769263A (zh) 2006-05-10
DE60129728D1 (de) 2007-09-13
EP1334963A4 (en) 2005-08-17
AU2001294265A1 (en) 2002-04-29
WO2002032854A1 (fr) 2002-04-25
US20070167523A1 (en) 2007-07-19
TWI251588B (en) 2006-03-21
EP1334963B1 (en) 2007-08-01
US20040030182A1 (en) 2004-02-12
KR20030059203A (ko) 2003-07-07
MXPA03003484A (es) 2003-07-14
CN100384814C (zh) 2008-04-30
PT1334963E (pt) 2007-09-20
DK1334963T3 (da) 2007-09-24
CA2425538C (en) 2010-10-12
US7208622B2 (en) 2007-04-24
KR100819358B1 (ko) 2008-04-04

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