JPS54138556A - Preparation of hydantoin - Google Patents
Preparation of hydantoinInfo
- Publication number
- JPS54138556A JPS54138556A JP4481678A JP4481678A JPS54138556A JP S54138556 A JPS54138556 A JP S54138556A JP 4481678 A JP4481678 A JP 4481678A JP 4481678 A JP4481678 A JP 4481678A JP S54138556 A JPS54138556 A JP S54138556A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- hydantoin
- mixture
- sulfuric
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain hydantoin in high selectivity and yield economically, by reacting an inorganic acid addition salt of glycine nitrile with an alkali metal cyanate in an aqueous medium, and by heat-treating the reaction mixture incorporated with sulfuric or hydrochloric acid.
CONSTITUTION: An inorganic acid addition salt of glycine nitrile of formula I: (Z is HCl or H2SO4) is reacted with an alkali metal cyanate of formula II: (Me is Na or K) in an aqueous medium (usually water) at 0W20°C, and the reactiom mixture is aged for 1W2 hr. OneWtwo moles of sulfuric or hydrochloric acid is added slowly to one mole of the compound of formula I within 1 hr, and the mixture is heat- treated at 70W110°C for 1W4 hr to complete the reaction, thus giving the objective hydantoin.
EFFECT: Few side reactions, easy purification, and extremely slight discoloration of product.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4481678A JPS54138556A (en) | 1978-04-18 | 1978-04-18 | Preparation of hydantoin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4481678A JPS54138556A (en) | 1978-04-18 | 1978-04-18 | Preparation of hydantoin |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54138556A true JPS54138556A (en) | 1979-10-27 |
JPS6115872B2 JPS6115872B2 (en) | 1986-04-26 |
Family
ID=12701949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4481678A Granted JPS54138556A (en) | 1978-04-18 | 1978-04-18 | Preparation of hydantoin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54138556A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3525922A1 (en) * | 1984-09-27 | 1986-04-03 | Showa Denko K.K., Tokio/Tokyo | Process for the preparation of hydantoin |
CN100427471C (en) * | 2002-12-31 | 2008-10-22 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Process for preparing hydantoin |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62146360U (en) * | 1986-03-07 | 1987-09-16 |
-
1978
- 1978-04-18 JP JP4481678A patent/JPS54138556A/en active Granted
Non-Patent Citations (2)
Title |
---|
JOURNAL FUER PRAKTISCHE CHEMIC=P233-240 * |
JOURNAL FUER PRAKTISCHECHEMIC * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3525922A1 (en) * | 1984-09-27 | 1986-04-03 | Showa Denko K.K., Tokio/Tokyo | Process for the preparation of hydantoin |
CN100427471C (en) * | 2002-12-31 | 2008-10-22 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Process for preparing hydantoin |
Also Published As
Publication number | Publication date |
---|---|
JPS6115872B2 (en) | 1986-04-26 |
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