ATE229021T1 - Verfahren zur herstellung von imidazochinazolinon-derivaten - Google Patents
Verfahren zur herstellung von imidazochinazolinon-derivatenInfo
- Publication number
- ATE229021T1 ATE229021T1 AT99126260T AT99126260T ATE229021T1 AT E229021 T1 ATE229021 T1 AT E229021T1 AT 99126260 T AT99126260 T AT 99126260T AT 99126260 T AT99126260 T AT 99126260T AT E229021 T1 ATE229021 T1 AT E229021T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazoquinazolinone
- derivatives
- producing
- producing imidazoquinazolinone
- imidazoquinazolinone derivatives
- Prior art date
Links
- FVGAJEWYPIQRJX-UHFFFAOYSA-N imidazo[4,5-h]quinazolin-2-one Chemical class N1=CN=C2C3=NC(=O)N=C3C=CC2=C1 FVGAJEWYPIQRJX-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56686295A | 1995-12-04 | 1995-12-04 | |
| EP96301593A EP0778258A3 (de) | 1995-12-04 | 1996-03-08 | Verfahren zur Herstellung von Ethyl-n-(2,3-Dichloro-6-Nitrobenzyl)Glycin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE229021T1 true ATE229021T1 (de) | 2002-12-15 |
Family
ID=24264711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99126260T ATE229021T1 (de) | 1995-12-04 | 1996-03-08 | Verfahren zur herstellung von imidazochinazolinon-derivaten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5801245A (de) |
| EP (2) | EP0994114B1 (de) |
| JP (1) | JP4275748B2 (de) |
| AR (1) | AR001244A1 (de) |
| AT (1) | ATE229021T1 (de) |
| AU (1) | AU711273B2 (de) |
| BR (1) | BR9601294A (de) |
| CA (1) | CA2171073A1 (de) |
| DE (1) | DE69625253T2 (de) |
| ES (1) | ES2186297T3 (de) |
| MX (1) | MX9601105A (de) |
| ZA (1) | ZA961909B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7604400A (en) * | 1999-09-21 | 2001-04-24 | Emory University | Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents |
| US6194420B1 (en) * | 1999-11-30 | 2001-02-27 | Roberts Laboratories Inc. | 2-amino-5,6-dichloro-3,4-dihydroquinazoline, its method of making and using and pharmaceutical compositions thereof |
| US6388073B1 (en) | 2000-07-26 | 2002-05-14 | Shire Us Inc. | Method for the manufacture of anagrelide |
| KR20100110378A (ko) | 2002-05-24 | 2010-10-12 | 안지오테크 인터내셔날 아게 | 의료용 임플란트를 피복하기 위한 조성물 및 방법 |
| US8313760B2 (en) | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
| AU2004206783B2 (en) * | 2003-01-23 | 2009-03-26 | Shire Holdings Ag | Formulation and methods for the treatment of thrombocythemia |
| AT412873B (de) * | 2004-02-20 | 2005-08-25 | Aop Orphan Pharmaceuticals Ag | Verfahren zur herstellung von anagrelid hydrochlorid |
| US7700608B2 (en) * | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
| US20060030574A1 (en) * | 2004-08-04 | 2006-02-09 | Shire Holdings Ag | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors |
| US8304420B2 (en) * | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
| US7910597B2 (en) | 2006-11-28 | 2011-03-22 | Shire Llc | Substituted quinazolines |
| CA2675265A1 (en) * | 2007-02-06 | 2008-07-14 | Cipla Limited | Process for the preparation of ethyl-n-(2, 3-dichloro-6-nitrobenzyl) glycine hydrochloride |
| CN101463035A (zh) * | 2007-12-19 | 2009-06-24 | 华生制药私人有限公司 | 生产盐酸阿那格雷一水合物的改进方法 |
| GB2462022B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof |
| GB0822970D0 (en) | 2008-12-17 | 2009-01-21 | Shire Llc | Process for the preparation of anagrelide and analogues |
| GB201017783D0 (en) | 2010-10-21 | 2010-12-01 | Shire Llc | Process for the preparation of anagrelide and analogues thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1947926A (en) * | 1934-02-20 | Seed grain dressings and process of | ||
| US2862966A (en) * | 1958-12-02 | archo | ||
| US2732403A (en) * | 1956-01-24 | Chclj | ||
| US2256999A (en) * | 1939-03-08 | 1941-09-23 | Du Pont | Nitration of organic compounds |
| US2469695A (en) * | 1946-02-02 | 1949-05-10 | Eastman Kodak Co | Nitroaminobenzene ester compounds |
| US2608584A (en) * | 1947-03-19 | 1952-08-26 | Nopco Chem Co | Preparation of n-alkyl arylamines |
| US2883435A (en) * | 1956-10-10 | 1959-04-21 | Gen Aniline & Film Corp | Purification of 1,2-dichloro-4-nitrobenzene |
| US3313854A (en) * | 1961-11-20 | 1967-04-11 | Universal Oil Prod Co | Preparation of para-nitrodiphenylamines utilizing a copper oxide catalyst |
| DE1543923A1 (de) * | 1966-05-20 | 1970-02-05 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen 2-Amino-halogen-benzylaminen |
| USRE31617E (en) * | 1972-02-04 | 1984-06-26 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
| US3932407A (en) * | 1973-11-19 | 1976-01-13 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
| US3927127A (en) * | 1972-10-24 | 1975-12-16 | Amchem Prod | Nitration process |
| JPS49132019A (de) * | 1973-02-26 | 1974-12-18 | ||
| DE2400887A1 (de) * | 1974-01-09 | 1975-08-28 | Bayer Ag | Verfahren zur herstellung von nitroderivaten aromatischer verbindungen |
| US4146718A (en) * | 1978-04-10 | 1979-03-27 | Bristol-Myers Company | Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides |
| US4208521A (en) * | 1978-07-31 | 1980-06-17 | Bristol-Myers Company | Process for the preparation of imidazo[2,1-b]quinazolinones |
| US4357330A (en) * | 1981-07-30 | 1982-11-02 | Bristol-Myers Company | Pharmaceutical compositions |
| JPS6028979A (ja) * | 1983-07-14 | 1985-02-14 | Dai Ichi Seiyaku Co Ltd | イミダゾキナゾリン類化合物 |
| JPH05271200A (ja) * | 1991-05-22 | 1993-10-19 | Egyt Gyogyszervegyeszeti Gyar | ６，７−ジクロロ−１，５−ジヒドロ−イミダゾ〔２，１−ｂ〕キナゾリン−２〔３Ｈ〕−オンの製造方法 |
| EP0546697A1 (de) * | 1991-11-27 | 1993-06-16 | AT&T Corp. | Verfahren zur Bromierung von desaktivierten Toluolen in der Benzylstellung |
-
1996
- 1996-03-05 CA CA002171073A patent/CA2171073A1/en not_active Abandoned
- 1996-03-07 AU AU47923/96A patent/AU711273B2/en not_active Ceased
- 1996-03-08 DE DE69625253T patent/DE69625253T2/de not_active Expired - Lifetime
- 1996-03-08 ZA ZA961909A patent/ZA961909B/xx unknown
- 1996-03-08 EP EP99126260A patent/EP0994114B1/de not_active Expired - Lifetime
- 1996-03-08 AT AT99126260T patent/ATE229021T1/de not_active IP Right Cessation
- 1996-03-08 ES ES99126260T patent/ES2186297T3/es not_active Expired - Lifetime
- 1996-03-08 EP EP96301593A patent/EP0778258A3/de not_active Withdrawn
- 1996-03-14 AR AR33575596A patent/AR001244A1/es unknown
- 1996-03-19 JP JP06307196A patent/JP4275748B2/ja not_active Expired - Lifetime
- 1996-03-25 MX MX9601105A patent/MX9601105A/es unknown
- 1996-04-08 BR BR9601294A patent/BR9601294A/pt not_active Application Discontinuation
-
1997
- 1997-08-28 US US08/919,964 patent/US5801245A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0778258A2 (de) | 1997-06-11 |
| AR001244A1 (es) | 1997-09-24 |
| CA2171073A1 (en) | 1997-06-05 |
| AU711273B2 (en) | 1999-10-07 |
| ZA961909B (en) | 1996-11-26 |
| JPH09157227A (ja) | 1997-06-17 |
| AU4792396A (en) | 1997-06-12 |
| EP0994114A3 (de) | 2000-12-06 |
| BR9601294A (pt) | 1998-01-13 |
| EP0994114A2 (de) | 2000-04-19 |
| ES2186297T3 (es) | 2003-05-01 |
| US5801245A (en) | 1998-09-01 |
| EP0994114B1 (de) | 2002-12-04 |
| JP4275748B2 (ja) | 2009-06-10 |
| EP0778258A3 (de) | 1998-12-09 |
| DE69625253D1 (de) | 2003-01-16 |
| DE69625253T2 (de) | 2003-08-28 |
| MX9601105A (es) | 1997-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |