SE8002627L - Amider av polyenmakrolidantibiotika - Google Patents
Amider av polyenmakrolidantibiotikaInfo
- Publication number
- SE8002627L SE8002627L SE8002627A SE8002627A SE8002627L SE 8002627 L SE8002627 L SE 8002627L SE 8002627 A SE8002627 A SE 8002627A SE 8002627 A SE8002627 A SE 8002627A SE 8002627 L SE8002627 L SE 8002627L
- Authority
- SE
- Sweden
- Prior art keywords
- reaction
- mixture
- polyene macrolide
- polyene
- ethyl ether
- Prior art date
Links
- 150000004291 polyenes Chemical class 0.000 title abstract 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL1979214802A PL122086B1 (en) | 1979-04-09 | 1979-04-09 | Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8002627L true SE8002627L (sv) | 1980-10-10 |
| SE450639B SE450639B (sv) | 1987-07-13 |
Family
ID=19995636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8002627A SE450639B (sv) | 1979-04-09 | 1980-04-08 | Amider fran gruppen polyen-makrolider samt forfarande for deras framstellning |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4783527A (sv) |
| JP (1) | JPS55157598A (sv) |
| BE (1) | BE882710A (sv) |
| DE (1) | DE3013631C2 (sv) |
| FI (1) | FI70226C (sv) |
| FR (1) | FR2453645A1 (sv) |
| GB (1) | GB2049658B (sv) |
| NL (1) | NL8002086A (sv) |
| NO (1) | NO800995L (sv) |
| PL (1) | PL122086B1 (sv) |
| SE (1) | SE450639B (sv) |
| SU (2) | SU1017165A3 (sv) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2598434B1 (fr) * | 1986-05-12 | 1988-09-16 | Pf Medicament | Nouveaux immunomodulateurs obtenus par hemisynthese a partir d'un polysaccharide bacterien isole d'une souche mutante non capsulee de klebsiella pneumoniae |
| FR2614306B1 (fr) * | 1987-04-22 | 1989-07-28 | Pf Medicament | Nouveau derive de d.25, procede de preparation, utilisation a titre d'agent immunostimulant et compositions pharmaceutiques le contenant. |
| DE3836599A1 (de) * | 1988-10-27 | 1990-05-03 | Wolff Walsrode Ag | Neue polysaccharide, verfahren zu ihrer herstellung und ihre verwendung |
| IT1237772B (it) * | 1989-11-16 | 1993-06-17 | Tiberio Bruzzese | Derivati di macrolidi polienici. |
| IT1243404B (it) * | 1990-12-03 | 1994-06-10 | Prodotti Antibiotici Spa | Derivati della partricina |
| CA2394833A1 (en) | 2000-01-14 | 2001-07-19 | Binh T. Dang | Derivatives of polyene macrolides and preparation and use thereof |
| US6664241B2 (en) | 2000-05-31 | 2003-12-16 | Micrologix Biotech Inc. | Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof |
| RU2007138884A (ru) * | 2005-03-23 | 2009-04-27 | Консехо Супериор Де Инвестигасьонес Сьентификас (Es) | Полиеновые антибиотики, композиции, содержащие указанные антибиотики, способ и микроорганизмы, применяемые для их получения, и их применение |
| ES2323397B1 (es) * | 2005-08-03 | 2010-04-23 | Consejo Sup. De Invest. Cientificas | Macrolidos polienos metilados, procedimiento para su obtencion y sus aplicaciones. |
| ES2323253B1 (es) * | 2005-03-23 | 2010-04-23 | Consejo Sup. De Invest. Cientificas | Nuevos polienos amidados, procedimiento para su obtencion y aplicaciones. |
| WO2009015541A1 (fr) * | 2007-07-30 | 2009-02-05 | Shanghai Institute Of Pharmaceutical Industry | Antibiotiques à base de diesters de polyènes |
| MX365184B (es) * | 2010-12-21 | 2019-05-21 | Centro De Investig Y De Estudios Avanzados Del I P N | Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen. |
| WO2015190587A1 (ja) | 2014-06-12 | 2015-12-17 | 塩野義製薬株式会社 | ポリエンマクロライド誘導体 |
| SG11202107818VA (en) * | 2019-01-31 | 2021-08-30 | Sigma Aldrich Co Llc | Antifungal agents with improved water solubility |
| US20230016424A1 (en) * | 2019-08-08 | 2023-01-19 | The Board Of Trustees Of The University Of Illinois | Hybrid amide derivatives of amphotericin b |
| RU2751333C1 (ru) * | 2020-12-16 | 2021-07-13 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" | Способ получения противогрибкового полусинтетического полиенового антибиотика |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4035568A (en) * | 1971-06-07 | 1977-07-12 | Rutgers Research And Educational Foundation | Derivatives of polyene macrolide antibiotics |
| US4041232A (en) * | 1976-02-23 | 1977-08-09 | E. R. Squibb & Sons, Inc. | Amphotericin B methyl ester salts |
| PL100966B1 (pl) * | 1976-04-22 | 1978-11-30 | Sposob otrzymywania n-glikozylowych pochodnych makrolidow polienowych oraz ich soli,zwlaszcza soli n-metyloglukaminowej |
-
1979
- 1979-04-09 PL PL1979214802A patent/PL122086B1/pl unknown
-
1980
- 1980-04-02 SU SU802901347A patent/SU1017165A3/ru active
- 1980-04-02 SU SU802902549A patent/SU1152954A1/ru active
- 1980-04-08 FR FR8007814A patent/FR2453645A1/fr active Granted
- 1980-04-08 SE SE8002627A patent/SE450639B/sv not_active IP Right Cessation
- 1980-04-08 NO NO800995A patent/NO800995L/no unknown
- 1980-04-08 FI FI801099A patent/FI70226C/fi not_active IP Right Cessation
- 1980-04-09 JP JP4672380A patent/JPS55157598A/ja active Granted
- 1980-04-09 GB GB8011653A patent/GB2049658B/en not_active Expired
- 1980-04-09 NL NL8002086A patent/NL8002086A/nl not_active Application Discontinuation
- 1980-04-09 DE DE3013631A patent/DE3013631C2/de not_active Expired
- 1980-04-09 BE BE0/200168A patent/BE882710A/fr not_active IP Right Cessation
-
1981
- 1981-06-23 US US06/276,462 patent/US4783527A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE3013631A1 (de) | 1980-10-23 |
| FR2453645B1 (sv) | 1982-11-19 |
| NL8002086A (nl) | 1980-10-13 |
| PL122086B1 (en) | 1982-06-30 |
| DE3013631C2 (de) | 1986-08-28 |
| US4783527A (en) | 1988-11-08 |
| SU1152954A1 (ru) | 1985-04-30 |
| GB2049658B (en) | 1983-08-03 |
| SE450639B (sv) | 1987-07-13 |
| GB2049658A (en) | 1980-12-31 |
| JPS5728715B2 (sv) | 1982-06-18 |
| PL214802A1 (sv) | 1980-12-01 |
| SU1017165A3 (ru) | 1983-05-07 |
| FI70226C (fi) | 1986-09-15 |
| BE882710A (fr) | 1980-07-31 |
| FI801099A (fi) | 1980-10-10 |
| FI70226B (fi) | 1986-02-28 |
| FR2453645A1 (fr) | 1980-11-07 |
| NO800995L (no) | 1980-10-10 |
| JPS55157598A (en) | 1980-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8002627-1 Effective date: 19921108 Format of ref document f/p: F |