FR2453645A1 - Nouveaux amides d'antibiotiques du groupe de macrolides polyenes et leurs derives, ainsi qu'un procede de leur obtention - Google Patents

Nouveaux amides d'antibiotiques du groupe de macrolides polyenes et leurs derives, ainsi qu'un procede de leur obtention

Info

Publication number
FR2453645A1
FR2453645A1 FR8007814A FR8007814A FR2453645A1 FR 2453645 A1 FR2453645 A1 FR 2453645A1 FR 8007814 A FR8007814 A FR 8007814A FR 8007814 A FR8007814 A FR 8007814A FR 2453645 A1 FR2453645 A1 FR 2453645A1
Authority
FR
France
Prior art keywords
antibiotics
derivatives
group
isoalkyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8007814A
Other languages
English (en)
Other versions
FR2453645B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Politechnika Gdanska
Original Assignee
Politechnika Gdanska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Gdanska filed Critical Politechnika Gdanska
Publication of FR2453645A1 publication Critical patent/FR2453645A1/fr
Application granted granted Critical
Publication of FR2453645B1 publication Critical patent/FR2453645B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'INVENTION A POUR OBJET DES AMIDES NOUVELLES D'ANTIBIOTIQUES DU GROUPE DE MACROLIDES POLYENIQUES ET LEURS DERIVES A FORMULE GENERALE: (CF DESSIN DANS BOPI) OU R DESIGNE UN RESTE DE MACROLIDE POLYENE, R DESIGNE UN ALKYLE, UN ISOALKYLE A CHAINE EN C1-C18 NON SUBSTITUE, OU UN ALKYLE, UN ISOALKYLE A CHAINE EN C1-C18 SUBSTITUE PAR UN RESTE D'AMINES ALIPHATIQUES PRIMAIRE ET SECONDAIRE OU ENCORE PAR UN ARALKYLE, TANDIS QUE R DESIGNE UN ATOME D'HYDROGENE, UN ALKYLE, ISOALKYLE A CHAINE EN C1-C18 NON SUBSTITUE, OU UN ALKYLE, UN ISOALKYLE A CHAINE EN C1-C18 SUBSTITUE PAR UN RESTE D'AMINE ALIPHATIQUE PRIMAIRE OU SECONDAIRE OU ENCORE UN ARALKYLE. POUR PREPARER CES DERIVES, ON ACTIVE DANS L'ANTIBIOTIQUE LE GROUPE CARBOXYLE DANS UN MILIEU DE SOLVANT ORGANIQUE ET EN PRESENCE D'UN ACCEPTEUR D'ACIDE, PUIS ON FAIT REAGIR AVEC UN COMPOSE COMPORTANT UN GROUE AMINE ET, APRES REACTION, ON PRECIPITE A L'ETHER ETHYLIQUE LE PRODUIT FINAL.
FR8007814A 1979-04-09 1980-04-08 Nouveaux amides d'antibiotiques du groupe de macrolides polyenes et leurs derives, ainsi qu'un procede de leur obtention Granted FR2453645A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL1979214802A PL122086B1 (en) 1979-04-09 1979-04-09 Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh

Publications (2)

Publication Number Publication Date
FR2453645A1 true FR2453645A1 (fr) 1980-11-07
FR2453645B1 FR2453645B1 (fr) 1982-11-19

Family

ID=19995636

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8007814A Granted FR2453645A1 (fr) 1979-04-09 1980-04-08 Nouveaux amides d'antibiotiques du groupe de macrolides polyenes et leurs derives, ainsi qu'un procede de leur obtention

Country Status (12)

Country Link
US (1) US4783527A (fr)
JP (1) JPS55157598A (fr)
BE (1) BE882710A (fr)
DE (1) DE3013631C2 (fr)
FI (1) FI70226C (fr)
FR (1) FR2453645A1 (fr)
GB (1) GB2049658B (fr)
NL (1) NL8002086A (fr)
NO (1) NO800995L (fr)
PL (1) PL122086B1 (fr)
SE (1) SE450639B (fr)
SU (2) SU1152954A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0434943A1 (fr) * 1989-11-16 1991-07-03 S P A SOCIETA' PRODOTTI ANTIBIOTICI S.p.a. Dérivés de macrolides polyéniques

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2598434B1 (fr) * 1986-05-12 1988-09-16 Pf Medicament Nouveaux immunomodulateurs obtenus par hemisynthese a partir d'un polysaccharide bacterien isole d'une souche mutante non capsulee de klebsiella pneumoniae
FR2614306B1 (fr) * 1987-04-22 1989-07-28 Pf Medicament Nouveau derive de d.25, procede de preparation, utilisation a titre d'agent immunostimulant et compositions pharmaceutiques le contenant.
DE3836599A1 (de) * 1988-10-27 1990-05-03 Wolff Walsrode Ag Neue polysaccharide, verfahren zu ihrer herstellung und ihre verwendung
IT1243404B (it) * 1990-12-03 1994-06-10 Prodotti Antibiotici Spa Derivati della partricina
CA2394833A1 (fr) * 2000-01-14 2001-07-19 Binh T. Dang Derives de macrolides de polyene, preparation et utilisations correspondantes
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
AU2006226257A1 (en) * 2005-03-23 2006-09-28 Consejo Superior De Investigaciones Cientificas Polyene antibiotics, compositions containing said antibiotics, method and micro-organisms used to obtain same and applications thereof
ES2323253B1 (es) * 2005-03-23 2010-04-23 Consejo Sup. De Invest. Cientificas Nuevos polienos amidados, procedimiento para su obtencion y aplicaciones.
ES2323397B1 (es) * 2005-08-03 2010-04-23 Consejo Sup. De Invest. Cientificas Macrolidos polienos metilados, procedimiento para su obtencion y sus aplicaciones.
JP2010534688A (ja) * 2007-07-30 2010-11-11 上海医薬工業研究院 ポリエン類抗生物質ジエステル化合物
MX365184B (es) * 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
BR112016028890A8 (pt) 2014-06-12 2021-03-23 Shionogi & Co composto derivado de macrolídeo de polieno, composição farmacêutica compreendendo o referido composto e processo para a preparação do mesmo
WO2020160443A1 (fr) 2019-01-31 2020-08-06 Sigma-Aldrich Co. Llc Agents antifongiques ayant une solubilité aqueuse améliorée
EP4009985A4 (fr) * 2019-08-08 2023-09-06 The Board Of Trustees Of The University Of Illinois Dérivés amides hybrides d'amphotéricine b
RU2751333C1 (ru) * 2020-12-16 2021-07-13 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Способ получения противогрибкового полусинтетического полиенового антибиотика

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4035568A (en) * 1971-06-07 1977-07-12 Rutgers Research And Educational Foundation Derivatives of polyene macrolide antibiotics
US4041232A (en) * 1976-02-23 1977-08-09 E. R. Squibb & Sons, Inc. Amphotericin B methyl ester salts
PL100966B1 (pl) * 1976-04-22 1978-11-30 Sposob otrzymywania n-glikozylowych pochodnych makrolidow polienowych oraz ich soli,zwlaszcza soli n-metyloglukaminowej

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0434943A1 (fr) * 1989-11-16 1991-07-03 S P A SOCIETA' PRODOTTI ANTIBIOTICI S.p.a. Dérivés de macrolides polyéniques

Also Published As

Publication number Publication date
SU1017165A3 (ru) 1983-05-07
FR2453645B1 (fr) 1982-11-19
JPS5728715B2 (fr) 1982-06-18
DE3013631A1 (de) 1980-10-23
GB2049658B (en) 1983-08-03
PL214802A1 (fr) 1980-12-01
US4783527A (en) 1988-11-08
GB2049658A (en) 1980-12-31
SE8002627L (sv) 1980-10-10
FI70226C (fi) 1986-09-15
SU1152954A1 (ru) 1985-04-30
FI801099A (fi) 1980-10-10
DE3013631C2 (de) 1986-08-28
PL122086B1 (en) 1982-06-30
NO800995L (no) 1980-10-10
FI70226B (fi) 1986-02-28
JPS55157598A (en) 1980-12-08
BE882710A (fr) 1980-07-31
NL8002086A (nl) 1980-10-13
SE450639B (sv) 1987-07-13

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