MX365184B - Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.

Info

Publication number
MX365184B
MX365184B MX2010014422A MX2010014422A MX365184B MX 365184 B MX365184 B MX 365184B MX 2010014422 A MX2010014422 A MX 2010014422A MX 2010014422 A MX2010014422 A MX 2010014422A MX 365184 B MX365184 B MX 365184B
Authority
MX
Mexico
Prior art keywords
pharmaceutical compositions
compositions containing
analogous compounds
independently selected
amphotericin
Prior art date
Application number
MX2010014422A
Other languages
English (en)
Other versions
MX2010014422A (es
Inventor
Antillón Díaz Armando
Carrillo Tripp Mauricio
Fernández Zertuche Mario
David Flores Romero José
Eloisa Jiménez Montejo Fabiola
León Buitimea Ángel
Ocampo Martínez Lilia
Alberto Reyes Esparza Jorge
De Lourdes Rodríguez Fragoso María
Minerva Santiago Angelino Tania
Morales Nava Rosmarbel
Ortega Blake Iván
Cristina Vargas González María
Original Assignee
Centro De Investig Y De Estudios Avanzados Del I P N
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro De Investig Y De Estudios Avanzados Del I P N filed Critical Centro De Investig Y De Estudios Avanzados Del I P N
Priority to MX2010014422A priority Critical patent/MX365184B/es
Priority to PCT/IB2011/055721 priority patent/WO2012085784A2/en
Priority to CA2822806A priority patent/CA2822806C/en
Priority to US13/996,889 priority patent/US20140256663A1/en
Priority to EP11810890.1A priority patent/EP2655391B1/en
Publication of MX2010014422A publication Critical patent/MX2010014422A/es
Publication of MX365184B publication Critical patent/MX365184B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a derivados de macrólidos polínicos de acuerdo a la formula (A) (Ver fórmula A) en donde: M es un anillo macrocíclico de lactona; N es azúcar de polieno, sustituida o no sustituida; X se selecciona de manera independiente entre O, S, No NH; R se selecciona de manera independiente entre un grupo alquilo, cicloalquilo, heterocicloalquil arilo, heteroarilo, arilalquilo, y heteroarilalquilo; e i es un número entero de 1 a 3, con la condición de que se tenga una carga negativa o se restaure el carácter de zwiterion; o una sal farmacéuticamente aceptable de estos; útiles como agentes antibióticos.
MX2010014422A 2010-12-21 2010-12-21 Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen. MX365184B (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
MX2010014422A MX365184B (es) 2010-12-21 2010-12-21 Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
PCT/IB2011/055721 WO2012085784A2 (en) 2010-12-21 2011-12-16 New amphotericin analogous compounds and pharmaceutical compositions containing them
CA2822806A CA2822806C (en) 2010-12-21 2011-12-16 New amphotericin analogous compounds and pharmaceutical compositions containing them
US13/996,889 US20140256663A1 (en) 2010-12-21 2011-12-16 Amphotericin Analogous Compounds and Pharmaceutical Compositions Containing Them
EP11810890.1A EP2655391B1 (en) 2010-12-21 2011-12-16 New amphotericin analogous compounds and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MX2010014422A MX365184B (es) 2010-12-21 2010-12-21 Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.

Publications (2)

Publication Number Publication Date
MX2010014422A MX2010014422A (es) 2012-06-21
MX365184B true MX365184B (es) 2019-05-21

Family

ID=45507728

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010014422A MX365184B (es) 2010-12-21 2010-12-21 Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.

Country Status (5)

Country Link
US (1) US20140256663A1 (es)
EP (1) EP2655391B1 (es)
CA (1) CA2822806C (es)
MX (1) MX365184B (es)
WO (1) WO2012085784A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2925904C (en) 2013-10-07 2021-11-23 The Board Of Trustees Of The University Of Illinois Amphotericin b derivatives with improved therapeutic index
WO2015190587A1 (ja) 2014-06-12 2015-12-17 塩野義製薬株式会社 ポリエンマクロライド誘導体
WO2016040779A1 (en) * 2014-09-12 2016-03-17 The Board Of Trustees Of The University Of Illinois Urea derivatives of polyene macrolide antibiotics
EP3242554A4 (en) * 2015-01-08 2018-06-06 The Board of Trustees of the University of Illionis Concise synthesis of urea derivatives of amphotericin b
MX2019007278A (es) * 2019-06-19 2022-03-02 Univ Mexico Nac Autonoma Composicion farmaceutica conteniendo benznidazol y n-(l)-histidinamida de anfotericina b para el tratamiento de tripanosomiasis.
CA3149916A1 (en) * 2019-08-08 2021-02-11 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin b

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4035568A (en) * 1971-06-07 1977-07-12 Rutgers Research And Educational Foundation Derivatives of polyene macrolide antibiotics
US4041232A (en) * 1976-02-23 1977-08-09 E. R. Squibb & Sons, Inc. Amphotericin B methyl ester salts
PL122086B1 (en) * 1979-04-09 1982-06-30 Politechnika Gdanska Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh
PL124710B1 (en) * 1979-07-18 1983-02-28 Politechnika Gdanska Process for preparing esters of antibiotics from polyene macrolids group and their n-substituted derivatives
AU598958B2 (en) 1987-11-12 1990-07-05 Vestar, Inc. Improved amphotericin b liposome preparation
IT1237772B (it) * 1989-11-16 1993-06-17 Tiberio Bruzzese Derivati di macrolidi polienici.
AU6951491A (en) * 1989-12-08 1991-07-18 Beecham Group Plc Amphotericin b derivatives, their production and use
EP0431870A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Amphotericin B derivatives
IT1243404B (it) * 1990-12-03 1994-06-10 Prodotti Antibiotici Spa Derivati della partricina
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof

Also Published As

Publication number Publication date
CA2822806A1 (en) 2012-06-28
US20140256663A1 (en) 2014-09-11
MX2010014422A (es) 2012-06-21
EP2655391A2 (en) 2013-10-30
EP2655391B1 (en) 2019-09-04
WO2012085784A2 (en) 2012-06-28
WO2012085784A3 (en) 2012-11-22
CA2822806C (en) 2019-09-24

Similar Documents

Publication Publication Date Title
WO2012085784A3 (en) New amphotericin analogous compounds and pharmaceutical compositions containing them
MX2014000626A (es) Nuevos derivados de indol sustituidos como moduladores de gamma secretasa.
MX2012008260A (es) Novedosos derivados de triazol sustituidos como moduladores de la gamma secretasa.
EP4295841A3 (en) Sulfur (vi) fluoride compounds and their use in click-reaction
AU2010246749A8 (en) Thiophene derivatives
MX337714B (es) Derivado de imidazol de heteroanillo fusionado que tiene efecto de activacion de proteina cinasa activada por monofosfato de adenosina (amk).
RS52953B (en) PYRIDOPINIDINONSKI INHIBITORI PI3 KALFA
CA2757418C (en) Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making the same
MX348084B (es) Compuestos de cetolido.
MY151986A (en) Adamantyl diamide derivatives and uses of same
WO2007109578A3 (en) Substituted gamma lactams as prostaglandin ep2 agonists
WO2008155615A3 (en) An improved process for the preparation of cephalosporin antibiotic
MX340360B (es) Formulaciones farmaceuticas que comprenden derivados de nitrocatecol y metodos para hacer las mismas.
CA2891755C (en) Substituted pyrido-piperazinone derivatives as gamma secretase modulators
WO2012134184A8 (ko) 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물
PE20140649A1 (es) Derivado de macrolido sustituido en la posicion c4
NZ740051A (en) Tetracycline compounds
WO2013152277A3 (en) Moenomycin analogs, methods of synthesis, and uses thereof
IN2015DN02424A (es)
TN2012000105A1 (en) Spirolactam derivatives and uses of same
WO2016024792A1 (ja) 有機エレクトロルミネッセンス素子用モノアミン材料及びそれを用いた有機エレクトロルミネッセンス素子
MY164789A (en) Heterocyclic compounds for treating or preventing disorders caused by reduced neurotransmission of serotonin, norephnephrine or dopamine
SG10201406839VA (en) Benzazepine compound
NO20091779L (no) Nye indolforbindelser en prosess for deres fremstilling og farmasoytiske sammensetninger som inneholder dem
WO2011100838A9 (en) Derivatives of l-plienyl-1.5-diliydio-benzo[b] [1.4]diazepine-2.4-dione as inhibitors of hiv replication

Legal Events

Date Code Title Description
FG Grant or registration