MX348084B - Compuestos de cetolido. - Google Patents

Compuestos de cetolido.

Info

Publication number
MX348084B
MX348084B MX2013006461A MX2013006461A MX348084B MX 348084 B MX348084 B MX 348084B MX 2013006461 A MX2013006461 A MX 2013006461A MX 2013006461 A MX2013006461 A MX 2013006461A MX 348084 B MX348084 B MX 348084B
Authority
MX
Mexico
Prior art keywords
compounds
hydrogen
unsubstituted
fluorine
heteroaryl ring
Prior art date
Application number
MX2013006461A
Other languages
English (en)
Other versions
MX2013006461A (es
Inventor
Patel Mahesh
Tadiparthi Ravikumar
Trivedi Bharat
Solanki Manish
Deshpande Prasad
Gupta Sunil
Diwakar Santosh
Pawar Shivaji
patil Vijay
Dekhane Deepak
Bhavsar Satish
Mishra Amit
Jafri Mohammad
Bhagwat Sachin
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Publication of MX2013006461A publication Critical patent/MX2013006461A/es
Publication of MX348084B publication Critical patent/MX348084B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a compuestos de cetolida de la Fórmula (I) y sus sales aceptables farmacéuticamente, sus solvatos sus hidratos, sus polimorfos y sus estereoisómeros, que tengan actividad antimicrobiana. La invención provee también composiciones farmacéuticas que contienen los compuestos de la incención, y métodos para tratar o prevenir infecciones microbianas con los compuestos de la inveción.
MX2013006461A 2010-12-09 2011-02-03 Compuestos de cetolido. MX348084B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3352MU2010 2010-12-09
PCT/IB2011/050464 WO2012076989A1 (en) 2010-12-09 2011-02-03 Ketolide compounds

Publications (2)

Publication Number Publication Date
MX2013006461A MX2013006461A (es) 2013-10-01
MX348084B true MX348084B (es) 2017-05-26

Family

ID=54259620

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006461A MX348084B (es) 2010-12-09 2011-02-03 Compuestos de cetolido.

Country Status (18)

Country Link
US (2) US9175031B2 (es)
EP (2) EP3216798A3 (es)
JP (2) JP5851516B2 (es)
KR (1) KR101657751B1 (es)
CN (2) CN103384676B (es)
AU (1) AU2011340204B2 (es)
BR (1) BR112013014392B1 (es)
CA (2) CA2820451C (es)
DK (1) DK2673285T3 (es)
ES (1) ES2642287T3 (es)
HU (1) HUE036658T2 (es)
MX (1) MX348084B (es)
NZ (1) NZ623574A (es)
PL (1) PL2673285T3 (es)
PT (1) PT2673285T (es)
RU (1) RU2601550C2 (es)
WO (1) WO2012076989A1 (es)
ZA (1) ZA201304150B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ587490A (en) * 2010-08-20 2013-03-28 Greentide Ltd Anti-Microbial Compounds containing compounds with a sugar substituent
US8993739B2 (en) * 2011-03-22 2015-03-31 Wockhardt Ltd. Process for preparation of ketolide compounds
US9346828B2 (en) 2013-06-07 2016-05-24 Wisconsin Alumni Research Foundation Forazolines, compositions thereof and uses thereof
RU2697665C1 (ru) 2015-07-27 2019-08-16 Чонг Кун Данг Фармасьютикал Корп. Производные 1,3,4-оксадиазолсульфонамида в качестве ингибиторов деацетилазы гистонов 6 и фармацевтическая композиция, содержащая их
AU2016299486B2 (en) 2015-07-27 2019-08-01 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole sulfamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
NZ739211A (en) * 2015-07-27 2019-05-31 Chong Kun Dang Pharmaceutical Corp 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same
CA2994688C (en) 2015-08-04 2020-11-03 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
HUE061967T2 (hu) 2015-10-12 2023-09-28 Chong Kun Dang Pharmaceutical Corp Hiszton deacetiláz-6 inhibitor oxadiazol-amin származékok és az azokat tartalmazó gyógyászati készítmény
US10485812B2 (en) * 2016-01-12 2019-11-26 Wockhardt Limited Stable antibacterial composition
EP3402487A1 (en) * 2016-01-12 2018-11-21 Wockhardt Limited Pharmaceutical compositions for the treatment of bacterial infections
WO2017122147A1 (en) * 2016-01-12 2017-07-20 Wockhardt Limited Pharmaceutical compositions
WO2018167675A1 (en) * 2017-03-16 2018-09-20 Wockhardt Limited A process for preparing ketolide compounds
KR102316234B1 (ko) 2018-07-26 2021-10-22 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
JP2022554392A (ja) * 2019-11-05 2022-12-28 デルミラ インコーポレイテッド ＭｒｇｐｒＸ２アンタゴニストおよびその使用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
KR100523679B1 (ko) 1996-09-04 2005-10-26 아보트 러보러터리즈 항균 활성을 지닌 6-ｏ-치환된 케톨라이드
AU9649698A (en) * 1997-10-29 1999-05-17 Taisho Pharmaceutical Co., Ltd. Erythromycin a 11, 12-carbamate derivatives
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
FR2777282B1 (fr) 1998-04-08 2001-04-20 Hoechst Marion Roussel Inc Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
AU2001282105A1 (en) 2000-08-22 2002-03-04 Basilea Pharmaceutica Ag New macrolides with antibacterial activity
GB0031312D0 (en) 2000-12-21 2001-02-07 Glaxo Group Ltd Macrolides
ES2275621T3 (es) 2000-12-21 2007-06-16 Glaxo Group Limited Antibioticos macrolidos.
GB0127349D0 (en) 2001-11-14 2002-01-02 Glaxo Group Ltd Macrolides
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6727229B2 (en) 2002-08-19 2004-04-27 Enanta Pharmaceuticals, Inc. 11,12-substituted lactone ketolide derivatives having antibacterial activity
EP2056844A4 (en) * 2006-08-24 2010-11-24 Wockhardt Research Center NEW MACROLIDS AND KETOLIDS WITH ANTIMICROBIAL EFFECT
NZ584159A (en) * 2007-09-17 2012-08-31 Enanta Pharm Inc 6,11-bridged biaryl macrolides
WO2009137787A1 (en) 2008-05-09 2009-11-12 Enanta Pharmaceuticals, Inc. Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives
KR101566053B1 (ko) * 2009-05-27 2015-11-04 욱크하르트 리미티드 항균 활성을 갖는 케톨라이드

Also Published As

Publication number Publication date
DK2673285T3 (en) 2017-10-16
PT2673285T (pt) 2017-10-19
KR101657751B1 (ko) 2016-09-19
CN105669803A (zh) 2016-06-15
ES2642287T3 (es) 2017-11-16
BR112013014392A2 (pt) 2016-07-19
RU2013131234A (ru) 2015-01-20
US20140005133A1 (en) 2014-01-02
JP2015172085A (ja) 2015-10-01
EP2673285B1 (en) 2017-07-19
MX2013006461A (es) 2013-10-01
EP3216798A3 (en) 2017-10-25
EP2673285A1 (en) 2013-12-18
PL2673285T3 (pl) 2017-12-29
JP5851516B2 (ja) 2016-02-03
CA2820451A1 (en) 2012-06-14
EP3216798A2 (en) 2017-09-13
CN103384676A (zh) 2013-11-06
JP6102991B2 (ja) 2017-03-29
CA2964104A1 (en) 2012-06-14
ZA201304150B (en) 2014-11-26
US20160083412A1 (en) 2016-03-24
CN103384676B (zh) 2016-02-03
CA2820451C (en) 2017-12-12
RU2601550C2 (ru) 2016-11-10
AU2011340204A1 (en) 2013-07-04
US9175031B2 (en) 2015-11-03
KR20130112911A (ko) 2013-10-14
AU2011340204B2 (en) 2016-04-14
JP2013544877A (ja) 2013-12-19
HUE036658T2 (hu) 2018-07-30
NZ623574A (en) 2015-07-31
WO2012076989A1 (en) 2012-06-14
BR112013014392B1 (pt) 2021-09-21

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