KR880002889A - 일차 복조환식아민의 디세레노비스 벤조산아민과 그 제조방법 및 약제화합물 - Google Patents
일차 복조환식아민의 디세레노비스 벤조산아민과 그 제조방법 및 약제화합물 Download PDFInfo
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- KR880002889A KR880002889A KR1019870008679A KR870008679A KR880002889A KR 880002889 A KR880002889 A KR 880002889A KR 1019870008679 A KR1019870008679 A KR 1019870008679A KR 870008679 A KR870008679 A KR 870008679A KR 880002889 A KR880002889 A KR 880002889A
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- benzoic acid
- compound
- nitro
- dicerenobis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 하기 일반식 (Ⅰ)의 디세레노비스 벤조산 아미드여기서 R1및 R2는 상호 같거나 다르며, 히드로겐, 할로겐, C1-4-알킬, C1-4-알콕시, 트리플루오로메틸, 니트로 또는 이와 함께 메틸렌디옥시를 나타내고, n은 0 또는 1부터 4이며, R3는 니트로겐족, 술퍼족 및 옥시겐족으로부터 선택된 환식핵 내의 하나 또는 두개의 환식원자를 갖는 포화 또는 불포화된 이종환식 잔유물이고, 상기 잔유물은 치환되지 않거나 할로겐, C1-2-알킬, C1-2-알콕시, 니트로 또는 히드록시에 의해 동일한 방법이나 다른 방법으로 1회 또는 2회 치환된다.
- 제1항에 있어서, 상기 일반식(Ⅰ)의 R1및 R2가 상호 같거나 다를 수도 있으면서 히드로겐, 플루오린, 클로린 메틸, 메톡시, 니트로 또는 이와 함께 메틸렌디옥시를 나타내고, n은 0이거나 1부터 4이며, R3는 니트로겐족, 술퍼족 및 옥시겐족으로부터 선택된 환식핵 내의 하나 또는 두개의 이종원자를 포함하는 복소환식 잔유물을 나타내고, 상기 잔유물이 피리딘, 디아졸, 티오펜, 피페리딘, 피롤리딘, 퓨릴, 이소옥사졸 및 몰풀린으로부터 선택되며, 상기 북소환식 잔유물은 치환되지 않거나 클로린, 메틸, 메톡시 니트로 또는 히드록시에 의해 1회 또는 2회 치환되는 것일 특징인 일반식(Ⅰ)의 디세레노비스-벤조산 아미드.
- 제1항 내지 제2항의 화합물 제조방법에 있어서, 벤즈의 소세레나졸론이 하기의 일반식 (Ⅱ)으로 표시된 것을 특징으로 하는 화합물 제조방법.여기서 R1, R2, R3및 n은 일반식(Ⅰ)에서와 같은 의미를 가지며, 일반식(Ⅱ)이 실온에서 적합한 유기용매내의 메르캅탄의 동일반자량 반응에 의해 일반식(Ⅲ)의 중간화합물 수율로 변환되며 일반식(Ⅲ)은 메틸아민의 부가에 의해 변환되며 상기 일반식(Ⅲ)의 중간화합물은 일반식(Ⅰ)의 디세레노비스 벤조산 아미드 수율로 변환된다.
- 제1항 및 제2항에 있어서, 일반식(Ⅱ)의 벤즈이소세레나졸론이 실온의 적합한 유기용매에서 디티올의 등분자량 반응에 의해 일반식(Ⅰ)의 디세레노비스 벤조산 아미드로 변환되는 것이 특징인 화합물 제조방법.
- 제1항 및 제2항에 따른 일반식(Ⅰ)의 화합물을 상용의약 보조제 및 보균제와 함께 혼합제 내에서 활성성분으로 포함하는 것이 특징인 약제화합물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863626554 DE3626554A1 (de) | 1986-08-06 | 1986-08-06 | Diselenobis-benzoesaeureamide primaerer heterocyclischer amine, verfahren zur ihrer herstellung und diese enthaltende pharmazeutische praeparate |
DEP3626554.3 | 1986-08-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880002889A true KR880002889A (ko) | 1988-05-12 |
KR960001202B1 KR960001202B1 (ko) | 1996-01-24 |
Family
ID=6306768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870008679A KR960001202B1 (ko) | 1986-08-06 | 1987-08-06 | 일차 복소환 아민의 디셀레노비스 벤조산 아미드와 그 제조방법 |
Country Status (19)
Country | Link |
---|---|
US (1) | US4910313A (ko) |
EP (1) | EP0257306B1 (ko) |
JP (1) | JPH0830060B2 (ko) |
KR (1) | KR960001202B1 (ko) |
AT (1) | ATE56436T1 (ko) |
AU (1) | AU598285B2 (ko) |
CA (1) | CA1303038C (ko) |
DD (1) | DD261597A5 (ko) |
DE (2) | DE3626554A1 (ko) |
DK (1) | DK169407B1 (ko) |
ES (1) | ES2017483B3 (ko) |
FI (1) | FI85018C (ko) |
GR (1) | GR3001180T3 (ko) |
HU (1) | HU197753B (ko) |
IE (1) | IE60366B1 (ko) |
NO (1) | NO171215C (ko) |
PT (1) | PT85501B (ko) |
SU (1) | SU1597097A3 (ko) |
ZA (1) | ZA875821B (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5128365A (en) * | 1989-07-19 | 1992-07-07 | The Trustees Of Columbia University In The City Of New York | Compounds having glutathione peroxidase activity and use thereof |
DE3937170A1 (de) * | 1989-11-08 | 1991-05-16 | Nattermann A & Cie | Benzylselenobenzamide von aminopyridinen und picolylaminen |
DE3937171A1 (de) * | 1989-11-08 | 1991-05-16 | Nattermann A & Cie | Picolylselenobenzamide von aminopyridinen, anilinen und picolylaminen |
KR100214453B1 (ko) * | 1992-01-17 | 1999-08-02 | 스즈키 다다시 | 경피적 관상동맥 형성술 후의 재협착 억제제 |
FR2757857B1 (fr) * | 1996-12-27 | 1999-04-23 | Oxis International Sa | Diselenures et selenosulfures aromatiques, leur preparation et leurs utilisations, notamment therapeutiques |
EP1174423A4 (en) | 1999-03-31 | 2008-03-19 | Arne Holmgren | SUBSTRATES FOR THIOREDOXINE REDUCTASE |
US7776925B2 (en) * | 2002-03-06 | 2010-08-17 | Duke University | Reversing, postponing or preventing the occurrence of GTN tolerance and/or generation of reactive oxygen species from mitochondria |
US10058542B1 (en) | 2014-09-12 | 2018-08-28 | Thioredoxin Systems Ab | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3027075A1 (de) * | 1980-07-17 | 1982-02-18 | A. Nattermann & Cie GmbH, 5000 Köln | Benzisoselenazolone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
DE3027074A1 (de) * | 1980-07-17 | 1982-02-18 | A. Nattermann & Cie GmbH, 5000 Köln | Benzisoselenazolon enthaltende pharmazeutische praeparate und ihre verwendung |
DE3027073C2 (de) * | 1980-07-17 | 1985-03-07 | A. Nattermann & Cie GmbH, 5000 Köln | Pharmazeutische Präparate, enthaltend 2-Phenyl-1,2-benzisoselenazol-3(2H)-on |
DE3226284A1 (de) * | 1982-07-14 | 1984-01-19 | A. Nattermann & Cie GmbH, 5000 Köln | Neue benzisoselenazolone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
EP0165534B1 (de) * | 1984-06-22 | 1989-03-15 | A. Nattermann & Cie. GmbH | S-(Carbamoyl-phenylselenyl)-Derivate des Glutathions und von Aminomercaptocarbonsäuren, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
DE3443467A1 (de) * | 1984-11-29 | 1986-05-28 | A. Nattermann & Cie GmbH, 5000 Köln | Mercaptanderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
EP0198277B1 (de) * | 1985-04-12 | 1989-05-03 | A. Nattermann & Cie. GmbH | Diselenobis-benzoesäureamide primärer und sekundärer Amine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
DE3515272C2 (de) * | 1985-04-27 | 1993-10-14 | Nattermann A & Cie | Benzisoselenazolone, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
-
1986
- 1986-08-06 DE DE19863626554 patent/DE3626554A1/de not_active Withdrawn
-
1987
- 1987-07-23 DE DE8787110648T patent/DE3764910D1/de not_active Expired - Fee Related
- 1987-07-23 ES ES87110648T patent/ES2017483B3/es not_active Expired - Lifetime
- 1987-07-23 AT AT87110648T patent/ATE56436T1/de not_active IP Right Cessation
- 1987-07-23 EP EP87110648A patent/EP0257306B1/en not_active Expired - Lifetime
- 1987-07-27 IE IE203387A patent/IE60366B1/en not_active IP Right Cessation
- 1987-07-30 CA CA000543452A patent/CA1303038C/en not_active Expired - Fee Related
- 1987-08-03 NO NO873231A patent/NO171215C/no unknown
- 1987-08-04 FI FI873383A patent/FI85018C/fi not_active IP Right Cessation
- 1987-08-05 HU HU873576A patent/HU197753B/hu not_active IP Right Cessation
- 1987-08-05 DK DK409087A patent/DK169407B1/da not_active IP Right Cessation
- 1987-08-06 JP JP62195406A patent/JPH0830060B2/ja not_active Expired - Lifetime
- 1987-08-06 SU SU874203234A patent/SU1597097A3/ru active
- 1987-08-06 PT PT85501A patent/PT85501B/pt active IP Right Revival
- 1987-08-06 US US07/082,438 patent/US4910313A/en not_active Expired - Fee Related
- 1987-08-06 AU AU76651/87A patent/AU598285B2/en not_active Ceased
- 1987-08-06 KR KR1019870008679A patent/KR960001202B1/ko not_active IP Right Cessation
- 1987-08-06 ZA ZA875821A patent/ZA875821B/xx unknown
- 1987-08-06 DD DD87305765A patent/DD261597A5/de not_active IP Right Cessation
-
1990
- 1990-12-11 GR GR90401048T patent/GR3001180T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK409087D0 (da) | 1987-08-05 |
AU7665187A (en) | 1988-02-11 |
NO873231L (no) | 1988-02-08 |
DD261597A5 (de) | 1988-11-02 |
FI873383A0 (fi) | 1987-08-04 |
EP0257306B1 (en) | 1990-09-12 |
NO873231D0 (no) | 1987-08-03 |
NO171215B (no) | 1992-11-02 |
DK409087A (da) | 1988-02-07 |
DE3626554A1 (de) | 1988-02-18 |
IE872033L (en) | 1988-02-06 |
HU197753B (en) | 1989-05-29 |
AU598285B2 (en) | 1990-06-21 |
DE3764910D1 (de) | 1990-10-18 |
GR3001180T3 (en) | 1992-06-30 |
FI873383A (fi) | 1988-02-07 |
KR960001202B1 (ko) | 1996-01-24 |
JPH0830060B2 (ja) | 1996-03-27 |
PT85501A (en) | 1987-09-01 |
JPS6379875A (ja) | 1988-04-09 |
FI85018C (fi) | 1992-02-25 |
IE60366B1 (en) | 1994-07-13 |
ES2017483B3 (es) | 1991-02-16 |
PT85501B (pt) | 1990-06-29 |
ATE56436T1 (de) | 1990-09-15 |
SU1597097A3 (ru) | 1990-09-30 |
CA1303038C (en) | 1992-06-09 |
ZA875821B (en) | 1988-02-10 |
NO171215C (no) | 1993-02-10 |
US4910313A (en) | 1990-03-20 |
FI85018B (fi) | 1991-11-15 |
HUT44572A (en) | 1988-03-28 |
EP0257306A1 (en) | 1988-03-02 |
DK169407B1 (da) | 1994-10-24 |
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