MX352672B - Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. - Google Patents

Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.

Info

Publication number
MX352672B
MX352672B MX2014003642A MX2014003642A MX352672B MX 352672 B MX352672 B MX 352672B MX 2014003642 A MX2014003642 A MX 2014003642A MX 2014003642 A MX2014003642 A MX 2014003642A MX 352672 B MX352672 B MX 352672B
Authority
MX
Mexico
Prior art keywords
treatment
cancer
heterocyclic compounds
mdm2 inhibitors
compounds
Prior art date
Application number
MX2014003642A
Other languages
English (en)
Other versions
MX2014003642A (es
Inventor
Chen Xiaoqi
Li Zhihong
D Bartberger Michael
Plake Beck Hilary
V Connors Richard
Deignan Jeffrey
A Duquette Jason
Eksterowicz John
M Fox Brian
Fu Jiasheng
Gonzalez Buenrostro Ana
Gonzalez Lopez De Turiso Felix
J Gustin Darin
A Heath Julie
G Johnson Michael
Kayser Frank
J Kopecky David
Li Yihong
Ma Zhihua
mcintosh Joel
C Medina Julio
T Mihalic Jeffrey
H Olson Steven
Rew Yosup
M Roveto Philip
J Schmitt Michael
Sun Daqing
Wang Xiaodong
Wanska Malgorzata
Weathers Christine
Yan Xuelei
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2014003642A publication Critical patent/MX2014003642A/es
Publication of MX352672B publication Critical patent/MX352672B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención actual proporciona compuestos inhibidores MDM2 de la Fórmula I o II, o las sales farmacéuticamente aceptables de los mismos, (ver fórmula), en donde las variables se definen anteriormente, cuyos compuestos son útiles como agentes terapéuticos, particularmente para el tratamiento de cánceres. La invención actual también se refiere a composiciones farmacéuticas que contiene un inhibidor MDM2.
MX2014003642A 2011-09-27 2012-09-26 Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. MX352672B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161539715P 2011-09-27 2011-09-27
US201161566449P 2011-12-02 2011-12-02
PCT/US2012/057389 WO2013049250A1 (en) 2011-09-27 2012-09-26 Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer

Publications (2)

Publication Number Publication Date
MX2014003642A MX2014003642A (es) 2014-08-26
MX352672B true MX352672B (es) 2017-12-04

Family

ID=47071456

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003642A MX352672B (es) 2011-09-27 2012-09-26 Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.

Country Status (7)

Country Link
US (1) US9376425B2 (es)
EP (1) EP2760845B1 (es)
JP (1) JP6093770B2 (es)
AU (1) AU2012316055B2 (es)
CA (1) CA2850166C (es)
MX (1) MX352672B (es)
WO (1) WO2013049250A1 (es)

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CA2850166A1 (en) 2013-04-04
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