AR073578A1 - Pirrolidin-2-onas - Google Patents
Pirrolidin-2-onasInfo
- Publication number
- AR073578A1 AR073578A1 ARP090103497A ARP090103497A AR073578A1 AR 073578 A1 AR073578 A1 AR 073578A1 AR P090103497 A ARP090103497 A AR P090103497A AR P090103497 A ARP090103497 A AR P090103497A AR 073578 A1 AR073578 A1 AR 073578A1
- Authority
- AR
- Argentina
- Prior art keywords
- heterocycloalkyl
- alkylcycloalkyl
- heteroaryl
- aralkyl
- cycloalkyl
- Prior art date
Links
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 20
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 19
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 19
- 125000001072 heteroaryl group Chemical group 0.000 abstract 19
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 18
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 18
- 125000003342 alkenyl group Chemical group 0.000 abstract 17
- 125000000217 alkyl group Chemical group 0.000 abstract 17
- 125000000304 alkynyl group Chemical group 0.000 abstract 17
- 125000003118 aryl group Chemical group 0.000 abstract 17
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 17
- 150000001875 compounds Chemical class 0.000 abstract 5
- 150000002148 esters Chemical class 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- -1 heteroalkylalkyl Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102100032257 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 abstract 1
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 abstract 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
- 208000034486 Multi-organ failure Diseases 0.000 abstract 1
- 208000010718 Multiple Organ Failure Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 231100000357 carcinogen Toxicity 0.000 abstract 1
- 239000003183 carcinogenic agent Substances 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 235000019256 formaldehyde Nutrition 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 208000020431 spinal cord injury Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente provee compuestos de formula (1) o (2) que son ligandos que se unen a la proteína HDM2, induciendo apoptosis e inhibiendo la proliferacion, y que tienen utilidad terapéutica en la terapia y prevencion del cáncer. Los compuestos de formula (1) o (2) pueden ser utilizados como terapéuticos para tratar apoplejía, infarto de miocardio, isquemia, insuficiencia de multiples organos, lesion de la médula espinal, enfermedad de Alzheimer, lesion de eventos isquémicos y valvulopatía degenerativa. Además, los compuestos de la formula (1) o (2) se pueden utilizar para disminuir los efectos colaterales de agentes cancerígenos citotoxicos, y la radiacion para tratar infecciones virales. Reivindicacion 1: Un compuesto de formula (1) en donde V es C=O, C=S o CH2; X es azufre, oxígeno o un grupo de formula CH2, CR4bR4c, NH, NR4b, SO, SO2 o un enlace; Y es un grupo de formula CONR6, CH2NR6, CO, COO, CH2O, SO2NR6, NR6CO, NR6SO2, NR5aCONR6, NR6COO, OCONR6, CONR5aNR6, CONR5aOR6, CH2COCH2CONR6, CH2COO, COCR5aR6 o un enlace; n es 1, 2, 3 o 0; R1 es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R2 es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R3 es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R4 es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R4b es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R4c es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R5 es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R5a es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R6 es un átomo de hidrogeno, o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; los residuos R7 son independientemente unos de otros, un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; los residuos R8 son independientemente unos de otros, un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; o dos de los radicales R1, R2, R3, R4, R4b, R4c, R5, R5a, R6, R7 y R8 juntos, son parte de un sistema de anillo cicloalquilo, heterocicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heteroarilo, aralquilo o heteroarilalquilo opcionalmente sustituido; o una sal, éster, solvato o hidrato farmacéuticamente aceptable o una formulacion farmacéuticamente aceptable de los mismos. Reivindicacion 2: Un compuesto de formula (2) en donde R1 es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R2 es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R3 es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R4 es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R5 es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; R6 es un átomo de hidrogeno o un radical alquilo, alquenilo, alquinilo, heteroalquilo, arilo, heteroarilo, cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo; o los radicales R5 y R6 juntos son parte de un sistema de anillo heterocicloalquilo, heteroalquilcicloalquilo, heteroarilo o heteroarilalquilo opcionalmente sustituido, y/o R2 y R3 juntos son parte de un sistema de anillo cicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, heterocicloalquilo, aralquilo o heteroaralquilo opcionalmente sustituido; o una sal, éster, solvato o hidrato farmacéuticamente aceptable o una formulacion farmacéuticamente aceptable de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9696408P | 2008-09-15 | 2008-09-15 | |
| EP08016236 | 2008-09-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073578A1 true AR073578A1 (es) | 2010-11-17 |
Family
ID=40303570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103497A AR073578A1 (es) | 2008-09-15 | 2009-09-11 | Pirrolidin-2-onas |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8119623B2 (es) |
| EP (1) | EP2346852B1 (es) |
| JP (1) | JP5701758B2 (es) |
| KR (1) | KR20110063542A (es) |
| CN (1) | CN102149708A (es) |
| AR (1) | AR073578A1 (es) |
| AU (1) | AU2009291155A1 (es) |
| BR (1) | BRPI0918603A2 (es) |
| CA (1) | CA2736295A1 (es) |
| EA (1) | EA201100483A1 (es) |
| NZ (1) | NZ591073A (es) |
| PE (1) | PE20110931A1 (es) |
| TW (1) | TW201011009A (es) |
| WO (1) | WO2010028862A1 (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| WO2010051561A1 (en) * | 2008-11-03 | 2010-05-06 | Chemocentryx, Inc. | Compounds for the treatment of osteoporosis and cancers |
| CN102574789B (zh) * | 2009-09-21 | 2014-12-10 | 凯莫森特里克斯股份有限公司 | 吡咯烷酮甲酰胺衍生物作为趋化素-r(chemr23)调节剂 |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| EP3381899B1 (en) | 2010-04-22 | 2021-01-06 | Vertex Pharmaceuticals Incorporated | Intermediate compound for process of producing cycloalkylcarboxamido-indole compounds |
| JO2998B1 (ar) * | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| JP2014502152A (ja) * | 2010-11-12 | 2014-01-30 | ダナ ファーバー キャンサー インスティテュート，インコーポレイテッド | 癌の治療及び診断 |
| US8629133B2 (en) | 2011-03-10 | 2014-01-14 | Daiichi Sankyo Company, Limited | Dispiropyrrolidine derivatives |
| US9745288B2 (en) * | 2011-08-16 | 2017-08-29 | Indiana University Research And Technology Corporation | Compounds and methods for treating cancer by inhibiting the urokinase receptor |
| US9376425B2 (en) | 2011-09-27 | 2016-06-28 | Amgen, Inc. | Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer |
| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| WO2014070976A1 (en) | 2012-11-03 | 2014-05-08 | Boehringer Ingelheim International Gmbh | Inhibitors of cytomegalovirus |
| RU2690663C2 (ru) | 2012-12-20 | 2019-06-05 | Мерк Шарп И Доум Корп. | Замещенные имидазопиридины в качестве ингибиторов hdm2 |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| WO2014134201A1 (en) | 2013-02-28 | 2014-09-04 | Amgen Inc. | A benzoic acid derivative mdm2 inhibitor for the treatment of cancer |
| CA2906538C (en) | 2013-03-14 | 2021-02-02 | Ana Gonzalez Buenrostro | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
| JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
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| US3361759A (en) * | 1963-10-07 | 1968-01-02 | Upjohn Co | 3-(2-pyrrolidinyl)-indoles and method of preparation |
| US4219560A (en) * | 1978-04-17 | 1980-08-26 | Sandoz, Inc. | Piperidine and pyrrolidine alcohols |
| US5574044A (en) * | 1994-10-27 | 1996-11-12 | Merck & Co., Inc. | Muscarine antagonists |
| CA2371618A1 (en) | 1999-04-28 | 2000-11-09 | Yuji Ishihara | Cyclic amide compounds, their production and use |
| CA2656398A1 (en) * | 2006-06-30 | 2008-01-10 | Schering Corporation | Substituted piperidines that increase p53 activity and the uses thereof |
| US7977358B2 (en) * | 2007-07-26 | 2011-07-12 | Hoffmann-La Roche Inc. | Pyrazol derivatives |
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2009
- 2009-09-11 AR ARP090103497A patent/AR073578A1/es not_active Application Discontinuation
- 2009-09-11 TW TW098130660A patent/TW201011009A/zh unknown
- 2009-09-15 CA CA2736295A patent/CA2736295A1/en not_active Abandoned
- 2009-09-15 EP EP09778533.1A patent/EP2346852B1/en active Active
- 2009-09-15 JP JP2011526418A patent/JP5701758B2/ja active Active
- 2009-09-15 CN CN200980135970XA patent/CN102149708A/zh active Pending
- 2009-09-15 PE PE2011000624A patent/PE20110931A1/es not_active Application Discontinuation
- 2009-09-15 NZ NZ591073A patent/NZ591073A/xx not_active IP Right Cessation
- 2009-09-15 EA EA201100483A patent/EA201100483A1/ru unknown
- 2009-09-15 AU AU2009291155A patent/AU2009291155A1/en not_active Abandoned
- 2009-09-15 BR BRPI0918603A patent/BRPI0918603A2/pt not_active IP Right Cessation
- 2009-09-15 KR KR1020117008667A patent/KR20110063542A/ko not_active Application Discontinuation
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- 2009-09-15 WO PCT/EP2009/006670 patent/WO2010028862A1/en active Application Filing
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2012
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|---|---|
| EA201100483A1 (ru) | 2011-10-31 |
| BRPI0918603A2 (pt) | 2017-06-20 |
| JP2012502887A (ja) | 2012-02-02 |
| WO2010028862A1 (en) | 2010-03-18 |
| US20120122839A1 (en) | 2012-05-17 |
| JP5701758B2 (ja) | 2015-04-15 |
| TW201011009A (en) | 2010-03-16 |
| PE20110931A1 (es) | 2012-01-25 |
| EP2346852B1 (en) | 2015-02-25 |
| US9045414B2 (en) | 2015-06-02 |
| US20100075949A1 (en) | 2010-03-25 |
| AU2009291155A1 (en) | 2010-03-18 |
| US8119623B2 (en) | 2012-02-21 |
| CA2736295A1 (en) | 2010-03-18 |
| EP2346852A1 (en) | 2011-07-27 |
| CN102149708A (zh) | 2011-08-10 |
| KR20110063542A (ko) | 2011-06-10 |
| NZ591073A (en) | 2012-11-30 |
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