CY1117113T1 - Αναστολεις πρωτεασης σερινης hcv λαμβανομενοι απο μακροκυκλικη προλινη - Google Patents

Αναστολεις πρωτεασης σερινης hcv λαμβανομενοι απο μακροκυκλικη προλινη

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Publication number
CY1117113T1
CY1117113T1 CY20161100029T CY161100029T CY1117113T1 CY 1117113 T1 CY1117113 T1 CY 1117113T1 CY 20161100029 T CY20161100029 T CY 20161100029T CY 161100029 T CY161100029 T CY 161100029T CY 1117113 T1 CY1117113 T1 CY 1117113T1
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CY
Cyprus
Prior art keywords
hcv
compounds
present
series
protection
Prior art date
Application number
CY20161100029T
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English (en)
Inventor
Yat Sun Or
Jun Ma
Guoqiang Wang
Jiang Long
Bin Wang
Original Assignee
Enanta Pharmaceuticals, Inc.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45817947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117113(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Enanta Pharmaceuticals, Inc. filed Critical Enanta Pharmaceuticals, Inc.
Publication of CY1117113T1 publication Critical patent/CY1117113T1/el

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    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P31/12—Antivirals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
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    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
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    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
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Abstract

Η παρούσα εφεύρεση φανερώνει ενώσεις με Τύπο Ι ή φαρμακευτικώς αποδεκτά άλατα, εστέρες, ή προφάρμακα αυτών: Τύπο (Ι) που αναστέλλουν δράση πρωτεάσης σερίνης, ιδιαίτερα τη δράση πρωτεάσης NS3-NS4A ιού ηπατίτιδας C(HCV). Κατά συνέπεια, οι ενώσεις της παρούσας εφεύρεσης παρεμβαίνουν στον κύκλο ζωής του ιού ηπατίτιδας C και είναι επίσης χρήσιμες ως αντιιικοί παράγοντες. Η παρούσα εφεύρεση περαιτέρω σχετίζεται με φαρμακευτικές συνθέσεις που περιλαμβάνουν τις προαναφερθείσες ενώσεις για χορήγηση σε ένα υποκείμενο που πάσχει από λοίμωξη με HCV. Η εφεύρεση επίσης σχετίζεται με μεθόδους αντιμετώπισης λοίμωξης με HCV σε ένα υποκείμενο χορηγώντας μία φαρμακευτική σύνθεση που περιλαμβάνει τις ενώσεις της παρούσας εφεύρεσης.
CY20161100029T 2010-09-21 2016-01-13 Αναστολεις πρωτεασης σερινης hcv λαμβανομενοι απο μακροκυκλικη προλινη CY1117113T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38505810P 2010-09-21 2010-09-21
US201161499994P 2011-06-22 2011-06-22
US201161504616P 2011-07-05 2011-07-05
EP11827336.6A EP2618831B1 (en) 2010-09-21 2011-09-20 Macrocyclic proline derived hcv serine protease inhibitors

Publications (1)

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CY1117113T1 true CY1117113T1 (el) 2017-04-05

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CY20161100029T CY1117113T1 (el) 2010-09-21 2016-01-13 Αναστολεις πρωτεασης σερινης hcv λαμβανομενοι απο μακροκυκλικη προλινη
CY2017033C CY2017033I1 (el) 2010-09-21 2017-10-24 Αναστολεις πρωτεασης σερινης hcv λαμβανομενοι απο μακροκυκλικη προλινη

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US (7) US8648037B2 (el)
EP (2) EP3020723A1 (el)
JP (5) JP5857053B2 (el)
KR (5) KR102163902B1 (el)
CN (2) CN104829688B (el)
AR (1) AR083052A1 (el)
AU (2) AU2011305695B2 (el)
BR (1) BR112013006693B1 (el)
CA (1) CA2812261C (el)
CL (2) CL2013000791A1 (el)
CO (1) CO6700835A2 (el)
CR (2) CR20180517A (el)
CY (2) CY1117113T1 (el)
DK (1) DK2618831T3 (el)
DO (2) DOP2013000062A (el)
EA (2) EA023009B1 (el)
EC (2) ECSP13012559A (el)
ES (1) ES2560003T3 (el)
GT (2) GT201300077AA (el)
HK (2) HK1186979A1 (el)
HR (1) HRP20160083T1 (el)
HU (2) HUE028384T2 (el)
IL (1) IL225412A (el)
LT (1) LTC2618831I2 (el)
LU (1) LUC00037I2 (el)
MX (3) MX343275B (el)
MY (1) MY164754A (el)
NL (1) NL300900I2 (el)
NO (2) NO2017056I2 (el)
NZ (2) NZ608720A (el)
PE (1) PE20140015A1 (el)
PL (1) PL2618831T3 (el)
PT (1) PT2618831E (el)
RS (1) RS54638B1 (el)
SG (1) SG188618A1 (el)
SI (1) SI2618831T1 (el)
SM (1) SMT201600100B (el)
TW (1) TWI523658B (el)
UA (1) UA116616C2 (el)
UY (2) UY38339A (el)
WO (1) WO2012040167A1 (el)
ZA (2) ZA201302317B (el)

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