HRP20171024T1 - Novi spoj, koristan u liječenju degenerativnih i upalnih bolesti - Google Patents

Novi spoj, koristan u liječenju degenerativnih i upalnih bolesti Download PDF

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Publication number
HRP20171024T1
HRP20171024T1 HRP20171024TT HRP20171024T HRP20171024T1 HR P20171024 T1 HRP20171024 T1 HR P20171024T1 HR P20171024T T HRP20171024T T HR P20171024TT HR P20171024 T HRP20171024 T HR P20171024T HR P20171024 T1 HRP20171024 T1 HR P20171024T1
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HR
Croatia
Prior art keywords
pharmaceutically acceptable
acceptable salt
compound according
intended
treatment
Prior art date
Application number
HRP20171024TT
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English (en)
Inventor
Javier Blanc
Christel Jeanne Marie Menet
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Galapagos Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Galapagos Nv filed Critical Galapagos Nv
Publication of HRP20171024T1 publication Critical patent/HRP20171024T1/hr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Claims (5)

1. Spoj prema Formuli I: [image] ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u liječenju, sprječavanju ili profilaksi osteoartritisa, alergijske bolesti dišnih puteva ili upalnih bolesti crijeva.
2. Spoj u skladu s patentnim zahtjevom 1, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što je stanje osteoartritis.
3. Spoj u skladu s patentnim zahtjevom 1, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što je stanje upalne bolesti crijeva.
4. Spoj u skladu s patentnim zahtjevom 1, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što se spoj u skladu s patentnim zahtjevom 1, ili njegovu farmaceutski prihvatljivu sol, primijenjuje u kombinaciji s dodatnim terapijskim sredstvom.
5. Spoj u skladu s patentnim zahtjevom 1, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačen time što je dodatno terapijsko sredstvo sredstvo za liječenje, sprječavanje ili profilaksu upalnih stanja, autoimunih bolesti, proliferativnih bolesti, odbacivanja presatka, bolesti koje uključuju poremećaj metabolizma hrskavice ili urođenih malformacija hrskavice.
HRP20171024TT 2009-06-26 2017-07-04 Novi spoj, koristan u liječenju degenerativnih i upalnih bolesti HRP20171024T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22068509P 2009-06-26 2009-06-26
US29818810P 2010-01-25 2010-01-25
EP14175887.0A EP2792677B1 (en) 2009-06-26 2010-06-25 Novel compound useful for the treatment of degenerative and inflammatory diseases

Publications (1)

Publication Number Publication Date
HRP20171024T1 true HRP20171024T1 (hr) 2017-10-06

Family

ID=42340530

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20141057AT HRP20141057T1 (en) 2009-06-26 2014-11-03 Novel compound useful for the treatment of degenerative and inflammatory diseases
HRP20171024TT HRP20171024T1 (hr) 2009-06-26 2017-07-04 Novi spoj, koristan u liječenju degenerativnih i upalnih bolesti

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HRP20141057AT HRP20141057T1 (en) 2009-06-26 2014-11-03 Novel compound useful for the treatment of degenerative and inflammatory diseases

Country Status (38)

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US (2) US8796457B2 (hr)
EP (2) EP2445912B1 (hr)
JP (1) JP5486084B2 (hr)
KR (1) KR101712561B1 (hr)
CN (1) CN102459261B (hr)
AR (1) AR077221A1 (hr)
AU (1) AU2010264635B2 (hr)
BR (1) BRPI1014759A2 (hr)
CA (1) CA2765988C (hr)
CL (1) CL2011003276A1 (hr)
CO (1) CO6491039A2 (hr)
CR (1) CR20110673A (hr)
CY (1) CY1119711T1 (hr)
DK (2) DK2445912T3 (hr)
DO (1) DOP2011000378A (hr)
EA (1) EA020111B1 (hr)
ES (2) ES2634325T3 (hr)
HK (2) HK1168098A1 (hr)
HR (2) HRP20141057T1 (hr)
HU (1) HUE034205T2 (hr)
IL (1) IL216618A (hr)
JO (1) JO3030B1 (hr)
LT (1) LT2792677T (hr)
MA (1) MA33447B1 (hr)
ME (1) ME01916B (hr)
MX (1) MX2011013451A (hr)
NZ (1) NZ596836A (hr)
PE (1) PE20120494A1 (hr)
PL (2) PL2445912T3 (hr)
PT (2) PT2445912E (hr)
RS (1) RS53617B1 (hr)
SG (1) SG177359A1 (hr)
SI (2) SI2445912T1 (hr)
SM (1) SMT201400169B (hr)
TW (1) TWI469981B (hr)
UY (1) UY32741A (hr)
WO (1) WO2010149771A1 (hr)
ZA (1) ZA201109502B (hr)

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Publication number Publication date
AU2010264635B2 (en) 2015-05-07
DK2445912T3 (da) 2014-11-10
CN102459261A (zh) 2012-05-16
DK2792677T3 (en) 2017-07-10
JP5486084B2 (ja) 2014-05-07
KR20120059487A (ko) 2012-06-08
AU2010264635A1 (en) 2011-12-22
CN102459261B (zh) 2014-11-05
EP2792677A1 (en) 2014-10-22
CA2765988A1 (en) 2010-12-29
NZ596836A (en) 2013-02-22
UY32741A (es) 2011-01-31
HUE034205T2 (en) 2018-01-29
ES2634325T3 (es) 2017-09-27
CA2765988C (en) 2017-08-29
ES2519170T3 (es) 2014-11-06
EP2792677B1 (en) 2017-04-26
HK1168098A1 (en) 2012-12-21
PL2792677T3 (pl) 2017-09-29
PT2792677T (pt) 2017-07-06
US8796457B2 (en) 2014-08-05
SI2445912T1 (sl) 2014-12-31
KR101712561B1 (ko) 2017-03-06
PT2445912E (pt) 2014-11-07
TWI469981B (zh) 2015-01-21
SI2792677T1 (sl) 2017-08-31
EP2445912B1 (en) 2014-08-13
HRP20141057T1 (en) 2015-03-13
US20150031671A1 (en) 2015-01-29
DOP2011000378A (es) 2012-02-15
CR20110673A (es) 2012-02-09
LT2792677T (lt) 2017-07-25
WO2010149771A1 (en) 2010-12-29
MX2011013451A (es) 2012-04-30
BRPI1014759A2 (pt) 2016-04-19
TW201103937A (en) 2011-02-01
IL216618A0 (en) 2012-02-29
CO6491039A2 (es) 2012-07-31
JP2012530767A (ja) 2012-12-06
PL2445912T3 (pl) 2015-02-27
EA201270076A1 (ru) 2012-08-30
EA020111B1 (ru) 2014-08-29
SMT201400169B (it) 2015-01-15
ZA201109502B (en) 2012-09-26
ME01916B (me) 2015-05-20
PE20120494A1 (es) 2012-05-17
US20100331359A1 (en) 2010-12-30
CY1119711T1 (el) 2018-06-27
HK1202537A1 (en) 2015-10-02
MA33447B1 (fr) 2012-07-03
RS53617B1 (en) 2015-04-30
CL2011003276A1 (es) 2012-08-31
IL216618A (en) 2014-09-30
EP2445912A1 (en) 2012-05-02
SG177359A1 (en) 2012-02-28
JO3030B1 (ar) 2016-09-05
AR077221A1 (es) 2011-08-10
US9505754B2 (en) 2016-11-29

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