MA33447B1 - Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires - Google Patents

Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires

Info

Publication number
MA33447B1
MA33447B1 MA34555A MA34555A MA33447B1 MA 33447 B1 MA33447 B1 MA 33447B1 MA 34555 A MA34555 A MA 34555A MA 34555 A MA34555 A MA 34555A MA 33447 B1 MA33447 B1 MA 33447B1
Authority
MA
Morocco
Prior art keywords
compound used
inflammatory diseases
novel compound
diseases
treat degenerative
Prior art date
Application number
MA34555A
Other languages
Arabic (ar)
English (en)
Inventor
Christel Jeanne Marie Menet
Javier Blanc
Original Assignee
Galapagos Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos Nv filed Critical Galapagos Nv
Publication of MA33447B1 publication Critical patent/MA33447B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un composé représenté par la formule (I). Ce composé peut être préparé comme une composition pharmaceutique, et peut être utilisé pour prévenir et traiter une variété d'états chez les mammifères, en particulier chez l'homme, comprenant à titre d'exemple notamment et de manière non restrictive, les états inflammatoires, les maladies auto-immunes, les maladies prolifératives, les rejets de transplantation, les maladies impliquant l'incapacité de renouvellement du cartilage, les malformations congénitales du cartilage, et/ou les maladies associées à l'hypersécrétion de IL6.
MA34555A 2009-06-26 2010-06-25 Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires MA33447B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22068509P 2009-06-26 2009-06-26
US29818810P 2010-01-25 2010-01-25
PCT/EP2010/059067 WO2010149771A1 (fr) 2009-06-26 2010-06-25 Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires

Publications (1)

Publication Number Publication Date
MA33447B1 true MA33447B1 (fr) 2012-07-03

Family

ID=42340530

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34555A MA33447B1 (fr) 2009-06-26 2010-06-25 Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires

Country Status (38)

Country Link
US (2) US8796457B2 (fr)
EP (2) EP2792677B1 (fr)
JP (1) JP5486084B2 (fr)
KR (1) KR101712561B1 (fr)
CN (1) CN102459261B (fr)
AR (1) AR077221A1 (fr)
AU (1) AU2010264635B2 (fr)
BR (1) BRPI1014759A2 (fr)
CA (1) CA2765988C (fr)
CL (1) CL2011003276A1 (fr)
CO (1) CO6491039A2 (fr)
CR (1) CR20110673A (fr)
CY (1) CY1119711T1 (fr)
DK (2) DK2445912T3 (fr)
DO (1) DOP2011000378A (fr)
EA (1) EA020111B1 (fr)
ES (2) ES2519170T3 (fr)
HK (2) HK1168098A1 (fr)
HR (2) HRP20141057T1 (fr)
HU (1) HUE034205T2 (fr)
IL (1) IL216618A (fr)
JO (1) JO3030B1 (fr)
LT (1) LT2792677T (fr)
MA (1) MA33447B1 (fr)
ME (1) ME01916B (fr)
MX (1) MX2011013451A (fr)
NZ (1) NZ596836A (fr)
PE (1) PE20120494A1 (fr)
PL (2) PL2792677T3 (fr)
PT (2) PT2445912E (fr)
RS (1) RS53617B1 (fr)
SG (1) SG177359A1 (fr)
SI (2) SI2445912T1 (fr)
SM (1) SMT201400169B (fr)
TW (1) TWI469981B (fr)
UY (1) UY32741A (fr)
WO (1) WO2010149771A1 (fr)
ZA (1) ZA201109502B (fr)

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JO3041B1 (ar) 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
TWI462920B (zh) 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
JO3030B1 (ar) 2009-06-26 2016-09-05 Galapagos Nv مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
WO2012142160A1 (fr) * 2011-04-12 2012-10-18 Rigel Pharmaceuticals, Inc. Méthodes d'inhibition d'un rejet d'allogreffe
TWI589299B (zh) * 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
KR20200039028A (ko) * 2011-10-11 2020-04-14 사노피 바이오테크놀로지, 소시에떼 빠르 악씨옹 셍쁠리피에 류마티스 관절염 치료를 위한 조성물 및 이의 이용방법
MX368511B (es) * 2012-06-22 2019-10-07 Galapagos Nv Aminotriazolopiridina para uso en tratamiento de inflamacion y composiciones farmaceuticas de la misma.
JP6472803B2 (ja) 2013-09-05 2019-02-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ トリアゾロピリジン化合物、その組成物及び使用方法
KR101930603B1 (ko) 2013-12-05 2018-12-18 화이자 인코포레이티드 피롤로[2,3-d]피리미디닐, 피롤로[2,3-b]피라지닐 및 피롤로[2,3-d]피리디닐 아크릴아미드
GB201402070D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Pharmaceutical compositions for the treatment of inflammatory disorders
GB201402071D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
PL3283114T3 (pl) * 2015-04-13 2024-01-03 Galapagos Nv Sposoby leczenia zaburzeń sercowo-naczyniowych
US11414413B2 (en) 2016-07-26 2022-08-16 Suzhou Longbiotech Pharmaceuticals Co., Ltd. Heterocyclic compound as JAK inhibitor, and salts and therapeutic use thereof
WO2019149244A1 (fr) * 2018-01-31 2019-08-08 南京明德新药研发股份有限公司 Inhibiteur de jak et son utilisation
KR20210049871A (ko) 2018-08-29 2021-05-06 리제너론 파아마슈티컬스, 인크. 류마티스성 관절염을 갖는 대상체를 치료하기 위한 방법 및 조성물
CN114206442A (zh) 2019-01-31 2022-03-18 赛诺菲生物技术公司 用于治疗幼年特发性关节炎的抗il-6受体抗体
CN111072655B (zh) * 2019-12-30 2021-12-10 深圳市坤健创新药物研究院 一种三氮唑并吡啶类化合物及其制备方法和药用组合物与应用
US20230219889A1 (en) 2020-05-19 2023-07-13 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
US11596612B1 (en) 2022-03-08 2023-03-07 PTC Innovations, LLC Topical anesthetics

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ES2228451T3 (es) 1999-01-29 2005-04-16 Chugai Seiyaku Kabushiki Kaisha Promotores de condrogenesis y derivados de indolin-2-ona.
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WO2010010184A1 (fr) 2008-07-25 2010-01-28 Galapagos Nv [1, 2, 4]triazolo[1, 5-a]pyridines utilisées comme inhibiteurs de jak
WO2010010189A1 (fr) 2008-07-25 2010-01-28 Galapagos Nv Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires
WO2010010188A1 (fr) 2008-07-25 2010-01-28 Galapagos Nv Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires
JO3041B1 (ar) * 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
WO2010010186A1 (fr) * 2008-07-25 2010-01-28 Galapagos Nv Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires
CN102459258B (zh) 2009-06-05 2015-11-25 赛福伦公司 1,2,4-三唑并[1,5a]吡啶衍生物的制备和用途
JO3030B1 (ar) 2009-06-26 2016-09-05 Galapagos Nv مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
TWI462920B (zh) * 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物

Also Published As

Publication number Publication date
US20150031671A1 (en) 2015-01-29
SI2445912T1 (sl) 2014-12-31
ES2634325T3 (es) 2017-09-27
JP2012530767A (ja) 2012-12-06
HK1202537A1 (en) 2015-10-02
IL216618A0 (en) 2012-02-29
RS53617B1 (en) 2015-04-30
EA020111B1 (ru) 2014-08-29
SG177359A1 (en) 2012-02-28
SMT201400169B (it) 2015-01-15
UY32741A (es) 2011-01-31
EA201270076A1 (ru) 2012-08-30
EP2445912B1 (fr) 2014-08-13
CA2765988C (fr) 2017-08-29
BRPI1014759A2 (pt) 2016-04-19
AR077221A1 (es) 2011-08-10
LT2792677T (lt) 2017-07-25
US8796457B2 (en) 2014-08-05
HRP20141057T1 (en) 2015-03-13
US9505754B2 (en) 2016-11-29
PL2792677T3 (pl) 2017-09-29
EP2792677B1 (fr) 2017-04-26
SI2792677T1 (sl) 2017-08-31
CA2765988A1 (fr) 2010-12-29
DK2445912T3 (da) 2014-11-10
WO2010149771A1 (fr) 2010-12-29
HUE034205T2 (en) 2018-01-29
DK2792677T3 (en) 2017-07-10
HRP20171024T1 (hr) 2017-10-06
EP2445912A1 (fr) 2012-05-02
PT2445912E (pt) 2014-11-07
PT2792677T (pt) 2017-07-06
ZA201109502B (en) 2012-09-26
DOP2011000378A (es) 2012-02-15
KR20120059487A (ko) 2012-06-08
AU2010264635B2 (en) 2015-05-07
TW201103937A (en) 2011-02-01
CN102459261A (zh) 2012-05-16
ME01916B (me) 2015-05-20
JP5486084B2 (ja) 2014-05-07
CO6491039A2 (es) 2012-07-31
US20100331359A1 (en) 2010-12-30
TWI469981B (zh) 2015-01-21
PE20120494A1 (es) 2012-05-17
AU2010264635A1 (en) 2011-12-22
PL2445912T3 (pl) 2015-02-27
CL2011003276A1 (es) 2012-08-31
HK1168098A1 (en) 2012-12-21
CY1119711T1 (el) 2018-06-27
IL216618A (en) 2014-09-30
NZ596836A (en) 2013-02-22
CN102459261B (zh) 2014-11-05
CR20110673A (es) 2012-02-09
JO3030B1 (ar) 2016-09-05
KR101712561B1 (ko) 2017-03-06
EP2792677A1 (fr) 2014-10-22
ES2519170T3 (es) 2014-11-06
MX2011013451A (es) 2012-04-30

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