MA33448B1 - 5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-carboxamides utilises en tant qu'inhibiteurs de jak - Google Patents
5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-carboxamides utilises en tant qu'inhibiteurs de jakInfo
- Publication number
- MA33448B1 MA33448B1 MA34556A MA34556A MA33448B1 MA 33448 B1 MA33448 B1 MA 33448B1 MA 34556 A MA34556 A MA 34556A MA 34556 A MA34556 A MA 34556A MA 33448 B1 MA33448 B1 MA 33448B1
- Authority
- MA
- Morocco
- Prior art keywords
- diseases
- jak
- carboxamides
- triazolo
- pyridin
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 210000000845 cartilage Anatomy 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010010356 Congenital anomaly Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000036244 malformation Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 230000007306 turnover Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Cette invention concerne un nouveau composé capable d'inhiber JAK. Le composé selon l'invention peut être préparé sous la forme d'une composition pharmaceutique, et peut être utilisé pour prévenir et traiter diverses affections chez les mammifères, dont l'homme, comprenant, à titre d'exemple mais non exclusif, les affections inflammatoires, les maladies auto-immunes, les maladies prolifératives, le rejet de greffe, les maladies impliquant un défaut de renouvellement des cartilages, les malformations cartilagineuses congénitales, et/ou les maladies associées à une hypersécrétion d'IL6. (I)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22068809P | 2009-06-26 | 2009-06-26 | |
PCT/EP2010/059064 WO2010149769A1 (fr) | 2009-06-26 | 2010-06-25 | 5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-carboxamides utilises en tant qu'inhibiteurs de jak |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33448B1 true MA33448B1 (fr) | 2012-07-03 |
Family
ID=42562363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34556A MA33448B1 (fr) | 2009-06-26 | 2010-06-25 | 5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-carboxamides utilises en tant qu'inhibiteurs de jak |
Country Status (43)
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
TWI462920B (zh) * | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
EP2343294A1 (fr) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines substituées |
AR086042A1 (es) * | 2011-04-28 | 2013-11-13 | Galapagos Nv | Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica |
JP2014532654A (ja) * | 2011-10-26 | 2014-12-08 | シュタイン, エミリー, エイ.STEIN, Emily, A. | 神経機能に影響を及ぼす薬剤、方法、およびデバイス |
WO2013173506A2 (fr) | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Procédé de traitement d'une dégradation musculaire |
CA2875619C (fr) * | 2012-06-22 | 2020-11-24 | Galapagos Nv | Aminotriazolopyridine pour l'utilisation dans le traitement de l'inflammation, et compositions pharmaceutiques associees |
GB201302036D0 (en) * | 2013-02-05 | 2013-03-20 | Queen Mary & Westfield College | Diagnosis |
CA2932596A1 (fr) * | 2013-12-11 | 2015-06-18 | Cephalon, Inc. | Traitement de la sclerose en plaques avec un derive de 1,2,4-triazolo[1,5a]pyridine |
GB201402071D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
GB201402070D0 (en) * | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
TWI679205B (zh) | 2014-09-02 | 2019-12-11 | 日商日本新藥股份有限公司 | 吡唑并噻唑化合物及醫藥 |
MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
MX2017013103A (es) | 2015-04-13 | 2018-01-30 | Galapagos Nv | Metodos para el tratamiento de trastornos cardiovasculares. |
KR20170134750A (ko) * | 2015-04-13 | 2017-12-06 | 갈라파고스 엔.브이. | 염증 질환의 치료 방법 |
WO2016179207A1 (fr) * | 2015-05-05 | 2016-11-10 | Concert Pharmaceuticals, Inc. | Filgotinib deutéré |
CN105061420B (zh) * | 2015-06-04 | 2017-09-05 | 南京旗昌医药科技有限公司 | 一种jak抑制剂的晶型及其制备方法和应用 |
CN104987333B (zh) * | 2015-07-14 | 2017-01-11 | 苏州富士莱医药股份有限公司 | 一种Filgotinib的合成方法 |
WO2017012773A1 (fr) | 2015-07-23 | 2017-01-26 | Ratiopharm Gmbh | Formes solides de base libre de filgotinib |
WO2017012771A1 (fr) | 2015-07-23 | 2017-01-26 | Ratiopharm Gmbh | Sels d'addition d'acide sulfonique de filgotinib cristallin |
WO2017012770A1 (fr) | 2015-07-23 | 2017-01-26 | Ratiopharm Gmbh | Sels d'addition d'acide de filgotinib |
CN105111207B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物d晶型及其制备方法 |
CN105198880B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物a晶型及其制备方法 |
CN105198876B (zh) * | 2015-09-18 | 2017-09-29 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物h晶型及其制备方法 |
CN105218539B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物b晶型及其制备方法 |
CN105198878B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物f晶型及其制备方法 |
CN105198877B (zh) * | 2015-09-18 | 2017-09-22 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物g晶型及其制备方法 |
CN105198879B (zh) * | 2015-09-18 | 2017-09-22 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物c晶型及其制备方法 |
CN105111206B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物e晶型及其制备方法 |
US20170173034A1 (en) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders |
WO2017106566A1 (fr) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combinaison d'un inhibiteur des jak et d'une protéine fixant mmp9 pour traiter des troubles inflammatoires |
WO2017106568A1 (fr) * | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combinaison d'un inhibiteur de jak et d'un inhibiteur de bromodomaine pour le traitement de cancers |
WO2017133423A1 (fr) * | 2016-02-02 | 2017-08-10 | 深圳市塔吉瑞生物医药有限公司 | Fig. 1 : s102 % % % diviser m ports dmrs en k groupes de ports dmrs, k et m étant des entiers positifs et k étant inférieur ou égal à m s104 % % % utilisent un précodage indépendante sur chaque groupe de ports dmrs pour transmettre dmrs |
TWI712604B (zh) | 2016-03-01 | 2020-12-11 | 日商日本新藥股份有限公司 | 具jak抑制作用之化合物之結晶 |
CN105669669A (zh) * | 2016-03-04 | 2016-06-15 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物的a晶型、b晶型、d晶型、g晶型和m晶型及其制备方法 |
KR20180120273A (ko) | 2016-03-21 | 2018-11-05 | 크리스탈 파마테크 씨오., 엘티디. | Jak 관련 질병 예방 또는 치료용 약물의 염산 결정성 형태 및 이의 제조 방법 |
US10071079B2 (en) * | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
EP3492469B1 (fr) * | 2016-07-26 | 2021-12-01 | Suzhou Longbiotech Pharmaceuticals Co., Ltd. | Composé en tant qu'inhibiteur sélectif jak, son sel et son utilisation thérapeutique |
EA038972B1 (ru) | 2016-07-30 | 2021-11-16 | Бристол-Маерс Сквибб Компани | Диметоксифенилзамещенные соединения индола в качестве ингибиторов tlr7, tlr8 или tlr9 |
CN107759587B (zh) * | 2016-08-19 | 2021-01-26 | 中国医药研究开发中心有限公司 | [1,2,4]三唑并[1,5-a]吡啶类化合物及其制备方法和医药用途 |
MX2020012139A (es) | 2016-09-08 | 2021-01-29 | Vyne Pharmaceuticals Inc | Composiciones y metodos para tratar rosacea y acne. |
MA46188A (fr) | 2016-09-09 | 2019-07-17 | Bristol Myers Squibb Co | Composés indole substitués par pyridyle |
CN107880038B (zh) * | 2016-09-30 | 2021-09-28 | 中国医药研究开发中心有限公司 | [1,2,4]三唑并[1,5-a]吡啶类化合物及其制备方法和医药用途 |
EP3538103A1 (fr) | 2016-11-10 | 2019-09-18 | Galapagos NV | Composés et compositions pharmaceutiques associées pour le traitement de maladies inflammatoires |
EA039344B1 (ru) * | 2017-01-19 | 2022-01-17 | Сучжоу Лонгбайотек Фармасьютикалз Ко., Лтд. | Гетероциклическое соединение в качестве ингибитора jak и его соли и терапевтическое применение |
GB201702603D0 (en) | 2017-02-17 | 2017-04-05 | Galápagos Nv | Novel compositions and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
JOP20180018A1 (ar) | 2017-03-14 | 2019-01-30 | Gilead Sciences Inc | تركيبات صيدلية تتضمن مثبط jak |
JP7266576B2 (ja) | 2017-08-04 | 2023-04-28 | ブリストル-マイヤーズ スクイブ カンパニー | [1,2,4]トリアゾロ[4,3-a]ピリジニル置換のインドール化合物 |
WO2019028302A1 (fr) | 2017-08-04 | 2019-02-07 | Bristol-Myers Squibb Company | Composés indole substitués utiles en tant qu'inhibiteurs de tlr7/8/9 |
US20210253593A1 (en) | 2017-11-14 | 2021-08-19 | Bristol-Myers Squibb Company | Substituted indole compounds |
MX2020006093A (es) | 2017-12-15 | 2020-08-24 | Bristol Myers Squibb Co | Compuestos de indol eter sustituidos. |
JP7289301B2 (ja) | 2017-12-18 | 2023-06-09 | ブリストル-マイヤーズ スクイブ カンパニー | 4-アザインドール化合物 |
KR20200101398A (ko) | 2017-12-19 | 2020-08-27 | 브리스톨-마이어스 스큅 컴퍼니 | Tlr 억제제로서 유용한 아미드 치환된 인돌 화합물 |
BR112020011788A2 (pt) | 2017-12-19 | 2020-11-24 | Bristol-Myers Squibb Company | compostos 6-azaindóis |
MX2020005462A (es) | 2017-12-19 | 2020-09-07 | Bristol Myers Squibb Co | Compuestos de indol sustituidos utiles como inhibidores de receptores tipo toll (tlr). |
EA202091479A1 (ru) | 2017-12-20 | 2020-11-24 | Бристол-Маерс Сквибб Компани | Арил- и гетероарилзамещенные индольные соединения |
BR112020012002A2 (pt) | 2017-12-20 | 2020-11-17 | Bristol-Myers Squibb Company | compostos diazaindol |
KR20200101399A (ko) | 2017-12-20 | 2020-08-27 | 브리스톨-마이어스 스큅 컴퍼니 | Tlr 억제제로서 유용한 아미노 인돌 화합물 |
GB201808575D0 (en) * | 2018-05-24 | 2018-07-11 | Galapagos Nv | Methods for the treatment of psoriatic arthrits |
US10815227B2 (en) | 2018-08-27 | 2020-10-27 | Cadila Healthcare Limited | Processes for the preparation of filgotinib |
CN112912382B (zh) | 2018-10-24 | 2024-07-02 | 百时美施贵宝公司 | 经取代的吲哚二聚体化合物 |
CN111154711B (zh) * | 2018-11-07 | 2022-08-05 | 杭州瑞普晨创科技有限公司 | JAK2抑制剂在胰岛β细胞诱导分化中的应用 |
WO2020177705A1 (fr) * | 2019-03-05 | 2020-09-10 | 苏州科睿思制药有限公司 | Forme cristalline csi de maléate de filgotinib, son procédé de préparation et son utilisation |
WO2020182159A1 (fr) | 2019-03-14 | 2020-09-17 | 上海华汇拓医药科技有限公司 | Inhibiteur de kinase jak, son procédé de préparation et ses applications dans le domaine de la médecine |
EP3942045A1 (fr) | 2019-03-21 | 2022-01-26 | Onxeo | Molécule dbait associée à un inhibiteur de kinase pour le traitement du cancer |
EP3947381A4 (fr) * | 2019-03-30 | 2024-07-24 | Unichem Lab Ltd | Nouveau procédé de préparation de filgotinib et de ses intermédiaires |
CN110204542B (zh) * | 2019-05-23 | 2022-05-20 | 四川伊诺达博医药科技有限公司 | 一种JAK1抑制剂Filgotinib的合成方法 |
CN110151738A (zh) * | 2019-06-03 | 2019-08-23 | 上海基科生物化学有限公司 | 一种Jak2抑制剂联合虎杖苷雾化剂及其制备方法和应用 |
IT201900020240A1 (it) | 2019-11-04 | 2021-05-04 | Advitech Advisory And Tech Sa | Procedimento per la preparazione di Filgotinib e intermedi di sintesi |
AU2020378630A1 (en) | 2019-11-08 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
CN110878097B (zh) * | 2019-11-29 | 2021-11-02 | 杭州科巢生物科技有限公司 | 菲格替尼的制备方法 |
CN111072655B (zh) * | 2019-12-30 | 2021-12-10 | 深圳市坤健创新药物研究院 | 一种三氮唑并吡啶类化合物及其制备方法和药用组合物与应用 |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
US20230113620A1 (en) * | 2020-02-13 | 2023-04-13 | Zhuhai United Laboratories Co., Ltd. | Use of jak inhibitors in preparation of drugs for treating jak kinase-related diseases |
EP4196477A1 (fr) * | 2020-08-17 | 2023-06-21 | Vyne Therapeutics Inc. | Formulations de gel à base d'élastomère anhydre contenant du tofacitinib |
WO2022072238A1 (fr) * | 2020-10-02 | 2022-04-07 | University Of Massachusetts | Ciblage de cellules initiatrices de la maladie de vaquez (pv) par blocage de la liaison des leucotriènes à leurs récepteurs |
CN113773322B (zh) * | 2021-11-10 | 2022-02-11 | 奥锐特药业(天津)有限公司 | 一种Filgotinib的制备方法 |
CN114409675B (zh) * | 2022-01-07 | 2023-08-04 | 重庆医科大学 | 螺环异恶唑酮色满衍生物在制备用于治疗jak1介导的疾病药物中的用途 |
WO2023194842A1 (fr) | 2022-04-05 | 2023-10-12 | Unichem Laboratories Limited | Composés tricycliques substitués et leur utilisation dans la polyarthrite rhumatoïde |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ208996A (en) | 1983-07-28 | 1989-08-29 | American Cyanamid Co | 5-substituted(1,2,4 triazpyrimidin-2-amine derivatives and pharmaceutical compositions |
EP1156037B1 (fr) | 1999-01-29 | 2004-12-01 | Chugai Seiyaku Kabushiki Kaisha | Promoteurs de la chondrogenese et derives d'indolin-2-one |
EP1391211A1 (fr) | 2001-04-27 | 2004-02-25 | Chugai Seiyaku Kabushiki Kaisha | Promoteurs de la chondrogenese |
US6514989B1 (en) * | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
CA2515190A1 (fr) | 2003-02-14 | 2004-08-26 | Pfizer Products Inc. | Triazolo-pyridines utilisees comme composes anti-inflammatoires |
US20050222171A1 (en) | 2004-01-22 | 2005-10-06 | Guido Bold | Organic compounds |
ES2427136T3 (es) | 2004-06-21 | 2013-10-29 | Galapagos N.V. | Métodos y medios para el tratamiento de la osteoartritis |
US20090209577A1 (en) | 2004-08-18 | 2009-08-20 | Pfizer Inc. | Novel Triazolopyridine Compounds |
US7524860B2 (en) | 2004-10-07 | 2009-04-28 | Pfizer Inc. | Antibacterial agents |
GB0515026D0 (en) | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
MX2009002171A (es) | 2006-08-30 | 2009-05-28 | Cellzome Ltd | Derivados de triazol como inhibidores de cinasas. |
TW200904816A (en) | 2007-06-05 | 2009-02-01 | Takeda Pharmaceutical | Fused heterocycle derivatives and use thereof |
EA201000130A1 (ru) | 2007-07-18 | 2010-08-30 | Новартис Аг | Бициклические гетероарильные соединения и их применение в качестве ингибиторов киназы |
WO2009017954A1 (fr) * | 2007-08-01 | 2009-02-05 | Phenomix Corporation | Inhibiteurs de kinase jak2 |
EA201070328A1 (ru) | 2007-08-31 | 2010-08-30 | Мерк Сероно С.А. | Соединения триазолопиридина и их применение в качестве ингибиторов ask |
GB0719803D0 (en) * | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
AU2009259867A1 (en) | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine JAK inhibitor compounds and methods |
AU2009259853A1 (en) | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine JAK inhibitor compounds and methods |
WO2010010187A1 (fr) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires |
JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
WO2010010186A1 (fr) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires |
WO2010010184A1 (fr) | 2008-07-25 | 2010-01-28 | Galapagos Nv | [1, 2, 4]triazolo[1, 5-a]pyridines utilisées comme inhibiteurs de jak |
WO2010010189A1 (fr) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires |
WO2010010188A1 (fr) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires |
WO2010141796A2 (fr) | 2009-06-05 | 2010-12-09 | Cephalon, Inc. | Préparation et utilisation de dérivés de 1,2,4-triazolo[1,5a]pyridine |
TWI462920B (zh) * | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
WO2013173506A2 (fr) | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Procédé de traitement d'une dégradation musculaire |
CA2875619C (fr) | 2012-06-22 | 2020-11-24 | Galapagos Nv | Aminotriazolopyridine pour l'utilisation dans le traitement de l'inflammation, et compositions pharmaceutiques associees |
-
2010
- 2010-06-23 TW TW099120586A patent/TWI462920B/zh active
- 2010-06-24 AR ARP100102235A patent/AR077220A1/es active IP Right Grant
- 2010-06-25 EA EA201270075A patent/EA021637B1/ru unknown
- 2010-06-25 SI SI201031467A patent/SI2445911T1/sl unknown
- 2010-06-25 ME MEP-2017-122A patent/ME02699B/fr unknown
- 2010-06-25 CN CN201410408911.8A patent/CN104262337A/zh active Pending
- 2010-06-25 MA MA34556A patent/MA33448B1/fr unknown
- 2010-06-25 WO PCT/EP2010/059064 patent/WO2010149769A1/fr active Application Filing
- 2010-06-25 PL PL10724881T patent/PL2445911T3/pl unknown
- 2010-06-25 SG SG10201703497YA patent/SG10201703497YA/en unknown
- 2010-06-25 AU AU2010264633A patent/AU2010264633B2/en active Active
- 2010-06-25 KR KR1020187010516A patent/KR101916194B1/ko active IP Right Grant
- 2010-06-25 NZ NZ596838A patent/NZ596838A/en unknown
- 2010-06-25 KR KR1020127001940A patent/KR101696669B1/ko active IP Right Grant
- 2010-06-25 CA CA2765985A patent/CA2765985C/fr active Active
- 2010-06-25 ES ES10724881.7T patent/ES2626908T3/es active Active
- 2010-06-25 CN CN201080028631.4A patent/CN102482273B/zh active Active
- 2010-06-25 HU HUE17152084A patent/HUE047478T2/hu unknown
- 2010-06-25 PT PT171520844T patent/PT3178819T/pt unknown
- 2010-06-25 RS RS20170532A patent/RS56035B1/sr unknown
- 2010-06-25 LT LTEP17152084.4T patent/LT3178819T/lt unknown
- 2010-06-25 DK DK17152084.4T patent/DK3178819T3/da active
- 2010-06-25 DK DK10724881.7T patent/DK2445911T3/en active
- 2010-06-25 ES ES17152084T patent/ES2766573T3/es active Active
- 2010-06-25 SI SI201031962T patent/SI3178819T1/sl unknown
- 2010-06-25 GB GB1200457.8A patent/GB2483424B/en not_active Expired - Fee Related
- 2010-06-25 EP EP17152084.4A patent/EP3178819B1/fr active Active
- 2010-06-25 PE PE2011002153A patent/PE20121032A1/es active IP Right Grant
- 2010-06-25 PT PT107248817T patent/PT2445911T/pt unknown
- 2010-06-25 MY MYPI2011006263A patent/MY156664A/en unknown
- 2010-06-25 SG SG2011096211A patent/SG177363A1/en unknown
- 2010-06-25 BR BRPI1015569A patent/BRPI1015569B8/pt active IP Right Grant
- 2010-06-25 HU HUE10724881A patent/HUE033154T2/en unknown
- 2010-06-25 KR KR1020177000585A patent/KR101850716B1/ko active IP Right Grant
- 2010-06-25 LT LTEP10724881.7T patent/LT2445911T/lt unknown
- 2010-06-25 US US12/823,654 patent/US8088764B2/en active Active
- 2010-06-25 JP JP2012516761A patent/JP5591925B2/ja active Active
- 2010-06-25 EP EP10724881.7A patent/EP2445911B1/fr active Active
- 2010-06-25 PL PL17152084T patent/PL3178819T3/pl unknown
- 2010-06-25 UA UAA201200745A patent/UA107935C2/ru unknown
- 2010-06-25 MX MX2011013450A patent/MX344951B/es active IP Right Grant
-
2011
- 2011-11-29 IL IL216667A patent/IL216667A/en active IP Right Grant
- 2011-12-02 US US13/310,090 patent/US8563545B2/en active Active
- 2011-12-14 DO DO2011000388A patent/DOP2011000388A/es unknown
- 2011-12-20 ZA ZA2011/09386A patent/ZA201109386B/en unknown
- 2011-12-21 CL CL2011003247A patent/CL2011003247A1/es unknown
- 2011-12-21 NI NI201100222A patent/NI201100222A/es unknown
-
2012
- 2012-01-11 CR CR20120016A patent/CR20120016A/es unknown
- 2012-01-16 CO CO12005379A patent/CO6491040A2/es active IP Right Grant
- 2012-01-26 EC EC2012011626A patent/ECSP12011626A/es unknown
- 2012-08-21 HK HK12108186.3A patent/HK1167403A1/xx unknown
-
2013
- 2013-09-13 US US14/026,027 patent/US8999979B2/en active Active
-
2014
- 2014-07-30 JP JP2014154379A patent/JP2014221825A/ja not_active Withdrawn
-
2015
- 2015-04-02 US US14/677,058 patent/US9309244B2/en active Active
- 2015-08-28 AU AU2015218544A patent/AU2015218544B2/en active Active
-
2016
- 2016-04-11 US US15/095,317 patent/US9707237B2/en active Active
-
2017
- 2017-05-30 HR HRP20170826TT patent/HRP20170826T1/hr unknown
- 2017-05-31 CY CY20171100569T patent/CY1119214T1/el unknown
- 2017-07-10 AU AU2017204744A patent/AU2017204744A1/en not_active Abandoned
- 2017-07-17 US US15/651,116 patent/US10328081B2/en active Active
-
2019
- 2019-05-09 US US16/407,593 patent/US11000528B2/en active Active
-
2020
- 2020-01-09 HR HRP20200033TT patent/HRP20200033T1/hr unknown
- 2020-01-09 CY CY20201100020T patent/CY1122649T1/el unknown
-
2021
- 2021-03-03 FR FR21C1011C patent/FR21C1011I2/fr active Active
- 2021-03-04 HU HUS2100007C patent/HUS2100007I1/hu unknown
- 2021-03-17 NL NL301096C patent/NL301096I2/nl unknown
- 2021-03-19 LT LTPA2021504C patent/LTC2445911I2/lt unknown
- 2021-03-23 NO NO2021013C patent/NO2021013I1/no unknown
- 2021-04-14 US US17/230,483 patent/US12042498B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA33448B1 (fr) | 5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-carboxamides utilises en tant qu'inhibiteurs de jak | |
MA33447B1 (fr) | Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires | |
MA47399B1 (fr) | Dérivés de 7-phényléthylamino-4h-pyrimido[4,5-d][1,3]oxazin-2-one en tant qu'inhibiteurs de la forme mutée des protéines idh1 et idh2 | |
EP1841426A4 (fr) | Carbinamines tertiaires incluant des heterocycles substitues, agissant en tant qu'inhibiteurs de la beta-secretase et utilisees dans le traitement de la maladie d'alzheimer | |
GT200800265A (es) | Pirido (3,2-e)piracinas, su uso como inhibidores de fosfadiesterasa 10, y procesos para prepararlas. | |
TW200613305A (en) | Polymorphic and amorphous forms of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one | |
MA41238A (fr) | Dérivés 5-[(pipérazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione en tant qu'inhibiteurs d'adamts pour le traitement de l'ostéoarthrit | |
EA201391251A1 (ru) | ПРОИЗВОДНЫЕ 6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4-ИЛАМИНА, ПРИГОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ БЕТА-СЕКРЕТАЗЫ (BACE) | |
WO2006099379A3 (fr) | Derives de benzazole, compositions et methodes d'utilisation des derives comme inhibiteurs de la b-secretase | |
MA34926B1 (fr) | Composition effervescente sous forme solide utilisable dans des applications vaginales pour le traitement d'infections vaginales | |
UA117016C2 (uk) | 6,7-ДИГІДРОПІРАЗОЛО[1,5-a]ПІРАЗИН-4(5H)-ОНОВІ СПОЛУКИ ТА ЇХ ЗАСТОСУВАННЯ ЯК НЕГАТИВНИХ АЛОСТЕРИЧНИХ МОДУЛЯТОРІВ РЕЦЕПТОРІВ MGLUR2 | |
MA37775A1 (fr) | Aminotriazolopyridine pour l'utilisation dans le traitement de l'inflammation, et compositions pharmaceutiques associées | |
EA201391296A1 (ru) | ПРОИЗВОДНЫЕ 3,4-ДИГИДРОПИРРОЛО[1,2-a]ПИРАЗИН-1-ИЛАМИНА, ПРИГОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ БЕТА-СЕКРЕТАЗЫ (BACE) | |
EA201390932A1 (ru) | ПРОИЗВОДНЫЕ 5,6-ДИГИДРОИМИДАЗО[1,2-а]ПИРАЗИН-8-ИЛАМИНА, ПРИГОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ БЕТА-СЕКРЕТАЗЫ (ВАСЕ) | |
MA33295B1 (fr) | Nouvelle formulation de diclofénac | |
EP2091328A4 (fr) | Composés de spiropipéridine inhibiteurs de la bêta-sécrétase pour le traitement de la maladie d'alzheimer | |
MA34820B1 (fr) | Ligandise se liant au récepteur ii du tgf-bêta | |
MA37798B1 (fr) | 4-méthyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphtalènes | |
MA39018A1 (fr) | (aza)pyridopyrazolopyrimidinones et indazolopyrimidinones utilisées comme inhibiteurs de la fibrinolyse | |
AR052056A1 (es) | Tratamiento antiangiogenico de enfermedades autoinmunitarias en pacientes que no han respondido a untratamiento previo | |
MA50391B1 (fr) | Composés d' imidazo[4,5-b]pyridine et compositions pharmaceutiques les contenant destinés à traiter les troubles inflammatoires | |
EP1817312A4 (fr) | Inhibiteurs de l'aminopyridyle de la beta-secretase macrocyclique permettant de traiter la maladie d'alzheimer | |
WO2007058862A3 (fr) | Composes d’imidazolidinone utiles en tant qu’inhibiteurs de la beta-secretase lors du traitement de la maladie d’alzheimer | |
MX2011011459A (es) | Formulacion de clavulanato para neuroproteccion y tratamiento de trastornos neurodegenerativos. | |
MX2011011490A (es) | Derivados de isoxazol-tiazol como agonistas inversos del receptor de acido gamma-aminobutirico a (gaba a), para usarse en el tratamiento de trastornos cognitivos. |