CO2019000069A2 - Antiviral agents against hepatitis b - Google Patents

Antiviral agents against hepatitis b

Info

Publication number
CO2019000069A2
CO2019000069A2 CONC2019/0000069A CO2019000069A CO2019000069A2 CO 2019000069 A2 CO2019000069 A2 CO 2019000069A2 CO 2019000069 A CO2019000069 A CO 2019000069A CO 2019000069 A2 CO2019000069 A2 CO 2019000069A2
Authority
CO
Colombia
Prior art keywords
antiviral agents
present
hepatitis
compounds
agents against
Prior art date
Application number
CONC2019/0000069A
Other languages
Spanish (es)
Inventor
Yao-Ling Qiu
Xuri Gao
Wei Li
Hui Cao
Meizhong Jin
Jorden Kass
Xiaowen Peng
Yat Sun Or
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of CO2019000069A2 publication Critical patent/CO2019000069A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención describe compuestos de Fórmula (I), o sales aceptables farmacéuticamente de estos: que inhiben la(s) proteína(s) codificada(s) por el virus de la hepatitis B (VHB) o interfieren con la función del ciclo de vida del virus de la hepatitis B y son útiles además como agentes antivirales. La presente invención se relaciona además con las composiciones farmacéuticas que comprenden los compuestos antes mencionados para la administración a un sujeto que padece de infección por el VHB. La invención se refiere, además, a métodos para tratar una infección por VHB en un sujeto mediante la administración de una composición farmacéutica que comprende los compuestos de la presente invención.The present invention describes compounds of Formula (I), or pharmaceutically acceptable salts thereof: that inhibit the protein (s) encoded by the hepatitis B virus (HBV) or interfere with the function of the cycle of Hepatitis B virus life and are also useful as antiviral agents. The present invention also relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention further relates to methods for treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

CONC2019/0000069A 2016-06-10 2019-01-04 Antiviral agents against hepatitis b CO2019000069A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662348419P 2016-06-10 2016-06-10
US201762443245P 2017-01-06 2017-01-06
PCT/US2017/036553 WO2017214395A1 (en) 2016-06-10 2017-06-08 Hepatitis b antiviral agents

Publications (1)

Publication Number Publication Date
CO2019000069A2 true CO2019000069A2 (en) 2019-02-08

Family

ID=60573663

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0000069A CO2019000069A2 (en) 2016-06-10 2019-01-04 Antiviral agents against hepatitis b

Country Status (15)

Country Link
US (3) US10189846B2 (en)
EP (1) EP3468561A4 (en)
JP (1) JP2019521972A (en)
KR (1) KR20190027814A (en)
CN (1) CN109843296A (en)
AU (1) AU2017277664A1 (en)
BR (1) BR112018075465A2 (en)
CA (1) CA3028228A1 (en)
CL (1) CL2018003492A1 (en)
CO (1) CO2019000069A2 (en)
IL (1) IL263535A (en)
MX (1) MX2018015315A (en)
PH (1) PH12018550201A1 (en)
SG (1) SG11201810834WA (en)
WO (1) WO2017214395A1 (en)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016161268A1 (en) 2015-04-01 2016-10-06 Enanta Pharmaceuticals, Inc. Hepatitis b antviral agents
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
WO2017011552A1 (en) 2015-07-13 2017-01-19 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2017136403A1 (en) 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
ES2938341T3 (en) 2016-03-07 2023-04-10 Enanta Pharm Inc Antiviral agents against hepatitis B
US10189846B2 (en) 2016-06-10 2019-01-29 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
JOP20190024A1 (en) 2016-08-26 2019-02-19 Gilead Sciences Inc Substituted pyrrolizine compounds and uses thereof
EP4234691A3 (en) 2016-10-14 2023-10-18 Precision Biosciences, Inc. Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome
US11672800B2 (en) 2017-04-21 2023-06-13 Epizyme, Inc. Combination therapies with EHMT2 inhibitors
AR112481A1 (en) 2017-08-28 2019-10-30 Enanta Pharm Inc ANTIVIRAL AGENTS AGAINST HEPATITIS B
TW201927789A (en) * 2017-12-06 2019-07-16 美商因那塔製藥公司 Hepatitis B antiviral agents
WO2019113175A1 (en) * 2017-12-06 2019-06-13 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2019123340A1 (en) 2017-12-20 2019-06-27 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
EP3728282B1 (en) 2017-12-20 2023-11-22 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
US11058678B2 (en) 2018-01-22 2021-07-13 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
KR102526964B1 (en) 2018-02-26 2023-04-28 길리애드 사이언시즈, 인코포레이티드 Substituted pyrrolizine compounds as HBV replication inhibitors
US10729688B2 (en) 2018-03-29 2020-08-04 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2019195181A1 (en) 2018-04-05 2019-10-10 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis b virus protein x
TWI818007B (en) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-cyclic dinucleotides
TWI833744B (en) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-cyclic dinucleotides
TW202005654A (en) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 2'2'-cyclic dinucleotides
TW201945388A (en) 2018-04-12 2019-12-01 美商精密生物科學公司 Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis B virus genome
TW202014193A (en) 2018-05-03 2020-04-16 捷克科學院有機化學與生物化學研究所 2’3’-cyclic dinucleotides comprising carbocyclic nucleotide
WO2020028097A1 (en) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
KR20210065965A (en) 2018-09-21 2021-06-04 이난타 파마슈티칼스, 인코포레이티드 Heterocycles functionalized as antiviral agents
CA3116347A1 (en) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
FI3873903T3 (en) 2018-10-31 2024-03-26 Gilead Sciences Inc Substituted 6-azabenzimidazole compounds as hpk1 inhibitors
MX2021005850A (en) 2018-11-21 2021-10-13 Enanta Pharm Inc Functionalized heterocycles as antiviral agents.
EP3935065A1 (en) 2019-03-07 2022-01-12 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
CA3129011C (en) 2019-03-07 2023-12-19 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3'-cyclic dinucleotides and prodrugs thereof
CA3129022C (en) 2019-03-07 2023-08-01 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3'-cyclic dinucleotides and prodrugs thereof
TWI751516B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TWI751517B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
EP3972695A1 (en) 2019-05-23 2022-03-30 Gilead Sciences, Inc. Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2020247575A1 (en) * 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2020247561A1 (en) * 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
BR112021026376A2 (en) 2019-06-25 2022-05-10 Gilead Sciences Inc flt3l-fc fusion proteins and methods of use
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021031997A1 (en) * 2019-08-16 2021-02-25 西藏天晟泰丰药业有限公司 Dihydropyrimidine derivative and use thereof
WO2021034804A1 (en) 2019-08-19 2021-02-25 Gilead Sciences, Inc. Pharmaceutical formulations of tenofovir alafenamide
US20230012560A1 (en) * 2019-09-04 2023-01-19 Taigen Biotechnology Co., Ltd. Hepatitis b antiviral agents
WO2021055425A2 (en) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
KR20220074917A (en) 2019-09-30 2022-06-03 길리애드 사이언시즈, 인코포레이티드 HBV vaccines and methods of treating HBV
US20230031465A1 (en) 2019-12-06 2023-02-02 Precision Biosciences, Inc. Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome
WO2021188414A1 (en) 2020-03-16 2021-09-23 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
KR20220156884A (en) 2020-03-20 2022-11-28 길리애드 사이언시즈, 인코포레이티드 Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
JP2023536663A (en) 2020-08-07 2023-08-28 ギリアード サイエンシーズ， インコーポレイテッド Prodrugs of Phosphonamide Nucleotide Analogues and Pharmaceutical Uses Thereof
TWI815194B (en) 2020-10-22 2023-09-11 美商基利科學股份有限公司 INTERLEUKIN-2-Fc FUSION PROTEINS AND METHODS OF USE
CN114621219A (en) * 2020-12-09 2022-06-14 上海维申医药有限公司 Dihydropyrimidine compound, and preparation method and application thereof
CA3217107A1 (en) 2021-05-13 2022-11-17 Daniel J. CLOUTIER Combination of a tlr8 modulating compound and anti-hbv sirna therapeutics
JP2024520593A (en) 2021-06-23 2024-05-24 ギリアード サイエンシーズ， インコーポレイテッド DIACYLGLYERCOL KINASE MODULATORY COMPOUNDS
AU2022297367A1 (en) 2021-06-23 2023-12-07 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271684A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
KR20240023628A (en) 2021-06-23 2024-02-22 길리애드 사이언시즈, 인코포레이티드 Diacylglycerol Kinase Modulating Compounds

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3375160A (en) 1965-06-07 1968-03-26 Monsanto Co Methods of combatting gastropods with nitro substituted salicylanilides
US3975532A (en) 1973-06-14 1976-08-17 Ici United States Inc. Hexahydro-1H-furo(3,4-c) pyrrole compounds for treating pain
DE2853220A1 (en) 1978-12-09 1980-07-03 Hoechst Ag NEW AMINO-PYRIMIDINE CARBANILIDES, METHOD FOR THE PRODUCTION THEREOF, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS, AND THEIR USE
US4507481A (en) * 1983-07-29 1985-03-26 Pennwalt Corporation Pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines
WO1987002367A2 (en) 1985-10-18 1987-04-23 The Upjohn Company Cyclic hydrocarbons with an aminoalkyl sidechain
US5656644A (en) 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
US5510387A (en) 1992-11-16 1996-04-23 Nikolai Borisovich Leonidov Antimicrobial interferon-inducing medicament
GB9315595D0 (en) 1993-07-28 1993-09-08 Res Inst Medicine Chem New compounds
FR2765577A1 (en) 1997-07-02 1999-01-08 Hoechst Schering Agrevo Sa NEW AROMATIC AMIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS PESTICIDES
GB9805520D0 (en) 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
DE19817262A1 (en) * 1998-04-18 1999-10-21 Bayer Ag New dihydropyrimidine derivatives and their corresponding mesomers useful in treatment of hepatitis
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
ATE253915T1 (en) 1999-06-30 2003-11-15 Merck & Co Inc SRC KINASE INHIBITING COMPOUNDS
DE10012549A1 (en) 2000-03-15 2001-09-20 Bayer Ag New heterocyclic-substituted dihydropyrimidine derivatives useful for treatment of viral infections, especially hepatitis B infections
DE10012823A1 (en) * 2000-03-16 2001-09-20 Bayer Ag New alkyl-6-aminoalkyl-dihydropyrimidine-5-carboxylate derivatives, useful for the treatment of viral, especially hepatitis B, infections
DE10013126A1 (en) 2000-03-17 2001-09-20 Bayer Ag New 6-aminoalkyl-dihydropyrimidine-5-carboxylate ester derivatives, useful as antiviral agents having strong activity against hepatitis B virus and low cytotoxicity
EP1505966A4 (en) 2002-05-10 2006-08-30 Bristol Myers Squibb Co 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors
US20040209930A1 (en) 2002-10-02 2004-10-21 Carboni Joan M. Synergistic methods and compositions for treating cancer
US7232825B2 (en) 2003-05-02 2007-06-19 Guoqing P Chen Phenylaminopyrimidine derivatives and methods of use
CA2538188A1 (en) 2003-09-10 2005-03-24 Synta Pharmaceuticals Corp. Dihydropyridine compounds for treating or preventing metabolic disorders
US9115090B2 (en) 2003-12-02 2015-08-25 The Ohio State University Research Foundation Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors
EA200700243A1 (en) 2004-07-14 2007-08-31 ПиТиСи ТЕРАПЬЮТИКС, ИНК. METHODS OF TREATMENT OF HEPATITIS C
WO2006033995A2 (en) 2004-09-16 2006-03-30 Valeant Research And Development Thiazolidin-4-ones having anti-hepatitis b activity
EP1904452A2 (en) 2005-07-14 2008-04-02 Takeda San Diego, Inc. Histone deacetylase inhibitors
CA2620179C (en) 2005-08-16 2013-10-29 Icagen, Inc. Inhibitors of voltage-gated sodium channels
WO2008054454A2 (en) 2006-02-10 2008-05-08 Transtech Pharma, Inc. Nitrogen-containing heterocycle derivatives, pharmaceutical compositions, and methods of use thereof as antiviral agents
US8202876B2 (en) 2006-10-02 2012-06-19 Irm Llc Compounds and compositions as protein kinase inhibitors
US20080120759A1 (en) 2006-11-27 2008-05-29 Tolton Gary A Waterproof cuff assembly for outer wear garment
WO2008120759A1 (en) 2007-03-30 2008-10-09 Japan Tobacco Inc. Urea compound and use thereof
TWI394575B (en) 2007-07-09 2013-05-01 Golden Biotechnology Corp Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for the Suppression of Hepatitis B
WO2009012242A2 (en) 2007-07-13 2009-01-22 Icagen, Inc. Sodium channel inhibitors
JP5249344B2 (en) 2007-11-16 2013-07-31 メルク・シャープ・アンド・ドーム・コーポレーション Indole derivatives substituted at the 3-position of the heterocyclic ring and use thereof
AU2009239116B2 (en) 2008-04-24 2013-05-30 Msd K.K. Long-chain fatty acid elongation enzyme inhibitor comprising arylsulfonyl derivative as active ingredient
US20110281950A1 (en) 2010-05-11 2011-11-17 Baiocchi Robert A Compositions and methods for reducing proliferation and viability of lymphoblastoid cells
WO2013006394A1 (en) 2011-07-01 2013-01-10 Institute For Hepatitis And Virus Research Sulfamoylbenzamide derivatives as antiviral agents against hbv infection
JP5977837B2 (en) 2011-12-21 2016-08-24 ノヴィラ・セラピューティクス・インコーポレイテッド Hepatitis B antiviral agent
CA2858647C (en) * 2012-01-06 2020-03-31 Janssen R&D Ireland 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis b.
EP2819671A4 (en) 2012-02-29 2016-05-11 Baruch S Blumberg Inst Binhibitors of hepatitis b virus convalently closed circular dna formation and their method of use
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
WO2013144129A1 (en) 2012-03-31 2013-10-03 F. Hoffmann-La Roche Ag Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
BR112014029697A2 (en) 2012-06-01 2017-08-08 Baruch S Blumberg Inst method for modulating hepatitis b cccdna transcription in an individual, method for modulating covalently closed circular hepatitis b virus dna and compound
CN103626752B (en) 2012-08-24 2015-08-12 广东东阳光药业有限公司 Dihydropyrimidines and the application in medicine thereof
NZ743499A (en) 2012-08-28 2019-09-27 Janssen Sciences Ireland Uc Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
ES2617906T3 (en) 2012-09-10 2017-06-20 F. Hoffmann-La Roche Ag 6-Amino acid heteroaryl dihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
CA2886263C (en) * 2012-10-25 2021-04-13 Tetra Discovery Partners, LLC Heteroaryl inhibitors of pde4
EP2938338A4 (en) 2012-12-27 2016-11-23 Univ Drexel Novel antiviral agents against hbv infection
JO3603B1 (en) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
AU2014267235B2 (en) 2013-05-17 2017-10-05 Janssen Sciences Ireland Uc Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
SG11201509463YA (en) * 2013-05-17 2015-12-30 Hoffmann La Roche 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
JP6524081B2 (en) 2013-11-19 2019-06-05 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． Dihydropyrimidine compounds and their application in medicine
WO2015078393A1 (en) 2013-11-27 2015-06-04 Sunshine Lake Pharma Co., Ltd. Processes for preparing dihydropyrimidine derivatives and intermediates thereof
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
WO2015113990A1 (en) 2014-01-30 2015-08-06 F. Hoffmann-La Roche Ag Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
PL3114128T3 (en) 2014-03-07 2019-06-28 F. Hoffmann-La Roche Ag Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
US9771358B2 (en) 2014-03-28 2017-09-26 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
JP6568106B2 (en) 2014-05-13 2019-08-28 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Novel dihydroquinolidinones for the treatment and prevention of hepatitis B virus infection
NZ727601A (en) 2014-05-30 2022-01-28 Qilu Pharmaceutical Co Ltd Dihydropyrimido fused ring derivative as hbv inhibitor
US10065937B2 (en) 2014-07-31 2018-09-04 Inserm (Institut National De La Sante Et De La Recherche Medicale) FLT3 receptor antagonists
US9637485B2 (en) 2014-11-03 2017-05-02 Hoffmann-La Roche Inc. 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
AU2015373996B2 (en) 2014-12-30 2020-10-08 Novira Therapeutics, Inc. Derivatives and methods of treating hepatitis B infections
WO2016128335A1 (en) 2015-02-11 2016-08-18 F. Hoffmann-La Roche Ag Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
WO2016161268A1 (en) 2015-04-01 2016-10-06 Enanta Pharmaceuticals, Inc. Hepatitis b antviral agents
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
WO2017011552A1 (en) 2015-07-13 2017-01-19 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
CN107849037B (en) 2015-07-21 2020-04-17 豪夫迈·罗氏有限公司 Tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prevention of hepatitis B virus infection
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
EP3328855B1 (en) 2015-07-27 2019-05-15 H. Hoffnabb-La Roche Ag Novel tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
CN107835813B (en) 2015-07-28 2020-04-24 豪夫迈·罗氏有限公司 6, 7-dihydropyrido [2,1-a ] phthalazin-2-ones for the treatment and prevention of hepatitis b virus infections
CN108368113B (en) 2015-11-04 2020-11-24 齐鲁制药有限公司 Crystal forms of dihydropyrido ring compounds, methods of preparation and intermediates
WO2017136403A1 (en) 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
ES2897913T3 (en) 2016-02-19 2022-03-03 Novartis Ag Tetracyclic pyridone compounds as antivirals
ES2938341T3 (en) 2016-03-07 2023-04-10 Enanta Pharm Inc Antiviral agents against hepatitis B
BR102017010009A2 (en) 2016-05-27 2017-12-12 Gilead Sciences, Inc. COMPOUNDS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION
US10189846B2 (en) 2016-06-10 2019-01-29 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2017216686A1 (en) 2016-06-16 2017-12-21 Novartis Ag 8,9-fused 2-oxo-6,7-dihydropyrido-isoquinoline compounds as antivirals
WO2017216685A1 (en) 2016-06-16 2017-12-21 Novartis Ag Pentacyclic pyridone compounds as antivirals
WO2018019297A1 (en) 2016-07-29 2018-02-01 银杏树药业(苏州)有限公司 Isoquinolinone compound and use thereof in preparation of antiviral drugs
CN109715624B (en) 2016-07-29 2022-08-16 广州麓鹏制药有限公司 Novel therapeutic agents for the treatment of HBV infection
TW201811788A (en) 2016-09-09 2018-04-01 瑞士商諾華公司 Polycyclic pyridone compounds as antivirals
TW201819380A (en) 2016-10-18 2018-06-01 瑞士商諾華公司 Fused tetracyclic pyridone compounds as antivirals
JP7113009B2 (en) 2016-11-07 2022-08-04 アービュタス バイオファーマ コーポレイション Substituted pyridinone-containing tricyclic compounds and methods of using same
CN109369640B (en) 2017-01-13 2020-03-27 苏州爱科百发生物医药技术有限公司 Preparation method of dihydroisoquinoline compound
CN106928215B (en) 2017-03-06 2019-03-22 河南春风医药科技有限公司 A kind of preparation method of Quinolizinone type compounds
CN106928245B (en) 2017-03-06 2019-06-11 河南春风医药科技有限公司 A kind of Quinolizinone type compounds and its preparation method and application
WO2018196805A1 (en) 2017-04-28 2018-11-01 齐鲁制药有限公司 Polymorph of compound, preparation method therefor and use thereof
WO2019113175A1 (en) 2017-12-06 2019-06-13 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
TW201927789A (en) 2017-12-06 2019-07-16 美商因那塔製藥公司 Hepatitis B antiviral agents

Also Published As

Publication number Publication date
KR20190027814A (en) 2019-03-15
IL263535A (en) 2019-01-31
EP3468561A1 (en) 2019-04-17
US10640511B2 (en) 2020-05-05
CN109843296A (en) 2019-06-04
PH12018550201A1 (en) 2019-04-08
US20200317678A1 (en) 2020-10-08
US20190119288A1 (en) 2019-04-25
US20170355701A1 (en) 2017-12-14
AU2017277664A1 (en) 2019-01-24
JP2019521972A (en) 2019-08-08
CL2018003492A1 (en) 2019-04-05
BR112018075465A2 (en) 2019-03-19
SG11201810834WA (en) 2018-12-28
CA3028228A1 (en) 2017-12-14
WO2017214395A1 (en) 2017-12-14
EP3468561A4 (en) 2019-12-04
US10189846B2 (en) 2019-01-29
MX2018015315A (en) 2019-04-25

Similar Documents

Publication Publication Date Title
CO2019000069A2 (en) Antiviral agents against hepatitis b
CO2018010748A2 (en) Antiviral agents against hepatitis b
CO2021008055A2 (en) Heterocycles functionalized as antiviral agents
UY37997A (en) ANTIVIRAL AGENTS AGAINST HEPATITIS B
UY37998A (en) ANTIVIRAL AGENTS AGAINST HEPATITIS B
CO2020002980A2 (en) Antiviral agents against hepatitis b.
UY38059A (en) HETEROCICLES REPLACED AS ANTIVIRAL AGENTS
ECSP18069924A (en) TETRACYCLIC PIRIDONE COMPOUNDS AS ANTIVIRALS
CL2020001146A1 (en) New indole-2-carboxamides substituted with pyrazolopiperidine, of high activity, active against the hepatitis b virus (HBV).
UY38383A (en) HETEROCYCLES FUNCTIONALIZED AS ANTIVIRAL AGENTS
DOP2019000201A (en) HIV INHIBITING COMPOUNDS
CL2018002549A1 (en) Elimination of hepatitis B virus with antiviral agents
CO6571891A2 (en) Hepatitis C virus inhibitors
CU20150096A7 (en) AMIDA COMPOUNDS AND PHARMACEUTICAL COMPOSITION FOR HIV TREATMENT
NI201600018A (en) PYRROLAMIDE DERIVATIVES SUBSTITUTED WITH GLIOXAMIDE AND THEIR USE AS MEDICINES FOR THE TREATMENT OF HEPATITIS B.
CL2020001145A1 (en) New, high activity amino-thiazole substituted indole-2-carboxamides, active against hepatitis b virus (HBV).
UY35263A (en) THERAPEUTIC COMPOUNDS
EA201490254A1 (en) COMBINED TREATMENT OF HEPATITIS C
CL2021001388A1 (en) Useful compounds in hiv therapy
EA201792264A1 (en) METHODS OF TREATING INFLAMMATORY DISEASES
UY37166A (en) NUCLEOSID ALKYLIN ANALOGS AS INHIBITORS OF HUMAN RINOVIRUS
EA201892004A1 (en) ANTIVIRAL AGENTS FOR THE TREATMENT OF HEPATITIS B
EA201892732A1 (en) ANTI-VIRUS AGENTS FOR THE TREATMENT OF HEPATITIS B