UY37166A - Nucleósidos ánalogos de alquinilo como inhibidores de rinovirus humano - Google Patents

Nucleósidos ánalogos de alquinilo como inhibidores de rinovirus humano

Info

Publication number
UY37166A
UY37166A UY0001037166A UY37166A UY37166A UY 37166 A UY37166 A UY 37166A UY 0001037166 A UY0001037166 A UY 0001037166A UY 37166 A UY37166 A UY 37166A UY 37166 A UY37166 A UY 37166A
Authority
UY
Uruguay
Prior art keywords
rinovirus
alkylin
nucleosid
analogs
inhibitors
Prior art date
Application number
UY0001037166A
Other languages
English (en)
Inventor
Weidong Zhong
Martijn Fenaux
Oliver Saunders
Fumiaki Yokokawa
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of UY37166A publication Critical patent/UY37166A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención proporciona un compuesto de Fórmula (I) o una sal del mismo; y usos terapéuticos de estos compuestos. La presente invención proporciona además composiciones farmacéuticas que comprenden estos compuestos, y composiciones que comprenden estos compuestos con un co-agente terapéutico, y métodos para usar los compuestos y composiciones para el tratamiento de infecciones virales, especialmente HRV.
UY0001037166A 2016-03-24 2017-03-23 Nucleósidos ánalogos de alquinilo como inhibidores de rinovirus humano UY37166A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SG10201602360R 2016-03-24

Publications (1)

Publication Number Publication Date
UY37166A true UY37166A (es) 2017-10-31

Family

ID=58448587

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037166A UY37166A (es) 2016-03-24 2017-03-23 Nucleósidos ánalogos de alquinilo como inhibidores de rinovirus humano

Country Status (13)

Country Link
US (2) US9988416B2 (es)
EP (2) EP4292658A3 (es)
JP (1) JP7005508B2 (es)
CN (1) CN109311885A (es)
AR (1) AR107974A1 (es)
DK (1) DK3433257T3 (es)
ES (1) ES2962269T3 (es)
FI (1) FI3433257T3 (es)
PL (1) PL3433257T3 (es)
PT (1) PT3433257T (es)
TW (1) TWI746532B (es)
UY (1) UY37166A (es)
WO (1) WO2017163186A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI3433257T3 (fi) * 2016-03-24 2024-01-08 Novartis Ag Alkynyylinukleosidianalogeja ihmisen rinoviruksen estäjinä
WO2018048882A1 (en) 2016-09-06 2018-03-15 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
EP4705313A2 (en) * 2023-04-28 2026-03-11 The Scripps Research Institute 4'-substituted nucleosides and nucleotides as antiviral agents

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Also Published As

Publication number Publication date
EP3433257B1 (en) 2023-10-11
TW201736391A (zh) 2017-10-16
US20170275329A1 (en) 2017-09-28
EP3433257A1 (en) 2019-01-30
WO2017163186A1 (en) 2017-09-28
FI3433257T3 (fi) 2024-01-08
JP2019509316A (ja) 2019-04-04
US20180258129A1 (en) 2018-09-13
AR107974A1 (es) 2018-07-04
US10428105B2 (en) 2019-10-01
PT3433257T (pt) 2023-11-29
US9988416B2 (en) 2018-06-05
EP4292658A2 (en) 2023-12-20
EP4292658A3 (en) 2024-03-06
ES2962269T3 (es) 2024-03-18
PL3433257T3 (pl) 2024-02-12
CN109311885A (zh) 2019-02-05
JP7005508B2 (ja) 2022-01-21
DK3433257T3 (da) 2024-01-02
TWI746532B (zh) 2021-11-21

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Legal Events

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Effective date: 20230605