PE20120732A1 - Agonistas del receptor de esfingosina-1-fosfato - Google Patents

Agonistas del receptor de esfingosina-1-fosfato

Info

Publication number
PE20120732A1
PE20120732A1 PE2012000174A PE2012000174A PE20120732A1 PE 20120732 A1 PE20120732 A1 PE 20120732A1 PE 2012000174 A PE2012000174 A PE 2012000174A PE 2012000174 A PE2012000174 A PE 2012000174A PE 20120732 A1 PE20120732 A1 PE 20120732A1
Authority
PE
Peru
Prior art keywords
phenyl
alkyl
oxadiazol
sphingosine
crdrd
Prior art date
Application number
PE2012000174A
Other languages
English (en)
Inventor
John L Gilmore
James E Sheppeck
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20120732A1 publication Critical patent/PE20120732A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE R1 ES -(CRdRd)aOH, -(CRdRd)aCOOH, ENTRE OTROS, EN DONDE Rd ES H, OH, ALQUILO(C1-C4), ALCOXI(C1-C4), ENTRE OTROS; a ES DE 0 A 3; R2 ES HALO, -OH, ALQUILO(C1-C4), ENTRE OTROS; R3 Y R4 SON CADA UNO H, ALQUILO(C1-C6) O JUNTO AL ATOMO DE C AL QUE ESTAN UNIDOS FORMAN UN ANILLO DE 3 A 6 MIEMBROS; R5 ES H O ALQUILO(C1-C4); R6 ES ALQUILO(C1-C3), HALO, HALOALQUILO(C1-C3), ENTRE OTROS; m Y n SON CADA UNO 1 O 2; x ES DE 0 A 2; t ES DE 0 A 4; W ES O, CH2 O NH; A ES UN COMPUESTO DE FORMULA (i), (ii), (iii) O (iv), EN DONDE Q ES HETEROARILO MONOCICLICO DE 5 MIEMBROS. SON COMPUESTOS PREFERIDOS: ACIDO 1-(2-HIDROXI-2-(4-(5-(5-FENIL-4-PROPILISOXAZOL-3-IL)-1,2,4-OXADIAZOL-3-IL)FENIL)ETIL)ACETIDINA-3-CARBOXILICO; ACIDO (S)-1-((R)-2-HIDROXI-2-(4-(5-(3-FENIL-4-(TRIFLUOROMETIL)ISOXAZOL-5-IL)-1,2,4-OXADIAZOL-3-IL)FENIL)ETIL)PIPERIDINA-3-CARBOXILICO; 2-(3-(HIDROXIMETIL)PIPERIDIN-1-IL)-1-(4-(5-(3-FENIL-4-(TRIFLUOROMETIL)ISOXAZOL-5-IL)-1,2,4-OXADIAZOL-3-IL)FENIL)ETANOL; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR DE ESFINGOSINA-1-FOSFATO (S1P1) SIENDO UTILES EN EL TRATAMIENTO DE LUPUS ERITEMATOSO SISTEMICO, ARTRITIS REUMATOIDE, ESCLEROSIS MULTIPLE
PE2012000174A 2009-08-07 2010-08-06 Agonistas del receptor de esfingosina-1-fosfato PE20120732A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23205409P 2009-08-07 2009-08-07

Publications (1)

Publication Number Publication Date
PE20120732A1 true PE20120732A1 (es) 2012-06-20

Family

ID=43029859

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012000174A PE20120732A1 (es) 2009-08-07 2010-08-06 Agonistas del receptor de esfingosina-1-fosfato

Country Status (19)

Country Link
US (1) US8399451B2 (es)
EP (1) EP2462139B1 (es)
JP (1) JP5602230B2 (es)
KR (1) KR20120108963A (es)
CN (1) CN102548989A (es)
AR (1) AR077819A1 (es)
AU (1) AU2010279354A1 (es)
BR (1) BR112012002824A2 (es)
CA (1) CA2770194A1 (es)
CL (1) CL2012000326A1 (es)
CO (1) CO6430439A2 (es)
EA (1) EA201270266A1 (es)
ES (1) ES2533095T3 (es)
MX (1) MX2012001160A (es)
PE (1) PE20120732A1 (es)
SG (1) SG177691A1 (es)
TW (1) TW201109323A (es)
WO (1) WO2011017578A1 (es)
ZA (1) ZA201200641B (es)

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JP2010507619A (ja) * 2006-10-25 2010-03-11 ノイロサーチ アクティーゼルスカブ オキサジアゾール及びチアジアゾール化合物並びにニコチン性アセチルコリン受容体調節物質としてのその使用
CN103119038B (zh) * 2010-04-23 2016-05-04 百时美施贵宝公司 作为1-磷酸鞘氨醇1受体激动剂的4-(5-异噁唑基或5-吡唑基-1，2，4-噁二唑基-3-基)扁桃酰胺
ES2539256T3 (es) 2010-07-20 2015-06-29 Bristol-Myers Squibb Company Compuestos de 3-fenil-1,2,4-oxadiazol sustituidos
WO2012040532A1 (en) 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Substituted oxadiazole compounds and their use as s1p1 agonists
US8629282B2 (en) 2010-11-03 2014-01-14 Bristol-Myers Squibb Company Heterocyclic compounds as S1P1 agonists for the treatment of autoimmune and vascular diseases
UY35338A (es) 2013-02-21 2014-08-29 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Compuestos bicíclicos moduladores de la actividad de s1p1 y composiciones farmacéuticas que los contienen
UY36274A (es) 2014-08-20 2016-02-29 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Compuestos bicíclicos sustituidos como agonistas selectivos de la actividad del receptor s1p1 acoplado a la proteína g
TW202023386A (zh) * 2018-09-13 2020-07-01 瑞士商先正達合夥公司 殺有害生物活性唑-醯胺化合物
CN114181276A (zh) * 2021-12-17 2022-03-15 安徽大学 硫酯肽合成方法

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Also Published As

Publication number Publication date
CN102548989A (zh) 2012-07-04
JP2013501729A (ja) 2013-01-17
ES2533095T3 (es) 2015-04-07
EP2462139A1 (en) 2012-06-13
TW201109323A (en) 2011-03-16
KR20120108963A (ko) 2012-10-05
WO2011017578A1 (en) 2011-02-10
MX2012001160A (es) 2012-02-13
US8399451B2 (en) 2013-03-19
EP2462139B1 (en) 2015-01-14
AU2010279354A1 (en) 2012-02-09
SG177691A1 (en) 2012-02-28
CO6430439A2 (es) 2012-04-30
EA201270266A1 (ru) 2012-07-30
AR077819A1 (es) 2011-09-28
JP5602230B2 (ja) 2014-10-08
US20110190255A1 (en) 2011-08-04
CL2012000326A1 (es) 2012-10-19
ZA201200641B (en) 2013-06-26
CA2770194A1 (en) 2011-02-10
BR112012002824A2 (pt) 2019-09-24

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