CO6430439A2 - Agonistas del receptor de esfingosina -1- fosfato - Google Patents
Agonistas del receptor de esfingosina -1- fosfatoInfo
- Publication number
- CO6430439A2 CO6430439A2 CO12027713A CO12027713A CO6430439A2 CO 6430439 A2 CO6430439 A2 CO 6430439A2 CO 12027713 A CO12027713 A CO 12027713A CO 12027713 A CO12027713 A CO 12027713A CO 6430439 A2 CO6430439 A2 CO 6430439A2
- Authority
- CO
- Colombia
- Prior art keywords
- compounds
- phosphate
- receptor agonists
- disclosed
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Se divulgan compuestos de fórmula (I):o un estereoisómero o una sal farmacéuticamente aceptable del mismo, en la que:Q es un grupo heteroarilo monocíclico de 5 miembros;W es CH2, O, o NH; y R1, R2, R3, R4, R5, R6, m, n, t, y x se definen en la presente descripción. También se divulgan procedimientos de uso de los compuestos como agonistas selectivos para el receptor S1P1 acoplado a proteína G, y composiciones farmacéuticas que comprenden los compuestos. Estos compuestos son útiles en el tratamiento, la prevención o la ralentización de la progresión de enfermedades o trastornos en una variedad de áreas terapéuticas, tales como enfermedades autoinmunitarias y enfermedad vascular.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23205409P | 2009-08-07 | 2009-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6430439A2 true CO6430439A2 (es) | 2012-04-30 |
Family
ID=43029859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO12027713A CO6430439A2 (es) | 2009-08-07 | 2012-02-16 | Agonistas del receptor de esfingosina -1- fosfato |
Country Status (19)
Country | Link |
---|---|
US (1) | US8399451B2 (es) |
EP (1) | EP2462139B1 (es) |
JP (1) | JP5602230B2 (es) |
KR (1) | KR20120108963A (es) |
CN (1) | CN102548989A (es) |
AR (1) | AR077819A1 (es) |
AU (1) | AU2010279354A1 (es) |
BR (1) | BR112012002824A2 (es) |
CA (1) | CA2770194A1 (es) |
CL (1) | CL2012000326A1 (es) |
CO (1) | CO6430439A2 (es) |
EA (1) | EA201270266A1 (es) |
ES (1) | ES2533095T3 (es) |
MX (1) | MX2012001160A (es) |
PE (1) | PE20120732A1 (es) |
SG (1) | SG177691A1 (es) |
TW (1) | TW201109323A (es) |
WO (1) | WO2011017578A1 (es) |
ZA (1) | ZA201200641B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2667545A1 (en) * | 2006-10-25 | 2008-05-02 | Neurosearch A/S | Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators |
CN103119038B (zh) * | 2010-04-23 | 2016-05-04 | 百时美施贵宝公司 | 作为1-磷酸鞘氨醇1受体激动剂的4-(5-异噁唑基或5-吡唑基-1,2,4-噁二唑基-3-基)扁桃酰胺 |
CN103124727B (zh) | 2010-07-20 | 2015-03-25 | 百时美施贵宝公司 | 取代的3-苯基-1,2,4-噁二唑化合物 |
WO2012040532A1 (en) | 2010-09-24 | 2012-03-29 | Bristol-Myers Squibb Company | Substituted oxadiazole compounds and their use as s1p1 agonists |
JP2013544811A (ja) * | 2010-11-03 | 2013-12-19 | ブリストル−マイヤーズ スクイブ カンパニー | 自己免疫疾患および血管疾患の治療用のs1p1アゴニストとしての複素環式化合物 |
US9115054B2 (en) | 2013-02-21 | 2015-08-25 | Bristol-Myers Squibb Company | Tetrahydronaphthalenyl compounds useful as sipi agonists |
UY36274A (es) | 2014-08-20 | 2016-02-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Compuestos bicíclicos sustituidos como agonistas selectivos de la actividad del receptor s1p1 acoplado a la proteína g |
UY38367A (es) * | 2018-09-13 | 2020-04-30 | Syngenta Participations Ag | Compuestos de azol-amida pesticidamente activos |
CN114181276A (zh) * | 2021-12-17 | 2022-03-15 | 安徽大学 | 硫酯肽合成方法 |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4200750A (en) | 1977-01-07 | 1980-04-29 | Westwood Pharmaceuticals Inc. | 4-Substituted imidazo [1,2-a]quinoxalines |
JPS6480026A (en) | 1987-09-21 | 1989-03-24 | Mitsubishi Electric Corp | Resist coater |
DE4102024A1 (de) * | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
TW432061B (en) | 1994-08-09 | 2001-05-01 | Pfizer Res & Dev | Lactams |
US6069143A (en) * | 1994-12-20 | 2000-05-30 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
AU4064597A (en) | 1996-08-16 | 1998-03-06 | Du Pont Pharmaceuticals Company | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof |
WO2003062252A1 (en) * | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | Edg receptor agonists |
WO2003062248A2 (en) | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists |
WO2003061567A2 (en) | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | Selective s1p1/edg1 receptor agonists |
JP2005531506A (ja) | 2002-03-01 | 2005-10-20 | メルク エンド カムパニー インコーポレーテッド | Edg受容体作動薬としてのアミノアルキルホスホネートおよび関連化合物 |
MXPA04010379A (es) * | 2002-04-23 | 2005-02-17 | Squibb Bristol Myers Co | Compuestos de pirrolo-triazina anilina utiles como inhibidores de cinasa. |
CA2488117A1 (en) | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
AU2003279915A1 (en) | 2002-10-15 | 2004-05-04 | Merck And Co., Inc. | Process for making azetidine-3-carboxylic acid |
CA2509218C (en) | 2002-12-20 | 2010-09-07 | Merck & Co., Inc. | 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as edg receptor agonists |
BRPI0407401A (pt) | 2003-02-11 | 2006-02-21 | Irm Llc | compostos bicìclicos e composições |
CA2524867A1 (en) | 2003-05-15 | 2004-12-02 | Merck & Co., Inc. | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists |
MXPA05012460A (es) | 2003-05-19 | 2006-05-25 | Irm Llc | Compuestos y composiciones inmunosupresoras. |
SI1638551T1 (sl) | 2003-05-19 | 2012-04-30 | Irm Llc | Imunosupresivne spojine in sestavki |
MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
MXPA05012461A (es) | 2003-05-19 | 2006-02-22 | Irm Llc | Compuestos y composiciones inmunosupresores. |
CA2539438A1 (en) | 2003-10-01 | 2005-04-14 | Merck And Co., Inc. | 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists |
AU2004299456B2 (en) | 2003-12-17 | 2010-10-07 | Merck Sharp & Dohme Corp. | (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists |
TW200538433A (en) | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
EP1804793A4 (en) | 2004-10-22 | 2010-03-31 | Merck Sharp & Dohme | 2- (ARYL) AZACYCLYLMETHYL-CARBOXYLATE, SULPHONATE, PHOSPHONATE, PHOSPHINATE AND HETEROCYCLES AS S1P RECEPTOR AGONISTS |
CA2596990A1 (en) | 2005-02-14 | 2006-08-24 | University Of Virginia Patent Foundation | Sphingosine 1-phosphate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups |
PT1863474E (pt) | 2005-03-23 | 2009-01-20 | Actelion Pharmaceuticals Ltd | Novos derivados de tiofeno como agonistas dos receptores 1 de esfingosina-1-fosfato |
PT1863787E (pt) | 2005-03-23 | 2011-07-29 | Actelion Pharmaceuticals Ltd | Derivados de benzo(c)tiofenos hidrogenados como imunomoduladores |
TW200642683A (en) | 2005-04-22 | 2006-12-16 | Sankyo Co | Heterocyclic compound |
MX2007015422A (es) | 2005-06-08 | 2008-02-21 | Novartis Ag | Oxadiazoles o isoxazoles policiclicos y su uso como ligandos del receptor de s1p. |
RU2008101805A (ru) | 2005-06-24 | 2009-07-27 | Актелион Фармасьютиклз Лтд (Ch) | Новые производные тиофена |
AU2006283175A1 (en) | 2005-08-23 | 2007-03-01 | Irm Llc | Immunosuppressant compounds and compositions |
TW200800911A (en) | 2005-10-20 | 2008-01-01 | Biolipox Ab | Pyrazoles useful in the treatment of inflammation |
WO2007061458A2 (en) * | 2005-11-23 | 2007-05-31 | Epix Delaware, Inc. | S1p receptor modulating compounds and use thereof |
TWI404706B (zh) | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
GB0601744D0 (en) | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
TW200806611A (en) | 2006-02-09 | 2008-02-01 | Daiichi Seiyaku Co | Novel amidopropionic acid derivatives and medicine containing the same |
TW200806633A (en) * | 2006-03-21 | 2008-02-01 | Epix Pharm Inc | S1P receptor modulating compounds and use thereof |
BRPI0709866B8 (pt) | 2006-04-03 | 2021-05-25 | Astellas Pharma Inc | compostos héteros e composição farmacêutica compreendendo ditos compostos |
EP2046766A1 (en) | 2006-08-01 | 2009-04-15 | Praecis Pharmaceuticals Incorporated | Agonists of the sphingosine- 1- phosphate receptor (slp) |
JP2009269819A (ja) * | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
MX2009002233A (es) | 2006-09-07 | 2009-03-16 | Actelion Pharmaceuticals Ltd | Derivados de piridin-4-il como agentes inmunomoduladores. |
AR061841A1 (es) | 2006-09-07 | 2008-09-24 | Actelion Pharmaceuticals Ltd | Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores. |
BRPI0716815A2 (pt) | 2006-09-07 | 2013-11-05 | Allergan Inc | Co posto heteroatomáticos tendo atividade biológia agonista e/ou antagonista de receptor de esfinfosina-1-fosfato (s1p) |
JP5253400B2 (ja) * | 2006-09-08 | 2013-07-31 | アクテリオン ファーマシューティカルズ リミテッド | 免疫調節薬としてのピリジン−3−イル誘導体 |
JP2010502675A (ja) | 2006-09-08 | 2010-01-28 | ノバルティス アクチエンゲゼルシャフト | リンパ球相互作用が介在する疾患または障害を処置するために有用なn−ビアリール(ヘテロ)アリールスルホンアミド誘導体 |
CN101522645B (zh) | 2006-09-21 | 2013-01-09 | 埃科特莱茵药品有限公司 | 苯衍生物及其免疫调节剂的用途 |
BRPI0717656A2 (pt) | 2006-09-29 | 2014-04-29 | Novartis Ag | Derivados de diaril oxadiazol |
CA2669102A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Tetralin analogs having sphingosine 1-phosphate agonist activity |
CA2672616A1 (en) | 2006-12-15 | 2008-06-26 | Abbott Laboratories | Novel oxadiazole compounds |
GB0625648D0 (en) | 2006-12-21 | 2007-01-31 | Glaxo Group Ltd | Compounds |
JP2010513532A (ja) | 2006-12-21 | 2010-04-30 | アボット・ラボラトリーズ | スフィンゴシン−1−ホスフェート受容体作働薬および拮抗薬化合物 |
JO2701B1 (en) | 2006-12-21 | 2013-03-03 | جلاكسو جروب ليميتد | Vehicles |
WO2008091967A1 (en) | 2007-01-26 | 2008-07-31 | Smithkline Beecham Corporation | Chemical compounds |
AU2008227979B2 (en) | 2007-03-16 | 2014-02-06 | Actelion Pharmaceuticals Ltd | Amino- pyridine derivatives as S1P1 /EDG1 receptor agonists |
AR066095A1 (es) * | 2007-04-19 | 2009-07-22 | Glaxo Group Ltd | Compuesto de oxadiazol su uso para preparar un medicamento composicion farmaceutica que lo comprende y procedimiento para prepararla |
WO2009011850A2 (en) | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
CN101815707B (zh) | 2007-10-04 | 2015-09-02 | 默克雪兰诺有限公司 | 噁二唑二芳基化合物 |
WO2009043889A2 (en) | 2007-10-04 | 2009-04-09 | Merck Serono S.A. | Oxadiazole derivatives |
CN101970430B (zh) | 2007-11-01 | 2013-05-08 | 埃科特莱茵药品有限公司 | 嘧啶衍生物 |
US8202856B2 (en) | 2007-12-21 | 2012-06-19 | Merck Serono Sa | Triazole oxadiazoles derivatives |
DK2291080T3 (en) | 2008-05-14 | 2015-12-07 | Scripps Research Inst | Novel modulator of sphingosinphosphatreceptorer |
WO2010041655A1 (ja) | 2008-10-06 | 2010-04-15 | 昭和電工株式会社 | 触媒およびその製造方法ならびにその用途 |
WO2010065760A1 (en) * | 2008-12-04 | 2010-06-10 | Exelixis, Inc. | Imidazo [1,2a] pyridine derivatives, their use as s1p1 agonists and methods for their production |
KR101589332B1 (ko) | 2008-12-05 | 2016-01-27 | 아스텔라스세이야쿠 가부시키가이샤 | 2h-크로멘 화합물 및 그의 유도체 |
US8741923B2 (en) | 2008-12-18 | 2014-06-03 | Merck Serono Sa | Oxadiazole fused heterocyclic derivatives useful for the treatment of multiple sclerosis |
AR075319A1 (es) | 2008-12-23 | 2011-03-23 | Novartis Ag | Compuestos de biaril- bencil-amina, procesos para su produccion, su uso como productos farmaceuticos, y composiciones farmaceuticas que los comprenden |
EP2202232A1 (en) | 2008-12-26 | 2010-06-30 | Laboratorios Almirall, S.A. | 1,2,4-oxadiazole derivatives and their therapeutic use |
EP2210890A1 (en) | 2009-01-19 | 2010-07-28 | Almirall, S.A. | Oxadiazole derivatives as S1P1 receptor agonists |
WO2010085582A1 (en) | 2009-01-23 | 2010-07-29 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
US8389509B2 (en) | 2009-01-23 | 2013-03-05 | Bristol-Myers Squibb Company | Substituted pyrazole compounds |
WO2010085581A1 (en) | 2009-01-23 | 2010-07-29 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
JP5669363B2 (ja) | 2009-03-31 | 2015-02-12 | 昭和電工株式会社 | 樹脂組成物及びこれで処理された紙又は繊維加工品 |
WO2010113528A1 (en) | 2009-04-03 | 2010-10-07 | Panasonic Corporation | Mobile communication method, mobile communication system, and corresponding apparatus |
-
2010
- 2010-08-05 US US12/850,892 patent/US8399451B2/en active Active
- 2010-08-06 EP EP10742067.1A patent/EP2462139B1/en not_active Not-in-force
- 2010-08-06 EA EA201270266A patent/EA201270266A1/ru unknown
- 2010-08-06 MX MX2012001160A patent/MX2012001160A/es not_active Application Discontinuation
- 2010-08-06 AU AU2010279354A patent/AU2010279354A1/en not_active Abandoned
- 2010-08-06 TW TW099126390A patent/TW201109323A/zh unknown
- 2010-08-06 KR KR1020127005901A patent/KR20120108963A/ko not_active Application Discontinuation
- 2010-08-06 JP JP2012523967A patent/JP5602230B2/ja not_active Expired - Fee Related
- 2010-08-06 PE PE2012000174A patent/PE20120732A1/es not_active Application Discontinuation
- 2010-08-06 AR ARP100102904A patent/AR077819A1/es not_active Application Discontinuation
- 2010-08-06 CA CA2770194A patent/CA2770194A1/en not_active Abandoned
- 2010-08-06 ES ES10742067.1T patent/ES2533095T3/es active Active
- 2010-08-06 SG SG2012003430A patent/SG177691A1/en unknown
- 2010-08-06 BR BR112012002824A patent/BR112012002824A2/pt not_active IP Right Cessation
- 2010-08-06 CN CN2010800453726A patent/CN102548989A/zh active Pending
- 2010-08-06 WO PCT/US2010/044627 patent/WO2011017578A1/en active Application Filing
-
2012
- 2012-01-24 ZA ZA2012/00641A patent/ZA201200641B/en unknown
- 2012-02-07 CL CL2012000326A patent/CL2012000326A1/es unknown
- 2012-02-16 CO CO12027713A patent/CO6430439A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AR077819A1 (es) | 2011-09-28 |
TW201109323A (en) | 2011-03-16 |
JP2013501729A (ja) | 2013-01-17 |
EA201270266A1 (ru) | 2012-07-30 |
KR20120108963A (ko) | 2012-10-05 |
ES2533095T3 (es) | 2015-04-07 |
JP5602230B2 (ja) | 2014-10-08 |
US20110190255A1 (en) | 2011-08-04 |
SG177691A1 (en) | 2012-02-28 |
PE20120732A1 (es) | 2012-06-20 |
CL2012000326A1 (es) | 2012-10-19 |
EP2462139A1 (en) | 2012-06-13 |
US8399451B2 (en) | 2013-03-19 |
CA2770194A1 (en) | 2011-02-10 |
MX2012001160A (es) | 2012-02-13 |
WO2011017578A1 (en) | 2011-02-10 |
CN102548989A (zh) | 2012-07-04 |
EP2462139B1 (en) | 2015-01-14 |
ZA201200641B (en) | 2013-06-26 |
AU2010279354A1 (en) | 2012-02-09 |
BR112012002824A2 (pt) | 2019-09-24 |
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