EA200100071A1 - Замещенное производное триазоло-пиридазина, фармацевтические композиции, приготовленные на его основе - Google Patents

Замещенное производное триазоло-пиридазина, фармацевтические композиции, приготовленные на его основе

Info

Publication number
EA200100071A1
EA200100071A1 EA200100071A EA200100071A EA200100071A1 EA 200100071 A1 EA200100071 A1 EA 200100071A1 EA 200100071 A EA200100071 A EA 200100071A EA 200100071 A EA200100071 A EA 200100071A EA 200100071 A1 EA200100071 A1 EA 200100071A1
Authority
EA
Eurasian Patent Office
Prior art keywords
triazol
pyridazine
basis
pharmaceutical compositions
compositions prepared
Prior art date
Application number
EA200100071A
Other languages
English (en)
Other versions
EA003332B1 (ru
Inventor
Уилльям Роберт Карлинг
Хосе Луис Кастро Пинейро
Кэмерон Джон Кауден
Энтони Джон Дэвис
Эндрю Мэдин
Джеймс Фрэнсис МакКабе
Гарет Эдвард Стефен Пирс
Лесли Джозеф Стрит
Original Assignee
Мерк Шарп Энд Домэ Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Шарп Энд Домэ Лимитед filed Critical Мерк Шарп Энд Домэ Лимитед
Publication of EA200100071A1 publication Critical patent/EA200100071A1/ru
Publication of EA003332B1 publication Critical patent/EA003332B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение раскрывает 7-(1,1-диметилэтил)-6-(2-этил-2H-1,2,4-триазол-3-илметокси)-3-(2-фторфенил)-1,2,4-триазоло[4,3-b]пиридазин и его фармацевтически приемлемые соли, которые являются селективными лигандами ГАМК-рецепторов, в частности, имеющие высокую аффинность для их α2-и/или β3-субъединицы и, следовательно, они являются полезными для лечения или профилактики заболеваний центральной нервной системы, включая состояние тревоги и судороги.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100071A 1998-06-24 1999-06-15 Замещенное производное триазолопиридазина, фармацевтические композиции, приготовленные на его основе EA003332B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9813576.7A GB9813576D0 (en) 1998-06-24 1998-06-24 Therapeutic agents
PCT/GB1999/001897 WO1999067245A1 (en) 1998-06-24 1999-06-15 A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom

Publications (2)

Publication Number Publication Date
EA200100071A1 true EA200100071A1 (ru) 2001-06-25
EA003332B1 EA003332B1 (ru) 2003-04-24

Family

ID=10834265

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100071A EA003332B1 (ru) 1998-06-24 1999-06-15 Замещенное производное триазолопиридазина, фармацевтические композиции, приготовленные на его основе

Country Status (35)

Country Link
US (1) US6630471B1 (ru)
EP (1) EP1090004B1 (ru)
JP (1) JP4749545B2 (ru)
KR (1) KR100604108B1 (ru)
CN (1) CN1138779C (ru)
AR (1) AR018925A1 (ru)
AT (1) ATE239730T1 (ru)
AU (1) AU757315B2 (ru)
BG (1) BG64989B1 (ru)
BR (1) BR9911563A (ru)
CA (1) CA2335328C (ru)
CO (1) CO5031239A1 (ru)
CZ (1) CZ291409B6 (ru)
DE (1) DE69907675T2 (ru)
EA (1) EA003332B1 (ru)
EE (1) EE200000767A (ru)
ES (1) ES2196824T3 (ru)
GB (1) GB9813576D0 (ru)
GE (1) GEP20033143B (ru)
HR (1) HRP20000879A2 (ru)
HU (1) HUP0102894A3 (ru)
ID (1) ID27771A (ru)
IL (2) IL139775A0 (ru)
IS (1) IS2258B (ru)
MY (1) MY124341A (ru)
NO (1) NO317992B1 (ru)
NZ (1) NZ508290A (ru)
PE (1) PE20000710A1 (ru)
PL (1) PL204650B1 (ru)
RS (1) RS49746B (ru)
SK (1) SK285307B6 (ru)
TR (1) TR200003789T2 (ru)
TW (1) TWI222449B (ru)
WO (1) WO1999067245A1 (ru)
ZA (1) ZA200007485B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2345443A (en) * 1999-01-08 2000-07-12 Merck Sharp & Dohme Use of triazolo-pyridazines for treating premenstrual syndrome
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
GB0111191D0 (en) * 2001-05-08 2001-06-27 Merck Sharp & Dohme Therapeutic agents
KR101075812B1 (ko) * 2002-12-18 2011-10-25 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제로서의 트리아졸로피리다진
WO2006061428A2 (en) * 2004-12-10 2006-06-15 Universität Zürich Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
US8501738B2 (en) 2009-06-23 2013-08-06 Concert Pharmaceuticals, Inc. Substituted triazolo-pyridazine derivatives
EP2456311A4 (en) * 2009-07-24 2013-01-23 Concert Pharmaceuticals Inc SUBSTITUTED IMIDASOTRIAZINES
US8278460B2 (en) 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles
SG182297A1 (en) 2009-12-31 2012-08-30 Ct Nac Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en) * 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
JP6042438B2 (ja) 2011-09-27 2016-12-14 ジェンフィットＧｅｎｆｉｔ Ｒｅｖ−ｅｒｂアゴニストとしての６−置換トリアゾロピリダジン類の誘導体
UA125463C2 (uk) 2016-01-27 2022-03-16 Універсітет Цюріх ЗАСТОСУВАННЯ МОДУЛЯТОРІВ GABA<sub>A</sub>-РЕЦЕПТОРА ДЛЯ ЛІКУВАННЯ СВЕРБЕЖУ
AU2019255282B2 (en) * 2018-04-18 2024-08-08 Neurocycle Therapeutics, Inc. Gabaa positive allosteric modulator compounds, methods of making, and uses thereof
HUE060943T2 (hu) * 2018-09-13 2023-04-28 Saniona As A gaba A receptor ligandum
HU231223B1 (hu) 2018-09-28 2022-01-28 Richter Gedeon Nyrt. GABAA A5 receptor modulátor hatású biciklusos vegyületek
WO2021191837A1 (en) 2020-03-26 2021-09-30 Richter Gedeon Nyrt. 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa α5 receptor modulators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE236904T1 (de) * 1996-07-25 2003-04-15 Merck Sharp & Dohme Substituierte triazolo-pyridazin-derivate als liganden von gaba-rezeptoren

Also Published As

Publication number Publication date
JP2002518501A (ja) 2002-06-25
CA2335328C (en) 2007-11-27
CN1138779C (zh) 2004-02-18
HUP0102894A2 (hu) 2001-11-28
NZ508290A (en) 2003-09-26
DE69907675D1 (de) 2003-06-12
TWI222449B (en) 2004-10-21
CO5031239A1 (es) 2001-04-27
TR200003789T2 (tr) 2001-04-20
CZ20004872A3 (cs) 2001-07-11
SK19552000A3 (sk) 2001-08-06
EP1090004B1 (en) 2003-05-07
NO317992B1 (no) 2005-01-17
WO1999067245A1 (en) 1999-12-29
YU77800A (sh) 2003-10-31
AU4630199A (en) 2000-01-10
ID27771A (id) 2001-04-26
ES2196824T3 (es) 2003-12-16
RS49746B (sr) 2008-04-04
MY124341A (en) 2006-06-30
ATE239730T1 (de) 2003-05-15
BR9911563A (pt) 2001-03-20
KR20010053136A (ko) 2001-06-25
JP4749545B2 (ja) 2011-08-17
DE69907675T2 (de) 2004-03-04
AR018925A1 (es) 2001-12-12
CN1307579A (zh) 2001-08-08
BG105152A (en) 2001-10-31
PL204650B1 (pl) 2010-01-29
EA003332B1 (ru) 2003-04-24
NO20006576D0 (no) 2000-12-21
NO20006576L (no) 2001-02-14
ZA200007485B (en) 2002-01-07
AU757315B2 (en) 2003-02-13
HUP0102894A3 (en) 2003-03-28
EE200000767A (et) 2002-06-17
IS2258B (is) 2007-06-15
EP1090004A1 (en) 2001-04-11
HRP20000879A2 (en) 2001-06-30
IL139775A (en) 2007-02-11
IL139775A0 (en) 2002-02-10
GEP20033143B (en) 2003-12-25
GB9813576D0 (en) 1998-08-19
BG64989B1 (bg) 2006-11-30
PE20000710A1 (es) 2000-08-14
SK285307B6 (sk) 2006-10-05
US6630471B1 (en) 2003-10-07
CA2335328A1 (en) 1999-12-29
IS5730A (is) 2000-11-24
KR100604108B1 (ko) 2006-07-26
PL345332A1 (en) 2001-12-17
CZ291409B6 (cs) 2003-03-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU