PE20000710A1 - Derivados de triazolo-piridazina como ligandos para receptores de gaba - Google Patents

Derivados de triazolo-piridazina como ligandos para receptores de gaba

Info

Publication number
PE20000710A1
PE20000710A1 PE1999000557A PE00055799A PE20000710A1 PE 20000710 A1 PE20000710 A1 PE 20000710A1 PE 1999000557 A PE1999000557 A PE 1999000557A PE 00055799 A PE00055799 A PE 00055799A PE 20000710 A1 PE20000710 A1 PE 20000710A1
Authority
PE
Peru
Prior art keywords
triazolo
ligands
pyridazine
pyridazine derivatives
gaba receptors
Prior art date
Application number
PE1999000557A
Other languages
English (en)
Inventor
Alexander Richard Guiblin
William Robert Carling
Leslie Joseph Street
James Francis Mccabe
Gareth Edward Stephen Pearce
Cameron John Cowden
Pineiro Jose Luis Castro
Antony John Davies
Andrew Madin
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of PE20000710A1 publication Critical patent/PE20000710A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO 7-(1,1-DIMETILETIL)-6-(2-ETIL-2H-1,2,4-TRIAZOL-3-ILMETOXI)-3-(2-FLUOROFENIL)-1,2,4-TRIAZOLO[4,3-b]-PIRIDAZINA, POLIMORFO A. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION QUE COMPRENDE HACER REACCIONAR 6-CLORO-7-(1,1-DIMETILETIL)-3-(2-FLUOROFENIL)-1,2,4-TRIAZOLO[4,3-b]PIRIDAZINA EN 1-METIL-2-PIRROLIDINONA, EN PRESENCIA DE HIDROXIDO DE SODIO A UNA TEMPERATURA DE 0°C. TAMBIEN SE REFIERE A 7-CICLOBUTIL-3-(2,6-DIFLUOROFENIL)-6-(2-METIL-2H-1,2,4-TRIAZOL-3-ILMETOXI)-1,2,4-TRIAZOLO[4,3-b]PIRIDAZINA. EL COMPUESTO ES AGONISTA DEL RECEPTOR GABA A POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO O LA PREVENCION DE LA ANSIEDAD
PE1999000557A 1998-06-24 1999-06-22 Derivados de triazolo-piridazina como ligandos para receptores de gaba PE20000710A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9813576.7A GB9813576D0 (en) 1998-06-24 1998-06-24 Therapeutic agents

Publications (1)

Publication Number Publication Date
PE20000710A1 true PE20000710A1 (es) 2000-08-14

Family

ID=10834265

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000557A PE20000710A1 (es) 1998-06-24 1999-06-22 Derivados de triazolo-piridazina como ligandos para receptores de gaba

Country Status (35)

Country Link
US (1) US6630471B1 (es)
EP (1) EP1090004B1 (es)
JP (1) JP4749545B2 (es)
KR (1) KR100604108B1 (es)
CN (1) CN1138779C (es)
AR (1) AR018925A1 (es)
AT (1) ATE239730T1 (es)
AU (1) AU757315B2 (es)
BG (1) BG64989B1 (es)
BR (1) BR9911563A (es)
CA (1) CA2335328C (es)
CO (1) CO5031239A1 (es)
CZ (1) CZ291409B6 (es)
DE (1) DE69907675T2 (es)
EA (1) EA003332B1 (es)
EE (1) EE200000767A (es)
ES (1) ES2196824T3 (es)
GB (1) GB9813576D0 (es)
GE (1) GEP20033143B (es)
HR (1) HRP20000879A2 (es)
HU (1) HUP0102894A3 (es)
ID (1) ID27771A (es)
IL (2) IL139775A0 (es)
IS (1) IS2258B (es)
MY (1) MY124341A (es)
NO (1) NO317992B1 (es)
NZ (1) NZ508290A (es)
PE (1) PE20000710A1 (es)
PL (1) PL204650B1 (es)
RS (1) RS49746B (es)
SK (1) SK285307B6 (es)
TR (1) TR200003789T2 (es)
TW (1) TWI222449B (es)
WO (1) WO1999067245A1 (es)
ZA (1) ZA200007485B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2345443A (en) * 1999-01-08 2000-07-12 Merck Sharp & Dohme Use of triazolo-pyridazines for treating premenstrual syndrome
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
GB0111191D0 (en) * 2001-05-08 2001-06-27 Merck Sharp & Dohme Therapeutic agents
KR101075812B1 (ko) * 2002-12-18 2011-10-25 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제로서의 트리아졸로피리다진
WO2006061428A2 (en) * 2004-12-10 2006-06-15 Universität Zürich Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
US8501738B2 (en) * 2009-06-23 2013-08-06 Concert Pharmaceuticals, Inc. Substituted triazolo-pyridazine derivatives
WO2011011712A1 (en) * 2009-07-24 2011-01-27 Concert Pharmaceuticals, Inc. Substituted imidazotriazines
WO2011047315A1 (en) 2009-10-15 2011-04-21 Concert Pharmaceuticals, Inc. Subsitituted benzimidazoles
CN102791715B (zh) 2009-12-31 2016-04-27 卡洛斯三世国家癌症研究中心基金会 用作激酶抑制剂的三环化合物
WO2012098387A1 (en) * 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
CA2848518C (en) 2011-09-27 2019-06-18 Genfit Derivatives of 6-substituted triazolopyridazines as rev-erb agonists
JP7115746B2 (ja) 2016-01-27 2022-08-09 ウニヴェルズィテート・ツューリヒ 掻痒の処置のためのｇａｂａａ受容体モジュレーターの使用
KR20210011921A (ko) * 2018-04-18 2021-02-02 뉴로사이클 테라퓨틱스, 인크. Gabaa 양성 알로스테릭 조절제 화합물, 이의 제조 방법 및 용도
DK3849976T3 (da) 2018-09-13 2023-01-23 Saniona As GABAA-receptorligand
HU231223B1 (hu) 2018-09-28 2022-01-28 Richter Gedeon Nyrt. GABAA A5 receptor modulátor hatású biciklusos vegyületek
WO2021191837A1 (en) 2020-03-26 2021-09-30 Richter Gedeon Nyrt. 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa α5 receptor modulators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004559A2 (en) * 1996-07-25 1998-02-05 Merck Sharp & Dohme Limited Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Also Published As

Publication number Publication date
EA003332B1 (ru) 2003-04-24
EA200100071A1 (ru) 2001-06-25
BR9911563A (pt) 2001-03-20
AU4630199A (en) 2000-01-10
SK285307B6 (sk) 2006-10-05
DE69907675T2 (de) 2004-03-04
SK19552000A3 (sk) 2001-08-06
BG64989B1 (bg) 2006-11-30
TWI222449B (en) 2004-10-21
CZ291409B6 (cs) 2003-03-12
CO5031239A1 (es) 2001-04-27
GEP20033143B (en) 2003-12-25
EP1090004A1 (en) 2001-04-11
CZ20004872A3 (cs) 2001-07-11
AR018925A1 (es) 2001-12-12
GB9813576D0 (en) 1998-08-19
JP4749545B2 (ja) 2011-08-17
CN1307579A (zh) 2001-08-08
NZ508290A (en) 2003-09-26
ZA200007485B (en) 2002-01-07
ID27771A (id) 2001-04-26
IS5730A (is) 2000-11-24
PL204650B1 (pl) 2010-01-29
EE200000767A (et) 2002-06-17
PL345332A1 (en) 2001-12-17
IS2258B (is) 2007-06-15
CA2335328A1 (en) 1999-12-29
EP1090004B1 (en) 2003-05-07
KR20010053136A (ko) 2001-06-25
IL139775A0 (en) 2002-02-10
IL139775A (en) 2007-02-11
AU757315B2 (en) 2003-02-13
NO20006576L (no) 2001-02-14
WO1999067245A1 (en) 1999-12-29
NO317992B1 (no) 2005-01-17
JP2002518501A (ja) 2002-06-25
HRP20000879A2 (en) 2001-06-30
CN1138779C (zh) 2004-02-18
MY124341A (en) 2006-06-30
NO20006576D0 (no) 2000-12-21
HUP0102894A2 (hu) 2001-11-28
HUP0102894A3 (en) 2003-03-28
DE69907675D1 (de) 2003-06-12
US6630471B1 (en) 2003-10-07
ES2196824T3 (es) 2003-12-16
KR100604108B1 (ko) 2006-07-26
RS49746B (sr) 2008-04-04
TR200003789T2 (tr) 2001-04-20
BG105152A (en) 2001-10-31
YU77800A (sh) 2003-10-31
ATE239730T1 (de) 2003-05-15
CA2335328C (en) 2007-11-27

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed