YU26499A - Derivati diaza-spiro/3,5/nonana - Google Patents
Derivati diaza-spiro/3,5/nonanaInfo
- Publication number
- YU26499A YU26499A YU26499A YU26499A YU26499A YU 26499 A YU26499 A YU 26499A YU 26499 A YU26499 A YU 26499A YU 26499 A YU26499 A YU 26499A YU 26499 A YU26499 A YU 26499A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- hydrogen
- lower alkyl
- naphtalene
- optionally substituted
- ch2or5
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Ovaj pronalazak se odnosi na jedinjenja opste formule (I) u kojoj R1 je C6-C12-cikloalkil, proizvoljno supstituisan nizim alkilom ili C(O)O nizim alkilom, indan-1-il ili indan-2-il, proizvoljno supstituisan nizim alkilom; acenaften-1-il; biciklo[3.3.1] non-9-il, oktahidro-inden-2-il; 2,3-dihidro-1H-fenalen-1-il; 2,3,3a,4,5,6-heksahidro-1H-fenalen-1-il, dekahidro-azulen-2-il; biciklo[6.2.0] dek-9-il; dekahidronaftalen-1-il; dekahidro-naftalen-2-il; tetrahidro-naftalen-2-il, tetrahidro-naftalen-2-il ili 2-okso-1,2-difenil-etil; R2 je =O ili vodonik, R3 je vodonik, izoindolil-1,3-dion, nizi alkoksi, nizi alkil, amino, benziloksi, -CH2OR5 ili -CH2N(R5)2; R4 je vodonik ili -CH2OR5; R5 je vodonik ili nizi alkil; A je cikloheksil ili fenil, proizvoljno supstituisan nizim alkilom, halogenom ili alkoksijem, i na njihove farmaceutski prihvatljive kisele adicione soli. Jedinjenja ovog pronalaska su agonisti i/ili antagonisti orfamin FQ (OFQ) receptora i zato korisni u tretiranju bolesti, vezanih za ovaj receptor.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98110804 | 1998-06-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU26499A true YU26499A (sh) | 2002-09-19 |
Family
ID=8232114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU26499A YU26499A (sh) | 1998-06-12 | 1999-06-10 | Derivati diaza-spiro/3,5/nonana |
Country Status (28)
Country | Link |
---|---|
US (1) | US6113527A (sh) |
EP (1) | EP0970957B1 (sh) |
JP (1) | JP3286268B2 (sh) |
KR (1) | KR100344732B1 (sh) |
CN (1) | CN1107066C (sh) |
AR (1) | AR019859A1 (sh) |
AT (1) | ATE204279T1 (sh) |
AU (1) | AU743983B2 (sh) |
BR (1) | BR9902651A (sh) |
CA (1) | CA2274202A1 (sh) |
DE (1) | DE69900220T2 (sh) |
DK (1) | DK0970957T3 (sh) |
ES (1) | ES2162503T3 (sh) |
HR (1) | HRP990188A2 (sh) |
HU (1) | HU220894B1 (sh) |
ID (1) | ID23304A (sh) |
IL (1) | IL130377A0 (sh) |
MA (1) | MA26644A1 (sh) |
NO (1) | NO312590B1 (sh) |
NZ (1) | NZ336189A (sh) |
PE (1) | PE20000548A1 (sh) |
PL (1) | PL333695A1 (sh) |
PT (1) | PT970957E (sh) |
SG (1) | SG79259A1 (sh) |
SI (1) | SI0970957T1 (sh) |
TR (1) | TR199901381A3 (sh) |
YU (1) | YU26499A (sh) |
ZA (1) | ZA993852B (sh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030040479A1 (en) * | 2001-07-02 | 2003-02-27 | Omeros Corporation | Rotational intrathecal analgesia method and device |
CA2490386A1 (en) * | 2001-07-02 | 2003-01-16 | Omeros Corporation | Method for producing analgesia comprising administration of an opioid receptor agonist in rotation with an opioid receptor like-1 receptor agonist |
US7566728B2 (en) | 2002-03-29 | 2009-07-28 | Mitsubishi Tanabe Pharma Corporation | Remedy for sleep disturbance |
JP2005289816A (ja) | 2002-05-14 | 2005-10-20 | Banyu Pharmaceut Co Ltd | ベンズイミダゾール誘導体 |
JP4749715B2 (ja) | 2002-07-05 | 2011-08-17 | ターガセプト,インコーポレイテッド | N−アリールジアザスピロ環式化合物、並びにその製造及び使用方法 |
WO2004022558A2 (en) * | 2002-09-09 | 2004-03-18 | Janssen Pharmaceutica, N.V. | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders |
GB0323204D0 (en) * | 2003-10-03 | 2003-11-05 | Novartis Ag | Organic compounds |
US20050228023A1 (en) * | 2003-12-19 | 2005-10-13 | Sri International | Agonist and antagonist ligands of the nociceptin receptor |
US20060178390A1 (en) * | 2004-08-02 | 2006-08-10 | Alfonzo Jordan | 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
CN101022801A (zh) * | 2004-08-20 | 2007-08-22 | 塔加西普特公司 | N-芳基二氮杂螺环化合物在成瘾治疗中的用途 |
US20080247964A1 (en) * | 2006-05-08 | 2008-10-09 | Yuelian Xu | Substituted azaspiro derivatives |
WO2008067167A1 (en) * | 2006-11-28 | 2008-06-05 | Janssen Pharmaceutica N.V. | Salts of 3-(3-amino-2-(r)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one |
CN101679430B (zh) * | 2007-04-09 | 2013-12-25 | 詹森药业有限公司 | 用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物 |
KR101704226B1 (ko) | 2015-06-30 | 2017-02-07 | 현대자동차주식회사 | 자동차의 쿼터글라스 어셈블리 |
TW202340202A (zh) * | 2021-12-22 | 2023-10-16 | 美國加利福尼亞大學董事會 | Gtp酶抑制劑及其用途 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5756743A (en) * | 1996-04-10 | 1998-05-26 | Hoechst Marion Roussel Inc. | Spiro cyclopent b!indole-piperidines! |
-
1999
- 1999-06-07 AT AT99110943T patent/ATE204279T1/de not_active IP Right Cessation
- 1999-06-07 PT PT99110943T patent/PT970957E/pt unknown
- 1999-06-07 DE DE69900220T patent/DE69900220T2/de not_active Expired - Lifetime
- 1999-06-07 SI SI9930008T patent/SI0970957T1/xx unknown
- 1999-06-07 EP EP99110943A patent/EP0970957B1/en not_active Expired - Lifetime
- 1999-06-07 DK DK99110943T patent/DK0970957T3/da active
- 1999-06-07 ES ES99110943T patent/ES2162503T3/es not_active Expired - Lifetime
- 1999-06-08 ID IDP990543D patent/ID23304A/id unknown
- 1999-06-08 PE PE1999000487A patent/PE20000548A1/es not_active Application Discontinuation
- 1999-06-08 ZA ZA9903852A patent/ZA993852B/xx unknown
- 1999-06-09 HU HU9901911A patent/HU220894B1/hu not_active IP Right Cessation
- 1999-06-09 CA CA002274202A patent/CA2274202A1/en not_active Abandoned
- 1999-06-09 NZ NZ336189A patent/NZ336189A/xx unknown
- 1999-06-09 IL IL13037799A patent/IL130377A0/xx unknown
- 1999-06-09 SG SG9903066A patent/SG79259A1/en unknown
- 1999-06-10 MA MA25616A patent/MA26644A1/fr unknown
- 1999-06-10 KR KR1019990021485A patent/KR100344732B1/ko not_active IP Right Cessation
- 1999-06-10 JP JP16357099A patent/JP3286268B2/ja not_active Expired - Fee Related
- 1999-06-10 AR ARP990102763A patent/AR019859A1/es active IP Right Grant
- 1999-06-10 AU AU34987/99A patent/AU743983B2/en not_active Ceased
- 1999-06-10 YU YU26499A patent/YU26499A/sh unknown
- 1999-06-11 PL PL99333695A patent/PL333695A1/xx unknown
- 1999-06-11 US US09/330,851 patent/US6113527A/en not_active Expired - Fee Related
- 1999-06-11 HR HR98110804.6A patent/HRP990188A2/hr not_active Application Discontinuation
- 1999-06-11 CN CN99108373A patent/CN1107066C/zh not_active Expired - Fee Related
- 1999-06-11 BR BR9902651-1A patent/BR9902651A/pt not_active Application Discontinuation
- 1999-06-11 TR TR1999/01381A patent/TR199901381A3/tr unknown
- 1999-06-11 NO NO19992873A patent/NO312590B1/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU26499A (sh) | Derivati diaza-spiro/3,5/nonana | |
US5958931A (en) | Phenyl-substituted 5H-thiazolo 3,2-A!pyrimidine derivative glutamate receptor antagonists | |
MX9709951A (es) | Derivados de benzamida y su uso como antagonistas de vasopresina. | |
BG103785A (en) | Pyrrolo[2,3-d]pyrimidines and their application as tyrosine kinase inhibitors | |
EP1465631A4 (en) | A2B RECEPTOR-BASED ANTAGONIST PYRIMIDINE COMPOUNDS, THEIR SYNTHESIS AND USE THEREOF | |
EP0445811A3 (en) | Nitrogen-containing heterocyclic compounds, their production and use | |
DE60329513D1 (de) | Antagonist des melanin-concentrating-hormone-rezeptors, enthaltend ein benzimidazolderivat als wirkstoff | |
MX2007004250A (es) | Derivados de imidazo[1,5-a]triazolo[1,5-d]benzodiazepina para el tratamiento de trastornos cognitivos. | |
TW200504085A (en) | Derivatives of [2-(8,9-dioxo-2, 6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of use thereof | |
TW377352B (en) | Pyrido[2,3-d]pyrimidine derivatives and pharmaceutical compositions thereof | |
MXPA02004448A (es) | Derivados de imidazopiridina como inhibidores de la fosfodiesterasa vii. | |
CA2244777A1 (en) | 2,3-benzodiazepine derivatives and their use as ampa-receptor inhibitors | |
DE69401716D1 (de) | Imidazo [1,2-a] pyrasin-4-on-derivate welche als ampa und nmda receptor antagonisten dienen | |
ES2000935A6 (es) | Un procedimiento para la preparacion de 3-imidazolin-metiltetrahidrocarbazolonas. | |
EP0997462A4 (en) | NOVEL NAPHTHYRIDINE DERIVATIVES OR THEIR SALTS | |
CA2134077A1 (en) | 4-imidomethyl-1-[2'phenyl-2'oxoethyl-]piperidines as serotonin 5ht2-antagonists, their preparation and use in therapy | |
CA2375671A1 (en) | 4-phenyl-pyrimidine derivatives | |
GB9011469D0 (en) | Chemical process | |
CA2194877A1 (en) | Heterocycle-condensed morphinoid derivatives | |
JO2307B1 (en) | Papermidine derivatives | |
MXPA04003278A (es) | Derivados de 5-metoxi-8-aril-?1,2,4?triazolo?1,5-a?piridina como antagonistas del receptor de adenosina. | |
PE20000540A1 (es) | Derivados de diaza-espiro [4.5]decan | |
ATE325790T1 (de) | Harnstoff-verbindungen, ein verfahren zu deren herstellung und ihre verwendung | |
AP9801410A0 (en) | Indoline derivatives useful as 5-HT-2C receptor antagonists. | |
GB9720270D0 (en) | Medicaments for the treatment of migraine |