ES2162503T3 - Derivados diaza-espiro(3,5)nonanos. - Google Patents

Derivados diaza-espiro(3,5)nonanos.

Info

Publication number
ES2162503T3
ES2162503T3 ES99110943T ES99110943T ES2162503T3 ES 2162503 T3 ES2162503 T3 ES 2162503T3 ES 99110943 T ES99110943 T ES 99110943T ES 99110943 T ES99110943 T ES 99110943T ES 2162503 T3 ES2162503 T3 ES 2162503T3
Authority
ES
Spain
Prior art keywords
sup
lower alkyl
hydrogen
decahydro
naphthalen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99110943T
Other languages
English (en)
Inventor
Geo Adam
Andrea Cesura
Francois Jenck
Sabine Kolczewski
Stephan Roever
Jurgen Wichmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2162503T3 publication Critical patent/ES2162503T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La invención se refiere a compuestos de la fórmula general *fórmula*en la que R{sup,1} es cicloalquilo de 6-12 carbonos, opcionalmente substituido por alquilo inferior o C(O)O alquilo inferior, indan-1-ilo o indan-2-ilo, opcionalmente substituido por alquilo inferior; acenaften-1-ilo; biciclo[3.3.1]non-9-ilo, octahidro-inden-2-ilo; 2,3- dihidro-1H-fenalen-1-ilo; 2,3,3a,4,5,6-hexahidro-1H-fenalen-1-ilo, decahidro-azulen-2-ilo; biciclo[6.2.0]dec-9-ilo; decahidro-naftalen-1- ilo, decahidro-nafalen-2-ilo; tetrahidro-naftalen-1-ilo, tetrahidro- naftalen-2-ilo o 2-oxo-1,2-difenil-etilo; R{sup,2} es = O o hidrógeno, R{sup,3} es hidrógeno, isoindolil-1,3-diona, alcóxido inferior, alquilo inferior, amino, benzilóxido, -CH2OR{sup,5} o - CH2N(R{sup,5})2; R{sup,4} es hidrógeno o -CH2OR{sup,5}; R{sup,5} es hidrógeno o alquilo inferior; A es ciclohexilo o fenilo, opcionalmente substituido por alquilo inferior , halógeno o alcóxido; a mezclas racémicas y sus correspondientes enantiómeros y/o sales de adición cida farmacológicamente aceptables. Los compuestos de la presente invención son agonistas y/o antagonistas del receptor de la orfamina FQ (OFQ) y por lo tanto son útiles en el tratamiento de los trastornos relacionados con este receptor.
ES99110943T 1998-06-12 1999-06-07 Derivados diaza-espiro(3,5)nonanos. Expired - Lifetime ES2162503T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98110804 1998-06-12

Publications (1)

Publication Number Publication Date
ES2162503T3 true ES2162503T3 (es) 2001-12-16

Family

ID=8232114

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99110943T Expired - Lifetime ES2162503T3 (es) 1998-06-12 1999-06-07 Derivados diaza-espiro(3,5)nonanos.

Country Status (28)

Country Link
US (1) US6113527A (es)
EP (1) EP0970957B1 (es)
JP (1) JP3286268B2 (es)
KR (1) KR100344732B1 (es)
CN (1) CN1107066C (es)
AR (1) AR019859A1 (es)
AT (1) ATE204279T1 (es)
AU (1) AU743983B2 (es)
BR (1) BR9902651A (es)
CA (1) CA2274202A1 (es)
DE (1) DE69900220T2 (es)
DK (1) DK0970957T3 (es)
ES (1) ES2162503T3 (es)
HR (1) HRP990188A2 (es)
HU (1) HU220894B1 (es)
ID (1) ID23304A (es)
IL (1) IL130377A0 (es)
MA (1) MA26644A1 (es)
NO (1) NO312590B1 (es)
NZ (1) NZ336189A (es)
PE (1) PE20000548A1 (es)
PL (1) PL333695A1 (es)
PT (1) PT970957E (es)
SG (1) SG79259A1 (es)
SI (1) SI0970957T1 (es)
TR (1) TR199901381A2 (es)
YU (1) YU26499A (es)
ZA (1) ZA993852B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
CA2490386A1 (en) * 2001-07-02 2003-01-16 Omeros Corporation Method for producing analgesia comprising administration of an opioid receptor agonist in rotation with an opioid receptor like-1 receptor agonist
US7566728B2 (en) * 2002-03-29 2009-07-28 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
JP2005289816A (ja) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
AU2003245753B2 (en) 2002-07-05 2009-12-24 Targacept, Inc. N-aryl diazaspiracyclic compounds and methods of preparation and use thereof
EA009369B1 (ru) * 2002-09-09 2007-12-28 Янссен Фармацевтика, Н.В. Производные гидроксизамещенного 1,3,8-триазинспиро[4,5]декан-4-она, полезные для лечения расстройств, опосредованных orl-рецептором
GB0323204D0 (en) * 2003-10-03 2003-11-05 Novartis Ag Organic compounds
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
NZ552792A (en) * 2004-08-20 2009-12-24 Targacept Inc The use of N-aryl diazaspiracyclic compounds in the treatment of addiction
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
KR20090083954A (ko) * 2006-11-28 2009-08-04 얀센 파마슈티카 엔.브이. 3-(3-아미노-2-(ｒ)-하이드록시프로필)-1-(4-플루오로페닐)-8-(8-메틸나프탈렌-1-일메틸)-1,3,8-트리아자-스피로[4.5]데칸-4-온의 염
JP5490677B2 (ja) * 2007-04-09 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体
KR101704226B1 (ko) 2015-06-30 2017-02-07 현대자동차주식회사 자동차의 쿼터글라스 어셈블리
TW202340202A (zh) * 2021-12-22 2023-10-16 美國加利福尼亞大學董事會 Gtp酶抑制劑及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!

Also Published As

Publication number Publication date
KR20000006060A (ko) 2000-01-25
CN1242366A (zh) 2000-01-26
CN1107066C (zh) 2003-04-30
DK0970957T3 (da) 2001-12-03
SI0970957T1 (es) 2001-12-31
PE20000548A1 (es) 2000-07-15
CA2274202A1 (en) 1999-12-12
DE69900220D1 (de) 2001-09-20
IL130377A0 (en) 2000-06-01
SG79259A1 (en) 2001-03-20
PL333695A1 (en) 1999-12-20
NZ336189A (en) 2000-10-27
JP3286268B2 (ja) 2002-05-27
KR100344732B1 (ko) 2002-07-19
US6113527A (en) 2000-09-05
JP2000053679A (ja) 2000-02-22
AU743983B2 (en) 2002-02-14
NO992873L (no) 1999-12-13
HRP990188A2 (en) 2000-02-29
TR199901381A3 (tr) 2000-01-21
EP0970957A1 (en) 2000-01-12
ATE204279T1 (de) 2001-09-15
HU220894B1 (en) 2002-06-29
YU26499A (sh) 2002-09-19
ZA993852B (en) 1999-12-13
MA26644A1 (fr) 2004-12-20
NO312590B1 (no) 2002-06-03
PT970957E (pt) 2002-02-28
HU9901911D0 (en) 1999-08-30
ID23304A (id) 2000-04-05
NO992873D0 (no) 1999-06-11
TR199901381A2 (xx) 2000-01-21
AU3498799A (en) 1999-12-23
HUP9901911A1 (hu) 2000-05-28
EP0970957B1 (en) 2001-08-16
DE69900220T2 (de) 2002-05-08
BR9902651A (pt) 2000-05-16
AR019859A1 (es) 2002-03-20

Similar Documents

Publication Publication Date Title
ES2162503T3 (es) Derivados diaza-espiro(3,5)nonanos.
HUP0402376A2 (hu) Imidazol-4-karboxamid-származékok, előállításuk és az ezeket tartalmazó, elhízás kezelésére alkalmas gyógyszerkészítmények
TWI255807B (en) Therapeutic agents
AR042632A1 (es) Compuestos derivados del acido (2s)-3-(4-{2-[amino]-2-oxoetoxi} fenil)-2-etoxipropanoico como agentes terapeuticos para trastornos en el metabolismo de los lipidos y composiciones farmaceuticas
ES2163071T3 (es) Sulfonamidas y su utilizacion.
MXPA05010824A (es) Compuestos biciclicos como antagonistas del receptor nr2b.
CO4560551A1 (es) Derivados de acidos carboxilicos, medicamentos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion
CO5590895A2 (es) Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos
AR051325A1 (es) Analogos de biarilquinolin-4-ilamina sustituidos
RU2006105777A (ru) Индол-6-ильные сульфонамидные производные, их получение и их применение в качестве модуляторов 5-нт-6
MX9602979A (es) Compuestos heterociclicos terapeuticos.
PT957080E (pt) Novos derivados de etilamina
Tsotinis et al. Mapping the melatonin receptor. 7. Subtype selective ligands based on β-substituted N-acyl-5-methoxytryptamines and β-substituted N-acyl-5-methoxy-1-methyltryptamines
DE69323712T2 (de) Indol derivate zur behandlung von migräne
CO4900047A1 (es) Amidas del acido 4-(n -benzoilamino)-penten-2-enoico que tienen actividad como antagonistas de neuroquinina
TW429255B (en) Pyrazine compounds having treatment of central nervous system diseases and disorders
PA8563601A1 (es) Acidos-3-(imidazolil)-2- alcoxipropanoicos
BRPI0508404A (pt) derivado de (indol-3-il)-heterociclo, composição farmacêutica, uso de um derivado de (indol-3-il)-heterociclo, e método de tratamento da dor
AR035818A1 (es) Fenil-heterociclil-eteres con actividad como inhibidores selectivos de recaptacion de serotonina, composiciones farmaceuticas y su uso en la fabricacion de medicamentos
AR036735A1 (es) Derivados de 5-metoxi-8-aril-[1,2,4]triazolo[1,5-a]piridina
CO5040061A1 (es) Derivados de di-o triaza-espiro [4,5] decano
ES2150913T3 (es) Enantiomeros de derivados de ciclopenteno.
CO4930268A1 (es) BENZO[e]ISOINDOLES Y BENZO[h]ISOQUINOLINAS TRICICLICOS
AR027578A1 (es) Derivados de indano
ECSP993008A (es) Derivados de diaza- espiro [3,5] nonano

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 970957

Country of ref document: ES