PA8563601A1 - Acidos-3-(imidazolil)-2- alcoxipropanoicos - Google Patents

Acidos-3-(imidazolil)-2- alcoxipropanoicos

Info

Publication number
PA8563601A1
PA8563601A1 PA20038563601A PA8563601A PA8563601A1 PA 8563601 A1 PA8563601 A1 PA 8563601A1 PA 20038563601 A PA20038563601 A PA 20038563601A PA 8563601 A PA8563601 A PA 8563601A PA 8563601 A1 PA8563601 A1 PA 8563601A1
Authority
PA
Panama
Prior art keywords
rent
alcoxipropanoics
imidazolil
acids
hydrogen
Prior art date
Application number
PA20038563601A
Other languages
English (en)
Inventor
Allerton Charlotte Moira Norfor
John Steele
Mark Edward Bunnage
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0201387A external-priority patent/GB0201387D0/en
Priority claimed from GB0201911A external-priority patent/GB0201911D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of PA8563601A1 publication Critical patent/PA8563601A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

LOS COMPUESTOS DE ACUERDO CON LA FORMULA (I) EN LA QUE N ES 1-4, R1 ESTA OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-6, ALQUENILO C2-6 O ALQUINILO C2-6, HETEROCICLO, HETEROCICLO AROMATICO, ARILO O HIDROGENO Y CADA UNO DE R2, R3, R4, R5, R6, R7 Y R8 SE SELECCIONA INDEPENDIENTEMENTE ENTRE HIDROGENO Y UN GRUPO ALQUILO C1-6 OPCIONALMENTE SUSTITUIDO, SON NOVEDOSOS. ELLOS SON UTILES EN EL TRATAMIENTO DE AFECCIONES TROMBOTICAS Y OTRAS PATOLOGIAS ASOCIADAS CON EL DEPOSITO DE FIBRINA.
PA20038563601A 2002-01-22 2003-01-22 Acidos-3-(imidazolil)-2- alcoxipropanoicos PA8563601A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0201387A GB0201387D0 (en) 2002-01-22 2002-01-22 3-(imidazolyl)-2-aminopropanoic acids
GB0201911A GB0201911D0 (en) 2002-01-28 2002-01-28 3-(Imidazolyl)-2-Aminopropanoic acids

Publications (1)

Publication Number Publication Date
PA8563601A1 true PA8563601A1 (es) 2003-12-10

Family

ID=27614791

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20038563601A PA8563601A1 (es) 2002-01-22 2003-01-22 Acidos-3-(imidazolil)-2- alcoxipropanoicos

Country Status (11)

Country Link
US (2) US6759426B2 (es)
EP (1) EP1467732A1 (es)
JP (1) JP2005516972A (es)
BR (1) BR0307033A (es)
CA (1) CA2472239A1 (es)
HN (1) HN2003000040A (es)
MX (1) MXPA04005940A (es)
PA (1) PA8563601A1 (es)
PE (1) PE20030858A1 (es)
TW (1) TW200302093A (es)
WO (1) WO2003061653A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003061653A1 (en) * 2002-01-22 2003-07-31 Pfizer Limited 3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases
US7119068B2 (en) 2002-08-29 2006-10-10 American Diagnostica, Inc. Methods of screening for compounds that modulate TAFIa activity, compounds, and methods of using the compounds
DE102004020186A1 (de) 2004-04-22 2005-11-17 Aventis Pharma Deutschland Gmbh Heterocyclylessigsäuren als Inhibitoren von TAFla
US8710232B2 (en) 2004-04-22 2014-04-29 Sanofi-Aventis Deutschland Gmbh Imidazole derivatives used as TAFIa inhibitors
JP4046708B2 (ja) * 2004-06-04 2008-02-13 明治製菓株式会社 ３−アルケニルセフェム化合物の製造方法
WO2006041808A2 (en) * 2004-10-05 2006-04-20 Bayer Schering Pharma Aktiengesellschaft Tafi inhibitors and their use to treat pulmonary fibrosis
US20060234986A1 (en) * 2005-04-18 2006-10-19 Schering Aktiengesellschaft Use of TAFI inhibitors for enhanced myocardial reperfusion and facilitated PCI
DE102005049385A1 (de) * 2005-10-15 2007-04-19 Sanofi-Aventis Deutschland Gmbh Imidazolderivate als Inhibitoren von TAFIa
JPWO2010050525A1 (ja) 2008-10-29 2012-03-29 大正製薬株式会社 ＴＡＦＩａ阻害活性を有する化合物
TW201121964A (en) * 2009-09-17 2011-07-01 Taisho Pharmaceutical Co Ltd Compounds having TAFIa inhibitory activity
JP5778133B2 (ja) * 2010-03-18 2015-09-16 第一三共株式会社 シクロプロパンカルボン酸誘導体
MX358628B (es) 2010-03-18 2018-08-28 Daiichi Sankyo Co Ltd Derivado de imidazol sustituido con cicloalquilo.
JP2013542235A (ja) 2010-11-11 2013-11-21 サノフイ ３−（６−アミノ−ピリジン−３イル）−２−アクリル酸誘導体の製造方法
WO2014198620A1 (en) 2013-06-10 2014-12-18 Sanofi Macrocyclic urea derivatives as inhibitors of tafia, their preparation and their use as pharmaceuticals
KR20180123038A (ko) 2016-03-29 2018-11-14 다이이찌 산쿄 가부시키가이샤 염증성 장질환 치료제

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6033439B2 (ja) * 1980-03-07 1985-08-02 財団法人相模中央化学研究所 ジペプチドの製造方法
IL68218A (en) * 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US4932973A (en) * 1983-09-30 1990-06-12 El Gendler Cartilage and bone induction by artificially perforated organic bone matrix
US4757017A (en) * 1984-09-14 1988-07-12 Mcw Research Foundation, Inc. In vitro cell culture system
US5053049A (en) * 1985-05-29 1991-10-01 Baxter International Flexible prostheses of predetermined shapes and process for making same
US4681763A (en) * 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
GB8618374D0 (en) * 1986-07-28 1986-09-03 Hsc Res Dev Corp Biological vascular prostheses
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US5041138A (en) * 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US5736372A (en) * 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5496722A (en) * 1988-06-30 1996-03-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture conditions and the products produced therefrom
US5152791A (en) * 1989-12-07 1992-10-06 Olympus Optical Co., Ltd. Prosthetic artificial bone having ceramic layers of different porosity
US5067964A (en) * 1989-12-13 1991-11-26 Stryker Corporation Articular surface repair
FR2664808A1 (fr) * 1990-07-23 1992-01-24 Gersberg Eduardo Systeme d'implants dentaires.
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5326357A (en) * 1992-03-18 1994-07-05 Mount Sinai Hospital Corporation Reconstituted cartridge tissue
US5916265A (en) * 1994-03-30 1999-06-29 Hu; Jie Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant
US5723331A (en) * 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5632745A (en) * 1995-02-07 1997-05-27 R&D Biologicals, Inc. Surgical implantation of cartilage repair unit
US5769899A (en) * 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5707962A (en) * 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
US5749874A (en) * 1995-02-07 1998-05-12 Matrix Biotechnologies, Inc. Cartilage repair unit and method of assembling same
GB9721585D0 (en) * 1997-10-10 1997-12-10 Geistlich Soehne Ag Chemical product
US5782835A (en) * 1995-03-07 1998-07-21 Innovasive Devices, Inc. Apparatus and methods for articular cartilage defect repair
US5904716A (en) * 1995-04-26 1999-05-18 Gendler; El Method for reconstituting cartilage tissue using demineralized bone and product thereof
US5782915A (en) * 1995-09-15 1998-07-21 Stone; Kevin R. Articular cartilage heterografts
US20020111695A1 (en) * 1995-11-06 2002-08-15 Mount Sinai Hospital Corporation Reconstituted mineralized cartilage tissue
US6352558B1 (en) * 1996-02-22 2002-03-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damage joint
US5989269A (en) * 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US5759190A (en) * 1996-08-30 1998-06-02 Vts Holdings Limited Method and kit for autologous transplantation
US6569172B2 (en) * 1996-08-30 2003-05-27 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
US5964805A (en) * 1997-02-12 1999-10-12 Stone; Kevin R. Method and paste for articular cartilage transplantation
US5993815A (en) 1996-11-08 1999-11-30 University Of Vermont Methods and compositions for inhibiting the activation of thrombin-activatable fibrinolysis inhibitor (TAFI)
US20010016646A1 (en) * 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US5866415A (en) * 1997-03-25 1999-02-02 Villeneuve; Peter E. Materials for healing cartilage and bone defects
AU742613B2 (en) * 1997-04-04 2002-01-10 Barnes-Jewish Hospital Neocartilage and methods of use
US5910315A (en) * 1997-07-18 1999-06-08 Stevenson; Sharon Allograft tissue material for filling spinal fusion cages or related surgical spaces
US6511958B1 (en) * 1997-08-14 2003-01-28 Sulzer Biologics, Inc. Compositions for regeneration and repair of cartilage lesions
EP0896825B1 (en) * 1997-08-14 2002-07-17 Sulzer Innotec Ag Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors
US6090998A (en) * 1997-10-27 2000-07-18 University Of Florida Segmentally demineralized bone implant
US6197586B1 (en) * 1997-12-12 2001-03-06 The Regents Of The University Of California Chondrocyte-like cells useful for tissue engineering and methods
DE19803673A1 (de) * 1998-01-30 1999-08-05 Norbert M Dr Meenen Biohybrider Gelenkflächenersatz
US6911212B2 (en) * 1998-02-27 2005-06-28 Musculoskeletal Transplant Foundation Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects
US7045141B2 (en) * 1998-02-27 2006-05-16 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
US6143293A (en) * 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
US20040044408A1 (en) * 1998-04-08 2004-03-04 Hungerford David S. Cell-culture and polymer constructs
US6734018B2 (en) * 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
DE69911609T2 (de) * 1998-07-13 2004-07-01 University Of Southern California, Los Angeles Verfahren zur beschleunigen den zuwachs und heilen von knochen und knorpel
SG115519A1 (en) * 1998-08-14 2005-10-28 Verigen Transplantation Serv Methods, instruments and materials for chondrocyte cell transplantation
US6530956B1 (en) * 1998-09-10 2003-03-11 Kevin A. Mansmann Resorbable scaffolds to promote cartilage regeneration
DE69928678T2 (de) * 1998-09-18 2006-07-20 Massachusetts Institute Of Technology, Cambridge Verwendung von wachstumsfaktoren und hormonen zur vermehrung menschlicher chondrozyten und knorpelgewebeherstellung
CA2346119C (en) * 1998-10-14 2011-04-05 Orquest, Inc. A method of inducing or enhancing chondrogenesis with extracellular matrix containing gdf-5
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
US6294187B1 (en) * 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
SE9901573D0 (sv) 1999-05-03 1999-05-03 Astra Ab New compounds
AR023819A1 (es) 1999-05-03 2002-09-04 Astrazeneca Ab FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION
SE9901572D0 (sv) 1999-05-03 1999-05-03 Astra Ab New compounds
US6251143B1 (en) * 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
US6652872B2 (en) * 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
US6429013B1 (en) * 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
US7078232B2 (en) * 1999-08-19 2006-07-18 Artecel, Inc. Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
MXPA02002671A (es) 1999-09-14 2002-07-30 Meiji Seika Kaisha Derivado de acido fosfonico que tiene actividad inhibidora contra la carboxipeptidasa b.
DE19957388A1 (de) * 1999-11-24 2001-06-13 Michael Sittinger Chondroinduktive und implantierbare Substrate zur Knorpelheilung und -protektion
EP1498089A1 (de) * 1999-12-15 2005-01-19 Zimmer GmbH Präparat für die Reparatur von Knorpel- oder Knorpel/Knochen-Defekten in menschlichen oder tierischen Gelenken
US6623963B1 (en) * 1999-12-20 2003-09-23 Verigen Ag Cellular matrix
WO2001078798A1 (en) * 2000-02-10 2001-10-25 Regeneration Technologies, Inc. Assembled implant
US6626945B2 (en) * 2000-03-14 2003-09-30 Chondrosite, Llc Cartilage repair plug
AR027685A1 (es) * 2000-03-22 2003-04-09 Synthes Ag Forma de tejido y metodo para realizarlo
US6932977B2 (en) * 2000-04-14 2005-08-23 Depuy Spine, Inc. Method of inducing or enhancing chondrogenesis with extracellular matrix containing BMP-4
ES2247113T3 (es) * 2000-05-12 2006-03-01 Osteotech, Inc. Implante oseo desmineralizado en la superficie y metodo para fabricarlo.
DK177997B1 (da) * 2000-07-19 2015-02-23 Ed Geistlich Söhne Ag Für Chemische Ind Knoglemateriale og collagenkombination til opheling af beskadigede led
CA2417688A1 (en) * 2000-07-29 2002-02-07 Smith & Nephew Plc Tissue implant for cartilage repair
AU2001276605A1 (en) * 2000-08-17 2002-02-25 Pfizer Inc. Substituted imidazoles as tafia inhibitors
DE10042484A1 (de) * 2000-08-29 2002-03-28 Merck Patent Gmbh Verfahren zur Herstellung von humanen Knorpelimplantaten mittels in vitro gezüchteter Chondrozyten
US20030050709A1 (en) * 2001-02-23 2003-03-13 Ulrich Noth Trabecular bone-derived human mesenchymal stem cells
US7252982B2 (en) * 2001-03-15 2007-08-07 Massachusetts Institute Of Technology Tissue engineering enhanced by the transfer of a growth factor gene
WO2002076285A2 (en) * 2001-03-23 2002-10-03 Histogenics Corporation Composition and methods fro the production of biological tissues and tissue constructs
WO2003061653A1 (en) * 2002-01-22 2003-07-31 Pfizer Limited 3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases
US6852331B2 (en) * 2002-02-11 2005-02-08 Taipei Biotechnology Ltd., Inc. Fabrication of a cartilage implant
US20040062753A1 (en) * 2002-09-27 2004-04-01 Alireza Rezania Composite scaffolds seeded with mammalian cells
US6761739B2 (en) * 2002-11-25 2004-07-13 Musculoskeletal Transplant Foundation Cortical and cancellous allograft spacer
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7217294B2 (en) * 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof

Also Published As

Publication number Publication date
US20030191107A1 (en) 2003-10-09
PE20030858A1 (es) 2003-10-21
WO2003061653A1 (en) 2003-07-31
CA2472239A1 (en) 2003-07-31
WO2003061653A9 (en) 2003-12-24
US6919457B2 (en) 2005-07-19
HN2003000040A (es) 2003-08-01
US20040192668A1 (en) 2004-09-30
MXPA04005940A (es) 2004-09-13
TW200302093A (en) 2003-08-01
US6759426B2 (en) 2004-07-06
EP1467732A1 (en) 2004-10-20
BR0307033A (pt) 2004-12-07
JP2005516972A (ja) 2005-06-09

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