AR013153A1 - Derivados de 2-arildihidropirimidina, proceso para su preparacion, composiciones farmaceuticas que contienen dichos derivados, y el uso de dichosderivados y composiciones como ligandos para canales de calcio neuronales de tipo n. - Google Patents
Derivados de 2-arildihidropirimidina, proceso para su preparacion, composiciones farmaceuticas que contienen dichos derivados, y el uso de dichosderivados y composiciones como ligandos para canales de calcio neuronales de tipo n.Info
- Publication number
- AR013153A1 AR013153A1 ARP980103175A ARP980103175A AR013153A1 AR 013153 A1 AR013153 A1 AR 013153A1 AR P980103175 A ARP980103175 A AR P980103175A AR P980103175 A ARP980103175 A AR P980103175A AR 013153 A1 AR013153 A1 AR 013153A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- derivatives
- ring
- alkoxy
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Derivados de 2-arildihidropirimidina, que comprende la formula I incluyendo su forma tautomérica 3,4-dihidropirimidina en la cual: R1 representa un anillomonocíclico aromático que optativamente incorpora una o tres heteroátomos que pueden ser iguales o diferentes y que son elegidos entre N, O o S, anillo quepuede ser optativamente sustituido con halogeno, alquilo C1 a 6, alcoxi C1 a 6 trifluorometilo; R2 represena alquilo C1 a 6 o alquilo C2 a 6, optativamenteincluyendo O, o bien S, y que está sustituido con un anillo de fenilo o heteroarilo monocíclico, anillo aromático que está sustituido con uno o mássustituyentes seleccionados entre halogeno, alquilo C1 a 6 o alcoxi C1 a 6; R3 representa un anillo monocíclico o bicíclico optativamente incorpora un átomoseleccionado entre N, O o S, optativamente sustituido con uno o más sustituyentes independientemenete seleccionados entre, alquilo C1 a 6, alcoxiC1 a 6, ciano, trifluorometilo, amino, hidroxi, nitro o carbometoxi; R4 y R5 representan independientemente hidrogeno, alquilo C1 a 6 o bencilo; o el grupoNR4R5 junto representa piperidinilo, morfolinilo, 3,4-deshidropiperidinilo, tiomorfolinilo, perhidroazepinilo, pirrolidinilo, piperazinilo o piperaziniloque también esta sustituido en N-4 por alquilo C1 a 6; R6 y R7 representan independientemente alquilo C1 a 6 o cicloalquilo C3 a 6, o bencilo,optativamente sustituido en el anillo fenilo por alquilo C1 a 6 alcoxi C1 a 6 o halogeno; X representaO, S o NR6; R8 representa hidrogeno o alquilo C1 a 6; yn representa un entero de 2 a 4; y los isomeros opticos y racematos de los mismos, así como las sales farmacéuticamente aceptables; de los mismos,procesos para su preparacion, composicionesque los contienen y su uso como antagonistas de los canales de calcio neuronales tipo N que sirven para el
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9702564A SE9702564D0 (sv) | 1997-07-02 | 1997-07-02 | New compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR013153A1 true AR013153A1 (es) | 2000-12-13 |
Family
ID=20407620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980103175A AR013153A1 (es) | 1997-07-02 | 1998-06-30 | Derivados de 2-arildihidropirimidina, proceso para su preparacion, composiciones farmaceuticas que contienen dichos derivados, y el uso de dichosderivados y composiciones como ligandos para canales de calcio neuronales de tipo n. |
Country Status (9)
Country | Link |
---|---|
US (1) | US6218538B1 (es) |
EP (1) | EP0993450A1 (es) |
JP (1) | JP2002508780A (es) |
AR (1) | AR013153A1 (es) |
AU (1) | AU8249998A (es) |
CA (1) | CA2294746A1 (es) |
SE (1) | SE9702564D0 (es) |
WO (1) | WO1999001438A1 (es) |
ZA (1) | ZA985323B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19817265A1 (de) * | 1998-04-18 | 1999-10-21 | Bayer Ag | Verwendung von Dihydropyrimidinen als Arzneimittel und neue Stoffe |
DE19817264A1 (de) * | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
US20040259866A1 (en) * | 1998-06-30 | 2004-12-23 | Snutch Terrance P. | Calcium channel blockers comprising two benzhydril moieties |
WO2000058302A1 (de) * | 1999-03-25 | 2000-10-05 | Bayer Aktiengesellschaft | Dihydropyrimidine und ihre verwendung zur behandlung von hepatitis b |
AU5568400A (en) | 1999-06-23 | 2001-01-09 | Ajinomoto Co., Inc. | Novel dihydropyrimidine derivatives |
DE10012823A1 (de) | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
DE10012824A1 (de) * | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
DE10013126A1 (de) * | 2000-03-17 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
EP1318147A1 (en) | 2000-09-14 | 2003-06-11 | Ajinomoto Co., Inc. | Novel pyrimidine derivative and novel pyridine derivative |
TW200418814A (en) * | 2003-01-02 | 2004-10-01 | Ardent Pharmaceuticals Inc | Cardioprotective delta opioid receptor agonists and methods of using same |
US7314880B2 (en) * | 2003-01-02 | 2008-01-01 | Mount Cook Biosciences, Inc. | Cardioprotective delta opioid receptor agonists and methods of using same |
CA2603926A1 (en) * | 2005-04-08 | 2006-10-12 | Neuromed Pharmaceuticals Ltd. | Combination therapy comprising an n-type calcium channel blocker for the alleviation of pain |
US8362021B2 (en) * | 2006-05-11 | 2013-01-29 | Zalicus Pharmaceuticals Ltd. | Method for increasing the bioavailability of benzhydryl piperazine containing compounds |
CN101225084A (zh) | 2007-01-16 | 2008-07-23 | 北京摩力克科技有限公司 | 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途 |
US8409560B2 (en) | 2011-03-08 | 2013-04-02 | Zalicus Pharmaceuticals Ltd. | Solid dispersion formulations and methods of use thereof |
EP2654726A4 (en) | 2011-03-08 | 2013-10-30 | Zalicus Pharmaceuticals Ltd | SOLID DISPERSION FORMULATIONS AND METHODS OF USE |
US20130267517A1 (en) | 2012-03-31 | 2013-10-10 | Hoffmann-La Roche Inc. | Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
KR20140143160A (ko) * | 2012-03-31 | 2014-12-15 | 에프. 호프만-라 로슈 아게 | B형 간염 바이러스 감염의 치료 및 예방을 위한 신규한 4-메틸-다이하이드로피리미딘 |
PL2888241T3 (pl) | 2012-08-24 | 2017-12-29 | Sunshine Lake Pharma Co., Ltd. | 2,4,5,6-Podstawione pochodne 3,6-dihydropirymidyny jako inhibitory polimerazy wirusa zapalenia wątroby typu B (HBV) do leczenia np. przewlekłego zapalenia wątroby |
PE20150776A1 (es) * | 2012-09-10 | 2015-05-21 | Hoffmann La Roche | 6-aminoacido-heteroarildihidropirimidinas para el tratamiento y profilaxis de la infeccion del virus de la hepatitis b |
CN104650068B (zh) | 2013-11-19 | 2018-08-10 | 广东东阳光药业有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
WO2015078392A1 (en) | 2013-11-27 | 2015-06-04 | Sunshine Lake Pharma Co., Ltd. | Processes for preparing dihydropyrimidine derivatives and intermediates thereof |
EP3122747B1 (en) | 2014-03-28 | 2020-05-20 | North & South Brother Pharmacy Investment Company Limited | Dihydropyrimidine compounds and their application in pharmaceuticals |
CN105859709B (zh) | 2015-02-07 | 2018-12-04 | 广东东阳光药业有限公司 | 二氢嘧啶衍生物的复合物及其在药物中的应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3234684A1 (de) * | 1982-09-18 | 1984-03-22 | Bayer Ag, 5090 Leverkusen | Neue dihydropyrimidine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
EP0202654A3 (en) | 1985-05-20 | 1987-12-16 | E.R. Squibb & Sons, Inc. | 5-carboxy-1,4-dihydropyrimidine derivatives |
DE69500377T2 (de) * | 1994-08-19 | 1997-10-09 | Mitsui Toatsu Chemicals | Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen |
-
1997
- 1997-07-02 SE SE9702564A patent/SE9702564D0/xx unknown
-
1998
- 1998-06-18 ZA ZA985323A patent/ZA985323B/xx unknown
- 1998-06-22 JP JP50700899A patent/JP2002508780A/ja active Pending
- 1998-06-22 CA CA002294746A patent/CA2294746A1/en not_active Abandoned
- 1998-06-22 WO PCT/SE1998/001208 patent/WO1999001438A1/en not_active Application Discontinuation
- 1998-06-22 EP EP98932675A patent/EP0993450A1/en not_active Ceased
- 1998-06-22 AU AU82499/98A patent/AU8249998A/en not_active Abandoned
- 1998-06-22 US US09/171,174 patent/US6218538B1/en not_active Expired - Fee Related
- 1998-06-30 AR ARP980103175A patent/AR013153A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU8249998A (en) | 1999-01-25 |
EP0993450A1 (en) | 2000-04-19 |
WO1999001438A1 (en) | 1999-01-14 |
SE9702564D0 (sv) | 1997-07-02 |
ZA985323B (en) | 1999-01-11 |
JP2002508780A (ja) | 2002-03-19 |
CA2294746A1 (en) | 1999-01-14 |
US6218538B1 (en) | 2001-04-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR013153A1 (es) | Derivados de 2-arildihidropirimidina, proceso para su preparacion, composiciones farmaceuticas que contienen dichos derivados, y el uso de dichosderivados y composiciones como ligandos para canales de calcio neuronales de tipo n. | |
PA8480101A1 (es) | Derivados de quinolin-2-ona alquinilsustituidos utiles como agentes anticancerosos | |
AR039868A1 (es) | Inhibidores selectivos de la enzima kalikreina plasmatica | |
PA8593101A1 (es) | Composiciones para el tratamiento de crecimiento celular anormal | |
CR7698A (es) | Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos | |
UY28514A1 (es) | Nuevos compuestos | |
PE20040832A1 (es) | Derivados de indolil pirazinona | |
ES2187983T3 (es) | Derivados 1,2,3,4-tetrahidronaftaleno sustituidos. | |
PE20040411A1 (es) | Compuestos de aril cetona pirrolo triazina | |
ECSP056020A (es) | Inhibidores del factor inhibidor de la migración de los macrofagos y metodos para su identificacion | |
AR032136A1 (es) | Compuestos espiroheterociclicos utiles como inhibidores reversibles de cisteina-proteasas | |
AR009892A1 (es) | Aplicacion de compuestos de imidazolidin-2,4-diona sustituidos, como medicamentos para el tratamiento del dolor | |
AR009938A1 (es) | Nuevos derivados de arilglicinamida, procedimientos para su preparacion y composiciones farmaceuticas que contienen estos compuestos | |
AR013152A1 (es) | Derivados de 2-alquilheterodihidropirimidina, proceso para su preparacion, composiciones farmaceuticas que contienen dichos derivados y el uso de dichosderivados y composiciones como ligandos para canales de calcio neuronales de tipo n. | |
UY27850A1 (es) | Nuevos carbamatos de quinuclidina y composiciones farmacéuticas que los contienen | |
ES2052521T3 (es) | Derivados de aminoimidazoquinolina. | |
UY27338A1 (es) | Nuevos derivados de ácido sulfónico | |
ECSP045420A (es) | Derivados de benzoxazina como moduladores 5-ht6 y usos de los mismos | |
AR044662A1 (es) | Compuestos de azetidina | |
PE20010631A1 (es) | Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen | |
PE20080126A1 (es) | Metodos para tratar trastornos cognitivos y otros afines | |
PA8589801A1 (es) | Aminoalcoxiindoles | |
AR016551A1 (es) | Derivados de 2-oxindol, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos | |
PA8563601A1 (es) | Acidos-3-(imidazolil)-2- alcoxipropanoicos | |
PT902684E (pt) | Derivados hexa-hidro-pirido(4,3-b)indolo utilizados como farmacos antipsicoticos |