PE20071040A1 - Derivados de 8-azabiciclo[3.2.1]octano como inhibidores de la recaptacion de monoaminas - Google Patents

Derivados de 8-azabiciclo[3.2.1]octano como inhibidores de la recaptacion de monoaminas

Info

Publication number
PE20071040A1
PE20071040A1 PE2006001521A PE2006001521A PE20071040A1 PE 20071040 A1 PE20071040 A1 PE 20071040A1 PE 2006001521 A PE2006001521 A PE 2006001521A PE 2006001521 A PE2006001521 A PE 2006001521A PE 20071040 A1 PE20071040 A1 PE 20071040A1
Authority
PE
Peru
Prior art keywords
octane
iloxi
exo
alkyl
recaptation
Prior art date
Application number
PE2006001521A
Other languages
English (en)
Inventor
Susan Elizabeth Napier
Matilda Jane Bingham
Neil Andrew Dunbar
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of PE20071040A1 publication Critical patent/PE20071040A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE 8-AZABICICLO[3.2.1]OCTANO DE FORMULA (I), DONDE R1 ES HIDROGENO O ALQUILO C1-C5; Y ES OXIGENO, S, O O(CH2)m; m ES 1 O 2; n ES 0 O 1; Ar1 ES FENILENO O PIRIDILENO SIENDO OPCIONALMENTE SUSTITUIDOS CON HALOGENO, ALQUILO C1-C5, ALCOXI C1-C5, FENILO, CN, ENTRE OTROS; Ar2 ES FENILO O UN HETEROARILO DE 5 A 6 ELEMENTOS SIENDO OPCIONALMENTE SUSTITUIDO CON UNO A TRES SUSTITUYENTES HALOGENO, ALQUILO C1-C5, ALCOXI C1-C5, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-EXO-(5-CLOROBIFENIL-3-ILOXI)-8-AZABICICLO[3.2.1]OCTANO, EXO-5-(8-AZABICICLO[3.2.1]OCT-3-ILOXI)BIFENIL-3-CARBONITRILO, EXO-3-(8-AZABICICLO[3.2.1]OCT-3-ILOXI)-5-FENOXIBENZONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA RECAPTACION DE MONOAMINAS Y SON UTILES EN EL TRATAMIENTO DE LA DEPRESION, ANSIEDAD, DESORDENES DE PANICO, DOLOR, DESORDENES DE HIPERACTIVIDAD CON DEFICIT DE ATENCION O DESORDEN COMPULSIVO OBSESIVO
PE2006001521A 2005-12-01 2006-11-29 Derivados de 8-azabiciclo[3.2.1]octano como inhibidores de la recaptacion de monoaminas PE20071040A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05111578 2005-12-01

Publications (1)

Publication Number Publication Date
PE20071040A1 true PE20071040A1 (es) 2007-11-19

Family

ID=36808780

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001521A PE20071040A1 (es) 2005-12-01 2006-11-29 Derivados de 8-azabiciclo[3.2.1]octano como inhibidores de la recaptacion de monoaminas

Country Status (10)

Country Link
EP (1) EP1957493B1 (es)
JP (1) JP2009517442A (es)
CN (1) CN101360745B (es)
AR (1) AR058257A1 (es)
AT (1) ATE496049T1 (es)
CA (1) CA2630511A1 (es)
DE (1) DE602006019775D1 (es)
PE (1) PE20071040A1 (es)
TW (1) TW200806662A (es)
WO (1) WO2007063071A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007137030A2 (en) 2006-05-19 2007-11-29 Abbott Laboratories Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives
EP2217596B8 (en) 2007-10-22 2013-11-20 Merck Sharp & Dohme Corp. Bicyclic heterocycle derivatives and their use as modulators of the activity of gpr119
CN101925599A (zh) * 2007-11-21 2010-12-22 雅培制药有限公司 作为烟碱性乙酰胆碱受体活性调节剂的联芳基取代的氮杂双环烷衍生物
JP2011511030A (ja) * 2008-02-05 2011-04-07 ノイロサーチ アクティーゼルスカブ ８−アザ−ビシクロ［３．２．１］オクタンの新規なフェニルエチニル誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用
FR2937641A1 (fr) * 2008-10-28 2010-04-30 Sanofi Aventis Derives d'urees de tropane, leur preparation et leur application en therapeutique
WO2010144586A1 (en) * 2009-06-09 2010-12-16 Abraxis Bioscience, Llc Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling
AR079724A1 (es) 2010-01-20 2012-02-15 Abbott Lab Metodos para el tratamiento del dolor
CN103562166B (zh) 2011-05-27 2016-03-16 默克专利股份有限公司 1-溴-3-卤-2-环烷基苯化合物
JP2014533258A (ja) 2011-11-15 2014-12-11 ゼンション・リミテッドＸｅｎｔｉｏｎ Ｌｉｍｉｔｅｄ カリウムチャネル阻害剤としてのチエノ［２，３−ｃ］ピラゾールの使用
CN104478793A (zh) * 2014-11-20 2015-04-01 盐城恒盛化工有限公司 一种2,3,5-三氯吡啶的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1164555A (en) * 1966-09-20 1969-09-17 Chinoin Gyogyszer Es Vegyeszet New Tropine Derivatives
CA2530023A1 (en) * 2003-06-24 2004-12-29 Neurosearch A/S Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Also Published As

Publication number Publication date
EP1957493B1 (en) 2011-01-19
JP2009517442A (ja) 2009-04-30
EP1957493A1 (en) 2008-08-20
ATE496049T1 (de) 2011-02-15
AR058257A1 (es) 2008-01-30
TW200806662A (en) 2008-02-01
WO2007063071A1 (en) 2007-06-07
CN101360745A (zh) 2009-02-04
CN101360745B (zh) 2011-12-14
CA2630511A1 (en) 2007-06-07
DE602006019775D1 (de) 2011-03-03

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