AR058257A1 - Derivados de 8-azabiciclo[3.2.1]octano. composiciones farmaceuticas. - Google Patents

Derivados de 8-azabiciclo[3.2.1]octano. composiciones farmaceuticas.

Info

Publication number
AR058257A1
AR058257A1 ARP060105286A ARP060105286A AR058257A1 AR 058257 A1 AR058257 A1 AR 058257A1 AR P060105286 A ARP060105286 A AR P060105286A AR P060105286 A ARP060105286 A AR P060105286A AR 058257 A1 AR058257 A1 AR 058257A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
hydroxy
optionally substituted
pyridylene
Prior art date
Application number
ARP060105286A
Other languages
English (en)
Inventor
S E Napier
M J Bingham
N A Dunbar
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of AR058257A1 publication Critical patent/AR058257A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente se relaciona con una composicion farmacéutica que comprende un derivado 8-azabiciclo[3.2.1]octano, segun la presente, en asociacion con uno o más auxiliares farmacéuticamente aceptables. Reivindicacion 1: Un derivado de 8- azabiciclo[3.2.1]octano de formula (1) caracterizado porque R1 es H o alquilo C1-5; Y es O, S o O(CH2)m; m es 1 o 2; n es 0 o1; Ar1 es fenileno o piridileno; dicho fenileno y piridileno siendo unido en las posiciones 1,3 con respecto a O y cuando n es 1 con respecto a Y y cuado n es 0 con respecto a Ar2, dicho fenileno y piridileno siendo opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados de halogeno, alquilo C1-5, alcoxi C1-5, cicloalquilo C3-6, alquenilo C2- 5, alquinilo C2-5, fenilo, CN e hidroxi, donde dicho alquilo C1-5 y alcoxi C1-5 son opcionalmente sustituidos con 1 a 3 halogenos y donde el O de dicho hidroxi es opcionalmente unido a Ar2 para formar un anillo de 5 elementos; Ar2 es fenilo o un heteroarilo de 5-6 elementos, dicho fenilo o heteroarilo de 5-6 elementos siendo opcionalmente sustituido con 1 a 3 sustituyentes independientemente seleccionados de halogeno, alquilo C1-5, alcoxi C1-5, CN, CONR2R3, CO2R4, NHCOR5 e hidroxi, donde dicho alquilo C1-5 y alcoxi C1-5 son opcionalmente sustituidos con 1 a 3 halogenos y donde el O de dicho hidroxi es opcionalmente unido a Ar1 para formar un anillo de 5 elementos; R2-R4 son independientemente H o alquilo C1-5 y R5 es alquilo C1-5, o una sal o solvato de estos farmacéuticamente aceptables.
ARP060105286A 2005-12-01 2006-11-30 Derivados de 8-azabiciclo[3.2.1]octano. composiciones farmaceuticas. AR058257A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05111578 2005-12-01

Publications (1)

Publication Number Publication Date
AR058257A1 true AR058257A1 (es) 2008-01-30

Family

ID=36808780

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105286A AR058257A1 (es) 2005-12-01 2006-11-30 Derivados de 8-azabiciclo[3.2.1]octano. composiciones farmaceuticas.

Country Status (10)

Country Link
EP (1) EP1957493B1 (es)
JP (1) JP2009517442A (es)
CN (1) CN101360745B (es)
AR (1) AR058257A1 (es)
AT (1) ATE496049T1 (es)
CA (1) CA2630511A1 (es)
DE (1) DE602006019775D1 (es)
PE (1) PE20071040A1 (es)
TW (1) TW200806662A (es)
WO (1) WO2007063071A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2431368B1 (en) * 2006-05-19 2014-08-27 AbbVie Bahamas Ltd. CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives
AU2008317057B8 (en) 2007-10-22 2014-02-13 Merck Sharp & Dohme Corp. Bicyclic Heterocycle Derivatives and their use as modulators of the activity of GPR119
EP2280010B1 (en) * 2007-11-21 2012-12-19 Abbott Laboratories Biaryl substituted azabicyclic alkane derivatives as nicotinic acetylcholine receptor activity modulators
EP2240476A1 (en) * 2008-02-05 2010-10-20 NeuroSearch A/S Novel phenylethynyl derivatives of 8-aza-bicyclo[3.2.1]octane and their use as monoamine neurotransmitter re-uptake inhibitors
FR2937641A1 (fr) * 2008-10-28 2010-04-30 Sanofi Aventis Derives d'urees de tropane, leur preparation et leur application en therapeutique
AU2010258800B2 (en) 2009-06-09 2013-10-10 Nantbio, Inc. Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling
EP2525797A1 (en) 2010-01-20 2012-11-28 Abbott Laboratories Methods for treating pain
CN103562166B (zh) 2011-05-27 2016-03-16 默克专利股份有限公司 1-溴-3-卤-2-环烷基苯化合物
WO2013072693A1 (en) 2011-11-15 2013-05-23 Xention Limited Thieno [2, 3 - c] pyrazoles for use as potassium channel inhibitors
CN104478793A (zh) * 2014-11-20 2015-04-01 盐城恒盛化工有限公司 一种2,3,5-三氯吡啶的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1164555A (en) * 1966-09-20 1969-09-17 Chinoin Gyogyszer Es Vegyeszet New Tropine Derivatives
UA82517C2 (uk) * 2003-06-24 2008-04-25 Ньюросерч А/С Нові похідні 8-аза-біцикло[3.2.1]октану та їх застосування як інгібіторів ресорбції моноамінових медіаторів

Also Published As

Publication number Publication date
TW200806662A (en) 2008-02-01
CN101360745A (zh) 2009-02-04
EP1957493A1 (en) 2008-08-20
DE602006019775D1 (de) 2011-03-03
WO2007063071A1 (en) 2007-06-07
JP2009517442A (ja) 2009-04-30
CA2630511A1 (en) 2007-06-07
EP1957493B1 (en) 2011-01-19
PE20071040A1 (es) 2007-11-19
CN101360745B (zh) 2011-12-14
ATE496049T1 (de) 2011-02-15

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