AR058257A1 - Derivados de 8-azabiciclo[3.2.1]octano. composiciones farmaceuticas. - Google Patents
Derivados de 8-azabiciclo[3.2.1]octano. composiciones farmaceuticas.Info
- Publication number
- AR058257A1 AR058257A1 ARP060105286A ARP060105286A AR058257A1 AR 058257 A1 AR058257 A1 AR 058257A1 AR P060105286 A ARP060105286 A AR P060105286A AR P060105286 A ARP060105286 A AR P060105286A AR 058257 A1 AR058257 A1 AR 058257A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- hydroxy
- optionally substituted
- pyridylene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente se relaciona con una composicion farmacéutica que comprende un derivado 8-azabiciclo[3.2.1]octano, segun la presente, en asociacion con uno o más auxiliares farmacéuticamente aceptables. Reivindicacion 1: Un derivado de 8- azabiciclo[3.2.1]octano de formula (1) caracterizado porque R1 es H o alquilo C1-5; Y es O, S o O(CH2)m; m es 1 o 2; n es 0 o1; Ar1 es fenileno o piridileno; dicho fenileno y piridileno siendo unido en las posiciones 1,3 con respecto a O y cuando n es 1 con respecto a Y y cuado n es 0 con respecto a Ar2, dicho fenileno y piridileno siendo opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados de halogeno, alquilo C1-5, alcoxi C1-5, cicloalquilo C3-6, alquenilo C2- 5, alquinilo C2-5, fenilo, CN e hidroxi, donde dicho alquilo C1-5 y alcoxi C1-5 son opcionalmente sustituidos con 1 a 3 halogenos y donde el O de dicho hidroxi es opcionalmente unido a Ar2 para formar un anillo de 5 elementos; Ar2 es fenilo o un heteroarilo de 5-6 elementos, dicho fenilo o heteroarilo de 5-6 elementos siendo opcionalmente sustituido con 1 a 3 sustituyentes independientemente seleccionados de halogeno, alquilo C1-5, alcoxi C1-5, CN, CONR2R3, CO2R4, NHCOR5 e hidroxi, donde dicho alquilo C1-5 y alcoxi C1-5 son opcionalmente sustituidos con 1 a 3 halogenos y donde el O de dicho hidroxi es opcionalmente unido a Ar1 para formar un anillo de 5 elementos; R2-R4 son independientemente H o alquilo C1-5 y R5 es alquilo C1-5, o una sal o solvato de estos farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05111578 | 2005-12-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR058257A1 true AR058257A1 (es) | 2008-01-30 |
Family
ID=36808780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060105286A AR058257A1 (es) | 2005-12-01 | 2006-11-30 | Derivados de 8-azabiciclo[3.2.1]octano. composiciones farmaceuticas. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1957493B1 (es) |
JP (1) | JP2009517442A (es) |
CN (1) | CN101360745B (es) |
AR (1) | AR058257A1 (es) |
AT (1) | ATE496049T1 (es) |
CA (1) | CA2630511A1 (es) |
DE (1) | DE602006019775D1 (es) |
PE (1) | PE20071040A1 (es) |
TW (1) | TW200806662A (es) |
WO (1) | WO2007063071A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102516241B (zh) * | 2006-05-19 | 2015-07-29 | 艾伯维巴哈马有限公司 | Cns活性的稠合的双环杂环取代的氮杂双环烷烃衍生物 |
WO2009055331A2 (en) | 2007-10-22 | 2009-04-30 | Schering Corporation | Bicyclic heterocycle derivatives and their use as modulators of the activity of gpr119 |
EP2231657A1 (en) * | 2007-11-21 | 2010-09-29 | Abbott Laboratories | Biaryl substituted azabicyclic alkane derivatives as nicotinic acetylcholine receptor activity modulators |
JP2011511030A (ja) * | 2008-02-05 | 2011-04-07 | ノイロサーチ アクティーゼルスカブ | 8−アザ−ビシクロ[3.2.1]オクタンの新規なフェニルエチニル誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用 |
FR2937641A1 (fr) * | 2008-10-28 | 2010-04-30 | Sanofi Aventis | Derives d'urees de tropane, leur preparation et leur application en therapeutique |
AU2010258800B2 (en) * | 2009-06-09 | 2013-10-10 | Nantbio, Inc. | Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling |
EP2525797A1 (en) | 2010-01-20 | 2012-11-28 | Abbott Laboratories | Methods for treating pain |
DE102012009811A1 (de) | 2011-05-27 | 2012-11-29 | Merck Patent Gmbh | 1-Brom-3-Halo-2-Cycloalkylbenzol-Verbindungen |
EP2780344A1 (en) | 2011-11-15 | 2014-09-24 | Xention Limited | Thieno [2, 3 - c]pyrazoles for use as potassium channel inhibitors |
CN104478793A (zh) * | 2014-11-20 | 2015-04-01 | 盐城恒盛化工有限公司 | 一种2,3,5-三氯吡啶的合成方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1164555A (en) * | 1966-09-20 | 1969-09-17 | Chinoin Gyogyszer Es Vegyeszet | New Tropine Derivatives |
CN100368409C (zh) * | 2003-06-24 | 2008-02-13 | 神经研究公司 | 8-氮杂双环[3.2.1]辛烷衍生物及其用于制备单胺神经递质再摄取抑制剂的用途 |
-
2006
- 2006-11-23 TW TW095143382A patent/TW200806662A/zh unknown
- 2006-11-29 AT AT06830185T patent/ATE496049T1/de not_active IP Right Cessation
- 2006-11-29 DE DE602006019775T patent/DE602006019775D1/de active Active
- 2006-11-29 EP EP06830185A patent/EP1957493B1/en active Active
- 2006-11-29 CN CN2006800510417A patent/CN101360745B/zh not_active Expired - Fee Related
- 2006-11-29 CA CA002630511A patent/CA2630511A1/en not_active Abandoned
- 2006-11-29 PE PE2006001521A patent/PE20071040A1/es not_active Application Discontinuation
- 2006-11-29 JP JP2008542750A patent/JP2009517442A/ja active Pending
- 2006-11-29 WO PCT/EP2006/069047 patent/WO2007063071A1/en active Application Filing
- 2006-11-30 AR ARP060105286A patent/AR058257A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP1957493A1 (en) | 2008-08-20 |
JP2009517442A (ja) | 2009-04-30 |
CA2630511A1 (en) | 2007-06-07 |
EP1957493B1 (en) | 2011-01-19 |
TW200806662A (en) | 2008-02-01 |
WO2007063071A1 (en) | 2007-06-07 |
CN101360745A (zh) | 2009-02-04 |
PE20071040A1 (es) | 2007-11-19 |
ATE496049T1 (de) | 2011-02-15 |
DE602006019775D1 (de) | 2011-03-03 |
CN101360745B (zh) | 2011-12-14 |
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