ECSP12011867A - Derivados bencimidazol-imidazol - Google Patents
Derivados bencimidazol-imidazolInfo
- Publication number
- ECSP12011867A ECSP12011867A ECSP12011867A ECSP12011867A EC SP12011867 A ECSP12011867 A EC SP12011867A EC SP12011867 A ECSP12011867 A EC SP12011867A EC SP12011867 A ECSP12011867 A EC SP12011867A
- Authority
- EC
- Ecuador
- Prior art keywords
- bencimidazol
- heteroaryl
- aryl
- imidazol derivatives
- hcv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
Inhibidores de replicación de HCV de fórmula Ique incluye formas estereoquímicamente isoméricas, y sales, solvatos de los mismos, donde R y R' son, cada uno independientemente, -CR1R2R3, arilo, heteroarilo o heterocicloalquilo C4-6, donde arilo y heteroarilo pueden estar opcionalmente sustituidos con 1 o 2 sustituyentes seleccionados de halo y metilo.La presente invención se refiere a procedimientos para la preparación de dichos compuestos, composiciones farmacéuticas que los contienen y su uso en terapia de HCV.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09175015 | 2009-11-04 | ||
EP10154583 | 2010-02-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP12011867A true ECSP12011867A (es) | 2012-10-30 |
Family
ID=43266424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP12011867 ECSP12011867A (es) | 2009-11-04 | 2012-05-04 | Derivados bencimidazol-imidazol |
Country Status (22)
Country | Link |
---|---|
US (3) | US9427428B2 (es) |
EP (1) | EP2496572A1 (es) |
JP (1) | JP6005515B2 (es) |
KR (1) | KR20120091292A (es) |
CN (1) | CN102741241B (es) |
AP (1) | AP2012006216A0 (es) |
AR (1) | AR078888A1 (es) |
AU (1) | AU2010317085A1 (es) |
BR (1) | BR112012010502A2 (es) |
CA (1) | CA2780034C (es) |
CL (1) | CL2012001176A1 (es) |
CO (1) | CO6531445A2 (es) |
CR (1) | CR20120302A (es) |
EA (1) | EA022839B1 (es) |
EC (1) | ECSP12011867A (es) |
IL (1) | IL219087A0 (es) |
MX (1) | MX2012005178A (es) |
TW (1) | TW201127378A (es) |
UA (1) | UA108211C2 (es) |
UY (1) | UY32997A (es) |
WO (1) | WO2011054834A1 (es) |
ZA (1) | ZA201203205B (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
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BRPI0922366B8 (pt) | 2008-12-03 | 2021-05-25 | Presidio Pharmaceuticals Inc | composto, composição farmacêutica e uso de um composto |
JP2012513410A (ja) | 2008-12-23 | 2012-06-14 | アボット・ラボラトリーズ | 抗ウイルス化合物 |
RU2505540C2 (ru) | 2008-12-23 | 2014-01-27 | Эббви Инк. | Антивирусные соединения |
US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
KR101411889B1 (ko) * | 2009-02-27 | 2014-06-27 | 이난타 파마슈티칼스, 인코포레이티드 | C형 간염 바이러스 억제제 |
US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
MX2011010905A (es) | 2009-04-15 | 2011-11-01 | Abbott Lab | Compuestos antivirales. |
NZ619205A (en) | 2009-05-13 | 2015-04-24 | Gilead Pharmasset Llc | Antiviral compounds |
US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
JP5530514B2 (ja) | 2009-06-11 | 2014-06-25 | アッヴィ・バハマズ・リミテッド | Hcv感染を治療するための抗ウィルス化合物 |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
US20110274648A1 (en) * | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
AU2011207492A1 (en) | 2010-01-25 | 2012-08-16 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
WO2011127350A1 (en) | 2010-04-09 | 2011-10-13 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
EP2575866A4 (en) * | 2010-05-24 | 2013-10-16 | Presidio Pharmaceuticals Inc | HCV NS5A INHIBITORS |
US8778938B2 (en) | 2010-06-04 | 2014-07-15 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
EP2603080A4 (en) | 2010-08-12 | 2014-01-22 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2012154321A1 (en) * | 2011-03-31 | 2012-11-15 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
MD4589C1 (ro) | 2011-09-16 | 2019-03-31 | Gilead Pharmasset Llc | Compoziţie farmaceutică cu conţinut de sofosbuvir şi utilizarea acesteia în tratamentul hepatitei virale C |
WO2013098320A1 (en) | 2011-12-28 | 2013-07-04 | Janssen R&D Ireland | Quinazolinone derivatives as hcv inhibitors |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
SG11201404754TA (en) * | 2012-02-13 | 2014-09-26 | Presidio Pharmaceuticals Inc | Solid forms comprising inhibitors of hcv ns5a, compositions thereof, and uses therewith |
CN102796084A (zh) * | 2012-09-10 | 2012-11-28 | 合肥科尚医药科技有限公司 | 一种活性物质及其在治疗丙型肝炎中的应用及制备方法 |
NZ625087A (en) | 2013-01-31 | 2017-05-26 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
CN105530933B (zh) | 2013-07-17 | 2018-12-11 | 百时美施贵宝公司 | 用于治疗hcv的包含联苯衍生物的组合产品 |
ES2900570T3 (es) | 2013-08-27 | 2022-03-17 | Gilead Pharmasset Llc | Formulación de combinación de dos compuestos antivirales |
WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
US9988371B2 (en) | 2014-06-03 | 2018-06-05 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Benzimidazole analogues and related methods |
TWI721947B (zh) | 2014-06-11 | 2021-03-21 | 美商基利法瑪席特有限責任公司 | 抗病毒化合物的固態形式 |
TWI679203B (zh) | 2014-06-11 | 2019-12-11 | 美商基利法瑪席特有限責任公司 | 製備抗病毒化合物之方法 |
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US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
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HUP0004421A3 (en) | 1996-04-23 | 2002-10-28 | Vertex Pharmaceuticals Inc Cam | Urea derivatives and pharmaceutical compositions containing them, use thereof for the treatment of deseases mediated by impdh enzyme |
EP0966465B1 (en) | 1997-03-14 | 2003-07-09 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
EE200100492A (et) | 1999-03-19 | 2002-12-16 | Vertex Pharmaceuticals Incorporated | Ensüümi IMPDH inhibiitorid |
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BRPI0822335A2 (pt) | 2008-02-12 | 2019-09-24 | Bristol-Myers Squibb Company | inibidores do vírus da hepatite c |
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US7704992B2 (en) | 2008-02-13 | 2010-04-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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US7906655B2 (en) * | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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BRPI0922366B8 (pt) * | 2008-12-03 | 2021-05-25 | Presidio Pharmaceuticals Inc | composto, composição farmacêutica e uso de um composto |
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EP2398474A4 (en) * | 2009-02-23 | 2012-12-05 | Presidio Pharmaceuticals Inc | HCV NS5A SHEMMER |
US8101643B2 (en) * | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
KR101411889B1 (ko) * | 2009-02-27 | 2014-06-27 | 이난타 파마슈티칼스, 인코포레이티드 | C형 간염 바이러스 억제제 |
NZ619205A (en) | 2009-05-13 | 2015-04-24 | Gilead Pharmasset Llc | Antiviral compounds |
WO2010138791A1 (en) * | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
-
2010
- 2010-03-11 UA UAA201204598A patent/UA108211C2/uk unknown
- 2010-11-03 AU AU2010317085A patent/AU2010317085A1/en not_active Abandoned
- 2010-11-03 MX MX2012005178A patent/MX2012005178A/es not_active Application Discontinuation
- 2010-11-03 AP AP2012006216A patent/AP2012006216A0/xx unknown
- 2010-11-03 TW TW099137712A patent/TW201127378A/zh unknown
- 2010-11-03 JP JP2012537376A patent/JP6005515B2/ja not_active Expired - Fee Related
- 2010-11-03 EP EP10771766A patent/EP2496572A1/en not_active Withdrawn
- 2010-11-03 WO PCT/EP2010/066668 patent/WO2011054834A1/en active Application Filing
- 2010-11-03 CN CN201080050509.7A patent/CN102741241B/zh not_active Expired - Fee Related
- 2010-11-03 BR BR112012010502A patent/BR112012010502A2/pt not_active IP Right Cessation
- 2010-11-03 US US13/508,186 patent/US9427428B2/en not_active Expired - Fee Related
- 2010-11-03 UY UY0001032997A patent/UY32997A/es unknown
- 2010-11-03 CA CA2780034A patent/CA2780034C/en not_active Expired - Fee Related
- 2010-11-03 KR KR1020127014503A patent/KR20120091292A/ko not_active Application Discontinuation
- 2010-11-03 EA EA201290260A patent/EA022839B1/ru not_active IP Right Cessation
- 2010-11-04 AR ARP100104084A patent/AR078888A1/es not_active Application Discontinuation
-
2012
- 2012-04-05 IL IL219087A patent/IL219087A0/en unknown
- 2012-04-13 CO CO12061178A patent/CO6531445A2/es not_active Application Discontinuation
- 2012-05-03 ZA ZA2012/03205A patent/ZA201203205B/en unknown
- 2012-05-04 CL CL2012001176A patent/CL2012001176A1/es unknown
- 2012-05-04 EC ECSP12011867 patent/ECSP12011867A/es unknown
- 2012-06-04 CR CR20120302A patent/CR20120302A/es unknown
-
2013
- 2013-03-15 US US13/836,816 patent/US9433609B2/en not_active Expired - Fee Related
-
2016
- 2016-08-04 US US15/228,720 patent/US20160340344A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP6005515B2 (ja) | 2016-10-12 |
CL2012001176A1 (es) | 2012-08-31 |
CN102741241A (zh) | 2012-10-17 |
EA201290260A1 (ru) | 2013-12-30 |
EA022839B1 (ru) | 2016-03-31 |
AR078888A1 (es) | 2011-12-07 |
UY32997A (es) | 2011-05-31 |
US9427428B2 (en) | 2016-08-30 |
ZA201203205B (en) | 2014-10-29 |
US9433609B2 (en) | 2016-09-06 |
CO6531445A2 (es) | 2012-09-28 |
MX2012005178A (es) | 2012-06-08 |
JP2013510119A (ja) | 2013-03-21 |
UA108211C2 (uk) | 2015-04-10 |
BR112012010502A2 (pt) | 2016-03-15 |
US20140107172A1 (en) | 2014-04-17 |
AU2010317085A1 (en) | 2012-05-10 |
TW201127378A (en) | 2011-08-16 |
KR20120091292A (ko) | 2012-08-17 |
CN102741241B (zh) | 2015-05-20 |
CR20120302A (es) | 2012-10-25 |
US20160340344A1 (en) | 2016-11-24 |
IL219087A0 (en) | 2012-06-28 |
CA2780034A1 (en) | 2011-05-12 |
US20120219594A1 (en) | 2012-08-30 |
EP2496572A1 (en) | 2012-09-12 |
AP2012006216A0 (en) | 2012-04-30 |
WO2011054834A1 (en) | 2011-05-12 |
CA2780034C (en) | 2018-04-10 |
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