AR078888A1 - Derivados heterociclicos nitrogenados de bencimidazol-imidazol utiles para tratar infecciones por hvc y composiciones farmaceuticas que los comprenden. - Google Patents

Derivados heterociclicos nitrogenados de bencimidazol-imidazol utiles para tratar infecciones por hvc y composiciones farmaceuticas que los comprenden.

Info

Publication number
AR078888A1
AR078888A1 ARP100104084A ARP100104084A AR078888A1 AR 078888 A1 AR078888 A1 AR 078888A1 AR P100104084 A ARP100104084 A AR P100104084A AR P100104084 A ARP100104084 A AR P100104084A AR 078888 A1 AR078888 A1 AR 078888A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
imidazol
halo
bencimidazol
hvc
Prior art date
Application number
ARP100104084A
Other languages
English (en)
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of AR078888A1 publication Critical patent/AR078888A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reivindicacion 1: Un compuesto de formula (1) o una forma estereoisomérica del mismo, donde: A es fenileno o naftileno, cada uno de los cuales puede estar opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados de halo o alquilo C1-3; R y R', son cada uno independientemente, -CR1R2R3, arilo, heteroarilo o heterocicloalquilo C4-6, donde arilo y heteroarilo pueden estar opcionalmente sustituidos con 1 o 2 sustituyentes seleccionados de halo y metilo; y donde R1 es hidrogeno; alquilo C1-4 opcionalmente sustituido con metoxi, hidroxi o dimetilamino; fenilo opcionalmente sustituido con 1, 2 o 3 sustituyentes independientemente seleccionados de halo, alcoxi C1-4 y trifluorometoxi; 1,3-benzodioxolanilo; bencilo opcionalmente sustituido con 1, 2 o 3 sustituyentes independientemente seleccionados de halo o metoxi; cicloalquilo C3-6; heteroarilo; heterocicloalquilo C4-6; o heteroarilmetilo; R2 es hidrogeno, hidroxilo, amino, mono- o dialquilamino C1-4, alquilcarbonilamino C1-4, alquiloxicarbonilamino C1-4, alquilaminocarbonilamino C1-4, piperidin-1-ilo o imidazol-1-ilo; R3 es hidrogeno, o R1 y R3 forman conjuntamente un grupo ciclopropilo; o R2 y R3 forman oxo; o una sal farmacéuticamente aceptable o un solvato del mismo.
ARP100104084A 2009-11-04 2010-11-04 Derivados heterociclicos nitrogenados de bencimidazol-imidazol utiles para tratar infecciones por hvc y composiciones farmaceuticas que los comprenden. AR078888A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09175015 2009-11-04
EP10154583 2010-02-24

Publications (1)

Publication Number Publication Date
AR078888A1 true AR078888A1 (es) 2011-12-07

Family

ID=43266424

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104084A AR078888A1 (es) 2009-11-04 2010-11-04 Derivados heterociclicos nitrogenados de bencimidazol-imidazol utiles para tratar infecciones por hvc y composiciones farmaceuticas que los comprenden.

Country Status (22)

Country Link
US (3) US9427428B2 (es)
EP (1) EP2496572A1 (es)
JP (1) JP6005515B2 (es)
KR (1) KR20120091292A (es)
CN (1) CN102741241B (es)
AP (1) AP2012006216A0 (es)
AR (1) AR078888A1 (es)
AU (1) AU2010317085A1 (es)
BR (1) BR112012010502A2 (es)
CA (1) CA2780034C (es)
CL (1) CL2012001176A1 (es)
CO (1) CO6531445A2 (es)
CR (1) CR20120302A (es)
EA (1) EA022839B1 (es)
EC (1) ECSP12011867A (es)
IL (1) IL219087A0 (es)
MX (1) MX2012005178A (es)
TW (1) TW201127378A (es)
UA (1) UA108211C2 (es)
UY (1) UY32997A (es)
WO (1) WO2011054834A1 (es)
ZA (1) ZA201203205B (es)

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Also Published As

Publication number Publication date
US9433609B2 (en) 2016-09-06
JP6005515B2 (ja) 2016-10-12
US20160340344A1 (en) 2016-11-24
CR20120302A (es) 2012-10-25
US20120219594A1 (en) 2012-08-30
EP2496572A1 (en) 2012-09-12
WO2011054834A1 (en) 2011-05-12
TW201127378A (en) 2011-08-16
CO6531445A2 (es) 2012-09-28
AP2012006216A0 (en) 2012-04-30
JP2013510119A (ja) 2013-03-21
AU2010317085A1 (en) 2012-05-10
ECSP12011867A (es) 2012-10-30
EA022839B1 (ru) 2016-03-31
CN102741241A (zh) 2012-10-17
CL2012001176A1 (es) 2012-08-31
ZA201203205B (en) 2014-10-29
CA2780034A1 (en) 2011-05-12
CN102741241B (zh) 2015-05-20
US9427428B2 (en) 2016-08-30
IL219087A0 (en) 2012-06-28
US20140107172A1 (en) 2014-04-17
EA201290260A1 (ru) 2013-12-30
BR112012010502A2 (pt) 2016-03-15
CA2780034C (en) 2018-04-10
UA108211C2 (uk) 2015-04-10
UY32997A (es) 2011-05-31
MX2012005178A (es) 2012-06-08
KR20120091292A (ko) 2012-08-17

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