UY32997A - Derivados bencimidazol-imidazol - Google Patents
Derivados bencimidazol-imidazolInfo
- Publication number
- UY32997A UY32997A UY0001032997A UY32997A UY32997A UY 32997 A UY32997 A UY 32997A UY 0001032997 A UY0001032997 A UY 0001032997A UY 32997 A UY32997 A UY 32997A UY 32997 A UY32997 A UY 32997A
- Authority
- UY
- Uruguay
- Prior art keywords
- bencimidazol
- heteroaryl
- aryl
- imidazol derivatives
- hcv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
Inhibidores de replicación de HCV de fórmula I que incluye formas estereoquímicamente isoméricas, y sales, solvatos de los mismos,donde R y R' son, cada uno independientemente, -CR1R2R3, arilo, heteroarilo o heterocicloalquilo C4-6, donde arilo y heteroarilo pueden estar opcionalmente sustituidos con 1 o 2 sustituyente seleccionados de halo y metilo. La presente invención se refiere a procedimientos para la preparación de dichos compuestos, composiciones farmacéuticas que los contienen y su uso en terapia de HCV
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09175015 | 2009-11-04 | ||
EP10154583 | 2010-02-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY32997A true UY32997A (es) | 2011-05-31 |
Family
ID=43266424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001032997A UY32997A (es) | 2009-11-04 | 2010-11-03 | Derivados bencimidazol-imidazol |
Country Status (22)
Country | Link |
---|---|
US (3) | US9427428B2 (es) |
EP (1) | EP2496572A1 (es) |
JP (1) | JP6005515B2 (es) |
KR (1) | KR20120091292A (es) |
CN (1) | CN102741241B (es) |
AP (1) | AP2012006216A0 (es) |
AR (1) | AR078888A1 (es) |
AU (1) | AU2010317085A1 (es) |
BR (1) | BR112012010502A2 (es) |
CA (1) | CA2780034C (es) |
CL (1) | CL2012001176A1 (es) |
CO (1) | CO6531445A2 (es) |
CR (1) | CR20120302A (es) |
EA (1) | EA022839B1 (es) |
EC (1) | ECSP12011867A (es) |
IL (1) | IL219087A0 (es) |
MX (1) | MX2012005178A (es) |
TW (1) | TW201127378A (es) |
UA (1) | UA108211C2 (es) |
UY (1) | UY32997A (es) |
WO (1) | WO2011054834A1 (es) |
ZA (1) | ZA201203205B (es) |
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BRPI0922366B8 (pt) | 2008-12-03 | 2021-05-25 | Presidio Pharmaceuticals Inc | composto, composição farmacêutica e uso de um composto |
JP2012513410A (ja) | 2008-12-23 | 2012-06-14 | アボット・ラボラトリーズ | 抗ウイルス化合物 |
US8541424B2 (en) | 2008-12-23 | 2013-09-24 | Abbott Laboratories | Anti-viral compounds |
US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
SG10201400235PA (en) * | 2009-02-27 | 2014-07-30 | Enanta Pharm Inc | Hepatitis c virus inhibitors |
US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2010120935A1 (en) | 2009-04-15 | 2010-10-21 | Abbott Laboratories | Anti-viral compounds |
KR20190029771A (ko) | 2009-05-13 | 2019-03-20 | 길리애드 파마셋 엘엘씨 | 항바이러스 화합물 |
US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
ES2565536T3 (es) | 2009-06-11 | 2016-04-05 | Abbvie Bahamas Ltd. | Heterociclos trisustituidos como inhibidores de la replicación del virus de la Hepatitis C VHC |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US20110274648A1 (en) * | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EA201201031A1 (ru) | 2010-01-25 | 2013-02-28 | Энанта Фармасьютиклз, Инк. | Ингибиторы вируса гепатита с |
US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
WO2011127350A1 (en) | 2010-04-09 | 2011-10-13 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
US8877707B2 (en) | 2010-05-24 | 2014-11-04 | Presidio Pharmaceuticals, Inc. | Inhibitors of HCV NS5A |
EP2575819A4 (en) | 2010-06-04 | 2013-11-27 | Enanta Pharm Inc | INHIBITORS OF HEPATITIS C VIRUS |
NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
WO2012021704A1 (en) | 2010-08-12 | 2012-02-16 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2012154321A1 (en) * | 2011-03-31 | 2012-11-15 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
EP2709613B2 (en) | 2011-09-16 | 2020-08-12 | Gilead Pharmasset LLC | Methods for treating hcv |
BR112014016007A8 (pt) | 2011-12-28 | 2017-07-04 | Janssen R&D Ireland | derivados de quinazolinona como inibidores de vhc |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
BR112014019585A8 (pt) * | 2012-02-13 | 2017-07-11 | Presidio Pharmaceuticals Inc | Forma sólida de um composto, composição farmacêutica e cápsula em gel |
CN102796084A (zh) * | 2012-09-10 | 2012-11-28 | 合肥科尚医药科技有限公司 | 一种活性物质及其在治疗丙型肝炎中的应用及制备方法 |
WO2014120981A1 (en) | 2013-01-31 | 2014-08-07 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US9775831B2 (en) | 2013-07-17 | 2017-10-03 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of HCV |
EP3038601B1 (en) | 2013-08-27 | 2020-04-08 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
EP3089757A1 (en) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Solid antiviral dosage forms |
CN107074778B (zh) * | 2014-06-03 | 2019-12-13 | 代表亚利桑那大学的亚利桑那校董会 | 苯并咪唑类似物和相关方法 |
TWI679203B (zh) | 2014-06-11 | 2019-12-11 | 美商基利法瑪席特有限責任公司 | 製備抗病毒化合物之方法 |
TWI721947B (zh) | 2014-06-11 | 2021-03-21 | 美商基利法瑪席特有限責任公司 | 抗病毒化合物的固態形式 |
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WO2017023631A1 (en) | 2015-08-06 | 2017-02-09 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
CN116462622B (zh) * | 2023-03-10 | 2024-02-09 | 上海药坦药物研究开发有限公司 | 一种N-Boc-L-脯氨醛的制备方法 |
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US4213765A (en) | 1979-01-02 | 1980-07-22 | Union Carbide Corporation | Oxidative coal desulfurization using lime to regenerate alkali metal hydroxide from reaction product |
US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
US6054472A (en) | 1996-04-23 | 2000-04-25 | Vertex Pharmaceuticals, Incorporated | Inhibitors of IMPDH enzyme |
NZ332405A (en) | 1996-04-23 | 2000-06-23 | Vertex Pharma | oxazolyl, thiazolyl or phenyl urea derivatives as inhibitors of inosine monophosphate dehydrogenase enzyme |
WO1998040381A1 (en) | 1997-03-14 | 1998-09-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
NZ514540A (en) | 1999-03-19 | 2003-11-28 | Vertex Pharma | Phenyl derivative useful as inhibitors of IMPDH enzyme |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
AU2003298839A1 (en) * | 2002-12-03 | 2004-06-23 | Isis Pharmaceuticals, Inc. | Benzimidazoles and analogs thereof as antivirals |
US8143288B2 (en) | 2005-06-06 | 2012-03-27 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
US7659270B2 (en) | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7923004B2 (en) | 2006-10-13 | 2011-04-12 | Xtl Biopharmaceuticals Ltd. | 4-ethynyl pyrazole derivative compounds and methods for treatment of HCV |
EP2097405A2 (en) | 2006-11-21 | 2009-09-09 | Smithkline Beecham Corporation | Anti-viral compounds |
CA2715367C (en) | 2008-02-12 | 2015-05-05 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US7704992B2 (en) | 2008-02-13 | 2010-04-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
NZ587557A (en) | 2008-02-13 | 2012-04-27 | Bristol Myers Squibb Co | Imidazolyl biphenyl imidazoles as hepatitis c virus inhibitors |
TWI454476B (zh) * | 2008-07-08 | 2014-10-01 | Tibotec Pharm Ltd | 用作c型肝炎病毒抑制劑之巨環吲哚衍生物 |
US7906655B2 (en) * | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
BRPI0922366B8 (pt) * | 2008-12-03 | 2021-05-25 | Presidio Pharmaceuticals Inc | composto, composição farmacêutica e uso de um composto |
EA201190007A1 (ru) | 2008-12-03 | 2012-06-29 | Пресидио Фармасьютикалс, Инк. | Ингибиторы ns5a вгс |
EP2378883B1 (en) * | 2008-12-04 | 2015-12-23 | Intec Pharma Ltd. | Zaleplon gastroretentive drug delivery system |
WO2010091413A1 (en) * | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
TWI438200B (zh) * | 2009-02-17 | 2014-05-21 | 必治妥美雅史谷比公司 | C型肝炎病毒抑制劑 |
CA2753313A1 (en) * | 2009-02-23 | 2010-08-26 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
US8101643B2 (en) * | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
SG10201400235PA (en) * | 2009-02-27 | 2014-07-30 | Enanta Pharm Inc | Hepatitis c virus inhibitors |
KR20190029771A (ko) * | 2009-05-13 | 2019-03-20 | 길리애드 파마셋 엘엘씨 | 항바이러스 화합물 |
AU2010253791A1 (en) * | 2009-05-29 | 2011-11-24 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked Aryl moieties to treat diseases such as Hepatitis C |
-
2010
- 2010-03-11 UA UAA201204598A patent/UA108211C2/uk unknown
- 2010-11-03 MX MX2012005178A patent/MX2012005178A/es not_active Application Discontinuation
- 2010-11-03 TW TW099137712A patent/TW201127378A/zh unknown
- 2010-11-03 CA CA2780034A patent/CA2780034C/en not_active Expired - Fee Related
- 2010-11-03 AP AP2012006216A patent/AP2012006216A0/xx unknown
- 2010-11-03 EA EA201290260A patent/EA022839B1/ru not_active IP Right Cessation
- 2010-11-03 UY UY0001032997A patent/UY32997A/es unknown
- 2010-11-03 JP JP2012537376A patent/JP6005515B2/ja not_active Expired - Fee Related
- 2010-11-03 AU AU2010317085A patent/AU2010317085A1/en not_active Abandoned
- 2010-11-03 US US13/508,186 patent/US9427428B2/en not_active Expired - Fee Related
- 2010-11-03 EP EP10771766A patent/EP2496572A1/en not_active Withdrawn
- 2010-11-03 BR BR112012010502A patent/BR112012010502A2/pt not_active IP Right Cessation
- 2010-11-03 CN CN201080050509.7A patent/CN102741241B/zh not_active Expired - Fee Related
- 2010-11-03 KR KR1020127014503A patent/KR20120091292A/ko not_active Application Discontinuation
- 2010-11-03 WO PCT/EP2010/066668 patent/WO2011054834A1/en active Application Filing
- 2010-11-04 AR ARP100104084A patent/AR078888A1/es not_active Application Discontinuation
-
2012
- 2012-04-05 IL IL219087A patent/IL219087A0/en unknown
- 2012-04-13 CO CO12061178A patent/CO6531445A2/es not_active Application Discontinuation
- 2012-05-03 ZA ZA2012/03205A patent/ZA201203205B/en unknown
- 2012-05-04 CL CL2012001176A patent/CL2012001176A1/es unknown
- 2012-05-04 EC ECSP12011867 patent/ECSP12011867A/es unknown
- 2012-06-04 CR CR20120302A patent/CR20120302A/es unknown
-
2013
- 2013-03-15 US US13/836,816 patent/US9433609B2/en not_active Expired - Fee Related
-
2016
- 2016-08-04 US US15/228,720 patent/US20160340344A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR112012010502A2 (pt) | 2016-03-15 |
CL2012001176A1 (es) | 2012-08-31 |
US20120219594A1 (en) | 2012-08-30 |
CA2780034C (en) | 2018-04-10 |
US20140107172A1 (en) | 2014-04-17 |
ECSP12011867A (es) | 2012-10-30 |
CR20120302A (es) | 2012-10-25 |
KR20120091292A (ko) | 2012-08-17 |
AU2010317085A1 (en) | 2012-05-10 |
ZA201203205B (en) | 2014-10-29 |
JP2013510119A (ja) | 2013-03-21 |
CA2780034A1 (en) | 2011-05-12 |
US20160340344A1 (en) | 2016-11-24 |
AR078888A1 (es) | 2011-12-07 |
US9427428B2 (en) | 2016-08-30 |
CO6531445A2 (es) | 2012-09-28 |
EP2496572A1 (en) | 2012-09-12 |
AP2012006216A0 (en) | 2012-04-30 |
CN102741241B (zh) | 2015-05-20 |
JP6005515B2 (ja) | 2016-10-12 |
EA022839B1 (ru) | 2016-03-31 |
IL219087A0 (en) | 2012-06-28 |
US9433609B2 (en) | 2016-09-06 |
CN102741241A (zh) | 2012-10-17 |
EA201290260A1 (ru) | 2013-12-30 |
MX2012005178A (es) | 2012-06-08 |
WO2011054834A1 (en) | 2011-05-12 |
TW201127378A (en) | 2011-08-16 |
UA108211C2 (uk) | 2015-04-10 |
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