ZA993852B - Diaza-Spiro (3,5)nonane derivates. - Google Patents

Diaza-Spiro (3,5)nonane derivates.

Info

Publication number
ZA993852B
ZA993852B ZA9903852A ZA993852A ZA993852B ZA 993852 B ZA993852 B ZA 993852B ZA 9903852 A ZA9903852 A ZA 9903852A ZA 993852 A ZA993852 A ZA 993852A ZA 993852 B ZA993852 B ZA 993852B
Authority
ZA
South Africa
Prior art keywords
derivates
diaza
nonane
spiro
nonane derivates
Prior art date
Application number
ZA9903852A
Other languages
English (en)
Inventor
Juergen Wichmann
Stephan Roever
Geo Adam
Andrea Cesura
Sabine Kolczewski
Francois Jenck
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA993852B publication Critical patent/ZA993852B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
ZA9903852A 1998-06-12 1999-06-08 Diaza-Spiro (3,5)nonane derivates. ZA993852B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98110804 1998-06-12

Publications (1)

Publication Number Publication Date
ZA993852B true ZA993852B (en) 1999-12-13

Family

ID=8232114

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9903852A ZA993852B (en) 1998-06-12 1999-06-08 Diaza-Spiro (3,5)nonane derivates.

Country Status (28)

Country Link
US (1) US6113527A (xx)
EP (1) EP0970957B1 (xx)
JP (1) JP3286268B2 (xx)
KR (1) KR100344732B1 (xx)
CN (1) CN1107066C (xx)
AR (1) AR019859A1 (xx)
AT (1) ATE204279T1 (xx)
AU (1) AU743983B2 (xx)
BR (1) BR9902651A (xx)
CA (1) CA2274202A1 (xx)
DE (1) DE69900220T2 (xx)
DK (1) DK0970957T3 (xx)
ES (1) ES2162503T3 (xx)
HR (1) HRP990188A2 (xx)
HU (1) HU220894B1 (xx)
ID (1) ID23304A (xx)
IL (1) IL130377A0 (xx)
MA (1) MA26644A1 (xx)
NO (1) NO312590B1 (xx)
NZ (1) NZ336189A (xx)
PE (1) PE20000548A1 (xx)
PL (1) PL333695A1 (xx)
PT (1) PT970957E (xx)
SG (1) SG79259A1 (xx)
SI (1) SI0970957T1 (xx)
TR (1) TR199901381A3 (xx)
YU (1) YU26499A (xx)
ZA (1) ZA993852B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
JP2005502619A (ja) * 2001-07-02 2005-01-27 オメロス コーポレイション オピオイドレセプター様レセプター１アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
WO2003082333A1 (fr) 2002-03-29 2003-10-09 Mitsubishi Pharma Corporation Remede contre les troubles du sommeil
JP2005289816A (ja) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
US6956042B2 (en) * 2002-07-05 2005-10-18 Targacept, Inc. N-aryl diazaspiracyclic compounds and methods of preparation and use thereof
AU2003268512A1 (en) * 2002-09-09 2004-03-29 Janssen Pharmaceutica N.V. Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
GB0323204D0 (en) 2003-10-03 2003-11-05 Novartis Ag Organic compounds
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
BRPI0514509A (pt) * 2004-08-20 2008-06-10 Targacept Inc uso de composto n-aril diazaespiracìclicos no tratamento de dependência
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
EA200970517A1 (ru) * 2006-11-28 2009-12-30 Янссен Фармацевтика Н.В. Соли 3-(3-амино-2-(r)-гидроксипропил)-1-(4-фторфенил)-8-(8-метилнафталин-1-илметил)-1,3,8-триазаспиро[4,5]декан-4-она
WO2008124209A1 (en) * 2007-04-09 2008-10-16 Janssen Pharmaceutica, N.V. 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
KR101704226B1 (ko) 2015-06-30 2017-02-07 현대자동차주식회사 자동차의 쿼터글라스 어셈블리
CA3240772A1 (en) * 2021-12-22 2023-06-29 Kevan M. Shokat Covalently binding inhibitors of g12s, g12d and/or g12e mutants of k-ras gtpase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!

Also Published As

Publication number Publication date
CN1242366A (zh) 2000-01-26
ES2162503T3 (es) 2001-12-16
ATE204279T1 (de) 2001-09-15
CN1107066C (zh) 2003-04-30
IL130377A0 (en) 2000-06-01
MA26644A1 (fr) 2004-12-20
YU26499A (sh) 2002-09-19
NZ336189A (en) 2000-10-27
TR199901381A2 (xx) 2000-01-21
PL333695A1 (en) 1999-12-20
SG79259A1 (en) 2001-03-20
ID23304A (id) 2000-04-05
EP0970957A1 (en) 2000-01-12
TR199901381A3 (tr) 2000-01-21
BR9902651A (pt) 2000-05-16
NO312590B1 (no) 2002-06-03
CA2274202A1 (en) 1999-12-12
DE69900220T2 (de) 2002-05-08
KR100344732B1 (ko) 2002-07-19
AU743983B2 (en) 2002-02-14
AR019859A1 (es) 2002-03-20
HUP9901911A1 (hu) 2000-05-28
PT970957E (pt) 2002-02-28
AU3498799A (en) 1999-12-23
HU9901911D0 (en) 1999-08-30
NO992873L (no) 1999-12-13
KR20000006060A (ko) 2000-01-25
JP2000053679A (ja) 2000-02-22
NO992873D0 (no) 1999-06-11
SI0970957T1 (xx) 2001-12-31
JP3286268B2 (ja) 2002-05-27
DE69900220D1 (de) 2001-09-20
HRP990188A2 (en) 2000-02-29
EP0970957B1 (en) 2001-08-16
HU220894B1 (en) 2002-06-29
US6113527A (en) 2000-09-05
PE20000548A1 (es) 2000-07-15
DK0970957T3 (da) 2001-12-03

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