PE20000548A1 - Derivados de diaza-espiro[3.5]nonano - Google Patents

Derivados de diaza-espiro[3.5]nonano

Info

Publication number
PE20000548A1
PE20000548A1 PE1999000487A PE00048799A PE20000548A1 PE 20000548 A1 PE20000548 A1 PE 20000548A1 PE 1999000487 A PE1999000487 A PE 1999000487A PE 00048799 A PE00048799 A PE 00048799A PE 20000548 A1 PE20000548 A1 PE 20000548A1
Authority
PE
Peru
Prior art keywords
ilo
diaza
alkyl
phenyl
espiro
Prior art date
Application number
PE1999000487A
Other languages
English (en)
Inventor
Andrea Cesura
Jurgen Wichmann
Geo Adam
Sabine Kolczewski
Francois Jenck
Stephan Rover
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20000548A1 publication Critical patent/PE20000548A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A DERIVADOS DE DIAZA-ESPIRO[3.5]NONANO DE FORMULA I, DONDE R1 ES CICLOALQUILO C6-C12, INDAN-1-ILO, ACENAFTEN-1-ILO, BICICLO[3.3.1]NON-9-ILO, OCTAHIDRO-INDEN-2-ILO, 2,3-DIHIDRO-1H-FENALEN-1-ILO, ENTRE OTROS; R2 ES =O o H; R3 ES H, ISOINDOLIL-1,3-DIONA, ALCOXILO, ALQUILO, AMINO, BENCILOXILO, -CH2OR5, -CH2N(R5)2; R4 ES H, -CH2OR5; R5 ES H o ALQUILO; EL ANILLO A ES CICLOHEXILO, FENILO OPCIONALMENTE SUSTITUIDO CON ALQUILO, HALOGENO, ALCOXILO. SON COMPUESTOS PREFERIDOS 3,3-BIS-HIDROXIMETIL-7-(CIS-4-ISOPROPIL-CICLOHEXIL)-1-FENIL-1,7-DIAZA-ESPIRO[3.5]NONAN-2-ONA, 7-(CIS-4-ISOPROPIL-CICLOHEXIL)-1-FENIL-1,7-DIAZA-ESPIRO[3,5]NONAN-2-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN AGONISTA/ANTAGONISTA DEL RECEPTOR DE LA ORFANINA OFQ POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE TRASTORNOS PSIQUIATRICOS, NEUROLOGICOS, FISIOLOGICOS, TRASTORNOS DE ANSIEDAD, ESTRES, DEPRESION, TRAUMAS, EPILEPSIA, CONVULSIONES, CONDICIONES DE DOLOR AGUDO O CRONICO
PE1999000487A 1998-06-12 1999-06-08 Derivados de diaza-espiro[3.5]nonano PE20000548A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98110804 1998-06-12

Publications (1)

Publication Number Publication Date
PE20000548A1 true PE20000548A1 (es) 2000-07-15

Family

ID=8232114

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000487A PE20000548A1 (es) 1998-06-12 1999-06-08 Derivados de diaza-espiro[3.5]nonano

Country Status (28)

Country Link
US (1) US6113527A (es)
EP (1) EP0970957B1 (es)
JP (1) JP3286268B2 (es)
KR (1) KR100344732B1 (es)
CN (1) CN1107066C (es)
AR (1) AR019859A1 (es)
AT (1) ATE204279T1 (es)
AU (1) AU743983B2 (es)
BR (1) BR9902651A (es)
CA (1) CA2274202A1 (es)
DE (1) DE69900220T2 (es)
DK (1) DK0970957T3 (es)
ES (1) ES2162503T3 (es)
HR (1) HRP990188A2 (es)
HU (1) HU220894B1 (es)
ID (1) ID23304A (es)
IL (1) IL130377A0 (es)
MA (1) MA26644A1 (es)
NO (1) NO312590B1 (es)
NZ (1) NZ336189A (es)
PE (1) PE20000548A1 (es)
PL (1) PL333695A1 (es)
PT (1) PT970957E (es)
SG (1) SG79259A1 (es)
SI (1) SI0970957T1 (es)
TR (1) TR199901381A3 (es)
YU (1) YU26499A (es)
ZA (1) ZA993852B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005502619A (ja) * 2001-07-02 2005-01-27 オメロス コーポレイション オピオイドレセプター様レセプター１アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
DK1491212T3 (da) * 2002-03-29 2012-10-29 Mitsubishi Tanabe Pharma Corp Middel til behandling af søvnforstyrrelser
JP2005289816A (ja) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
NZ551552A (en) 2002-07-05 2008-03-28 Targacept Inc N-Aryl diazaspirocyclic compounds capable of affecting nicotinic cholinergic receptors and methods of preparation and use thereof
MXPA05002622A (es) * 2002-09-09 2005-09-08 Johnson & Johnson Derivados de 1,3,8,-triazaespiro [4.5]decan-4-ona sustituidos con hidroxialquilo utiles para el tratamiento de desordenes mediados por el receptor opioide huerfano.
GB0323204D0 (en) * 2003-10-03 2003-11-05 Novartis Ag Organic compounds
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
NZ552792A (en) * 2004-08-20 2009-12-24 Targacept Inc The use of N-aryl diazaspiracyclic compounds in the treatment of addiction
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
US8703948B2 (en) * 2006-11-28 2014-04-22 Janssen Pharmaceutica Nv Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
CN101679430B (zh) * 2007-04-09 2013-12-25 詹森药业有限公司 用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物
KR101704226B1 (ko) 2015-06-30 2017-02-07 현대자동차주식회사 자동차의 쿼터글라스 어셈블리
WO2023122662A1 (en) * 2021-12-22 2023-06-29 The Regents Of The University Of California Covalently binding inhibitors of g12s, g12d and/or g12e mutants of k-ras gtpase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!

Also Published As

Publication number Publication date
KR100344732B1 (ko) 2002-07-19
EP0970957B1 (en) 2001-08-16
CN1242366A (zh) 2000-01-26
JP3286268B2 (ja) 2002-05-27
NZ336189A (en) 2000-10-27
DE69900220T2 (de) 2002-05-08
TR199901381A2 (xx) 2000-01-21
JP2000053679A (ja) 2000-02-22
SG79259A1 (en) 2001-03-20
HU220894B1 (en) 2002-06-29
NO992873L (no) 1999-12-13
SI0970957T1 (es) 2001-12-31
HUP9901911A1 (hu) 2000-05-28
ZA993852B (en) 1999-12-13
BR9902651A (pt) 2000-05-16
ID23304A (id) 2000-04-05
AU3498799A (en) 1999-12-23
NO992873D0 (no) 1999-06-11
CN1107066C (zh) 2003-04-30
US6113527A (en) 2000-09-05
MA26644A1 (fr) 2004-12-20
EP0970957A1 (en) 2000-01-12
ATE204279T1 (de) 2001-09-15
AU743983B2 (en) 2002-02-14
DE69900220D1 (de) 2001-09-20
ES2162503T3 (es) 2001-12-16
YU26499A (sh) 2002-09-19
CA2274202A1 (en) 1999-12-12
NO312590B1 (no) 2002-06-03
HU9901911D0 (en) 1999-08-30
PT970957E (pt) 2002-02-28
HRP990188A2 (en) 2000-02-29
KR20000006060A (ko) 2000-01-25
TR199901381A3 (tr) 2000-01-21
IL130377A0 (en) 2000-06-01
AR019859A1 (es) 2002-03-20
PL333695A1 (en) 1999-12-20
DK0970957T3 (da) 2001-12-03

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