MX9602979A - Compuestos heterociclicos terapeuticos. - Google Patents

Compuestos heterociclicos terapeuticos.

Info

Publication number
MX9602979A
MX9602979A MX9602979A MX9602979A MX9602979A MX 9602979 A MX9602979 A MX 9602979A MX 9602979 A MX9602979 A MX 9602979A MX 9602979 A MX9602979 A MX 9602979A MX 9602979 A MX9602979 A MX 9602979A
Authority
MX
Mexico
Prior art keywords
group
agonists
linked
indole derivatives
optionally substituted
Prior art date
Application number
MX9602979A
Other languages
English (en)
Inventor
Robert Charles Glen
David Lawrence Selwood
Graeme Richard Martin
Christopher James Foster
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MX9602979A publication Critical patent/MX9602979A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invencion se refiere a los compuestos de la formula (I), en donde R y R1 son hidrogeno, alquilo con C1-4 o están unidos o enlazados para formar un anillo, A es un grupo cicloalquilo o alquil-cicloalquilo, n es un numero entero desde 0 hasta 3; W es un anillo heterocíclico de 5 o 6 elementos substituído opcionalmente; o W es un grupo arilo, heteroarilo, ariloxi o tiofenoxi substituido opcionalmente; o W es un grupo -SO2NR6R7 -NHC(O)R6R7 o -C(O)NHR6R7; que sonutiles en el tratamiento de las condiciones clínicas para las cuales está indicado un agonista del receptor "semejante a la 5-HT1".
MX9602979A 1994-01-26 1996-07-24 Compuestos heterociclicos terapeuticos. MX9602979A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9401436A GB9401436D0 (en) 1994-01-26 1994-01-26 Therapeutic heterocyclic compounds

Publications (1)

Publication Number Publication Date
MX9602979A true MX9602979A (es) 1998-01-31

Family

ID=10749321

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9602979A MX9602979A (es) 1994-01-26 1996-07-24 Compuestos heterociclicos terapeuticos.

Country Status (26)

Country Link
US (3) US5744466A (es)
EP (1) EP0741725A1 (es)
JP (1) JPH09512248A (es)
CN (1) CN1143960A (es)
AP (1) AP632A (es)
AU (2) AU689195B2 (es)
BG (1) BG100747A (es)
BR (1) BR9506581A (es)
CA (1) CA2181475A1 (es)
CZ (1) CZ216996A3 (es)
EE (1) EE9600095A (es)
FI (1) FI962969A7 (es)
GB (1) GB9401436D0 (es)
HU (1) HUT76288A (es)
IL (1) IL112443A (es)
MX (1) MX9602979A (es)
NO (1) NO963117L (es)
NZ (1) NZ278644A (es)
OA (1) OA10307A (es)
PL (1) PL315666A1 (es)
SG (1) SG44926A1 (es)
SK (1) SK96796A3 (es)
TW (1) TW377344B (es)
WO (1) WO1995020588A1 (es)
YU (1) YU4795A (es)
ZA (1) ZA95601B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376463B1 (en) * 1992-04-07 2002-04-23 Emory University Modified factor VIII
GB9515060D0 (en) * 1995-07-22 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
GB9515305D0 (en) * 1995-07-26 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
US6909005B1 (en) 1995-08-07 2005-06-21 Astrazeneca Uk Limited One post synthesis of 2-oxazolidinone derivatives
GB9516143D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
GB9516145D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
AU2104097A (en) * 1996-03-13 1997-10-01 Glaxo Group Limited Medicaments comprising 5ht1-like receptor agonists with an increased absorption
US5654431A (en) * 1996-05-30 1997-08-05 Meng; Qingchang 5-alkoxy tryptamine derivatives
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
AU5194999A (en) * 1998-08-07 2000-02-28 Takeda Chemical Industries Ltd. Benzothiepin derivatives, process for the preparation of the same and uses thereof
US6245799B1 (en) 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
CN1414962A (zh) * 1999-11-08 2003-04-30 惠氏公司 用于治疗中枢神经系统疾病的[(吲哚－3－基)－环烷基]－3－取代的氮杂环丁烷
AU2001262113A1 (en) * 2000-03-23 2001-10-03 Bayer Aktiengesellschaft Indoles for treating diseases that can be treated using thyroid hormones
US6462234B2 (en) * 2000-09-18 2002-10-08 Pharmacia & Upjohn Company Process to prepare (2S)-2-(dipropylamino)-6-ethoxy-2, 3-dihydro-1H-indene-5-carboxamide
WO2002051805A1 (de) 2000-12-27 2002-07-04 Bayer Aktiengesellschaft Indol-derivate
MX2007015165A (es) * 2005-06-03 2008-02-14 Abbott Lab Derivados de ciclobutil-amina.
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
MX2008016343A (es) 2006-06-23 2009-01-19 Abbott Lab Derivados ciclopropil amina como moduladores del receptro de histamina h3.
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
EP2970298A1 (en) 2013-03-13 2016-01-20 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2021004516A1 (en) * 2019-07-11 2021-01-14 Ascentage Pharma (Suzhou) Co., Ltd. Method for preparing 2-indolinospirone compound and intermediate thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
IL92096A0 (en) * 1988-10-25 1990-07-12 Abbott Lab Carboxylic nucleoside analogs
US4988703A (en) * 1989-05-22 1991-01-29 Abbott Laboratories Carbocyclic nucleoside analogs with antiviral activity
SI9111010B (sl) * 1990-06-07 2005-02-28 Astrazeneca Ab 3,5-disubstituirani indolni derivati kot "5-HT1-podobni" receptorski agonisti
WO1994002477A1 (en) * 1992-07-24 1994-02-03 Merck Sharp & Dohme Limited Imidazole, triazole and tetrazole derivatives

Also Published As

Publication number Publication date
PL315666A1 (en) 1996-11-25
CN1143960A (zh) 1997-02-26
AP632A (en) 1998-03-30
NO963117D0 (no) 1996-07-25
TW377344B (en) 1999-12-21
FI962969L (fi) 1996-07-25
SK96796A3 (en) 1997-06-04
EE9600095A (et) 1996-12-16
FI962969A0 (fi) 1996-07-25
US5744466A (en) 1998-04-28
CA2181475A1 (en) 1995-08-03
US5922748A (en) 1999-07-13
BG100747A (en) 1997-03-31
NO963117L (no) 1996-09-23
OA10307A (en) 1997-10-07
WO1995020588A1 (en) 1995-08-03
AU6348998A (en) 1998-06-18
ZA95601B (en) 1996-07-25
JPH09512248A (ja) 1997-12-09
FI962969A7 (fi) 1996-07-25
AU1462095A (en) 1995-08-15
CZ216996A3 (en) 1997-06-11
EP0741725A1 (en) 1996-11-13
YU4795A (sh) 1998-12-23
AU689195B2 (en) 1998-03-26
IL112443A0 (en) 1995-03-30
SG44926A1 (en) 1997-12-19
IL112443A (en) 1998-12-27
HUT76288A (en) 1997-07-28
NZ278644A (en) 1998-02-26
BR9506581A (pt) 1997-09-23
HU9602035D0 (en) 1996-09-30
GB9401436D0 (en) 1994-03-23
AP9600834A0 (en) 1996-07-31
US6103752A (en) 2000-08-15

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