NO963117L - Indol-derivater som 5-HT1-agonister - Google Patents

Indol-derivater som 5-HT1-agonister

Info

Publication number
NO963117L
NO963117L NO963117A NO963117A NO963117L NO 963117 L NO963117 L NO 963117L NO 963117 A NO963117 A NO 963117A NO 963117 A NO963117 A NO 963117A NO 963117 L NO963117 L NO 963117L
Authority
NO
Norway
Prior art keywords
group
agonists
indole derivatives
optionally substituted
ring
Prior art date
Application number
NO963117A
Other languages
English (en)
Other versions
NO963117D0 (no
Inventor
Robert Charles Glen
David Lawrence Selwood
Graeme Richard Martin
Christopher James Foster
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of NO963117D0 publication Critical patent/NO963117D0/no
Publication of NO963117L publication Critical patent/NO963117L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Forbindelser med formel (I) (I) NRR1 hvori R og R1 er hydrogen, C^alkyl eller er bundet sammen under dannelse av en ring; A er en cykloalkyl eller alkylcykloalkylgruppe, n er et helt tall fra O til 3; W er en eventuelt substituert 5 eller 6-leddet heterocyklisk ring; eller W er en eventuelt substituert aryl, heteroaryl, aryloksy eller j tiofenoksygruppe; eller 1 W er en gruppe -S02NR'R7, -NHC(0)R6R7 eller -C(0)NHR*R7; er anvendelige ved behandling av kliniske tilstander som | krever en "5-HTj-lignende" reseptoragonist.
NO963117A 1994-01-26 1996-07-25 Indol-derivater som 5-HT1-agonister NO963117L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9401436A GB9401436D0 (en) 1994-01-26 1994-01-26 Therapeutic heterocyclic compounds
PCT/GB1995/000142 WO1995020588A1 (en) 1994-01-26 1995-01-25 Indole derivatives as 5-ht1 agonists

Publications (2)

Publication Number Publication Date
NO963117D0 NO963117D0 (no) 1996-07-25
NO963117L true NO963117L (no) 1996-09-23

Family

ID=10749321

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963117A NO963117L (no) 1994-01-26 1996-07-25 Indol-derivater som 5-HT1-agonister

Country Status (26)

Country Link
US (3) US5744466A (no)
EP (1) EP0741725A1 (no)
JP (1) JPH09512248A (no)
CN (1) CN1143960A (no)
AP (1) AP632A (no)
AU (2) AU689195B2 (no)
BG (1) BG100747A (no)
BR (1) BR9506581A (no)
CA (1) CA2181475A1 (no)
CZ (1) CZ216996A3 (no)
EE (1) EE9600095A (no)
FI (1) FI962969A0 (no)
GB (1) GB9401436D0 (no)
HU (1) HUT76288A (no)
IL (1) IL112443A (no)
MX (1) MX9602979A (no)
NO (1) NO963117L (no)
NZ (1) NZ278644A (no)
OA (1) OA10307A (no)
PL (1) PL315666A1 (no)
SG (1) SG44926A1 (no)
SK (1) SK96796A3 (no)
TW (1) TW377344B (no)
WO (1) WO1995020588A1 (no)
YU (1) YU4795A (no)
ZA (1) ZA95601B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376463B1 (en) * 1992-04-07 2002-04-23 Emory University Modified factor VIII
GB9515060D0 (en) * 1995-07-22 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
GB9515305D0 (en) * 1995-07-26 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
US6909005B1 (en) 1995-08-07 2005-06-21 Astrazeneca Uk Limited One post synthesis of 2-oxazolidinone derivatives
GB9516145D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
GB9516143D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
AU2104097A (en) * 1996-03-13 1997-10-01 Glaxo Group Limited Medicaments comprising 5ht1-like receptor agonists with an increased absorption
US5654431A (en) * 1996-05-30 1997-08-05 Meng; Qingchang 5-alkoxy tryptamine derivatives
EP1103552A4 (en) * 1998-08-07 2003-01-15 Takeda Chemical Industries Ltd BENZOTHIEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE
US6245799B1 (en) 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
JP2003513970A (ja) * 1999-11-08 2003-04-15 ワイス 中枢神経系障害の治療のための［（インドール−３−イル）−シクロアルキル］−３−置換アゼチジン
WO2001070687A1 (de) * 2000-03-23 2001-09-27 Bayer Aktiengesellschaft Indole zur behandlung von krankheiten die mit schilddrüsenhormonen behandeln werden können
US6462234B2 (en) * 2000-09-18 2002-10-08 Pharmacia & Upjohn Company Process to prepare (2S)-2-(dipropylamino)-6-ethoxy-2, 3-dihydro-1H-indene-5-carboxamide
WO2002051805A1 (de) 2000-12-27 2002-07-04 Bayer Aktiengesellschaft Indol-derivate
EP1888523B1 (en) * 2005-06-03 2011-10-26 Abbott Laboratories Cyclobutyl amine derivatives
EP2049472B1 (en) 2006-06-23 2015-01-21 AbbVie Bahamas Ltd. Cyclopropyl amine derivatives as histamin h3 receptor modulators
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
CN105189511B (zh) 2013-03-13 2017-05-24 百时美施贵宝公司 人免疫缺陷病毒复制的抑制剂
WO2021004516A1 (en) * 2019-07-11 2021-01-14 Ascentage Pharma (Suzhou) Co., Ltd. Method for preparing 2-indolinospirone compound and intermediate thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
IL92096A0 (en) * 1988-10-25 1990-07-12 Abbott Lab Carboxylic nucleoside analogs
US4988703A (en) * 1989-05-22 1991-01-29 Abbott Laboratories Carbocyclic nucleoside analogs with antiviral activity
NZ238424A (en) * 1990-06-07 1993-12-23 Wellcome Found 3,5-substituted indole derivatives; medicaments and preparatory processes.
AU672802B2 (en) * 1992-07-24 1996-10-17 Merck Sharp & Dohme Limited Imidazole, triazole and tetrazole derivatives

Also Published As

Publication number Publication date
IL112443A (en) 1998-12-27
CZ216996A3 (en) 1997-06-11
GB9401436D0 (en) 1994-03-23
AU689195B2 (en) 1998-03-26
AU6348998A (en) 1998-06-18
HU9602035D0 (en) 1996-09-30
MX9602979A (es) 1998-01-31
ZA95601B (en) 1996-07-25
CA2181475A1 (en) 1995-08-03
US6103752A (en) 2000-08-15
SG44926A1 (en) 1997-12-19
US5922748A (en) 1999-07-13
WO1995020588A1 (en) 1995-08-03
SK96796A3 (en) 1997-06-04
AU1462095A (en) 1995-08-15
NO963117D0 (no) 1996-07-25
TW377344B (en) 1999-12-21
HUT76288A (en) 1997-07-28
OA10307A (en) 1997-10-07
AP632A (en) 1998-03-30
US5744466A (en) 1998-04-28
BR9506581A (pt) 1997-09-23
FI962969A (fi) 1996-07-25
NZ278644A (en) 1998-02-26
BG100747A (en) 1997-03-31
PL315666A1 (en) 1996-11-25
EP0741725A1 (en) 1996-11-13
FI962969A0 (fi) 1996-07-25
IL112443A0 (en) 1995-03-30
CN1143960A (zh) 1997-02-26
AP9600834A0 (en) 1996-07-31
EE9600095A (et) 1996-12-16
JPH09512248A (ja) 1997-12-09
YU4795A (sh) 1998-12-23

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