ES2093399T3 - Nuevos derivados de acido fosfono-succinico, procedimiento para su preparacion y medicamentos que contienen estos compuestos. - Google Patents

Nuevos derivados de acido fosfono-succinico, procedimiento para su preparacion y medicamentos que contienen estos compuestos.

Info

Publication number
ES2093399T3
ES2093399T3 ES93900042T ES93900042T ES2093399T3 ES 2093399 T3 ES2093399 T3 ES 2093399T3 ES 93900042 T ES93900042 T ES 93900042T ES 93900042 T ES93900042 T ES 93900042T ES 2093399 T3 ES2093399 T3 ES 2093399T3
Authority
ES
Spain
Prior art keywords
pct
compounds
lower alkyl
date jun
phosphone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93900042T
Other languages
English (en)
Inventor
Christos Tsaklakidis
Elmar Bosies
Angelika Esswein
Frieder Bauss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2093399T3 publication Critical patent/ES2093399T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Abstract

COMPUESTOS DE LA FORMULA (I) EN DONDE R ES UN GRUPO AMINO EVENTUALMENTE SUSTITUIDO DE LA FORMULA GENERAL DE R1 Y R2 SON DE FORMA INDEPENDIENTE UNO DE OTRO HIDROGENO, ALQUIL INFERIOR, ALQUENIL INFERIOR O ALQUINIL INFERIOR, O R ES UN ANILLO HETEROCICLICO AROMATICO SATURADO O NO SATURADO QUE PUEDE SER MONO O BISUSTITUIDO POR ALQUIL INFERIOR O HALOGENO; ALK ES UN ENLACE DE VALENCIA, UN METILENO, UNA CADENA DE ALQUILENO DE CADENA RECTA O RAMIFICADA, SATURADA O NO SATURADA CON 2 TRO HIDROGENO, ALQUIL INFERIOR O BENCIL; Y SUS SALES ACEPTABLES FARMACOLOGICAMENTE Y ENANTIOMEROS DONDE, SI R3 = R4 = R5 = CH3 Y ALK ES UN ENLACE DE VALENCIA, R PUEDE NO SER EL GRUPO AMINODIMETIL. PROCESO PARA SU ELABORACION Y MEDICAMENTOS QUE CONTIENEN ESTOS COMPUESTOS, PARA EL TRATAMIENTO DE ENFERMEDADES METABOLICAS DE CAMBIO DE SUSTANCIAS DE CALCIO.
ES93900042T 1991-12-19 1992-12-14 Nuevos derivados de acido fosfono-succinico, procedimiento para su preparacion y medicamentos que contienen estos compuestos. Expired - Lifetime ES2093399T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4141928A DE4141928A1 (de) 1991-12-19 1991-12-19 Neue phosphonobernsteinsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ES2093399T3 true ES2093399T3 (es) 1996-12-16

Family

ID=6447460

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93900042T Expired - Lifetime ES2093399T3 (es) 1991-12-19 1992-12-14 Nuevos derivados de acido fosfono-succinico, procedimiento para su preparacion y medicamentos que contienen estos compuestos.

Country Status (22)

Country Link
US (2) US5538957A (es)
EP (1) EP0618920B1 (es)
JP (1) JPH07507046A (es)
AT (1) ATE141277T1 (es)
AU (1) AU662790B2 (es)
CA (1) CA2125867A1 (es)
CZ (1) CZ151894A3 (es)
DE (2) DE4141928A1 (es)
DK (1) DK0618920T3 (es)
ES (1) ES2093399T3 (es)
FI (1) FI942910A0 (es)
GR (1) GR3021110T3 (es)
HU (1) HUT66771A (es)
IL (1) IL104090A (es)
MX (1) MX9207335A (es)
NO (1) NO300546B1 (es)
NZ (1) NZ246152A (es)
RU (1) RU2115656C1 (es)
SK (1) SK74694A3 (es)
TW (1) TW222636B (es)
WO (1) WO1993012122A1 (es)
ZA (1) ZA929815B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760021A (en) * 1992-05-29 1998-06-02 The Procter & Gamble Company Phosphonocarboxylate compounds pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
DE4320223A1 (de) * 1993-06-18 1994-12-22 Boehringer Mannheim Gmbh Neue Phosphonobernsteinsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4336099A1 (de) * 1993-10-22 1995-04-27 Boehringer Mannheim Gmbh Neue 2.4-Diphosphonoglutarsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4410601A1 (de) * 1994-03-26 1995-09-28 Boehringer Mannheim Gmbh Neue 2.4-Diphosphonoglutarsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US6011021A (en) * 1996-06-17 2000-01-04 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
GB2313126A (en) * 1996-05-14 1997-11-19 Albright & Wilson Uk Ltd Polymer compositions containing phosphorus
US5795877A (en) * 1996-12-31 1998-08-18 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US5902817A (en) * 1997-04-09 1999-05-11 Guilford Pharmaceuticals Inc. Certain sulfoxide and sulfone derivatives
US6384022B1 (en) 1996-06-17 2002-05-07 Guilford Pharmaceuticals Inc. Prodrugs of NAALAdase inhibitors
US5977090A (en) * 1996-09-27 1999-11-02 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors
US5863536A (en) * 1996-12-31 1999-01-26 Guilford Pharmaceuticals Inc. Phosphoramidate derivatives
US6054444A (en) * 1997-04-24 2000-04-25 Guilford Pharmaceuticals Inc. Phosphonic acid derivatives
US6025345A (en) * 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US5672592A (en) * 1996-06-17 1997-09-30 Guilford Pharmaceuticals Inc. Certain phosphonomethyl-pentanedioic acid derivatives thereof
US6046180A (en) * 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
HUP9903421A3 (en) 1996-06-17 2001-08-28 Guilford Pharmaceuticals Inc B Use of phosphonic and phosphinic acid derivatives for producing pharmaceutical compositions having naaladase inhibitor activity
US6025344A (en) 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
US6071965A (en) * 1996-06-17 2000-06-06 Guilford Pharmaceuticals Inc. Phosphinic alkanoic acid derivatives
US5962521A (en) * 1997-04-04 1999-10-05 Guilford Pharmaceuticals Inc. Hydroxamic acid derivatives
US5981209A (en) * 1997-12-04 1999-11-09 Guilford Pharmaceuticals Inc. Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia
US6028216A (en) * 1997-12-31 2000-02-22 Guilford Pharmaceuticals Inc. Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives
US6121252A (en) * 1998-03-30 2000-09-19 Guilford Pharmaceuticals Inc. Phosphinic acid derivatives
PL346762A1 (en) 1998-07-06 2002-02-25 Guilford Pharm Inc Naaladase inhibitors useful as pharmaceutical compounds and compositions
US6395718B1 (en) 1998-07-06 2002-05-28 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
US6265609B1 (en) 1998-07-06 2001-07-24 Guilford Pharmaceuticals Inc. Thio-substituted pentanedioic acid derivatives
IT1303672B1 (it) 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
US6313159B1 (en) 1999-08-20 2001-11-06 Guilford Pharmaceuticals Inc. Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
EP1383511B1 (en) * 2000-10-25 2006-10-25 SmithKline Beecham Corporation Calcilytic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2360797C2 (de) * 1973-12-06 1985-05-23 Henkel KGaA, 4000 Düsseldorf Pharmazeutische Präparate
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
US5004549A (en) * 1989-10-10 1991-04-02 Olin Corporation Method for inhibiting scale formation using calcium hypochlorite compositions

Also Published As

Publication number Publication date
TW222636B (es) 1994-04-21
AU662790B2 (en) 1995-09-14
CZ151894A3 (en) 1995-01-18
US5627170A (en) 1997-05-06
CA2125867A1 (en) 1993-06-24
NO942304D0 (no) 1994-06-17
US5538957A (en) 1996-07-23
DE4141928A1 (de) 1993-06-24
IL104090A0 (en) 1993-05-13
ZA929815B (en) 1994-06-20
EP0618920A1 (de) 1994-10-12
AU3158093A (en) 1993-07-19
GR3021110T3 (en) 1996-12-31
DE59206925D1 (de) 1996-09-19
SK74694A3 (en) 1995-02-08
MX9207335A (es) 1993-06-01
FI942910A (fi) 1994-06-17
FI942910A0 (fi) 1994-06-17
EP0618920B1 (de) 1996-08-14
JPH07507046A (ja) 1995-08-03
ATE141277T1 (de) 1996-08-15
IL104090A (en) 1997-03-18
NO942304L (es) 1994-08-16
DK0618920T3 (da) 1996-12-30
HUT66771A (en) 1994-12-28
HU9401834D0 (en) 1994-09-28
NO300546B1 (no) 1997-06-16
NZ246152A (en) 1995-12-21
RU2115656C1 (ru) 1998-07-20
WO1993012122A1 (de) 1993-06-24

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