FI942910A - Uusia fosfonimeripihkahappojohdannaisia, menetelmä niiden valmistamiseksi ja näitä yhdisteitä sisältäviä lääkkeitä - Google Patents
Uusia fosfonimeripihkahappojohdannaisia, menetelmä niiden valmistamiseksi ja näitä yhdisteitä sisältäviä lääkkeitä Download PDFInfo
- Publication number
- FI942910A FI942910A FI942910A FI942910A FI942910A FI 942910 A FI942910 A FI 942910A FI 942910 A FI942910 A FI 942910A FI 942910 A FI942910 A FI 942910A FI 942910 A FI942910 A FI 942910A
- Authority
- FI
- Finland
- Prior art keywords
- pct
- compounds
- lower alkyl
- date jun
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- KMDMOMDSEVTJTI-UHFFFAOYSA-N 2-phosphonobutanedioic acid Chemical class OC(=O)CC(C(O)=O)P(O)(O)=O KMDMOMDSEVTJTI-UHFFFAOYSA-N 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000006193 alkinyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5532—Seven-(or more) membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4141928A DE4141928A1 (de) | 1991-12-19 | 1991-12-19 | Neue phosphonobernsteinsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
PCT/EP1992/002890 WO1993012122A1 (de) | 1991-12-19 | 1992-12-14 | Neue phosphonobernsteinsäurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
FI942910A0 FI942910A0 (fi) | 1994-06-17 |
FI942910A true FI942910A (fi) | 1994-06-17 |
Family
ID=6447460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI942910A FI942910A (fi) | 1991-12-19 | 1994-06-17 | Uusia fosfonimeripihkahappojohdannaisia, menetelmä niiden valmistamiseksi ja näitä yhdisteitä sisältäviä lääkkeitä |
Country Status (22)
Country | Link |
---|---|
US (2) | US5538957A (fi) |
EP (1) | EP0618920B1 (fi) |
JP (1) | JPH07507046A (fi) |
AT (1) | ATE141277T1 (fi) |
AU (1) | AU662790B2 (fi) |
CA (1) | CA2125867A1 (fi) |
CZ (1) | CZ151894A3 (fi) |
DE (2) | DE4141928A1 (fi) |
DK (1) | DK0618920T3 (fi) |
ES (1) | ES2093399T3 (fi) |
FI (1) | FI942910A (fi) |
GR (1) | GR3021110T3 (fi) |
HU (1) | HUT66771A (fi) |
IL (1) | IL104090A (fi) |
MX (1) | MX9207335A (fi) |
NO (1) | NO300546B1 (fi) |
NZ (1) | NZ246152A (fi) |
RU (1) | RU2115656C1 (fi) |
SK (1) | SK74694A3 (fi) |
TW (1) | TW222636B (fi) |
WO (1) | WO1993012122A1 (fi) |
ZA (1) | ZA929815B (fi) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5760021A (en) * | 1992-05-29 | 1998-06-02 | The Procter & Gamble Company | Phosphonocarboxylate compounds pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
DE4320223A1 (de) * | 1993-06-18 | 1994-12-22 | Boehringer Mannheim Gmbh | Neue Phosphonobernsteinsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE4336099A1 (de) * | 1993-10-22 | 1995-04-27 | Boehringer Mannheim Gmbh | Neue 2.4-Diphosphonoglutarsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE4410601A1 (de) * | 1994-03-26 | 1995-09-28 | Boehringer Mannheim Gmbh | Neue 2.4-Diphosphonoglutarsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
US6011021A (en) * | 1996-06-17 | 2000-01-04 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
GB2313126A (en) * | 1996-05-14 | 1997-11-19 | Albright & Wilson Uk Ltd | Polymer compositions containing phosphorus |
US5795877A (en) * | 1996-12-31 | 1998-08-18 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
AU725455B2 (en) | 1996-06-17 | 2000-10-12 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using NAALADase inhibitors |
US6025344A (en) | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Certain dioic acid derivatives useful as NAALADase inhibitors |
US5902817A (en) * | 1997-04-09 | 1999-05-11 | Guilford Pharmaceuticals Inc. | Certain sulfoxide and sulfone derivatives |
US5977090A (en) * | 1996-09-27 | 1999-11-02 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors |
US6025345A (en) * | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
US6054444A (en) | 1997-04-24 | 2000-04-25 | Guilford Pharmaceuticals Inc. | Phosphonic acid derivatives |
US5672592A (en) * | 1996-06-17 | 1997-09-30 | Guilford Pharmaceuticals Inc. | Certain phosphonomethyl-pentanedioic acid derivatives thereof |
US5863536A (en) * | 1996-12-31 | 1999-01-26 | Guilford Pharmaceuticals Inc. | Phosphoramidate derivatives |
US6071965A (en) * | 1996-06-17 | 2000-06-06 | Guilford Pharmaceuticals Inc. | Phosphinic alkanoic acid derivatives |
US6046180A (en) * | 1996-06-17 | 2000-04-04 | Guilford Pharmaceuticals Inc. | NAALADase inhibitors |
US6384022B1 (en) | 1996-06-17 | 2002-05-07 | Guilford Pharmaceuticals Inc. | Prodrugs of NAALAdase inhibitors |
US5962521A (en) * | 1997-04-04 | 1999-10-05 | Guilford Pharmaceuticals Inc. | Hydroxamic acid derivatives |
US5981209A (en) * | 1997-12-04 | 1999-11-09 | Guilford Pharmaceuticals Inc. | Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia |
US6028216A (en) * | 1997-12-31 | 2000-02-22 | Guilford Pharmaceuticals Inc. | Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives |
US6121252A (en) * | 1998-03-30 | 2000-09-19 | Guilford Pharmaceuticals Inc. | Phosphinic acid derivatives |
JP4503836B2 (ja) | 1998-07-06 | 2010-07-14 | エイザイ インコーポレイテッド | 医薬化合物及び組成物として有用なNAALADase阻害剤 |
US6395718B1 (en) * | 1998-07-06 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors |
US6265609B1 (en) | 1998-07-06 | 2001-07-24 | Guilford Pharmaceuticals Inc. | Thio-substituted pentanedioic acid derivatives |
IT1303672B1 (it) | 1998-07-28 | 2001-02-23 | Nicox Sa | Sali nitrati di farmaci attivi nei disordini ossei |
US6313159B1 (en) | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
US20040014723A1 (en) * | 2000-10-25 | 2004-01-22 | Pradip Bhatnagar | Calcilytic compounds |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2360797C2 (de) * | 1973-12-06 | 1985-05-23 | Henkel KGaA, 4000 Düsseldorf | Pharmazeutische Präparate |
IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
US5004549A (en) * | 1989-10-10 | 1991-04-02 | Olin Corporation | Method for inhibiting scale formation using calcium hypochlorite compositions |
-
1991
- 1991-12-19 DE DE4141928A patent/DE4141928A1/de not_active Withdrawn
-
1992
- 1992-12-01 TW TW081109635A patent/TW222636B/zh active
- 1992-12-14 EP EP93900042A patent/EP0618920B1/de not_active Expired - Lifetime
- 1992-12-14 JP JP5510624A patent/JPH07507046A/ja active Pending
- 1992-12-14 IL IL104090A patent/IL104090A/xx not_active IP Right Cessation
- 1992-12-14 US US08/244,245 patent/US5538957A/en not_active Expired - Fee Related
- 1992-12-14 DE DE59206925T patent/DE59206925D1/de not_active Expired - Fee Related
- 1992-12-14 CZ CZ941518A patent/CZ151894A3/cs unknown
- 1992-12-14 CA CA002125867A patent/CA2125867A1/en not_active Abandoned
- 1992-12-14 WO PCT/EP1992/002890 patent/WO1993012122A1/de not_active Application Discontinuation
- 1992-12-14 AU AU31580/93A patent/AU662790B2/en not_active Ceased
- 1992-12-14 DK DK93900042.8T patent/DK0618920T3/da active
- 1992-12-14 ES ES93900042T patent/ES2093399T3/es not_active Expired - Lifetime
- 1992-12-14 HU HU9401834A patent/HUT66771A/hu unknown
- 1992-12-14 NZ NZ246152A patent/NZ246152A/en unknown
- 1992-12-14 AT AT93900042T patent/ATE141277T1/de active
- 1992-12-14 RU RU94030812A patent/RU2115656C1/ru active
- 1992-12-14 SK SK746-94A patent/SK74694A3/sk unknown
- 1992-12-16 MX MX9207335A patent/MX9207335A/es not_active IP Right Cessation
- 1992-12-18 ZA ZA929815A patent/ZA929815B/xx unknown
-
1994
- 1994-06-17 FI FI942910A patent/FI942910A/fi unknown
- 1994-06-17 NO NO942304A patent/NO300546B1/no not_active IP Right Cessation
-
1995
- 1995-06-05 US US08/465,360 patent/US5627170A/en not_active Expired - Fee Related
-
1996
- 1996-09-19 GR GR960402474T patent/GR3021110T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IL104090A0 (en) | 1993-05-13 |
US5538957A (en) | 1996-07-23 |
NO942304D0 (no) | 1994-06-17 |
EP0618920A1 (de) | 1994-10-12 |
HUT66771A (en) | 1994-12-28 |
RU2115656C1 (ru) | 1998-07-20 |
ES2093399T3 (es) | 1996-12-16 |
NO300546B1 (no) | 1997-06-16 |
ATE141277T1 (de) | 1996-08-15 |
FI942910A0 (fi) | 1994-06-17 |
EP0618920B1 (de) | 1996-08-14 |
TW222636B (fi) | 1994-04-21 |
WO1993012122A1 (de) | 1993-06-24 |
AU662790B2 (en) | 1995-09-14 |
HU9401834D0 (en) | 1994-09-28 |
CZ151894A3 (en) | 1995-01-18 |
DE4141928A1 (de) | 1993-06-24 |
GR3021110T3 (en) | 1996-12-31 |
NO942304L (fi) | 1994-08-16 |
MX9207335A (es) | 1993-06-01 |
ZA929815B (en) | 1994-06-20 |
JPH07507046A (ja) | 1995-08-03 |
CA2125867A1 (en) | 1993-06-24 |
US5627170A (en) | 1997-05-06 |
SK74694A3 (en) | 1995-02-08 |
IL104090A (en) | 1997-03-18 |
DE59206925D1 (de) | 1996-09-19 |
DK0618920T3 (da) | 1996-12-30 |
AU3158093A (en) | 1993-07-19 |
NZ246152A (en) | 1995-12-21 |
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Legal Events
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---|---|---|---|
HC | Name/ company changed in application |
Owner name: ROCHE DIAGNOSTICS GMBH |