ATE178588T1 - Amidino-derivate und ihre verwendung als no- synthase inhibitoren - Google Patents

Amidino-derivate und ihre verwendung als no- synthase inhibitoren

Info

Publication number
ATE178588T1
ATE178588T1 AT93900357T AT93900357T ATE178588T1 AT E178588 T1 ATE178588 T1 AT E178588T1 AT 93900357 T AT93900357 T AT 93900357T AT 93900357 T AT93900357 T AT 93900357T AT E178588 T1 ATE178588 T1 AT E178588T1
Authority
AT
Austria
Prior art keywords
group
6alkyl
pct
formula
sec
Prior art date
Application number
AT93900357T
Other languages
English (en)
Inventor
Richard Beams
Harold Francis Hodson
Richard Michael John La Palmer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE178588T1 publication Critical patent/ATE178588T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)
AT93900357T 1991-12-24 1992-12-23 Amidino-derivate und ihre verwendung als no- synthase inhibitoren ATE178588T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919127376A GB9127376D0 (en) 1991-12-24 1991-12-24 Amidino derivatives

Publications (1)

Publication Number Publication Date
ATE178588T1 true ATE178588T1 (de) 1999-04-15

Family

ID=10706815

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93900357T ATE178588T1 (de) 1991-12-24 1992-12-23 Amidino-derivate und ihre verwendung als no- synthase inhibitoren

Country Status (20)

Country Link
US (1) US5863931A (de)
EP (1) EP0618898B1 (de)
JP (1) JP3171850B2 (de)
AT (1) ATE178588T1 (de)
AU (1) AU669345B2 (de)
CA (1) CA2126327C (de)
CY (1) CY2197B1 (de)
DE (1) DE69228879T2 (de)
DK (1) DK0618898T3 (de)
ES (1) ES2130247T3 (de)
GB (1) GB9127376D0 (de)
GR (1) GR3030492T3 (de)
HU (1) HU217618B (de)
IL (1) IL104212A (de)
MY (1) MY109421A (de)
NZ (1) NZ246202A (de)
RU (1) RU2130014C1 (de)
TW (1) TW255881B (de)
WO (1) WO1993013055A1 (de)
ZA (1) ZA9210018B (de)

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MY109421A (en) 1997-01-31
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CA2126327A1 (en) 1993-07-08
HUT70502A (en) 1995-10-30
ES2130247T3 (es) 1999-07-01
HU217618B (hu) 2000-03-28
ZA9210018B (en) 1994-06-23
WO1993013055A1 (en) 1993-07-08
IL104212A (en) 1998-02-22
GR3030492T3 (en) 1999-10-29
DK0618898T3 (da) 1999-10-18
RU94031155A (ru) 1996-04-20
CY2197B1 (en) 2002-11-08
RU2130014C1 (ru) 1999-05-10
CA2126327C (en) 2005-05-17
EP0618898A1 (de) 1994-10-12
IL104212A0 (en) 1993-05-13
AU669345B2 (en) 1996-06-06
EP0618898B1 (de) 1999-04-07
JP3171850B2 (ja) 2001-06-04
DE69228879T2 (de) 1999-08-26
TW255881B (de) 1995-09-01
AU3169293A (en) 1993-07-28
US5863931A (en) 1999-01-26
JPH07502512A (ja) 1995-03-16
HU9401848D0 (en) 1994-09-28
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