RU94031155A - Амидин - производные, способ их получения, их использование в качестве ингибиторов no - синтазы, фармсостав, способ лечения - Google Patents
Амидин - производные, способ их получения, их использование в качестве ингибиторов no - синтазы, фармсостав, способ леченияInfo
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- RU94031155A RU94031155A RU94031155/04A RU94031155A RU94031155A RU 94031155 A RU94031155 A RU 94031155A RU 94031155/04 A RU94031155/04 A RU 94031155/04A RU 94031155 A RU94031155 A RU 94031155A RU 94031155 A RU94031155 A RU 94031155A
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- alkylamino
- cycloalkyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Представлены амидинпроизводные общей формулы I, их соли и фармацевтически приемлемые эфиры и амиды, где R- C- C-прямоцепная или разветвленная алкильная группа, C- C-алкиенильная группа, C- C-алкинильная группа, C- C-циклоалкильная группа или C- C-циклоалкил-С- C-алкильная группа; Q - алкилен, алкенилен или алкиниленогруппа с 3-6 атомами, которые необязательно могут быть замещены на одну или более C- C-алкильных групп, группа формулы -(CH)X(CH) -, где p = 2 или 3, q = 1 или 2; X представляет собой S(O), где х = 0,1 или 2, или Q - NR, где R- водород или C- C-алкил, или группа формулы -(CH)A(CH), где r и s = 0,1 или 2; A - 3 - 6-членное карбоциклическое или гетероциклическое кольцо, которое необязательно может быть замещено на один или более подходящих заместителей, например, таких как C- C-алкил, C- C-алкокси, гидрокси, галоген, нитро, циан, трифтор-С- C-алкил, амино, C- C-алкиламино или ди-С- C-алкиламино; представлены также содержащие их фармацевтические составы, используемые в медицине, а также новые соединения формулы I и получение этих новых соединений.
Claims (1)
- Представлены амидинпроизводные общей формулы I, их соли и фармацевтически приемлемые эфиры и амиды, где R1 - C1 - C6-прямоцепная или разветвленная алкильная группа, C2 - C6-алкиенильная группа, C2 - C6-алкинильная группа, C3 - C6-циклоалкильная группа или C3 - C6-циклоалкил-С1 - C6-алкильная группа; Q - алкилен, алкенилен или алкиниленогруппа с 3-6 атомами, которые необязательно могут быть замещены на одну или более C1 - C3-алкильных групп, группа формулы -(CH2)pX(CH2) -, где p = 2 или 3, q = 1 или 2; X представляет собой S(O)x, где х = 0,1 или 2, или Q - NR2, где R2 - водород или C1 - C6-алкил, или группа формулы -(CH2)rA(CH2)s, где r и s = 0,1 или 2; A - 3 - 6-членное карбоциклическое или гетероциклическое кольцо, которое необязательно может быть замещено на один или более подходящих заместителей, например, таких как C1 - C6-алкил, C1 - C6-алкокси, гидрокси, галоген, нитро, циан, трифтор-С1 - C6-алкил, амино, C1 - C6-алкиламино или ди-С1 - C6-алкиламино; представлены также содержащие их фармацевтические составы, используемые в медицине, а также новые соединения формулы I и получение этих новых соединений.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9127376.3 | 1991-12-24 | ||
GB919127376A GB9127376D0 (en) | 1991-12-24 | 1991-12-24 | Amidino derivatives |
PCT/GB1992/002387 WO1993013055A1 (en) | 1991-12-24 | 1992-12-23 | Amidino derivatives and their use as nitric oxide synthase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
RU94031155A true RU94031155A (ru) | 1996-04-20 |
RU2130014C1 RU2130014C1 (ru) | 1999-05-10 |
Family
ID=10706815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94031155A RU2130014C1 (ru) | 1991-12-24 | 1992-12-23 | Амидинпроизводные |
Country Status (20)
Country | Link |
---|---|
US (1) | US5863931A (ru) |
EP (1) | EP0618898B1 (ru) |
JP (1) | JP3171850B2 (ru) |
AT (1) | ATE178588T1 (ru) |
AU (1) | AU669345B2 (ru) |
CA (1) | CA2126327C (ru) |
CY (1) | CY2197B1 (ru) |
DE (1) | DE69228879T2 (ru) |
DK (1) | DK0618898T3 (ru) |
ES (1) | ES2130247T3 (ru) |
GB (1) | GB9127376D0 (ru) |
GR (1) | GR3030492T3 (ru) |
HU (1) | HU217618B (ru) |
IL (1) | IL104212A (ru) |
MY (1) | MY109421A (ru) |
NZ (1) | NZ246202A (ru) |
RU (1) | RU2130014C1 (ru) |
TW (1) | TW255881B (ru) |
WO (1) | WO1993013055A1 (ru) |
ZA (1) | ZA9210018B (ru) |
Families Citing this family (119)
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GB9312761D0 (en) * | 1993-06-21 | 1993-08-04 | Wellcome Found | Amino acid derivatives |
US5424447A (en) * | 1993-07-07 | 1995-06-13 | The Medical College Of Wisconsin Research Foundation, Inc. | Heme binding compounds and use thereof |
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US6225305B1 (en) | 1993-10-04 | 2001-05-01 | Glaxo Wellcome Inc. | Substituted urea and isothiorea derivatives as no synthase inhibitors |
US6297276B1 (en) | 1993-10-04 | 2001-10-02 | Glaxosmithkline | Substituted urea and isothiourea derivatives as no synthase inhibitors |
KR100342275B1 (ko) * | 1993-10-21 | 2002-12-05 | 지.디. 썰 엘엘씨 | 산화질소신타제저해제로서유용한아미디노유도체 |
WO1995011014A1 (en) * | 1993-10-21 | 1995-04-27 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
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FI832053L (fi) * | 1982-06-10 | 1983-12-11 | Syntex Inc | Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande |
US5028627A (en) * | 1989-09-13 | 1991-07-02 | Cornell Research Foundation, Inc. | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
GB8929076D0 (en) * | 1989-12-22 | 1990-02-28 | Scras | Treatment of shock by blocking agents of edrf effect or formation |
AU636713B2 (en) * | 1990-02-26 | 1993-05-06 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of nitric oxide biosynthesis |
-
1991
- 1991-12-24 GB GB919127376A patent/GB9127376D0/en active Pending
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1992
- 1992-12-23 TW TW081110312A patent/TW255881B/zh active
- 1992-12-23 CA CA002126327A patent/CA2126327C/en not_active Expired - Fee Related
- 1992-12-23 MY MYPI92002373A patent/MY109421A/en unknown
- 1992-12-23 IL IL104212A patent/IL104212A/en not_active IP Right Cessation
- 1992-12-23 ES ES93900357T patent/ES2130247T3/es not_active Expired - Lifetime
- 1992-12-23 ZA ZA9210018A patent/ZA9210018B/xx unknown
- 1992-12-23 RU RU94031155A patent/RU2130014C1/ru not_active IP Right Cessation
- 1992-12-23 JP JP51127393A patent/JP3171850B2/ja not_active Expired - Fee Related
- 1992-12-23 EP EP93900357A patent/EP0618898B1/en not_active Expired - Lifetime
- 1992-12-23 US US08/256,032 patent/US5863931A/en not_active Expired - Lifetime
- 1992-12-23 AT AT93900357T patent/ATE178588T1/de active
- 1992-12-23 HU HU9401848A patent/HU217618B/hu not_active IP Right Cessation
- 1992-12-23 DK DK93900357T patent/DK0618898T3/da active
- 1992-12-23 AU AU31692/93A patent/AU669345B2/en not_active Ceased
- 1992-12-23 DE DE69228879T patent/DE69228879T2/de not_active Expired - Lifetime
- 1992-12-23 NZ NZ246202A patent/NZ246202A/xx not_active IP Right Cessation
- 1992-12-23 WO PCT/GB1992/002387 patent/WO1993013055A1/en active IP Right Grant
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1999
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Also Published As
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---|---|
AU3169293A (en) | 1993-07-28 |
ATE178588T1 (de) | 1999-04-15 |
TW255881B (ru) | 1995-09-01 |
EP0618898B1 (en) | 1999-04-07 |
JPH07502512A (ja) | 1995-03-16 |
CY2197B1 (en) | 2002-11-08 |
GR3030492T3 (en) | 1999-10-29 |
MY109421A (en) | 1997-01-31 |
DE69228879T2 (de) | 1999-08-26 |
AU669345B2 (en) | 1996-06-06 |
US5863931A (en) | 1999-01-26 |
CA2126327A1 (en) | 1993-07-08 |
RU2130014C1 (ru) | 1999-05-10 |
HUT70502A (en) | 1995-10-30 |
WO1993013055A1 (en) | 1993-07-08 |
DK0618898T3 (da) | 1999-10-18 |
HU217618B (hu) | 2000-03-28 |
EP0618898A1 (en) | 1994-10-12 |
GB9127376D0 (en) | 1992-02-19 |
IL104212A (en) | 1998-02-22 |
CA2126327C (en) | 2005-05-17 |
ZA9210018B (en) | 1994-06-23 |
HU9401848D0 (en) | 1994-09-28 |
NZ246202A (en) | 1996-05-28 |
IL104212A0 (en) | 1993-05-13 |
DE69228879D1 (de) | 1999-05-12 |
JP3171850B2 (ja) | 2001-06-04 |
ES2130247T3 (es) | 1999-07-01 |
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