DE69228879T2 - Amidino-derivate und ihre verwendung als no-synthase inhibitoren - Google Patents

Amidino-derivate und ihre verwendung als no-synthase inhibitoren

Info

Publication number
DE69228879T2
DE69228879T2 DE69228879T DE69228879T DE69228879T2 DE 69228879 T2 DE69228879 T2 DE 69228879T2 DE 69228879 T DE69228879 T DE 69228879T DE 69228879 T DE69228879 T DE 69228879T DE 69228879 T2 DE69228879 T2 DE 69228879T2
Authority
DE
Germany
Prior art keywords
group
6alkyl
pct
formula
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69228879T
Other languages
English (en)
Other versions
DE69228879D1 (de
Inventor
Richard Beams
Harold Hodson
Richard Palmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE69228879D1 publication Critical patent/DE69228879D1/de
Application granted granted Critical
Publication of DE69228879T2 publication Critical patent/DE69228879T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69228879T 1991-12-24 1992-12-23 Amidino-derivate und ihre verwendung als no-synthase inhibitoren Expired - Lifetime DE69228879T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919127376A GB9127376D0 (en) 1991-12-24 1991-12-24 Amidino derivatives
PCT/GB1992/002387 WO1993013055A1 (en) 1991-12-24 1992-12-23 Amidino derivatives and their use as nitric oxide synthase inhibitors

Publications (2)

Publication Number Publication Date
DE69228879D1 DE69228879D1 (de) 1999-05-12
DE69228879T2 true DE69228879T2 (de) 1999-08-26

Family

ID=10706815

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69228879T Expired - Lifetime DE69228879T2 (de) 1991-12-24 1992-12-23 Amidino-derivate und ihre verwendung als no-synthase inhibitoren

Country Status (20)

Country Link
US (1) US5863931A (de)
EP (1) EP0618898B1 (de)
JP (1) JP3171850B2 (de)
AT (1) ATE178588T1 (de)
AU (1) AU669345B2 (de)
CA (1) CA2126327C (de)
CY (1) CY2197B1 (de)
DE (1) DE69228879T2 (de)
DK (1) DK0618898T3 (de)
ES (1) ES2130247T3 (de)
GB (1) GB9127376D0 (de)
GR (1) GR3030492T3 (de)
HU (1) HU217618B (de)
IL (1) IL104212A (de)
MY (1) MY109421A (de)
NZ (1) NZ246202A (de)
RU (1) RU2130014C1 (de)
TW (1) TW255881B (de)
WO (1) WO1993013055A1 (de)
ZA (1) ZA9210018B (de)

Families Citing this family (119)

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EP0618898A1 (de) 1994-10-12
WO1993013055A1 (en) 1993-07-08
HUT70502A (en) 1995-10-30
ES2130247T3 (es) 1999-07-01
TW255881B (de) 1995-09-01
DK0618898T3 (da) 1999-10-18
US5863931A (en) 1999-01-26
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ZA9210018B (en) 1994-06-23
JPH07502512A (ja) 1995-03-16
DE69228879D1 (de) 1999-05-12
ATE178588T1 (de) 1999-04-15
HU9401848D0 (en) 1994-09-28
AU3169293A (en) 1993-07-28
RU2130014C1 (ru) 1999-05-10
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JP3171850B2 (ja) 2001-06-04
CY2197B1 (en) 2002-11-08
RU94031155A (ru) 1996-04-20
GB9127376D0 (en) 1992-02-19
HU217618B (hu) 2000-03-28
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