PT724435E - Derivados amidino uteis como inibidores de oxido nitrico sintase - Google Patents
Derivados amidino uteis como inibidores de oxido nitrico sintaseInfo
- Publication number
- PT724435E PT724435E PT94931858T PT94931858T PT724435E PT 724435 E PT724435 E PT 724435E PT 94931858 T PT94931858 T PT 94931858T PT 94931858 T PT94931858 T PT 94931858T PT 724435 E PT724435 E PT 724435E
- Authority
- PT
- Portugal
- Prior art keywords
- nitric oxide
- pct
- uteis
- amidine derivatives
- oxide inhibitors
- Prior art date
Links
- 229940123134 Nitric oxide inhibitor Drugs 0.000 title 1
- 150000001409 amidines Chemical class 0.000 title 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
- 239000000236 nitric oxide synthase inhibitor Substances 0.000 abstract 1
- CSYSULGPHGCBQD-UHFFFAOYSA-N s-ethylisothiouronium diethylphosphate Chemical compound CCSC(N)=N.CCOP(O)(=O)OCC CSYSULGPHGCBQD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13997093A | 1993-10-21 | 1993-10-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT724435E true PT724435E (pt) | 2002-11-29 |
Family
ID=22489151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT94931858T PT724435E (pt) | 1993-10-21 | 1994-10-18 | Derivados amidino uteis como inibidores de oxido nitrico sintase |
Country Status (11)
Country | Link |
---|---|
US (1) | US5821267A (pt) |
EP (1) | EP0724435B1 (pt) |
JP (1) | JPH09504524A (pt) |
AT (1) | ATE222100T1 (pt) |
AU (1) | AU8078394A (pt) |
CA (1) | CA2170735A1 (pt) |
DE (1) | DE69431194T2 (pt) |
DK (1) | DK0724435T3 (pt) |
ES (1) | ES2181726T3 (pt) |
PT (1) | PT724435E (pt) |
WO (1) | WO1995011014A1 (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5821267A (en) * | 1993-10-21 | 1998-10-13 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
EP0749418B1 (en) * | 1994-03-10 | 2000-08-30 | G.D. Searle & Co. | L-n6 -(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors |
ATE182889T1 (de) * | 1994-05-07 | 1999-08-15 | Astra Ab | Bicyclische amidinderivate als no-synthetase inhibitoren |
US5684008A (en) * | 1994-11-09 | 1997-11-04 | G. D. Searle & Co. | Aminotetrazole derivatives useful as nitric oxide synthase inhibitors |
WO1996021445A1 (en) * | 1995-01-13 | 1996-07-18 | The General Hospital Corporation | Methods of inhibiting neurodegenerative diseases |
US5830917A (en) * | 1995-09-11 | 1998-11-03 | G. D. Searle & Co. | L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors |
US5981511A (en) * | 1996-03-06 | 1999-11-09 | G.D. Searle & Co. | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors |
WO1998030220A1 (en) * | 1997-01-09 | 1998-07-16 | G.D. Searle & Co. | Attenuation of opioid tolerance by inhibiting inducible nitric oxide synthase pathways in the treatment of pain |
AU765072B2 (en) * | 1998-02-09 | 2003-09-11 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines as protease inhibitors, in particular as urokinase inhibitors |
US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
US6552052B2 (en) | 1998-06-10 | 2003-04-22 | Monsanto/G.D. Searle | Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors |
EP1150979A1 (en) * | 1999-02-09 | 2001-11-07 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines as protease inhibitors |
JP2001220386A (ja) | 1999-11-30 | 2001-08-14 | Takeda Chem Ind Ltd | オキサジアゾリン誘導体の製造方法 |
KR100835265B1 (ko) | 2000-03-24 | 2008-06-09 | 파마시아 코포레이션 | 산화 질소 신타아제 억제제로 유용한 아미디노 화합물 및그들의 염 |
US6787668B2 (en) | 2000-04-13 | 2004-09-07 | Pharmacia Corporation | 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
AR030416A1 (es) | 2000-04-13 | 2003-08-20 | Pharmacia Corp | COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA |
AR034120A1 (es) | 2000-04-13 | 2004-02-04 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico |
AR032318A1 (es) | 2000-04-13 | 2003-11-05 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa |
US6956131B2 (en) | 2000-04-13 | 2005-10-18 | Pharmacia Corporation | 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors |
US6545170B2 (en) | 2000-04-13 | 2003-04-08 | Pharmacia Corporation | 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
US7012098B2 (en) | 2001-03-23 | 2006-03-14 | Pharmacia Corporation | Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers |
TW200744658A (en) * | 2005-10-12 | 2007-12-16 | Pentapharm Ag | Topical composition for use as a skin lightener |
US9688668B2 (en) | 2012-02-08 | 2017-06-27 | University Of Virginia Patent Foundation | Long chain base sphingosine kinase inhibitors |
IT202200000347A1 (it) * | 2022-01-12 | 2023-07-12 | Istituti Clinici Scient Maugeri Spa Sb | Composti utili nella prevenzione e/o trattamento di patologie e malattie associate a cellule senescenti. |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3445517A (en) * | 1966-06-03 | 1969-05-20 | Lilly Co Eli | Aryl acetamidines |
GB1188956A (en) * | 1967-07-14 | 1970-04-22 | Delalande Sa | N-Substituted Aromatic Amidines and process for obtaining same |
US3978219A (en) * | 1975-07-25 | 1976-08-31 | Stauffer Chemical Company | Nicotinamidoxime as an anti-inflammatory agent |
US3978202A (en) * | 1975-07-25 | 1976-08-31 | Stauffer Chemical Company | ο-Chlorobenzamidoxime as an anti-inflammatory agent |
JPS59139357A (ja) * | 1983-01-28 | 1984-08-10 | Torii Yakuhin Kk | アミジン誘導体 |
DE3505555A1 (de) * | 1985-02-18 | 1986-09-11 | Behringwerke Ag, 3550 Marburg | Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel |
US5196450A (en) * | 1985-12-19 | 1993-03-23 | Merrell Dow Pharmaceuticals Inc. | Method of inhibiting protozoal growth |
ZA898440B (en) * | 1988-11-10 | 1990-07-25 | Merrell Dow Pharma | Lactamimides in the treatment of drug-resistant protozoal infections |
US5028627A (en) * | 1989-09-13 | 1991-07-02 | Cornell Research Foundation, Inc. | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
US5059712A (en) * | 1989-09-13 | 1991-10-22 | Cornell Research Foundation, Inc. | Isolating aminoarginine and use to block nitric oxide formation in body |
GB8929076D0 (en) * | 1989-12-22 | 1990-02-28 | Scras | Treatment of shock by blocking agents of edrf effect or formation |
AU636713B2 (en) * | 1990-02-26 | 1993-05-06 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of nitric oxide biosynthesis |
CA2089261A1 (en) * | 1990-08-30 | 1992-03-01 | John F.W. Keana | Substituted amidines having high binding to the sigma receptor and the use thereof |
JPH06507392A (ja) * | 1991-02-26 | 1994-08-25 | エイアールシー 1,インコーポレイテッド | 交感神経性の持続性疼痛の治療のための組成物および方法 |
US5273875A (en) * | 1991-03-22 | 1993-12-28 | Cornell Research Foundation, Inc. | N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body |
US5132453A (en) * | 1991-03-22 | 1992-07-21 | Cornell Research Foundation, Inc. | N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body |
US5246965A (en) * | 1991-06-11 | 1993-09-21 | Ciba-Geigy | Arylethers, their manufacture and methods of treatment |
US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
EP0518819B1 (en) * | 1991-06-11 | 1995-08-02 | Ciba-Geigy Ag | Amidino compounds, their manufacture and use as medicament |
EP0600973A1 (en) * | 1991-08-27 | 1994-06-15 | The Upjohn Company | A method for treatment of metabolic disorders and metabolism |
GB9127376D0 (en) * | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
CA2128790A1 (en) * | 1992-01-28 | 1993-08-05 | Abraham Karpas | Use of a compound for the manufacture of a medicament for the treatment of hiv infection |
US5296466A (en) * | 1992-02-19 | 1994-03-22 | Board Of Regents, The University Of Texas System | Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein |
US5340833A (en) * | 1992-05-01 | 1994-08-23 | Eisai Co., Ltd. | Urokinase inhibitors |
US5281627A (en) * | 1992-05-28 | 1994-01-25 | Cornell Research Foundation, Inc. | Substituted arginines and substituted homoarginines and use thereof |
US5350770A (en) * | 1992-07-28 | 1994-09-27 | Elford Howard L | Therapeutic process for the treatment of septic shock |
US5455274A (en) * | 1992-12-09 | 1995-10-03 | Ciba-Geigy Corporation | Hydroxyamidine derivatives |
JPH06287180A (ja) * | 1993-03-31 | 1994-10-11 | Yamanouchi Pharmaceut Co Ltd | アミジノインダゾール誘導体 |
GB9301289D0 (en) * | 1993-01-22 | 1993-03-17 | Smithkline Beecham Plc | Novel composition |
GB9312761D0 (en) * | 1993-06-21 | 1993-08-04 | Wellcome Found | Amino acid derivatives |
US5424447A (en) * | 1993-07-07 | 1995-06-13 | The Medical College Of Wisconsin Research Foundation, Inc. | Heme binding compounds and use thereof |
US5821267A (en) * | 1993-10-21 | 1998-10-13 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
US5364881A (en) * | 1993-11-15 | 1994-11-15 | The Medical College Of Wisconsin Research Foundation, Inc. | S-alkyl-isothioureido-amino acids and use thereof |
US5362744A (en) * | 1993-11-22 | 1994-11-08 | Warner-Lambert Company | Tetrazole-substituted urea acat inhibitors |
US6124351A (en) * | 1994-08-18 | 2000-09-26 | Chugai Seiyaku Kabushiki Kaisha | Amino acid derivatives having a nitric oxide synthase inhibiting action |
-
1994
- 1994-10-18 US US08/604,972 patent/US5821267A/en not_active Expired - Fee Related
- 1994-10-18 JP JP7512100A patent/JPH09504524A/ja active Pending
- 1994-10-18 DK DK94931858T patent/DK0724435T3/da active
- 1994-10-18 PT PT94931858T patent/PT724435E/pt unknown
- 1994-10-18 WO PCT/US1994/011724 patent/WO1995011014A1/en active IP Right Grant
- 1994-10-18 AU AU80783/94A patent/AU8078394A/en not_active Abandoned
- 1994-10-18 EP EP94931858A patent/EP0724435B1/en not_active Expired - Lifetime
- 1994-10-18 ES ES94931858T patent/ES2181726T3/es not_active Expired - Lifetime
- 1994-10-18 CA CA002170735A patent/CA2170735A1/en not_active Abandoned
- 1994-10-18 AT AT94931858T patent/ATE222100T1/de not_active IP Right Cessation
- 1994-10-18 DE DE69431194T patent/DE69431194T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU8078394A (en) | 1995-05-08 |
ES2181726T3 (es) | 2003-03-01 |
CA2170735A1 (en) | 1995-04-27 |
DE69431194T2 (de) | 2002-12-12 |
ATE222100T1 (de) | 2002-08-15 |
JPH09504524A (ja) | 1997-05-06 |
DK0724435T3 (da) | 2002-11-25 |
EP0724435B1 (en) | 2002-08-14 |
US5821267A (en) | 1998-10-13 |
EP0724435A1 (en) | 1996-08-07 |
DE69431194D1 (de) | 2002-09-19 |
WO1995011014A1 (en) | 1995-04-27 |
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