ATE222100T1 - Amidino-derivate nützlich als no synthase-hemmer - Google Patents

Amidino-derivate nützlich als no synthase-hemmer

Info

Publication number
ATE222100T1
ATE222100T1 AT94931858T AT94931858T ATE222100T1 AT E222100 T1 ATE222100 T1 AT E222100T1 AT 94931858 T AT94931858 T AT 94931858T AT 94931858 T AT94931858 T AT 94931858T AT E222100 T1 ATE222100 T1 AT E222100T1
Authority
AT
Austria
Prior art keywords
pct
synthase inhibitors
derivatives useful
amidino derivatives
sec
Prior art date
Application number
AT94931858T
Other languages
English (en)
Inventor
Foe S Tjoeng
Kam F Fok
R Keith Webber
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE222100T1 publication Critical patent/ATE222100T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
AT94931858T 1993-10-21 1994-10-18 Amidino-derivate nützlich als no synthase-hemmer ATE222100T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13997093A 1993-10-21 1993-10-21
PCT/US1994/011724 WO1995011014A1 (en) 1993-10-21 1994-10-18 Amidino derivatives useful as nitric oxide synthase inhibitors

Publications (1)

Publication Number Publication Date
ATE222100T1 true ATE222100T1 (de) 2002-08-15

Family

ID=22489151

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94931858T ATE222100T1 (de) 1993-10-21 1994-10-18 Amidino-derivate nützlich als no synthase-hemmer

Country Status (11)

Country Link
US (1) US5821267A (de)
EP (1) EP0724435B1 (de)
JP (1) JPH09504524A (de)
AT (1) ATE222100T1 (de)
AU (1) AU8078394A (de)
CA (1) CA2170735A1 (de)
DE (1) DE69431194T2 (de)
DK (1) DK0724435T3 (de)
ES (1) ES2181726T3 (de)
PT (1) PT724435E (de)
WO (1) WO1995011014A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT724435E (pt) * 1993-10-21 2002-11-29 Searle & Co Derivados amidino uteis como inibidores de oxido nitrico sintase
DE69518631T2 (de) * 1994-03-10 2001-01-11 G.D. Searle & Co., Chicago L-n6-(1-iminoethyl)lysin - derivate und ihre verwendung als no-synthase - inhibitoren
CA2188680A1 (en) * 1994-05-07 1996-01-25 James Edwin Macdonald Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
US5684008A (en) * 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
WO1996021445A1 (en) * 1995-01-13 1996-07-18 The General Hospital Corporation Methods of inhibiting neurodegenerative diseases
US5830917A (en) * 1995-09-11 1998-11-03 G. D. Searle & Co. L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
CA2272941A1 (en) * 1997-01-09 1998-07-16 Daniela Salvemini Attenuation of opioid tolerance by inhibiting inducible nitric oxide synthase pathways in the treatment of pain
US6291514B1 (en) * 1998-02-09 2001-09-18 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
NZ506507A (en) * 1998-02-09 2003-08-29 Dimensional Pharm Inc Heteroaryl amidine, methylamidine or guanidine derivatives useful as urokinase inhibitors
US6552052B2 (en) 1998-06-10 2003-04-22 Monsanto/G.D. Searle Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors
BR9917036A (pt) * 1999-02-09 2002-07-30 Dimensional Pharm Inc Amidinas heteroarila, metilamidinas e guanidinas como inibidores de protease
JP2001220386A (ja) 1999-11-30 2001-08-14 Takeda Chem Ind Ltd オキサジアゾリン誘導体の製造方法
JP4216502B2 (ja) 2000-03-24 2009-01-28 ファルマシア コーポレーション 酸化窒素シンターゼ阻害剤として有用なアミジノ化合物
AR032318A1 (es) 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
US6956131B2 (en) 2000-04-13 2005-10-18 Pharmacia Corporation 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
US6545170B2 (en) 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
US6787668B2 (en) 2000-04-13 2004-09-07 Pharmacia Corporation 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR030416A1 (es) 2000-04-13 2003-08-20 Pharmacia Corp COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
AR034120A1 (es) 2000-04-13 2004-02-04 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
TW200744658A (en) * 2005-10-12 2007-12-16 Pentapharm Ag Topical composition for use as a skin lightener
US9688668B2 (en) 2012-02-08 2017-06-27 University Of Virginia Patent Foundation Long chain base sphingosine kinase inhibitors
IT202200000347A1 (it) * 2022-01-12 2023-07-12 Istituti Clinici Scient Maugeri Spa Sb Composti utili nella prevenzione e/o trattamento di patologie e malattie associate a cellule senescenti.

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3445517A (en) * 1966-06-03 1969-05-20 Lilly Co Eli Aryl acetamidines
GB1188956A (en) * 1967-07-14 1970-04-22 Delalande Sa N-Substituted Aromatic Amidines and process for obtaining same
US3978219A (en) * 1975-07-25 1976-08-31 Stauffer Chemical Company Nicotinamidoxime as an anti-inflammatory agent
US3978202A (en) * 1975-07-25 1976-08-31 Stauffer Chemical Company ο-Chlorobenzamidoxime as an anti-inflammatory agent
JPS59139357A (ja) * 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
US5196450A (en) * 1985-12-19 1993-03-23 Merrell Dow Pharmaceuticals Inc. Method of inhibiting protozoal growth
ZA898440B (en) * 1988-11-10 1990-07-25 Merrell Dow Pharma Lactamimides in the treatment of drug-resistant protozoal infections
US5059712A (en) * 1989-09-13 1991-10-22 Cornell Research Foundation, Inc. Isolating aminoarginine and use to block nitric oxide formation in body
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
GB8929076D0 (en) * 1989-12-22 1990-02-28 Scras Treatment of shock by blocking agents of edrf effect or formation
CA2036770C (en) * 1990-02-26 2003-09-09 Jeffrey P. Whitten Inhibitors of nitric oxide biosynthesis
CA2089261A1 (en) * 1990-08-30 1992-03-01 John F.W. Keana Substituted amidines having high binding to the sigma receptor and the use thereof
JPH06507392A (ja) * 1991-02-26 1994-08-25 エイアールシー　１，インコーポレイテッド 交感神経性の持続性疼痛の治療のための組成物および方法
US5273875A (en) * 1991-03-22 1993-12-28 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
US5132453A (en) * 1991-03-22 1992-07-21 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
ES2075672T3 (es) * 1991-06-11 1995-10-01 Ciba Geigy Ag Amidinocompuestos, su fabricacion y uso como medicamento.
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
US5246965A (en) * 1991-06-11 1993-09-21 Ciba-Geigy Arylethers, their manufacture and methods of treatment
AU664710B2 (en) * 1991-08-27 1995-11-30 Upjohn Company, The A method for treatment of metabolic disorders
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
AU665052B2 (en) * 1992-01-28 1995-12-14 Abraham Karpas The use of a compound for the manufacture of a medicament for the treatment of HIV infection
US5296466A (en) * 1992-02-19 1994-03-22 Board Of Regents, The University Of Texas System Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein
US5340833A (en) * 1992-05-01 1994-08-23 Eisai Co., Ltd. Urokinase inhibitors
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof
US5350770A (en) * 1992-07-28 1994-09-27 Elford Howard L Therapeutic process for the treatment of septic shock
US5455274A (en) * 1992-12-09 1995-10-03 Ciba-Geigy Corporation Hydroxyamidine derivatives
JPH06287180A (ja) * 1993-03-31 1994-10-11 Yamanouchi Pharmaceut Co Ltd アミジノインダゾール誘導体
GB9301289D0 (en) * 1993-01-22 1993-03-17 Smithkline Beecham Plc Novel composition
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
US5424447A (en) * 1993-07-07 1995-06-13 The Medical College Of Wisconsin Research Foundation, Inc. Heme binding compounds and use thereof
PT724435E (pt) * 1993-10-21 2002-11-29 Searle & Co Derivados amidino uteis como inibidores de oxido nitrico sintase
US5364881A (en) * 1993-11-15 1994-11-15 The Medical College Of Wisconsin Research Foundation, Inc. S-alkyl-isothioureido-amino acids and use thereof
US5362744A (en) * 1993-11-22 1994-11-08 Warner-Lambert Company Tetrazole-substituted urea acat inhibitors
AU3230895A (en) * 1994-08-18 1996-03-14 Chugai Seiyaku Kabushiki Kaisha Amino acid derivative having nitrogen monoxide synthetase inhibitor activity

Also Published As

Publication number Publication date
DE69431194T2 (de) 2002-12-12
DK0724435T3 (da) 2002-11-25
JPH09504524A (ja) 1997-05-06
WO1995011014A1 (en) 1995-04-27
ES2181726T3 (es) 2003-03-01
DE69431194D1 (de) 2002-09-19
CA2170735A1 (en) 1995-04-27
PT724435E (pt) 2002-11-29
US5821267A (en) 1998-10-13
AU8078394A (en) 1995-05-08
EP0724435A1 (de) 1996-08-07
EP0724435B1 (de) 2002-08-14

Similar Documents

Publication Publication Date Title
ATE222100T1 (de) Amidino-derivate nützlich als no synthase-hemmer
NZ305799A (en) Cyclic amidino agents useful as nitric oxide synthase inhibitors
NO942064L (no) yminhibitorer
EP0528858A4 (en) Inhibitors of dipeptidyl-aminopeptidase type iv
ATE297898T1 (de) 4-carboxamino-2-subsitutierte-1,2,3,4- tetrahydrochinoline als cetp inhibitoren
ATE277906T1 (de) 4-carboxamino-2-methyl-1,2,3,4- tetrahydrochinoline als cetp inhibitoren
UA34466C2 (uk) Засіб для несистемної боротьби з паразитуючими комахами
TW353067B (en) Isoquinolines
MX9700557A (es) Dihidrobenzofuranos.
TR199800077T1 (xx) Kontroll� ��z�len paroksetin terkipleri.
AU2291097A (en) Novel phenanthridines substituted in the 6 position
BR9608873A (pt) Inibidores de selectina de moléculas pequenas di e trivalentes
DE69703201D1 (de) Hydroxyamidinderivate verwendbar als stickoxidsynthese inhibitoren
ZA949151B (en) 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents.
TW351718B (en) Acylated aminoalkanimidazoles and -triazoles
NO983802L (no) Benzothiofener, formuleringer inneholdende samme og fremgangsmåter
GB2324091A (en) Metalloproteinase inhibitors
ATE183100T1 (de) Neuartige glukohydrolase-inhibitoren nützlich als antidiabetische, antivirale und antimetastatische mittel
NO944487D0 (no) 8-klor-11[1-[(5-metyl-3-pyridyl)metylÅ-4-piperidylidenÅ-6,11-dihydro-5H-benzo[5,6Åsyklohepta-[1,2-bÅpyridinfumarat
TW328951B (en) Substituted 2-phenylpyridines
ATE68486T1 (de) 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl - 1h-imidazol.
RS47804A (en) 1,3-diarylprop-2-en-1-ones, compositions containing same and use thereof
FR2682064B1 (fr) Imprimante, en particulier imprimante de bureau portative.
UA33951A (uk) Вольфрамат 1,2,3-бензотриазолію як інгібітор малоциклового корозійно-втомного руйнування металів в нейтральних середовищах
IT231374Y1 (it) Sedile, particolarmente per pianisti

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee