ATE297898T1 - 4-carboxamino-2-subsitutierte-1,2,3,4- tetrahydrochinoline als cetp inhibitoren - Google Patents
4-carboxamino-2-subsitutierte-1,2,3,4- tetrahydrochinoline als cetp inhibitorenInfo
- Publication number
- ATE297898T1 ATE297898T1 AT99940424T AT99940424T ATE297898T1 AT E297898 T1 ATE297898 T1 AT E297898T1 AT 99940424 T AT99940424 T AT 99940424T AT 99940424 T AT99940424 T AT 99940424T AT E297898 T1 ATE297898 T1 AT E297898T1
- Authority
- AT
- Austria
- Prior art keywords
- tetrahydrocinolines
- carboxamino
- subsituted
- cetp inhibitors
- cetp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10086098P | 1998-09-17 | 1998-09-17 | |
PCT/IB1999/001532 WO2000017164A1 (en) | 1998-09-17 | 1999-09-10 | 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines as cetp inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE297898T1 true ATE297898T1 (de) | 2005-07-15 |
Family
ID=22281914
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99940424T ATE297898T1 (de) | 1998-09-17 | 1999-09-10 | 4-carboxamino-2-subsitutierte-1,2,3,4- tetrahydrochinoline als cetp inhibitoren |
Country Status (47)
Families Citing this family (126)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7906153B2 (en) * | 1998-04-08 | 2011-03-15 | Theta Biomedical Consulting & Development Co., Inc. | Anti-inflammatory compositions for treating multiple sclerosis |
US6984667B2 (en) * | 1998-04-08 | 2006-01-10 | Theta Biomedical Consulting And Development Co. | Synergistic proteoglycan compositions for inflammatory conditions |
US20050220909A1 (en) * | 2004-03-30 | 2005-10-06 | Theoharides Theoharis C | Composition for protection against superficial vasodilator flush syndrome |
US7799766B2 (en) * | 1998-04-08 | 2010-09-21 | Theta Biomedical Consulting & Development Co., Inc. | Composition for treating hormonally-dependent cancers |
US20080153761A1 (en) * | 1998-04-08 | 2008-06-26 | Theoharides Theoharis C | Compositions for protection against superficial vasodilator flush syndrome, and methods of use |
US6147089A (en) * | 1998-09-17 | 2000-11-14 | Pfizer Inc. | Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
US6197786B1 (en) * | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
US6147090A (en) * | 1998-09-17 | 2000-11-14 | Pfizer Inc. | 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
US20040230559A1 (en) * | 1999-08-09 | 2004-11-18 | Mark Newman | Information processing device and information processing method |
HN2000000203A (es) | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
CO5271716A1 (es) * | 1999-11-30 | 2003-04-30 | Pfizer Prod Inc | Cristales de 4- carboxamino 1,2,3,4-tetrahidroquinolina 2- sustituida |
US7115279B2 (en) * | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
MXPA03001419A (es) * | 2000-08-15 | 2003-06-06 | Pfizer Prod Inc | Combinacion terapeutica de un inhibidor de la proteina de transferencia de esteres de colesterol y atorvastatina. |
JPWO2002022585A1 (ja) * | 2000-09-14 | 2004-01-22 | 科研製薬株式会社 | テトラヒドロキノリン化合物 |
JP3924251B2 (ja) * | 2001-04-30 | 2007-06-06 | ファイザー・プロダクツ・インク | Cetp阻害剤の製造法 |
OA12619A (en) * | 2001-06-21 | 2006-06-12 | Pfizer Prod Inc | Self-emulsifying formulations of cholesteryl estertransfer protein inhibitors. |
JP2004534812A (ja) | 2001-06-22 | 2004-11-18 | ファイザー・プロダクツ・インク | 薬物および中性ポリマーの分散物の医薬組成物 |
JP2005500313A (ja) | 2001-06-22 | 2005-01-06 | ファイザー・プロダクツ・インク | 基材中の低可溶性薬物の固体分散体および溶解度向上性ポリマーを含有する医薬品組成物 |
AU2002302903B2 (en) * | 2001-06-22 | 2007-05-17 | Pfizer Products Inc. | Pharmaceutical compositions of adsorbates of amorphous drug |
BR0211028A (pt) * | 2001-06-22 | 2004-06-15 | Pfizer Prod Inc | Solução aquosa, método para formação de associações de fármaco e polìmero, composições farmacêuticas, método para formação de uma composição farmacêutica e produto |
EP1269994A3 (de) | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmazeutische Zusammensetzungen die ein Arzneimittel und die Konzentration verbesserende Polymere enthalten |
GT200200170A (es) * | 2001-09-28 | 2003-05-23 | Preparacion de inhibidor de cetp anhidro | |
WO2003053368A2 (en) * | 2001-12-19 | 2003-07-03 | Atherogenics, Inc. | Chalcone derivatives and their use to treat diseases |
US7202247B2 (en) | 2001-12-19 | 2007-04-10 | Atherogenics, Inc. | 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders |
BR0307332A (pt) * | 2002-02-01 | 2004-12-07 | Pfizer Prod Inc | Formas de dosagem farmacêuticas de liberação controlada de um inibidor da proteìna de transferência do éster de colesterol |
BR0307516A (pt) * | 2002-02-01 | 2004-12-07 | Pfizer Prod Inc | Formas de dosagem de liberação imediata contendo dispersões de uma droga sólida |
AR038375A1 (es) | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo |
BR0307333A (pt) | 2002-02-01 | 2004-12-07 | Pfizer Prod Inc | Métodos para a preparação de dispersões homogéneas de fármacos sólidos amorfos atomizados utilizando um sistema de secagem por pulverização |
EP1469832B2 (de) | 2002-02-01 | 2016-10-26 | Bend Research, Inc. | Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien |
US7071210B2 (en) * | 2002-07-02 | 2006-07-04 | Pfizer Inc. | CETP inhibitors in combination with antihypertensive agents and uses thereof |
US20040053842A1 (en) * | 2002-07-02 | 2004-03-18 | Pfizer Inc. | Methods of treatment with CETP inhibitors and antihypertensive agents |
KR100634195B1 (ko) | 2002-08-30 | 2006-10-16 | 니뽄 다바코 산교 가부시키가이샤 | 디벤질아민 화합물 및 그 의약 용도 |
US7504508B2 (en) * | 2002-10-04 | 2009-03-17 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
CA2500582A1 (en) * | 2002-10-04 | 2004-04-22 | Millennium Pharmaceuticals, Inc. | Pgd2 receptor antagonists for the treatment of inflammatory diseases |
US20090181966A1 (en) * | 2002-10-04 | 2009-07-16 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
DE60305724T2 (de) * | 2002-10-21 | 2006-11-09 | Warner-Lambert Co. Llc | Tetrahydrochinolin-derivate als crth2 antagonisten |
US20040181075A1 (en) * | 2002-12-19 | 2004-09-16 | Weingarten M. David | Process of making chalcone derivatives |
AU2003283769A1 (en) * | 2002-12-20 | 2004-07-14 | Pfizer Products Inc. | Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor |
WO2004056359A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Products Inc. | Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor |
US20040132771A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Inc | Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors |
WO2004072046A2 (en) * | 2003-02-12 | 2004-08-26 | Carex S.A. | Quinoline derivatives and their use for modulation of lxr activity |
WO2004072042A2 (en) * | 2003-02-12 | 2004-08-26 | Carex S.A. | Quinoline derivative and their use for modulation of lxr activity |
CN1761463A (zh) * | 2003-03-17 | 2006-04-19 | 日本烟草产业株式会社 | 提高s-[2-([[1-(2-乙基丁基)环己基]羰基]氨基)苯基]-2-甲基丙硫代酸酯口服生物利用度的方法 |
KR100857759B1 (ko) * | 2003-03-17 | 2008-09-09 | 니뽄 다바코 산교 가부시키가이샤 | Cetp 억제제의 약제학적 조성물 |
EP1603554A1 (de) * | 2003-03-17 | 2005-12-14 | Japan Tobacco Inc. | Methode zur verbesserung der oralen bioverfuegbarkeit von s-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]-2-methylpropanthioat |
US20040204450A1 (en) * | 2003-03-28 | 2004-10-14 | Pfizer Inc | Quinoline and quinoxaline compounds |
TWI494102B (zh) * | 2003-05-02 | 2015-08-01 | Japan Tobacco Inc | 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合 |
CA2753318A1 (en) * | 2003-05-30 | 2004-12-09 | Ranbaxy Laboratories Limited | Substituted pyrrole derivatives |
JP2007501217A (ja) * | 2003-08-04 | 2007-01-25 | ファイザー・プロダクツ・インク | コレステリルエステル転送タンパク質阻害剤を制御放出し、そしてHMG−CoAレダクターゼ阻害剤を即時放出する投薬形態 |
CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
ATE540671T1 (de) * | 2003-08-04 | 2012-01-15 | Bend Res Inc | Pharmazeutische zusammensetzungen von adsorbaten von amorphen arzneimitteln und lipophilen mikrophasen-bildenden materialien |
JP4536061B2 (ja) | 2003-09-26 | 2010-09-01 | 日本たばこ産業株式会社 | レムナントリポ蛋白生成阻害方法 |
BRPI0414671A (pt) * | 2003-09-30 | 2006-11-21 | Pfizer Prod Inc | inibidores da cetp e metabolitos dos mesmos |
SI1670768T1 (sl) * | 2003-10-08 | 2010-01-29 | Lilly Co Eli | Spojine in metode za zdravljenje dislipidemije |
ATE428411T1 (de) * | 2003-11-07 | 2009-05-15 | Jj Pharma Inc | Hdl-verstärkende kombinationstherapie-komplexe |
US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
DE602005008416D1 (de) | 2004-03-26 | 2008-09-04 | Lilly Co Eli | Verbindungen zur behandlung von dyslipidemie |
US7923043B2 (en) * | 2004-03-30 | 2011-04-12 | Theta Biomedical Consulting & Development Co., Inc. | Method for protecting humans against superficial vasodilator flush syndrome |
MY139887A (en) * | 2004-04-02 | 2009-11-30 | Mitsubishi Tanabe Pharma Corp | Tetrahydronaphthyridine derivatives and a process for preparing the same. |
UA90269C2 (ru) * | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
KR20070041452A (ko) * | 2004-06-24 | 2007-04-18 | 일라이 릴리 앤드 캄파니 | 이상지혈증 치료를 위한 화합물 및 방법 |
US20060063828A1 (en) * | 2004-06-28 | 2006-03-23 | Weingarten M D | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof |
US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
WO2006033001A1 (en) * | 2004-09-23 | 2006-03-30 | Pfizer Products Inc. | Quinoline compounds |
CA2624601C (en) | 2004-10-06 | 2018-07-03 | The Brigham And Women's Hospital, Inc. | Relevance of achieved levels of markers of systemic inflammation following treatment |
RU2007115900A (ru) | 2004-10-27 | 2008-11-10 | Дайити Санкио Компани, Лимитед (Jp) | Производные бензола, имеющие 2 или более заместителей |
CA2590533C (en) * | 2004-11-23 | 2010-09-07 | Warner-Lambert Company Llc | 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia |
US7700774B2 (en) | 2004-12-20 | 2010-04-20 | Dr. Reddy's Laboratories Ltd. | Heterocyclic compounds and their pharmaceutical compositions |
WO2006082518A1 (en) | 2005-02-03 | 2006-08-10 | Pfizer Products Inc. | Pharmaceutical compositions with enhanced performance |
ZA200707498B (en) * | 2005-02-24 | 2008-11-26 | Millennium Pharm Inc | PGD2 receptor antagonists for the treatment of inflammatory diseases |
WO2006098394A1 (ja) * | 2005-03-14 | 2006-09-21 | Japan Tobacco Inc. | 脂質吸収抑制方法および脂質吸収抑制剤 |
US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
JP4681526B2 (ja) * | 2005-09-29 | 2011-05-11 | 田辺三菱製薬株式会社 | 医薬組成物 |
EP1948599A1 (de) * | 2005-11-08 | 2008-07-30 | Ranbaxy Laboratories Limited | Verfahren zur herstellung von (3r,5r)-7-[2-(4-fluorphenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxymethylphenylamino)carbonyl]pyrrol-1-yl]-3,5-dihydroxyheptansäure-hemicalciumsalz |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
UY30117A1 (es) | 2006-01-31 | 2007-06-29 | Tanabe Seiyaku Co | Compuesto amina trisustituido |
UY30118A1 (es) * | 2006-01-31 | 2007-06-29 | Tanabe Seiyaku Co | Compueto amina trisustituido |
US20070238716A1 (en) * | 2006-03-14 | 2007-10-11 | Murthy Ayanampudi S R | Statin stabilizing dosage formulations |
TW200808731A (en) * | 2006-03-30 | 2008-02-16 | Tanabe Seiyaku Co | A process for preparing tetrahydroquinoline derivatives |
US20100029716A1 (en) * | 2006-04-10 | 2010-02-04 | Concert Pharmaceuticals, Inc. | Novel 1,2,3,4- tetrahydroquinoline derivatives |
JP2009543773A (ja) * | 2006-07-14 | 2009-12-10 | ランバクシー ラボラトリーズ リミテッド | HMG−CoAレダクターゼ阻害剤の多形体及びその使用 |
US7750019B2 (en) | 2006-08-11 | 2010-07-06 | Kowa Company, Ltd. | Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same |
ITMI20062254A1 (it) * | 2006-11-24 | 2008-05-25 | Acraf | Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca |
ATE547394T1 (de) | 2006-12-01 | 2012-03-15 | Bristol Myers Squibb Co | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen |
WO2008112166A2 (en) | 2007-03-09 | 2008-09-18 | Indigene Pharmaceuticals Inc. | Combination of metformin r-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications |
US7790737B2 (en) | 2007-03-13 | 2010-09-07 | Kowa Company, Ltd. | Substituted pyrimidine compounds and their utility as CETP inhibitors |
EP2136637B1 (de) | 2007-03-16 | 2015-11-11 | Concert Pharmaceuticals, Inc. | Hemmer des cholesterinestertransferproteins |
JP5244095B2 (ja) | 2007-04-13 | 2013-07-24 | 興和株式会社 | 新規なジベンジルアミン構造を有するピリミジン化合物及びこれを含有する医薬 |
JP4846769B2 (ja) * | 2007-07-30 | 2011-12-28 | 田辺三菱製薬株式会社 | 医薬組成物 |
US20110243940A1 (en) | 2008-12-16 | 2011-10-06 | Schering Corporation | Bicyclic pyranone derivatives and methods of use thereof |
WO2010075068A1 (en) | 2008-12-16 | 2010-07-01 | Schering Corporation | Pyridopyrimidine derivatives and methods of use thereof |
EA201101621A1 (ru) | 2009-05-15 | 2012-05-30 | Новартис Аг | Производные бензоксазолона в качестве ингибиторов альдостеронсинтазы |
CN104892502B (zh) | 2009-05-15 | 2017-08-04 | 诺华股份有限公司 | 作为醛固酮合酶抑制剂的芳基吡啶 |
SG176010A1 (en) | 2009-05-28 | 2011-12-29 | Novartis Ag | Substituted aminobutyric derivatives as neprilysin inhibitors |
DK2435409T3 (da) | 2009-05-28 | 2014-10-27 | Novartis Ag | Substituerede aminopropionsyrederivater som neprilysininhibitorer |
AR077208A1 (es) | 2009-06-30 | 2011-08-10 | Lilly Co Eli | Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam |
US9176146B2 (en) * | 2009-08-03 | 2015-11-03 | Theta Biomedical Consulting & Development Co., Inc. | Methods of treating autism spectrum disorders and compositions for same |
US9050275B2 (en) * | 2009-08-03 | 2015-06-09 | Theta Biomedical Consulting & Development Co., Inc. | Methods of screening for and treating autism spectrum disorders and compositions for same |
EP2501678B1 (de) | 2009-11-17 | 2015-09-23 | Novartis AG | Aryl-pyridin derivate als aldosteron synthase hemmer |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
WO2011064376A1 (en) | 2009-11-30 | 2011-06-03 | Novartis Ag | Imidazole derivatives as aldosterone synthase inhibitors |
CN102869667A (zh) | 2010-02-19 | 2013-01-09 | 贝林格尔.英格海姆国际有限公司 | 三环吡啶衍生物、包含此化合物的药物、其用途及其制备方法 |
US20130072519A1 (en) | 2010-05-21 | 2013-03-21 | Edward Lee Conn | 2-phenyl benzoylamides |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
EP2668507B1 (de) | 2011-01-26 | 2017-08-23 | INSERM - Institut National de la Santé et de la Recherche Médicale | Verfahren zur prüfung des risikos einer herz-kreislauf-erkrankung eines patienten |
EP2675811A1 (de) | 2011-02-17 | 2013-12-25 | Boehringer Ingelheim International GmbH | Tricyclische pyridinderivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür |
EP2680874A2 (de) | 2011-03-04 | 2014-01-08 | Pfizer Inc | Edn3-ähnliche peptide und ihre verwendung |
TWI537262B (zh) * | 2011-08-17 | 2016-06-11 | 美國禮來大藥廠 | 供治療糖尿病使用之新穎1,2,3,4-四氫喹啉衍生物 |
WO2013024130A1 (en) | 2011-08-17 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation |
WO2013080999A1 (ja) | 2011-11-29 | 2013-06-06 | 興和株式会社 | NPC1L1及び/又はLIPG mRNAの発現抑制剤並びに肥満症の予防及び/又は治療剤 |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
JP6295277B2 (ja) | 2013-02-14 | 2018-03-14 | ノバルティス アーゲー | Nep(中性エンドペプチダーゼ)阻害剤としての置換ビスフェニルブタン酸ホスホン酸誘導体 |
WO2014170786A1 (en) | 2013-04-17 | 2014-10-23 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
SG11201600211XA (en) | 2013-07-25 | 2016-02-26 | Novartis Ag | Cyclic polypeptides for the treatment of heart failure |
BR112016001376A2 (pt) | 2013-07-25 | 2017-10-24 | Novartis Ag | bioconjugados de polipeptídeos de apelin sintéticos |
WO2016016157A1 (en) | 2014-07-30 | 2016-02-04 | F. Hoffmann-La Roche Ag | Genetic markers for predicting responsiveness to therapy with hdl-raising or hdl mimicking agent |
KR102572626B1 (ko) * | 2014-08-12 | 2023-08-30 | 뉴암스테르담 파마 비.브이. | 테트라하이드로퀴놀린 유도체 제조용의 합성 중간체를 제조하기 위한 방법 |
MX2017002610A (es) | 2014-08-29 | 2017-10-11 | Tes Pharma S R L | INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA. |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
EA201791668A1 (ru) | 2015-01-23 | 2017-11-30 | Новартис Аг | Синтетические конъюгаты апелина с жирной кислотой с улучшенным периодом полураспада |
JOP20190086A1 (ar) | 2016-10-21 | 2019-04-18 | Novartis Ag | مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
WO2020150473A2 (en) | 2019-01-18 | 2020-07-23 | Dogma Therapeutics, Inc. | Pcsk9 inhibitors and methods of use thereof |
AR127698A1 (es) | 2021-11-23 | 2024-02-21 | Novartis Ag | Derivados de naftiridinona para el tratamiento de una enfermedad o un trastorno |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5231402A (en) * | 1985-04-02 | 1993-07-27 | Telefunken Systemtechnik Gmbh | Method for detecting and classifying helicopters |
US5231102A (en) | 1989-03-08 | 1993-07-27 | Merck Sharp & Dohme, Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
EP0386839B1 (de) * | 1989-03-08 | 1997-01-15 | Merck Sharp & Dohme Ltd. | Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten |
US5276168A (en) * | 1990-06-18 | 1994-01-04 | E. R. Squibb & Sons, Inc. | Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents |
US5401848A (en) * | 1990-11-26 | 1995-03-28 | E. R. Squibb & Sons, Inc. | Indane and quinoline derivatives |
JPH0676403B2 (ja) | 1991-01-18 | 1994-09-28 | エスエス製薬株式会社 | 新規なベンゾ[5,6 シクロヘプタ[1,2−b ピリジン誘導体及びこれを含有する抗アレルギー剤 |
US5288725A (en) | 1992-10-15 | 1994-02-22 | Merck & Co., Inc. | Pyrroloquinoline Bradykinin antagonist |
HRP970330B1 (en) | 1996-07-08 | 2004-06-30 | Bayer Ag | Cycloalkano pyridines |
DE19627431A1 (de) | 1996-07-08 | 1998-01-15 | Bayer Ag | Heterocyclisch kondensierte Pyridine |
US6170342B1 (en) * | 1997-05-19 | 2001-01-09 | Particle Science | Spiral sampler |
GT199900147A (es) * | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
US6147090A (en) * | 1998-09-17 | 2000-11-14 | Pfizer Inc. | 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
US6140342A (en) * | 1998-09-17 | 2000-10-31 | Pfizer Inc. | Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines |
US6147089A (en) * | 1998-09-17 | 2000-11-14 | Pfizer Inc. | Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
US6197786B1 (en) * | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
US6462091B1 (en) | 1998-12-23 | 2002-10-08 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications |
JP3924251B2 (ja) * | 2001-04-30 | 2007-06-06 | ファイザー・プロダクツ・インク | Cetp阻害剤の製造法 |
-
1999
- 1999-09-07 US US09/391,152 patent/US6197786B1/en not_active Expired - Fee Related
- 1999-09-08 PA PA19998481401A patent/PA8481401A1/es unknown
- 1999-09-09 HN HN1999000154A patent/HN1999000154A/es unknown
- 1999-09-10 JP JP2000574074A patent/JP3626685B2/ja not_active Expired - Fee Related
- 1999-09-10 EP EP99940424A patent/EP1114031B1/de not_active Expired - Lifetime
- 1999-09-10 BR BR9913810-7A patent/BR9913810A/pt not_active Application Discontinuation
- 1999-09-10 SK SK354-2001A patent/SK3542001A3/sk unknown
- 1999-09-10 NZ NZ509840A patent/NZ509840A/xx unknown
- 1999-09-10 CN CNB998110523A patent/CN1331858C/zh not_active Expired - Fee Related
- 1999-09-10 DE DE69925845T patent/DE69925845T2/de not_active Expired - Fee Related
- 1999-09-10 GT GT199900150A patent/GT199900150A/es unknown
- 1999-09-10 WO PCT/IB1999/001532 patent/WO2000017164A1/en active IP Right Grant
- 1999-09-10 AP APAP/P/2001/002101A patent/AP1346A/en active
- 1999-09-10 CO CO99057642A patent/CO5370678A1/es not_active Application Discontinuation
- 1999-09-10 ID IDW20010622A patent/ID28026A/id unknown
- 1999-09-10 IL IL14150599A patent/IL141505A0/xx not_active IP Right Cessation
- 1999-09-10 AR ARP990104555A patent/AR021481A1/es active IP Right Grant
- 1999-09-10 EA EA200100202A patent/EA004674B1/ru unknown
- 1999-09-10 CA CA002344350A patent/CA2344350C/en not_active Expired - Fee Related
- 1999-09-10 AT AT99940424T patent/ATE297898T1/de not_active IP Right Cessation
- 1999-09-10 GE GEAP19995805A patent/GEP20033051B/en unknown
- 1999-09-10 DK DK99940424T patent/DK1114031T3/da active
- 1999-09-10 HU HU0103506A patent/HUP0103506A3/hu unknown
- 1999-09-10 PT PT99940424T patent/PT1114031E/pt unknown
- 1999-09-10 AU AU54401/99A patent/AU752566B2/en not_active Ceased
- 1999-09-10 CZ CZ2001955A patent/CZ2001955A3/cs unknown
- 1999-09-10 ES ES99940424T patent/ES2243069T3/es not_active Expired - Lifetime
- 1999-09-10 MY MYPI99003917A patent/MY130670A/en unknown
- 1999-09-10 KR KR10-2001-7003402A patent/KR100428330B1/ko not_active IP Right Cessation
- 1999-09-10 PE PE1999000921A patent/PE20001069A1/es not_active Application Discontinuation
- 1999-09-10 PL PL99347099A patent/PL347099A1/xx not_active Application Discontinuation
- 1999-09-10 OA OA1200100061A patent/OA11650A/en unknown
- 1999-09-10 EE EEP200100166A patent/EE200100166A/xx unknown
- 1999-09-10 TR TR2001/00768T patent/TR200100768T2/xx unknown
- 1999-09-10 TW TW088115687A patent/TWI242007B/zh not_active IP Right Cessation
- 1999-09-10 YU YU16501A patent/YU16501A/sh unknown
- 1999-09-13 DZ DZ990190A patent/DZ2890A1/xx active
- 1999-09-13 MA MA25765A patent/MA26688A1/fr unknown
- 1999-09-13 TN TNTNSN99171A patent/TNSN99171A1/fr unknown
- 1999-10-09 UA UA2001031790A patent/UA68390C2/uk unknown
-
2000
- 2000-09-10 CU CU20010050A patent/CU23082A3/es unknown
- 2000-10-10 US US09/685,380 patent/US6586448B1/en not_active Expired - Fee Related
-
2001
- 2001-02-14 CR CR6310A patent/CR6310A/es unknown
- 2001-02-19 IL IL141505A patent/IL141505A/en unknown
- 2001-02-23 IS IS5859A patent/IS5859A/is unknown
- 2001-03-16 HR HR20010201A patent/HRP20010201A2/hr not_active Application Discontinuation
- 2001-03-16 NO NO20011350A patent/NO318830B1/no unknown
- 2001-04-10 BG BG105428A patent/BG65125B1/bg unknown
-
2002
- 2002-02-26 HK HK02101439.5A patent/HK1040243A1/zh unknown
-
2003
- 2003-06-27 US US10/607,640 patent/US6906082B2/en not_active Expired - Fee Related
-
2004
- 2004-08-18 JP JP2004238309A patent/JP2004339239A/ja active Pending
-
2005
- 2005-06-13 US US11/152,753 patent/US20050245570A1/en not_active Abandoned
-
2006
- 2006-01-26 IL IL173393A patent/IL173393A0/en unknown
- 2006-04-12 JP JP2006109338A patent/JP2006188542A/ja not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE297898T1 (de) | 4-carboxamino-2-subsitutierte-1,2,3,4- tetrahydrochinoline als cetp inhibitoren | |
ATE277906T1 (de) | 4-carboxamino-2-methyl-1,2,3,4- tetrahydrochinoline als cetp inhibitoren | |
DE69917790D1 (de) | 4-amino substituierte -2-subsituierte-1,2,3,4-tetrahydrochinoline als cetp inhibitoren | |
ATE254106T1 (de) | Cycloalkano-pyridine als cetp-inhibitoren | |
ID29241A (id) | Turunan-turunan kinolin teranelasi-1,2 | |
CU23049A3 (es) | Dihidropirimidinas. | |
ID28874A (id) | Inhibitor fosfodiesterase 4 turunan ftalazina. | |
ATE387448T1 (de) | 4,5-pyrazinoxindole als proteinkinasehemmer | |
ID26909A (id) | Turunan-turunan 1,3,4-oksadiazolon | |
ATE317396T1 (de) | 14,15-beta-methylen substituierte androgene | |
ATE234839T1 (de) | 4,5-azolo-oxindole | |
ID26368A (id) | Turunan-turunan 2 deoksi higromisin | |
NO980270L (no) | Trekkanordning | |
DE60017150D1 (de) | 1,4,5,6 -tetrahydropyrimidine-derivative als vitronectin-hemmer | |
NO981550D0 (no) | Trekkanordning | |
ES1039413Y (es) | Nueva ficha-deportista. | |
ES1040631Y (es) | Nuevo cepillo-baqueta. | |
ES1040173Y (es) | Nuevo bigudi. | |
IT1302206B1 (it) | Molletta per il bucato. | |
ES1040336Y (es) | Lingote mejorado. | |
DE29802738U1 (de) | Triebstock-Segment | |
ES1041021Y (es) | Antifaz magnetico. | |
ES1042117Y (es) | Mesa-sombrilla. | |
ES1040633Y (es) | Escalifono. | |
ES1039730Y (es) | Rodapie. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1114031 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |