DE69016667T2 - Stabilisierte komplexe bestehend aus stickoxyd/primäre amine zur verwendung als kardiovaskuläre wirkstoffe. - Google Patents

Stabilisierte komplexe bestehend aus stickoxyd/primäre amine zur verwendung als kardiovaskuläre wirkstoffe.

Info

Publication number
DE69016667T2
DE69016667T2 DE69016667T DE69016667T DE69016667T2 DE 69016667 T2 DE69016667 T2 DE 69016667T2 DE 69016667 T DE69016667 T DE 69016667T DE 69016667 T DE69016667 T DE 69016667T DE 69016667 T2 DE69016667 T2 DE 69016667T2
Authority
DE
Germany
Prior art keywords
stickoxyd
pharmaceutically acceptable
active substances
primary amine
complexes composed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69016667T
Other languages
English (en)
Other versions
DE69016667D1 (de
Inventor
Larry Keefer
David Wink
Tambra Dunams
Joseph Hrabie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
US Department of Commerce
Original Assignee
US Department of Health and Human Services
US Department of Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, US Department of Commerce filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of DE69016667D1 publication Critical patent/DE69016667D1/de
Publication of DE69016667T2 publication Critical patent/DE69016667T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69016667T 1989-02-28 1990-02-27 Stabilisierte komplexe bestehend aus stickoxyd/primäre amine zur verwendung als kardiovaskuläre wirkstoffe. Expired - Fee Related DE69016667T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/316,958 US4954526A (en) 1989-02-28 1989-02-28 Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
PCT/US1990/000888 WO1990009785A1 (en) 1989-02-28 1990-02-27 Stabilized nitric oxide-primary amine complexes useful as cardiovascular agents

Publications (2)

Publication Number Publication Date
DE69016667D1 DE69016667D1 (de) 1995-03-16
DE69016667T2 true DE69016667T2 (de) 1995-06-01

Family

ID=23231459

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69016667T Expired - Fee Related DE69016667T2 (de) 1989-02-28 1990-02-27 Stabilisierte komplexe bestehend aus stickoxyd/primäre amine zur verwendung als kardiovaskuläre wirkstoffe.

Country Status (11)

Country Link
US (1) US4954526A (de)
EP (1) EP0495776B1 (de)
JP (1) JPH07108855B2 (de)
AT (1) ATE117894T1 (de)
AU (1) AU621470B2 (de)
CA (1) CA2046910C (de)
DE (1) DE69016667T2 (de)
DK (1) DK0495776T3 (de)
ES (1) ES2067022T3 (de)
IL (1) IL93556A (de)
WO (1) WO1990009785A1 (de)

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JPS57200372A (en) * 1981-06-04 1982-12-08 Hiroyoshi Hidaka Novel 5-substituted-2-((n-morpholino)-n-nitrosoamino- methyl)oxadiazole derivative and preventing agent for thrombosis containing the same as principal constituent
JPS62175613A (ja) * 1986-01-30 1987-08-01 Yaskawa Electric Mfg Co Ltd アブソリユ−トエンコ−ダ

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JPH04505317A (ja) 1992-09-17
ATE117894T1 (de) 1995-02-15
EP0495776A4 (de) 1992-02-10
EP0495776B1 (de) 1995-02-01
JPH07108855B2 (ja) 1995-11-22
EP0495776A1 (de) 1992-07-29
AU621470B2 (en) 1992-03-12
AU5192290A (en) 1990-09-26
ES2067022T3 (es) 1995-03-16
DE69016667D1 (de) 1995-03-16
US4954526A (en) 1990-09-04
DK0495776T3 (da) 1995-07-03
IL93556A (en) 1996-10-16
IL93556A0 (en) 1990-11-29
WO1990009785A1 (en) 1990-09-07
CA2046910C (en) 1995-04-04

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